Category: 17351-62-1

Lai, Thu Hang published the artcileDevelopment of ¹⁸F-labeled radiotracers for PET imaging of the adenosine A₂A receptor: synthesis, radiolabeling and preliminary biological evaluation, COA of Formula: C17H37NO3, the publication is International Journal of Molecular Sciences (2021), 22(5), 2285, database is CAplus and MEDLINE.

The adenosine A2A receptor (A2AR) represents a potential therapeutic target for neurodegenerative diseases. Aiming at the development of a positron emission tomog. (PET) radiotracer to monitor changes of receptor d. and/or occupancy during the A2AR-tailored therapy, authors designed a library of fluorinated analogs based on a recently published lead compound (PPY). Among those, the highly affine 4-fluorobenzyl derivate (K_i(hA_2AR) = 5.3 nM) and the 2-fluorobenzyl derivate (K_i(hA_2AR) = 2.1 nM) were chosen for ¹⁸F-labeling via an alc. enhanced copper-mediated procedure starting from the corresponding boronic acid pinacol ester precursors. Investigations of the metabolic stability of compound I (R = p-¹⁸F, o-¹⁸F) in CD-1 mice by radio-HPLC anal. revealed parent fractions of more than 76% of total activity in the brain. Specific binding of I (R = o-¹⁸F)on mice brain slices was demonstrated by in vitro autoradiog. In vivo PET/magnetic resonance imaging (MRI) studies in CD-1 mice revealed a reasonable high initial brain uptake for both radiotracers, followed by a fast clearance.

International Journal of Molecular Sciences published new progress about 17351-62-1. 17351-62-1 belongs to catalysis-chemistry, auxiliary class Salt,Amine, name is Tetrabutylammonium hydrogencarbonate, and the molecular formula is C17H37NO3, COA of Formula: C17H37NO3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Taylor, M. D. published the artcileImproving the yield of 2-[¹⁸F]fluoro-2-deoxyglucose using a microwave cavity, Quality Control of 17351-62-1, the publication is Nuclear Medicine and Biology (1996), 23(5), 605-609, database is CAplus and MEDLINE.

We have investigated the use of a microwave cavity (Labwell AB, Sweden) to improve the radiochem. yield of 2-[¹⁸F]-fluoro-2-deoxyglucose (2-[¹⁸F]-FDG). After characterizing the heating properties of the cavity, three steps of the Hamacher 2-[¹⁸F]-FDG preparation which require heating-azeotropic distillation of the target water, nucleophilic substitution, and hydrolysis of the product-were investigated sep. The average radiochem. yield of 2-[¹⁸F]-FDG for the microwave preparation, using the phase transfer reagent tetrabutylammonium bicarbonate, was 62 ¡À 4% (72 ¡À 5%, decay corrected, preparation time = 31 min).

Nuclear Medicine and Biology published new progress about 17351-62-1. 17351-62-1 belongs to catalysis-chemistry, auxiliary class Salt,Amine, name is Tetrabutylammonium hydrogencarbonate, and the molecular formula is C12H16N2O2, Quality Control of 17351-62-1.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Nandy, Saikat published the artcileThe possibility of a fully automated procedure for radiosynthesis of fluorine-18-labeled fluoromisonidazole using a simplified single, neutral alumina column purification procedure, Name: Tetrabutylammonium hydrogencarbonate, the publication is Applied Radiation and Isotopes (2010), 68(10), 1937-1943, database is CAplus and MEDLINE.

A novel fully automated radiosynthesis procedure for [¹⁸F]Fluoromisonidazole using a simple alumina cartridge-column for purification instead of conventionally used semi-preparative HPLC was developed. [¹⁸F]FMISO was prepared via a one-pot, two-step synthesis procedure using a modified nuclear interface synthesis module. Nucleophilic fluorination of the precursor mol. 1-(2′-nitro-1′-imidazolyl)-2-O-tetrahydropyranyl-3-O-toluenesulfonylpropanediol (NITTP) with no-carrier added [¹⁸F]fluoride followed by hydrolysis of the protecting group with 1 M HCl. Purification was carried out using a single neutral alumina cartridge-column instead of semi-preparative HPLC. The maximum overall radiochem. yield obtained was 37.49¡À1.68% with 10 mg NITTP (n=3, without any decay correction) and the total synthesis time was 40¡À1 min. The radiochem. purity was greater than 95% and the product was devoid of other chem. impurities including residual aluminum and acetonitrile. The biodistribution study in fibrosarcoma tumor model showed maximum uptake in tumor, 2 h post injection. Finally, PET/CT imaging studies in normal healthy rabbit, showed clear uptake in the organs involved in the metabolic process of MISO. No bone uptake was observed excluding the presence of free [¹⁸F]fluoride. The reported method can be easily adapted in any com. FDG synthesis module.

Applied Radiation and Isotopes published new progress about 17351-62-1. 17351-62-1 belongs to catalysis-chemistry, auxiliary class Salt,Amine, name is Tetrabutylammonium hydrogencarbonate, and the molecular formula is C17H37NO3, Name: Tetrabutylammonium hydrogencarbonate.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wangler, Bjorn published the artcileKit-Like ¹⁸F-Labeling of Proteins: Synthesis of 4-(Di-tert-butyl[¹⁸F]fluorosilyl)benzenethiol (Si[¹⁸F]FA-SH) Labeled Rat Serum Albumin for Blood Pool Imaging with PET, Category: catalysis-chemistry, the publication is Bioconjugate Chemistry (2009), 20(2), 317-321, database is CAplus and MEDLINE.

Radiosyntheses of ¹⁸F-radiopharmaceuticals for positron emission tomog. (PET) normally require an extraordinarily high effort of tech. equipment and specially trained personnel. We recently reported a novel method for the introduction of fluorine-18 into peptides for PET-imaging based on silicon-¹⁸F-chem. (SiFA technique). We herewith introduce the first SiFA-based Kit-like radio-fluorination of a protein (rat serum albumin, RSA) and demonstrate its usefulness for in vivo imaging with ¦ÌPET in normal rats as well as in a rat heterotropic transplanted heart model. As a labeling agent, we prepared 4-(di-tert-butyl[¹⁸F]fluorosilyl)benzenethiol (Si[¹⁸F]FA-SH) by simple isotopic exchange in 40-60% radiochem. yield (RCY) and coupled it directly to a Sulfo-SMCC derivatized RSA in an overall RCY of 12% within 20-30 min. The tech. simple labeling procedure does not require any elaborated purification procedures and is a straightforward example of a successful application of Si-¹⁸F chem. for in vivo imaging with PET.

Bioconjugate Chemistry published new progress about 17351-62-1. 17351-62-1 belongs to catalysis-chemistry, auxiliary class Salt,Amine, name is Tetrabutylammonium hydrogencarbonate, and the molecular formula is C18H28N2O7, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wang, Limin published the artcileSynthesis, uptake mechanism characterization and biological evaluation of ¹⁸F labeled fluoroalkyl phenylalanine analogs as potential PET imaging agents, Application of Tetrabutylammonium hydrogencarbonate, the publication is Nuclear Medicine and Biology (2011), 38(1), 53-62, database is CAplus and MEDLINE.

Introduction: Amino acids based tracers represent a promising class of tumor metabolic imaging agents with successful clin. applications. Two new phenylalanine derivatives, p-(2-[¹⁸F]fluoroethyl)-L-phenylalanine (FEP, [¹⁸F]2) and p-(3-[¹⁸F]fluoropropyl)-L-phenylalanine (FPP, [¹⁸F]3) were synthesized and evaluated in comparison to clin. utilized O-(2-[¹⁸F]fluoroethyl)-L-tyrosine (FET, [¹⁸F]1). Methods: FEP ([¹⁸F]2) and FPP ([¹⁸F]3) were successfully synthesized by a rapid and efficient two-step nucleophilic fluorination of tosylate precursors and deprotection reaction. In vitro cell uptake studies were carried out in 9L glioma cells. In vivo studies, 9L tumor xenografts were implanted in Fisher 344 rats. Results: FEP ([¹⁸F]2) and FPP ([¹⁸F]3) could be efficiently labeled within 90 min with good enantiomeric purity (>95%), good yield (11-37%) and high specific activity (21-69 GBq/¦Ìmol). Cell uptake studies showed FEP had higher uptake than FPP as well as reference ligand FET ([¹⁸F]1). Uptake mechanism studies suggested that FEP is a selective substrate for system L and prefers its subtype LAT1. In vivo biodistribution studies demonstrated FEP had specific accumulation in tumor cells and tumor to background ratio reached 1.45 at 60 min. Small animal positron emission tomog. (PET) imaging studies showed FEP was comparable to FET for imaging rats bearing 9L tumor model. FEP had high uptake in 9L tumor compared to surrounding tissue and was quickly excreted through urinary tract. Conclusion: Biol. evaluations indicate that FEP ([¹⁸F]2) is a potential useful tracer for tumor imaging with PET.

Nuclear Medicine and Biology published new progress about 17351-62-1. 17351-62-1 belongs to catalysis-chemistry, auxiliary class Salt,Amine, name is Tetrabutylammonium hydrogencarbonate, and the molecular formula is C8H6ClF3, Application of Tetrabutylammonium hydrogencarbonate.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Beyerlein, Friederike published the artcileAutomated synthesis and purification of [¹⁸F]fluoro-[di-deutero]methyl tosylate, Related Products of catalysis-chemistry, the publication is Journal of Labelled Compounds and Radiopharmaceuticals (2013), 56(7), 360-363, database is CAplus and MEDLINE.

Automated synthetic procedures of [¹⁸F]fluoro-[di-deutero]methyl tosylate on a GE TRACERlab FX F-N module and a non-com. synthesis module have been developed. The syntheses included azeotropic drying of the [¹⁸F]fluoride, nucleophilic ¹⁸F-fluorination of bis(tosyloxy)-[di-deutero]methane, HPLC purification and subsequent formulation of the synthesized [¹⁸F]fluoro-[di-deutero]methyl tosylate (d₂-[¹⁸F]FMT) in organic solvents. Automation shortened the total synthesis time to 50 min, resulting in an average radiochem. yield of about 50% and high radiochem. purity (>98%). The possible application of this procedure to com. available synthesis modules might be of significance for the production of deuterated ¹⁸F-fluoromethylated imaging probes in the future. Copyright 2013 John Wiley & Sons, Ltd.

Journal of Labelled Compounds and Radiopharmaceuticals published new progress about 17351-62-1. 17351-62-1 belongs to catalysis-chemistry, auxiliary class Salt,Amine, name is Tetrabutylammonium hydrogencarbonate, and the molecular formula is C17H37NO3, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Mooney, Ciaran R. S. published the artcileCrystallographic Snapshot of an Arrested Intermediate in the Biomimetic Activation of CO₂ [Erratum to document cited in CA162:197128], Recommanded Product: Tetrabutylammonium hydrogencarbonate, the publication is Angewandte Chemie, International Edition (2015), 54(26), 7470, database is CAplus and MEDLINE.

The authors believe that that a single crystal of [(n-C₄H₉)₄N]⁺[CH₃CO₂]^– impurity was misidentified as [(n-C₄H₉)₄N]⁺[O₂C¡¤¡¤¡¤OH]^–; a discussion is provided.

Angewandte Chemie, International Edition published new progress about 17351-62-1. 17351-62-1 belongs to catalysis-chemistry, auxiliary class Salt,Amine, name is Tetrabutylammonium hydrogencarbonate, and the molecular formula is C17H37NO3, Recommanded Product: Tetrabutylammonium hydrogencarbonate.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Moon, Byung Seok published the artcileHighly efficient production of [¹⁸F]fallypride using small amounts of base concentration, Recommanded Product: Tetrabutylammonium hydrogencarbonate, the publication is Applied Radiation and Isotopes (2010), 68(12), 2279-2284, database is CAplus and MEDLINE.

To minimize the base concentration of a phase-transfer catalyst, [¹⁸F]fluoride was extracted from ¹⁸O-enriched water trapped on an activated ion exchange cartridge (Chromafix PS-HCO₃) using different concentrations of tetrabutylammonium bicarbonate (TBAHCO₃) or Kryptofix 2.2.2./K₂CO₃ in organic solvents such as CH₃CN/H₂O or MeOH/H₂O. The optimal labeling condition for [¹⁸F]fallypride with automated synthesis was that 2 mg of tosyl-fallypride in acetonitrile (1 mL) was heated at 100 ¡ãC for 10 min using 40% TBAHCO₃ (10 ¦ÌL). [¹⁸F]Fallypride was obtained with a high radiochem. yield of approx. 68¡À1.6% (decay-corrected, n=42) with a total synthesis time of 51¡À1.2 min, including HPLC purification and solid-phase purification for the final formulation.

Applied Radiation and Isotopes published new progress about 17351-62-1. 17351-62-1 belongs to catalysis-chemistry, auxiliary class Salt,Amine, name is Tetrabutylammonium hydrogencarbonate, and the molecular formula is C17H37NO3, Recommanded Product: Tetrabutylammonium hydrogencarbonate.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Niedermoser, Sabrina published the artcileEvaluation of an automated double-synthesis module: efficiency and reliability of subsequent radiosyntheses of FHBG and FLT, Application In Synthesis of 17351-62-1, the publication is Nuclear Medicine and Biology (2012), 39(4), 586-592, database is CAplus and MEDLINE.

We optimized the synthesis methods for 3′-deoxy-3′-[¹⁸F]fluorothymidine ([¹⁸F]FLT) and 9-(4-[¹⁸F]fluoro-3-[hydroxymethyl]butyl)guanine) ([¹⁸F]FHBG) and automated them on an Explora General Nucleophilic double-synthesis module. Furthermore, the synthesis efficiency and reliability and the formation of cross-contaminations of the products when preparing two consecutive batches were evaluated. Whereas the preinstalled FLT synthesis conditions required substantial modification in reaction and neutralization conditions to achieve radiochem. yields of up to 60% within 70¡À10 min including high-performance liquid chromatog. purification, the synthesis of FHBG had to be implemented to the module to obtain competitive radiochem. yields of up to 40% in an overall synthesis time of 60¡À10 min. The radiochem. purities obtained were ¡Ý99% and ¡Ý96% for the synthesis of [¹⁸F]FLT and [¹⁸F]FHBG, resp. No significant changes in yield or purity could be observed between both batch productions. We found that the yields and purities also did not change when performing FLT after FHBG syntheses and vice versa. Hence, we developed a synthesis setup that offers the opportunity to perform two subsequent syntheses of either [¹⁸F]FLT, [¹⁸F]FHBG or [¹⁸F]FLT after [¹⁸F]FHBG without decrease in radiochem. yields and purities. Also, no cross-contaminations were observed, which can be attributed to the use of sep. product delivery tubes, purification columns and an automated intermediate cleaning program. These results open up the possibility of producing consecutively either two equal ¹⁸F-fluorinated tracers or two different ones in high yields on the same synthesis module.

Nuclear Medicine and Biology published new progress about 17351-62-1. 17351-62-1 belongs to catalysis-chemistry, auxiliary class Salt,Amine, name is Tetrabutylammonium hydrogencarbonate, and the molecular formula is C17H37NO3, Application In Synthesis of 17351-62-1.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Heuser, Michael published the artcileSafety and efficacy of BAY1436032 in IDH1-mutant AML: phase I study results, Formula: C17H37NO3, the publication is Leukemia (2020), 34(11), 2903-2913, database is CAplus and MEDLINE.

The mutant IDH1 (mIDH1) inhibitor BAY1436032 demonstrated robust activity in preclin. AML models, supporting clin. evaluation. In the current dose-escalation study, BAY1436032 was orally administered to 27 mIDH1 AML subjects across 4 doses ranging from 300 to 1500 mg twice-daily. BAY1436032 exhibited a relatively short half-life and apparent non-linear pharmacokinetics after continuous dosing. Most subjects experienced only partial target inhibition as indicated by plasma R-2HG levels. BAY1436032 was safe and a maximum tolerated dose was not identified. The median treatment duration for all subjects was 3.0 mo (0.49-8.5). The overall response rate was 15% (4/27; 1 CRp, 1 PR, 2 MLFS), with responding subjects experiencing a median treatment duration of 6.0 mo (3.9-8.5) and robust R-2HG decreases. Thirty percent (8/27) achieved SD, with a median treatment duration of 5.5 mo (3.1-7.0). Degree of R-2HG inhibition and clin. benefit did not correlate with dose. Although BAY1436032 was safe and modestly effective as monotherapy, the low overall response rate and incomplete target inhibition achieved at even the highest dose tested do not support further clin. development of this investigational agent in AML.

Leukemia published new progress about 17351-62-1. 17351-62-1 belongs to catalysis-chemistry, auxiliary class Salt,Amine, name is Tetrabutylammonium hydrogencarbonate, and the molecular formula is C17H37NO3, Formula: C17H37NO3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia