Category: 17351-62-1

Lee, Sang Ju published the artcileSimple and highly efficient synthesis of 3′-deoxy-3′-[¹⁸F]fluorothymidine using nucleophilic fluorination catalyzed by protic solvent, Formula: C17H37NO3, the publication is European Journal of Nuclear Medicine and Molecular Imaging (2007), 34(9), 1406-1409, database is CAplus and MEDLINE.

The aim of this study was to develop a method of radiochem. synthesis of 3′-deoxy-3′-[¹⁸F]fluorothymidine ([¹⁸F]FLT) with an improved radiochem. yield using nucleophilic substitution catalyzed by protic solvent. We introduced t-BuOH as a new reaction solvent for nucleophilic [¹⁸F]fluorination with [¹⁸F]fluoride using (5′-O-DMTr-2′-deoxy-3′-O-furanosyl-¦Â-D-threo-pentofuranosyl)-3-N-BOC-thymine to synthesize [¹⁸F]FLT. [¹⁸F]F^– was eluted with (1) tetrabutylammonium bicarbonate (TBAHCO₃), (2) Cs₂CO₃ and kryptofix 2.2.2 (K₂₂₂) after trapping of [¹⁸F]F^– on an ion exchange cartridge, or (3) addition of tetrabutylammonium hydroxide (TBAOH) and [¹⁸F]F^– to the reactor without trapping [¹⁸F]F^– on an ion exchange cartridge. We optimized [¹⁸F]fluorination conditions with t-butanol and then applied them to automatic synthesis using com. available radiochem. modules (TracerLab MX, GE Healthcare). We achieved a high radiochem. yield of 85.3 ¡À 3.5% by radio-TLC with TBAHCO₃ as an elution solvent and 20 mg of precursor at 100¡ãC (n = 4). With the same labeling conditions, use of Cs₂CO₃ and K₂₂₂ with t-BuOH and TBAOH with t-BuOH generated radiochem. yields of 57.1 ¡À 22.5% and 55.0 ¡À 18.8% by radio-TLC, resp. (n = 3 for each condition). Automated synthesis with TBAHCO₃ and 20 mg of precursor at 120¡ãC for 10 min of [¹⁸F]fluorination led to radiochem. yields of 60.2 ¡À 5.2% after HPLC purification with an MX module (n = 10). Synthesized [¹⁸F]FLT was stable for 6 h. [¹⁸F]FLT was synthesized with a significantly improved radiochem. yield by nucleophilic substitution catalyzed by protic solvent with mild reaction conditions and a short preparation time.

European Journal of Nuclear Medicine and Molecular Imaging published new progress about 17351-62-1. 17351-62-1 belongs to catalysis-chemistry, auxiliary class Salt,Amine, name is Tetrabutylammonium hydrogencarbonate, and the molecular formula is C17H37NO3, Formula: C17H37NO3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Fedorova, Olga published the artcileAutomated SPE-based synthesis of 16¦Á-[¹⁸F]fluoroestradiol without HPLC purification step, Recommanded Product: Tetrabutylammonium hydrogencarbonate, the publication is Applied Radiation and Isotopes (2018), 57-63, database is CAplus and MEDLINE.

A [¹⁸F]fluoroestradiol ([¹⁸F]FES) is well-established PET radiotracer for diagnosing and monitoring treatment of estrogen-pos. breast cancer. The radiotracer is produced via one-pot two steps synthesis using cyclic sulfate precursor and is usually purified by semi-preparative HPLC. Here we suggested simple SPE purification procedure using OASIS WAX 3cc and Sep-Pak QMA light cartridges that afforded [¹⁸F]FES in typically 15% RCY (corrected for decay) within 45 min formulated in 5% EtOH/saline. All purity parameters were well within specifications recommended in the Investigator¡äs Brochure for [¹⁸F]Fluoroestradiol.

Applied Radiation and Isotopes published new progress about 17351-62-1. 17351-62-1 belongs to catalysis-chemistry, auxiliary class Salt,Amine, name is Tetrabutylammonium hydrogencarbonate, and the molecular formula is C17H37NO3, Recommanded Product: Tetrabutylammonium hydrogencarbonate.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Kuboyama, Takeshi published the artcileStoichiometry-focused ¹⁸F-labeling of alkyne-substituted oligodeoxynucleotides using azido([¹⁸F]fluoromethyl)benzenes by Cu-catalyzed Huisgen reaction, Synthetic Route of 17351-62-1, the publication is Bioorganic & Medicinal Chemistry (2011), 19(1), 249-255, database is CAplus and MEDLINE.

A novel method for ¹⁸F-radiolabeling of oligodeoxynucleotides (ODNs) by a Cu-catalyzed Huisgen reaction has been developed by using the lowest possible amount of the precursor biomol. for the realization of stoichiometry-oriented PET (positron emission tomog.) chem. Under the optimized cyclization conditions of p- or m-azido([¹⁸F]fluoromethyl)benzene and alkyne-substituted ODN (20 nmol) at 40 ¡ãC for 15 min in the presence of CuSO₄, TBTA [tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine], and sodium ascorbate (2:1:2), the synthesis of ¹⁸F-labeled ODNs with sufficiently high radioactivities of 2.1-2.5 GBq and specific radioactivities of 1800-2400 GBq/¦Ìmol have been accomplished for use in animal and human PET studies.

Bioorganic & Medicinal Chemistry published new progress about 17351-62-1. 17351-62-1 belongs to catalysis-chemistry, auxiliary class Salt,Amine, name is Tetrabutylammonium hydrogencarbonate, and the molecular formula is C17H37NO3, Synthetic Route of 17351-62-1.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Gade, Swapna M. published the artcileSynthesis of glycidol from glycerol and dimethyl carbonate using ionic liquid as a catalyst, Synthetic Route of 17351-62-1, the publication is Catalysis Communications (2012), 184-188, database is CAplus.

Transesterification of di-Me carbonate with glycerol has been investigated using various ionic liquids as catalysts. Synthesis of glycidol with high selectivity (78%) has been achieved using tetramethylammonium hydroxide ([TMA][OH]) as a catalyst at 80 ¡ãC. Effect of various reaction conditions on the activity and selectivity was investigated and catalyst concentration had a significant influence on conversion as well as selectivity to glycidol. Activity as well as selectivity of the catalyst decreased significantly with increase in moisture content. Recycle experiment indicated slight drop in glycerol conversion and selectivity to glycidol because of dilution of reaction mixture and also the presence of products from the initial experiment

Catalysis Communications published new progress about 17351-62-1. 17351-62-1 belongs to catalysis-chemistry, auxiliary class Salt,Amine, name is Tetrabutylammonium hydrogencarbonate, and the molecular formula is C17H37NO3, Synthetic Route of 17351-62-1.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Hishar, H. published the artcileImpact of prolonged reduced-pressure condition prior to precursor labeling on the labeling efficiency of f-18 fluorocholine synthesis, COA of Formula: C17H37NO3, the publication is International Journal of Pharmacy and Pharmaceutical Sciences (2018), 10(4), 143-145, database is CAplus.

Objective: The goal of this preliminary work was to observe the impact of the prolonged reduced-pressure condition prior to labeling stage on the F-18 Fluorocholine labeling yield at the end of synthesis. Methods: At this present work, the condition inside the reactor vial prior to labeling stage was manipulated. In the first technique of syntheses of F-18 Fluorocholine, the condition inside the reactor vial was set at 0 atm. pressure (0 atm) while in the second technique the condition inside the reactor was set at reduced-pressure (between-0.65 to-0.85 bars) with the delay time of 120 s. At the end of the synthesis, the impact of the prolonged reduced-pressure condition prior to precursor labeling was measured in terms of labeling yield of F-18 Fluorocholine. Results: With the second technique, the labeling yield of F-18 Fluorocholine was elevated from 9.7% (the first technique) to 24.3%. Conclusion: This preliminary work indicates that delay in a reduced-pressure condition prior to labeling step has greatly improved the labeling yield of F-18 Fluorocholine at the end of synthesis. Using this approach, the labeling yield of F-18 Fluorocholine was elevated from 7.5% to 24.3%.

International Journal of Pharmacy and Pharmaceutical Sciences published new progress about 17351-62-1. 17351-62-1 belongs to catalysis-chemistry, auxiliary class Salt,Amine, name is Tetrabutylammonium hydrogencarbonate, and the molecular formula is C17H37NO3, COA of Formula: C17H37NO3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Moldovan, Rares-Petru published the artcileDesign, radiosynthesis and preliminary biological evaluation in mice of a brain-penetrant ¹⁸F-Labelled ¦Ò₂ receptor ligand, Formula: C17H37NO3, the publication is International Journal of Molecular Sciences (2021), 22(11), 5447, database is CAplus and MEDLINE.

The ¦Ò₂ receptor (transmembrane protein 97), which is involved in cholesterol homeostasis, is of high relevance for neoplastic processes. The upregulated expression of ¦Ò₂ receptors in cancer cells and tissue in combination with the antiproliferative potency of ¦Ò₂ receptor ligands motivates the research in the field of ¦Ò₂ receptors for the diagnosis and therapy of different types of cancer. Starting from the well described 2-(4-(1H-indol-1-yl)butyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline class of compounds, we synthesized a novel series of fluorinated derivatives bearing the F-atom at the aromatic indole/azaindole subunit. RM273 (2-[4-(6-fluoro-1H-pyrrolo[2,3-b]pyridin-1-yl)butyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline) was selected for labeling with ¹⁸F and evaluation regarding detection of ¦Ò₂ receptors in the brain by positron emission tomog. Initial metabolism and biodistribution studies of [¹⁸F]RM273 in healthy mice revealed promising penetration of the radioligand into the brain. Preliminary in vitro autoradiog. on brain cryosections of an orthotopic rat glioblastoma model proved the potential of the radioligand to detect the upregulation of ¦Ò₂ receptors in glioblastoma cells compared to healthy brain tissue. The results indicate that the herein developed ¦Ò₂ receptor ligand [¹⁸F]RM273 has potential to assess by non-invasive mol. imaging the correlation between the availability of ¦Ò₂ receptors and properties of brain tumors such as tumor proliferation or resistance towards particular therapies.

International Journal of Molecular Sciences published new progress about 17351-62-1. 17351-62-1 belongs to catalysis-chemistry, auxiliary class Salt,Amine, name is Tetrabutylammonium hydrogencarbonate, and the molecular formula is C17H37NO3, Formula: C17H37NO3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Joshi, Raman Kumar published the artcileRadiosynthesis challenges of ¹¹C and ¹⁸F-labeled radiotracers in the FX2C/N tracerlab and their validation through PET-MR imaging, Formula: C17H37NO3, the publication is Applied Radiation and Isotopes (2021), 109486, database is CAplus and MEDLINE.

Glucose is the renowned source of the energy for the cancer growth, that¡äs the reason for [¹⁸F]FDG success and make it widely used radiotracer. Though [¹⁸F]FDG has its own inherent limitations therefore many tracers have been developed to target specific receptors, and other metabolic routes. We have used FX2C and FX2N Tracerlab modules for the synthesis of the [¹¹C]methionine, [¹⁸F]choline and [¹⁸F]fluorodopa via nucleophilic pathway in FX2C/N module. [¹¹C]methionine was standardized in FX2C module using two different precursors, and purified using C18 cartridge based technique. [¹⁸F]methylcholine was synthesized using dimethylaminoethanol precursor and purified using cartridge-based method. [¹⁸F]fluorodopa was synthesized using nucleophilic precursor and purified using in-built preparative HPLC on FX2N module. All radioactive intermediates and chem. impurities were evaluated by anal. HPLC. The radiochem. purity of D and L-[¹¹C]methionine were 4.6 ¡À 3.2% and 95.4 ¡À 3.6% while other chem. impurities were less than prescribed limits with yield of 20 ¡À 5%. [¹⁸F]fluoromethylcholine was prepared with high radiochem. purity of 97.3 ¡À 2.6% with yield of 8 ¡À 3%. [¹⁸F]fluorodopa was synthesized with high radiochem. purity of 95.8 ¡À 1.4% with 15 ¡À 3% yield. The adaptation of [¹⁸F]fluorodopa synthesis to FX2N module via designing synthesis sequence and purified through online HPLC has provided high radiochem. purity. PET-MR imaging was done using these tracers which have validated the synthesis and their availability for future clin. applications.

Applied Radiation and Isotopes published new progress about 17351-62-1. 17351-62-1 belongs to catalysis-chemistry, auxiliary class Salt,Amine, name is Tetrabutylammonium hydrogencarbonate, and the molecular formula is C17H37NO3, Formula: C17H37NO3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Silavwe, Ned D. published the artcileReduction of carbon dioxide and other substrates using photochemical reactions of the decacarbonylditungstate(2-) complex, Safety of Tetrabutylammonium hydrogencarbonate, the publication is Inorganic Chemistry (1989), 28(7), 1231-6, database is CAplus.

The photochem. of W₂(CO)₁₀^2- was studied with the goal of determining if irradiation of this dimer generates a powerful reducing agent, presumably a 19-electron species. In general, the photochem. of W₂(CO)₁₀^2- is comparable to that of other metal-metal-bonded carbony dimers. Irradiation into the low-energy tail of the d¦Ð ¡ú ¦Ò^* electronic transition of W₂(CO)₁₀^2- led to W-W bond homolysis. The resulting 17-electron W(CO)₅^– radicals could be trapped with suitable ligands such as 4-cyanopyridine to give 19-electron adducts [adducts that form when 17-electron radicals react with 2-electron ligands]. Evidence is presented that PPh₃ and PBu₃ also react with photogenerated W(CO)₅^– to form adducts: W(CO)₅^– + PR₃ ¡ú W(CO)₅PR₃^–. These adducts are powerful reducing agents, and they were used to reduce CO₂ to formate and CO. The only organometallic product formed in the reaction was W(CO)₅PPh₃, the oxidized form of the 19-electron complex. In a similar manner, Mn₂(CO)₁₀ was reduced to Mn(CO)₅^–, Cp₂Co⁺ to Cp₂Co, benzophenone to the radical anion, and methylviologen (MV²⁺) to MV⁺. Alternative reduction mechanisms involving the W(CO)₅^– radical, W(CO)₅^2-, or HW₂(CO)₁₀^– as reductants were shown not to be operating. Nineteen-electron complexes generated by irradiation of Cp₂Mo₂(CO)₆ proved incapable of reducing CO₂.

Inorganic Chemistry published new progress about 17351-62-1. 17351-62-1 belongs to catalysis-chemistry, auxiliary class Salt,Amine, name is Tetrabutylammonium hydrogencarbonate, and the molecular formula is C15H12O6, Safety of Tetrabutylammonium hydrogencarbonate.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Bhatt, Vasishta D. published the artcileIon exchange synthesis and thermal characteristics of some [N⁺₄₄₄₄] based ionic liquids, Related Products of catalysis-chemistry, the publication is Thermochimica Acta (2013), 23-29, database is CAplus.

Eight salts, derived from tetrabutylammonium cation [N⁺₄₄₄₄] and inorganic anions like BF₄^–, NO₃^–, NO₂^–, SCN^–, BrO₃^–, IO₃^–, PF₆^– and HCO₃^– were synthesized using the ion exchange method. These ionic liquids (ILs) were characterized using thermogravimetry, differential scanning calorimetry and IR spectroscopy. Thermophys. properties such as d., volume expansion, heat of fusion, heat of solid-solid transitions, sp. heat capacity and thermal energy storage capacity were determined The total of heat of solid-solid transitions observed below the m.ps. exceeded the heat of fusion in some cases. The thermal conductivity of the samples was determined both in solid and liquid phases. High values of thermal energy storage capacity and handsome liquid phase thermal conductivities made many of the ionic liquids under investigation were recommended as Thermal Energy Storage Devices (TESDs) as well as heat transfer fluids.

Thermochimica Acta published new progress about 17351-62-1. 17351-62-1 belongs to catalysis-chemistry, auxiliary class Salt,Amine, name is Tetrabutylammonium hydrogencarbonate, and the molecular formula is C17H37NO3, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Ema, Tadashi published the artcileQuaternary ammonium hydroxide as a metal-free and halogen-free catalyst for the synthesis of cyclic carbonates from epoxides and carbon dioxide, Quality Control of 17351-62-1, the publication is Catalysis Science & Technology (2015), 5(4), 2314-2321, database is CAplus.

Tetrabutylammonium hydroxide (TBAH) and other quaternary ammonium hydroxides catalyzed the cycloaddition of CO₂ to epoxides under solvent-free conditions to give cyclic carbonates. When TBAH was exposed to CO₂, TBAH was converted into tetrabutylammonium bicarbonate (TBABC), which was a catalytically active species. A D-labeled epoxide and an optically active epoxide were used to study the reaction mechanism, which invoked three plausible pathways. Among them, path A seemed to be predominant; the bicarbonate ion of TBABC attacks the less hindered C atom of the epoxide to generate a ring-opened alkoxide intermediate, which adds to CO₂ to give a carbonate ion, and the subsequent cyclization yields a cyclic carbonate. D. functional theory (DFT) calculations successfully delineated the potential energy profile for each reaction pathway, among which path A was the lowest-energy pathway in accordance with the exptl. results. The tetrabutylammonium (TBA) cation carries the pos. charges on the H atoms, but not on the central N atom, and the pos. charged H atoms close to the central N atom form an anion-binding site capable of stabilizing various anionic transition states and intermediates.

Catalysis Science & Technology published new progress about 17351-62-1. 17351-62-1 belongs to catalysis-chemistry, auxiliary class Salt,Amine, name is Tetrabutylammonium hydrogencarbonate, and the molecular formula is C17H37NO3, Quality Control of 17351-62-1.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia