Category: 16909-09-4

Veerakanellore, Giri Babu published the artcileSolid-state photochemistry of cis-cinnamic acids: a competition between [2+2] addition and cis-trans isomerization, Recommanded Product: (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, the publication is CrystEngComm (2016), 18(25), 4708-4712, database is CAplus.

With three examples, we have established that cis-cinnamic acids can dimerize via a diradical intermediate in the crystalline state provided that the intermol. distance is less than 4.2 ?. In the excited state of cis-isomers, C-C bond formation with an adjacent mol. competes with geometric isomerization.

CrystEngComm published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C13H10O2, Recommanded Product: (E)-3-(2,4-Dimethoxyphenyl)acrylic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Carreiro, Elisabete Palma published the artcileArylid-OX and Arylid-BOX derived catalysts: applications in catalytic asymmetric cyclopropanation, Recommanded Product: (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, the publication is Tetrahedron: Asymmetry (2009), 20(11), 1272-1278, database is CAplus.

A novel family of chiral non-racemic monodentate oxazoline ligands known as Arylid-OXs I (R = Ph, t-Bu) was prepared in good overall yields. These ligands were screened in bench-mark Cu(I)-catalyzed cyclopropanations and gave ees as high as 58%. Both ¹H NMR and computational studies using I (R= Ph) indicated that the active catalyst was most likely to be the di-coordinated complex, Cu(I)-I (R= Ph)₂ (MeCN)₂. Two novel ortho-substituted Arylid-BOX ligands II (X = Cl, OMe) were also synthesized in very good yields. These ligands were tested in the same reaction as for I (R = Ph, t-Bu) and, although excellent yields could be obtained with II (R = OMe), which is assumed to be due to an electron-donating effect from the ortho-methoxy group, a best ee of only 56% was obtained with II (R = Cl). In fact, both the enantioselectivities and diastereoselectivities obtained with these ortho-substituted ligands were in line with those previously obtained with the para-substituted series.

Tetrahedron: Asymmetry published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C11H12O4, Recommanded Product: (E)-3-(2,4-Dimethoxyphenyl)acrylic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Neggad, Abdelhamid published the artcileA new method of extracting polyphenols from honey using a biosorbent compared to the commercial resin amberlite XAD2, Safety of (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, the publication is Journal of Separation Science (2021), 44(10), 2089-2096, database is CAplus and MEDLINE.

A new extraction method of polyphenols from honey using a biodegradable resin was developed and compared with the common com. resin amberlite XAD2. For this purpose, three honey samples of Algerian origin were selected for the different physicochem. and biochem. parameters study. After extraction of the target compounds by both resins, the polyphenol content was determined, the antioxidant activity was tested, and liquid chromatog.-mass spectrometry analyses were performed for identification and quantification. The results showed that physicochem. and biochem. parameters meet the norms of the International Honey Commission, and the H1 sample seemed to be of high quality. The optimal conditions of extraction by biodegradable resin were a pH of 3, an adsorption dose of 40 g/L, a contact time of 50 min, an extraction temperature of 60°C, and no stirring. The regeneration and reuse number of both resins was three cycles. The polyphenol contents demonstrated a higher extraction efficiency of biosorbent than of XAD2, especially in H1. Liquid chromatog.-mass spectrometry analyses allowed for the identification and quantification of 15 compounds in the different honey samples extracted using both resins and the most abundant compound was 3,4,5-trimethoxybenzoic acid. In addition, the biosorbent extracts showed stronger antioxidant activities than the XAD2 extracts

Journal of Separation Science published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C11H12O4, Safety of (E)-3-(2,4-Dimethoxyphenyl)acrylic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Giel, Marie-Claire published the artcileAminium cation-radical catalyzed selective hydration of (E)-aryl enynes, Application In Synthesis of 16909-09-4, the publication is Chemical Communications (Cambridge, United Kingdom) (2021), 57(57), 6991-6994, database is CAplus and MEDLINE.

The hydration of carbon-carbon triple bonds is an important and atom economic synthetic transformation. Herein, authors report a mild and selective method for the catalytic Markovnikov hydration of (E)-aryl enynes to the corresponding enones, mediated through the bench-stable aminium salt, tris(4-bromophenyl)ammoniumyl hexachloroantimonate (TBPA). The chemoselective and diastereoselective method proceeds under neutral metal-free conditions, delivering excellent product yields from terminal and internal alkyne units. The synthesis of biol. important (E)-3-styrylisocoumarins, including a formal synthesis of the natural product achlisocoumarin III, demonstrates the utility of this novel transformation.

Chemical Communications (Cambridge, United Kingdom) published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C11H12O4, Application In Synthesis of 16909-09-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Peschke, Bernd published the artcileCinnamic amides of (S)-2-(aminomethyl)pyrrolidines are potent H₃ antagonists, Safety of (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, the publication is Bioorganic & Medicinal Chemistry (2004), 12(10), 2603-2616, database is CAplus and MEDLINE.

New imidazole-free H₃ antagonists have been found in a series of cinnamic amides of (S)-(aminomethyl)pyrrolidines. The influence of the substituent on the aromatic moiety on the potency and the inhibition of three cytochrome P 450 subtypes are also described.

Bioorganic & Medicinal Chemistry published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C11H12O4, Safety of (E)-3-(2,4-Dimethoxyphenyl)acrylic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Eudes, Aymerick published the artcileProduction of tranilast [N-(3′,4′-dimethoxycinnamoyl)-anthranilic acid] and its analogs in yeast Saccharomyces cerevisiae, COA of Formula: C11H12O4, the publication is Applied Microbiology and Biotechnology (2011), 89(4), 989-1000, database is CAplus and MEDLINE.

Biol. synthesis of therapeutic drugs beneficial for human health using microbes offers an alternative production strategy to the methods that are commonly employed such as direct extraction from source organisms or chem. synthesis. In this study, we evaluated the potential for yeast (Saccharomyces cerevisiae) to be used as a catalyst for the synthesis of tranilast and various tranilast analogs (cinnamoyl anthranilates). Several studies have demonstrated that these phenolic amides have antioxidant properties and potential therapeutic benefits including antiinflammatory, antiproliferative, and antigenotoxic effects. The few cinnamoyl anthranilates naturally produced in plants such as oats and carnations result from the coupling of various hydroxycinnamoyl-CoAs to anthranilic acid. In order to achieve the microbial production of tranilast and several of its analogs, we engineered a yeast strain to co-express a 4-coumarate/CoA ligase (4CL, EC 6.2.1.12) from Arabidopsis thaliana and a hydroxycinnamoyl/benzoyl-CoA/anthranilate N-hydroxycinnamoyl/benzoyltransferase (HCBT, EC 2.3.1.144) from Dianthus caryophyllus. This modified yeast strain allowed us to produce tranilast and 26 different cinnamoyl anthranilate mols. within a few hours after exogenous supply of various combinations of cinnamic acids and anthranilate derivatives Our data demonstrate the feasibility of rapidly producing a wide range of defined cinnamoyl anthranilates in yeast and underline a potential for the biol. designed synthesis of naturally and non-naturally occurring mols.

Applied Microbiology and Biotechnology published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C11H12O4, COA of Formula: C11H12O4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Swain, Baijayantimala published the artcileNew coumarin/sulfocoumarin linked phenylacrylamides as selective transmembrane carbonic anhydrase inhibitors: Synthesis and in-vitro biological evaluation, COA of Formula: C11H12O4, the publication is Bioorganic & Medicinal Chemistry (2020), 28(15), 115586, database is CAplus and MEDLINE.

Two novel series of phenylacrylamide linked coumarins I [R = H, Me; Ar = Ph, 4-FC₆H₄, 4-MeOC₆H₄, etc.] and sulfocoumarins II [Ar¹ = 4-FC₆H₄, 3-F₃CC₆H₄, 4-NCC₆H₄, etc.] were synthesized and evaluated against four physiol. relevant human carbonic anhydrases (hCAs, EC 4.2.1.1), isoforms hCA I, hCA II, hCA IX and hCA XII for their inhibitory action. Compounds I and II when screened for carbonic anhydrase inhibitory activity, they showned selective inhibition toward the tumor associated isoforms hCA IX and XII over CA I and II, with inhibition constants in the submicromolar to low nanomolar range. Compound I [R = H; Ar = 4-FC₆H₄] and II [Ar¹ = 4-NCC₆H₄] exhibited significant inhibition with low nanomolar potency against hCA IX, whereas I [R = H; Ar = 3,4-(OMe)₂C₆H₃] was effective against hCA XII. Compounds I [R = H; Ar = 4-FC₆H₄, 3,4-(OMe)₂C₆H₃] and II [Ar¹ = 4-NCC₆H₄] might be considered as lead mols. for future development of cancer therapeutics based on a novel mechanism of action.

Bioorganic & Medicinal Chemistry published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C18H14BrNO3, COA of Formula: C11H12O4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

De Simone, Filippo published the artcileCatalytic formal homo-Nazarov cyclization, Application of (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, the publication is Organic Letters (2009), 11(4), 1023-1026, database is CAplus and MEDLINE.

The first catalytic method for the cyclization of vinyl-cyclopropyl ketones (formal homo-Nazarov reaction) is reported. Starting from activated cyclopropanes, heterocyclic, and carbocyclic compounds were obtained under mild conditions using Bronsted acid catalysts. Preliminary investigation of the reaction mechanism indicated a stepwise process.

Organic Letters published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C11H12O4, Application of (E)-3-(2,4-Dimethoxyphenyl)acrylic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Levens, Alison published the artcileEnantioselective (4+2) Annulation of Donor-Acceptor Cyclobutanes by N-Heterocyclic Carbene Catalysis, Recommanded Product: (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, the publication is Angewandte Chemie, International Edition (2016), 55(52), 16136-16140, database is CAplus and MEDLINE.

Herein we report the enantioselective (4+2) annulation of donor-acceptor cyclobutanes and unsaturated acyl fluorides using N-heterocyclic carbene catalysis. The reaction allows a 3-step synthesis of cyclohexyl β-lactones (25 examples) in excellent chem. yield (most â‰?0 %) and stereochem. integrity (all >20:1 d.r., most â‰?7:3 e.r.). Mechanistic studies support ester enolate Claisen rearrangement, while derivatizations provide functionalized cyclohexenes and dihydroquinolinones.

Angewandte Chemie, International Edition published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C11H12O4, Recommanded Product: (E)-3-(2,4-Dimethoxyphenyl)acrylic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Kitazawa, Makio published the artcileStudies on the synthesis of antiulcer agents. VI. Synthesis and antiulcer activity of dihydrobenzofuranone derivatives, Quality Control of 16909-09-4, the publication is Yakugaku Zasshi (1989), 109(10), 718-36, database is CAplus and MEDLINE.

Dimethyldihydrobenzofuranones I [R = OH, OEt, (un)substituted amino], II (R¹ = 5-, 6-, or 7-CH:CHCOR²; R² = piperidino, morpholino; R³ = 7-, 6-, or 5-OMe, Br, NO₂, NH₂, NHAc, H, Me, CO₂Et), III (n = 0-2; R⁴ = OH, OEt, substituted amino), and IV [R⁵ = (un)substituted amino] were prepared and tested for antiulcer activity. I (R = piperidino, morpholino) showed the highest activity.

Yakugaku Zasshi published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C11H12O4, Quality Control of 16909-09-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia