Category: 17351-62-1

Zhu, Guizhi published the artcileCombinatorial Screening of DNA Aptamers for Molecular Imaging of HER2 in Cancer, COA of Formula: C17H37NO3, the publication is Bioconjugate Chemistry (2017), 28(4), 1068-1075, database is CAplus and MEDLINE.

HER2, a cell membrane protein overexpressed in many types of cancers, is correlated with poor diagnosis, suboptimal treatment outcome, and low survival rate. Multiple HER2-targeted drugs have been developed for the treatment of HER2-overexpressing tumor, which can in turn down-regulate HER2 expression. It is thus significant to profile HER2 expression for cancer prognosis, patient stratification, and monitoring therapy response. Aptamers, a class of single-stranded DNA/RNA (ssDNA/ssRNA) ligands, are promising for mol. biomarker imaging. Aptamers typically have strong binding affinity, high selectivity, batch-to-batch reproducibility, and low toxicity, and systemically injected aptamers often have high tumor-to-background ratio within a short time. However, current aptamers have been mostly screened in vitro, and these aptamers may lose binding ability in vivo due to conformational change under physiol. environments. Here, a DNA library was combinatorially screened in vitro and in vivo, to select HER2-targeting DNA aptamers, termed Heraptamers, and labeled with ¹⁸F for positron emission tomog. (PET) imaging of HER2 in ovarian cancer. Specifically, using systematic evolution of ligands by exponential enrichment (SELEX), Heraptamer candidates were first selected and validated in vitro using HER2 extracellular domain (ECD) and HER2-pos. SKOV3 cancer cells; then, aptamer candidates were modified with alkyne, radiolabeled with ¹⁸F using azide-functionalized precursors by click chem., and screened in SKOV3-tumor-bearing mice using PET. Two aptamers, Heraptamer1 and Heraptamer2, reached high tumor uptake ratios within as short as 1 h. At 1.5 h post injection, the tumor uptake ratio of these two aptamers was up to 0.5%ID/g (injection dose/g tissue), with tumor-to-muscle ratio of 4.55 ¡À 1.63 in SKOV3 tumor. In contrast, these aptamers have low uptake ratios in control MDA-MB-231 tumors. These preclin. studies showed that Heraptamers are promising for specific HER2 imaging.

Bioconjugate Chemistry published new progress about 17351-62-1. 17351-62-1 belongs to catalysis-chemistry, auxiliary class Salt,Amine, name is Tetrabutylammonium hydrogencarbonate, and the molecular formula is C12H14S, COA of Formula: C17H37NO3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Yuasa, M. published the artcileComputer-controlled synthesis of [¹⁸F]FDG by the tetrabutylammonium method: achievement of high yield, purity, reproducibility, reliability, and safety, HPLC of Formula: 17351-62-1, the publication is Applied Radiation and Isotopes (1997), 48(2), 201-205, database is CAplus.

The authors constructed a computer-controlled apparatus of no-carrier-added [¹⁸F]fluorodeoxyglucose ([¹⁸F]FDG) synthesis for routine clin. use. High yield, high reproducibility, and high quality of the product were achieved. The main step of the reaction is nucleophilic fluorination of the synthetic precursor, acetylated mannose triflate, with an activator, tetrabutylammonium bicarbonate. A biol. high quality medicinal environment (sterile and pyrogen-free) was achieved by employment of an inherently pyrodestructive chem. step within the process line and the use of pyrogen-free medical goods and heat-sterilized glassware. [¹⁸F]FDG was obtained in 70 min after EOB with a radiochem. yield of 57.7 ¡À 5.7% (decay corrected) and with radiochem. purity of > 99%.

Applied Radiation and Isotopes published new progress about 17351-62-1. 17351-62-1 belongs to catalysis-chemistry, auxiliary class Salt,Amine, name is Tetrabutylammonium hydrogencarbonate, and the molecular formula is C4H6O3, HPLC of Formula: 17351-62-1.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zhu, Xin Yi published the artcileConstruction of Supramolecular Fluorescent Probe by a Water-Soluble Pillar[5]arene and Its Recognition of Carbonate Ion, Category: catalysis-chemistry, the publication is Bulletin of the Chemical Society of Japan (2022), 95(1), 116-120, database is CAplus.

The interaction between pyridine pillar[5]arene (PyP5) and 2-naphthol with the former as the host mol. and the latter as the guest mol. is studied by fluorescence spectroscopy and NMR techniques, and the results show that PyP5 forms a 1:1 host-guest inclusion complex with 2-naphthol. Although free 2-naphthol has strong fluorescence, it is quenched in 2-naphthol@PyP5. Experiments were conducted with 2-naphthol@PyP5 as a fluorescent probe to detect different anions with results showing that only CO₃^2- causes a significant enhancement of the fluorescence of the fluorescent probe. Due to this high selectivity and high sensitivity, the fluorescent probe 2-naphthol@PyP5 may open up an effective way for the detection of CO₃^2-.

Bulletin of the Chemical Society of Japan published new progress about 17351-62-1. 17351-62-1 belongs to catalysis-chemistry, auxiliary class Salt,Amine, name is Tetrabutylammonium hydrogencarbonate, and the molecular formula is C20H17ClN4O3, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Kitani, Akira published the artcileElectrochemical reduction of carbon dioxide reduction in aqueous solution, Formula: C17H37NO3, the publication is Denki Kagaku oyobi Kogyo Butsuri Kagaku (1978), 46(10), 570-2, database is CAplus.

The current efficiency of carboxylic acids, especially that of nonvolatile ones, was examined on the electrolytic reduction of CO₂ on a Pb-Hg electrode at a controlled potential of -1.9 V vs. SCE in an aqueous solution containing Bu₄NHCO₃ as a supporting electrolyte. Although the formation of ?10 carboxylic acids with 2-5 C atoms was confirmed beside HCO₂H, the current efficiencies for them were low. The increase in a hydrophobic region on an electrode surface, either by the addition of a cationic surfactant to an electrolytic solution in a concentration above the critical micelle concentration or by the utilization of a Cu electrode with adsorbed octylmercaptan instead of a Pb-Hg electrode, resulted in the inhibition of the formation of carboxylic acids with 2-3 C atoms and in the acceleration of the formation of nonvolatile ones, although the current efficiency for the total non-volatile acids was somewhat lowered.

Denki Kagaku oyobi Kogyo Butsuri Kagaku published new progress about 17351-62-1. 17351-62-1 belongs to catalysis-chemistry, auxiliary class Salt,Amine, name is Tetrabutylammonium hydrogencarbonate, and the molecular formula is C17H37NO3, Formula: C17H37NO3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Ackermann, Sarah L. published the artcileCrystallographic Snapshot of an Arrested Intermediate in the Biomimetic Activation of CO₂, Application In Synthesis of 17351-62-1, the publication is Angewandte Chemie, International Edition (2015), 54(1), 164-168, database is CAplus and MEDLINE.

The design of mol. catalysts that mimic the behavior of enzymes is a topical field of activity in emerging technologies, and can lead to an improved understanding of biol. systems. Herein, we report how the bulky arms of the cations in [(n-C₄H₉)₄N]⁺[HCO₃]^– give rise to a host scaffold that emulates the substrate binding sites in carbonic anhydrase enzymes, affording a unique glimpse of an arrested intermediate in the base-mediated binding and activation of CO₂.

Angewandte Chemie, International Edition published new progress about 17351-62-1. 17351-62-1 belongs to catalysis-chemistry, auxiliary class Salt,Amine, name is Tetrabutylammonium hydrogencarbonate, and the molecular formula is C17H37NO3, Application In Synthesis of 17351-62-1.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Uddin, Jashim Md. published the artcileDiscovery of Furanone-Based Radiopharmaceuticals for Diagnostic Targeting of COX-1 in Ovarian Cancer, Safety of Tetrabutylammonium hydrogencarbonate, the publication is ACS Omega (2019), 4(5), 9251-9261, database is CAplus and MEDLINE.

In vivo targeting and visualization of cyclooxygenase-1 (COX-1) using multimodal positron emission tomog./computed tomog. imaging represents a unique opportunity for early detection and/or therapeutic evaluation of ovarian cancer because overexpression of COX-1 has been characterized as a pathol. hallmark of the initiation and progression of this disease. The furanone core is a common building block of many synthetic and natural products that exhibit a wide range of biol. activities. We hypothesize that furanone-based COX-1 inhibitors can be designed as imaging agents for the early detection, delineation of tumor margin, and evaluation of treatment response of ovarian cancer. We report the discovery of 3-(4-fluorophenyl)-5,5-dimethyl-4-(p-tolyl)furan-2(5H)-one (FDF), a furanone-based novel COX-1-selective inhibitor that exhibits adequate in vivo stability, plasma half-life, and pharmacokinetic properties for use as an imaging agent. We describe a novel synthetic scheme in which a Lewis acid-catalyzed nucleophilic aromatic deiodo[¹⁸F]fluorination reaction is utilized for the radiosynthesis of [¹⁸F]FDF. [¹⁸F]FDF binds efficiently to COX-1 in vivo and enables sensitive detection of ovarian cancer in s.c. and peritoneal xenograft models in mice. These results provide the proof of principle for COX-1-targeted imaging of ovarian cancer and identify [¹⁸F]FDF as a promising lead compound for further preclin. and clin. development.

ACS Omega published new progress about 17351-62-1. 17351-62-1 belongs to catalysis-chemistry, auxiliary class Salt,Amine, name is Tetrabutylammonium hydrogencarbonate, and the molecular formula is C13H11NO, Safety of Tetrabutylammonium hydrogencarbonate.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Rios, Alejandra published the artcileA novel multi-reaction microdroplet platform for rapid radiochemistry optimization, Quality Control of 17351-62-1, the publication is RSC Advances (2019), 9(35), 20370-20374, database is CAplus and MEDLINE.

During the development of novel tracers for positron emission tomog. (PET), the optimization of the synthesis is hindered by practical limitations on the number of experiments that can be performed per day. Here we present a microliter droplet chip that contains multiple sites (4 or 16) to perform reactions simultaneously under the same or different conditions to accelerate radiosynthesis optimization.

RSC Advances published new progress about 17351-62-1. 17351-62-1 belongs to catalysis-chemistry, auxiliary class Salt,Amine, name is Tetrabutylammonium hydrogencarbonate, and the molecular formula is C17H37NO3, Quality Control of 17351-62-1.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Iovkova, Ljuba published the artcilepara-functionalized aryl-di-tert-butylfluorosilanes as potential labeling synthons for ¹⁸F radiopharmaceuticals, Safety of Tetrabutylammonium hydrogencarbonate, the publication is Chemistry – A European Journal (2009), 15(9), 2140-2147, database is CAplus and MEDLINE.

The syntheses of the functionalized triorganofluorosilanes tBu₂-(p-XC₆H₄)SiF (3a, X = SH; 4a, X = NCS; 4b, X = NCO; 5, X = NC₄H₂O₂; 7, X = COOH; 8a, X = COONC₄H₄O₂; 8b, X = COOC₆F₅) are reported. These compounds display potential as silicon-based fluoride acceptors (SiFAs). The mol. structures of compounds 5, 7, and 8a have been determined by single-crystal X-ray diffraction studies. With the exception of compounds 8a and 8b, all of the compounds could be ¹⁸F-labeled by isotopic exchange in good to high radiochem. yields (RCY) with good to excellent specific activities. As proof of applicability, the maleimido-functionalized SiFA derivative 5, which is specific for thiol groups, has been used for the labeling of rat serum albumin (RSA) that had been derivatized with 2-iminothiolane. The incorporation of [¹⁸F]5 into the derivatized RSA reached a maximum yield after 30 min at ambient temperature After purification, the [¹⁸F]RSA was evaluated in a healthy rat by means of ¦ÌPET and displayed an expedient in vivo stability over 180 min.

Chemistry – A European Journal published new progress about 17351-62-1. 17351-62-1 belongs to catalysis-chemistry, auxiliary class Salt,Amine, name is Tetrabutylammonium hydrogencarbonate, and the molecular formula is C17H37NO3, Safety of Tetrabutylammonium hydrogencarbonate.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Teeter, T. E. published the artcileReduction of carbon dioxide on mercury cathodes, Synthetic Route of 17351-62-1, the publication is Proc. 6th Meeting Intern. Comm. Electrochem. Thermodynam. and Kinet. (1955), 538-42, database is CAplus.

cf. C.A. 48, 10451g. A summary of polarographic work on solutions of CO₂ in quaternary ammonium salts, of cathodic polarization experiments with solutions of KCl, NH₄Cl, NaHCO₃, N(CH₃)₄Br, etc., through which CO₂ was continuously bubbled, and of electrolysis experiments showing that HCOOH was the chief product of CO₂ reduction on Hg cathodes. Current efficiencies of HCOOH production were as follows (all solutions 0.1M): KCl 99.8; KBr 99.9; KI 99.2; NaHCO₃ 99; N(CH₃)₄HCO₃ 100; N(C₂H₅)₄HCO₃ 97; N(C₃H₇)₄HCO₃ 85; N(C₄H₈)₄HCO₃ 78%. The HCO_3- was found to be unreducible, while CO₂ was either directly reduced or reduced by amalgams or H formed in primary cathodic processes.

Proc. 6th Meeting Intern. Comm. Electrochem. Thermodynam. and Kinet. published new progress about 17351-62-1. 17351-62-1 belongs to catalysis-chemistry, auxiliary class Salt,Amine, name is Tetrabutylammonium hydrogencarbonate, and the molecular formula is C11H8F2, Synthetic Route of 17351-62-1.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Kondo, Naoya published the artcileDevelopment of PEGylated peptide probes conjugated with ¹⁸F-labeled BODIPY for PET/optical imaging of MT1-MMP activity, Formula: C17H37NO3, the publication is Journal of Controlled Release (2015), 220(Part_A), 476-483, database is CAplus and MEDLINE.

Since the processing activity of the matrix metalloproteinase MT1-MMP regulates various cellular functions such as motility, invasion, growth, differentiation and apoptosis, precise in vivo evaluation of MT1-MMP activity in cancers can provide beneficial information for both basic and clin. studies. For this purpose, we designed a cleavable Positron Emission Tomog. (PET)/optical imaging probe consisting of BODIPY650/665 and polyethylene glycol (PEG) conjugated to opposite ends of MT1-MMP substrate peptides. We used in vitro and in vivo fluorescence experiments to select suitable substrate peptide sequences and PEG sizes for the MT1-MMP probes and obtained an optimized structure referred to here as MBP-2k. Radiofluorinated MBP-2k ([¹⁸F]MBP-2k) was then successfully synthesized via an ¹⁸F-¹⁹F isotopic exchange reaction in BODIPY650/665. After i.v. injection into mice with xenografted tumors, [¹⁸F]MBP-2k showed significantly higher accumulation in HT1080 tumors with high MT1-MMP activity than in A549 tumors that have low MT1-MMP activity. Moreover, PET images showed better contrast in HT1080 tumors. These results show that [¹⁸F]MBP-2k can be used as a hybrid PET/optical imaging agent and is a promising probe for non-invasive monitoring of MT1-MMP activity in cancers. This probe may also efficiently combine targeted tumor imaging with image-guided surgery that could be beneficial for patients in the future.

Journal of Controlled Release published new progress about 17351-62-1. 17351-62-1 belongs to catalysis-chemistry, auxiliary class Salt,Amine, name is Tetrabutylammonium hydrogencarbonate, and the molecular formula is C17H37NO3, Formula: C17H37NO3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia