Category: 17351-62-1

Li, Zibo published the artcileAutomated synthesis of 2′-deoxy-2′-[¹⁸F]fluoro-5-methyl-1-¦Â-D-arabinofuranosyluracil ([¹⁸F]-FMAU) using a one reactor radiosynthesis module, SDS of cas: 17351-62-1, the publication is Nuclear Medicine and Biology (2011), 38(2), 201-206, database is CAplus and MEDLINE.

2′-Deoxy-2′-[¹⁸F]fluoro-5-methyl-1-¦Â-D-arabinofuranosyluracil ([¹⁸F]-FMAU) is an established PET probe used to monitor cellular proliferation. For clin. applications, a fully automated cGMP-compliant radiosynthesis would be preferred. However, the current synthesis of [¹⁸F]-FMAU requires a multistep procedure, making the development of an automated protocol difficult and complicated. Recently, we have developed a significantly simplified one-pot reaction condition for the synthesis of [¹⁸F]-FMAU in the presence of Friedel-Crafts catalysts. Here, we report a fully automated synthesis of [¹⁸F]-FMAU based on a one reactor radiosynthesis module using our newly developed synthetic method. The product was purified on a semi-preparative high-performance liquid chromatog. integrated with the synthesis module using 6% EtOH in 10 mM phosphate buffer or 8% MeCN/water. [¹⁸F]-FMAU was obtained in 12¡À3% radiochem. yield (decay corrected overall yield based on [¹⁸F]-F^–, n=4) with 383¡À33 mCi/¦Ìmol specific activity at the time of injection. The ¦Á/¦Â anomer ratio was 4:6. The overall reaction time was about 150 min from the end of bombardment and the radiochem. purity was >99%. This automated synthesis should also be suitable for the production of other 5-substituted thymidine analogs.

Nuclear Medicine and Biology published new progress about 17351-62-1. 17351-62-1 belongs to catalysis-chemistry, auxiliary class Salt,Amine, name is Tetrabutylammonium hydrogencarbonate, and the molecular formula is C17H37NO3, SDS of cas: 17351-62-1.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Pascali, Claudio published the artcileSimple preparation and purification of ethanol-free solutions of 3′-deoxy-3′-[¹⁸F]fluorothymidine by means of disposable solid-phase extraction cartridges, Computed Properties of 17351-62-1, the publication is Nuclear Medicine and Biology (2012), 39(4), 540-550, database is CAplus and MEDLINE.

3′-Deoxy-3′-[¹⁸F]fluorothymidine ([¹⁸F]FLT) shows great potential as a tracer for proliferative studies with PET. However, its regular application is often limited by low radiochem. yields and the use of a troublesome HPLC separation Moreover, a high content of ethanol, at least one-fold higher than the European Pharmacopoeia and US Pharmacopoeia’s established limit, is always present in the final product. The present study reports an optimization of the reaction conditions and a simple and straightforward purification step which affords a solution of [¹⁸F]FLT suitable for human use. Several conditions and materials were tested for both the nucleophilic substitution and purification step. The latter was achieved by means of a series of com. solid-phase extraction cartridges. Very conveniently, the whole one-pot synthesis was carried out on com. automated modules using basically the same setup employed for the synthesis of [¹⁸F]FDG. Under routine conditions, radiochem. yields of 37% [decay-corrected to start of synthesis (SOS)] were achieved in ca. 39 min from SOS, with radiochem. purities >98% (usually >99%). The negligible radiolysis observed could be easily suppressed by adding 0.5% of EtOH. Typical unlabeled chem. impurities detected were thymidine (0.15 ppm), thymine (0.28 ppm) and stavudine (0.05 ppm). A reliable, simple and efficient preparation of [¹⁸F]FLT has been developed, able to afford an ethanol-free solution of the tracer with no need for any HPLC purification Because of its similarity to the [¹⁸F]FDG synthesis, the method can be readily implemented on basically all the com. modules developed for this common radiotracer.

Nuclear Medicine and Biology published new progress about 17351-62-1. 17351-62-1 belongs to catalysis-chemistry, auxiliary class Salt,Amine, name is Tetrabutylammonium hydrogencarbonate, and the molecular formula is C17H37NO3, Computed Properties of 17351-62-1.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Cheng, Stephen C. published the artcileElectrochemical and IR Spectroelectrochemical Studies of the Electrocatalytic Reduction of Carbon Dioxide by [Ir₂(dimen)₄]²⁺ (dimen = 1,8-Diisocyanomenthane), Formula: C17H37NO3, the publication is Inorganic Chemistry (1996), 35(26), 7704-7708, database is CAplus.

The electrocatalytic reactions of carbon dioxide that are catalyzed by [Ir₂(dimen)₄]²⁺ (dimen = 1,8-diisocyanomenthane) were studied with cyclic voltammetry and IR spectroelectrochem. The hexafluorophosphate (PF₆^–) salt and the tetraphenylborate (BPh₄^–) salt are electrocatalysts for carbon dioxide reduction IR spectroelectrochem. allowed the identification of the carbon dioxide reduction products and provided information about the mechanism(s) of the reduction Bicarbonate and formate were identified as the electrocatalytic carbon dioxide reaction products by comparing the IR bands observed by spectroelectrochem. with authentic samples of tetrabutylammonium formate, tetrabutylammonium oxalate, and tetrabutylammonium bicarbonate. Formate arises from a net two-electron reduction of carbon dioxide that produces free formate and a formate complex of [Ir₂(dimen)₄]²⁺. Bicarbonate results from the reaction of hydroxide (produced when residual water is reduced to hydrogen) with carbon dioxide.

Inorganic Chemistry published new progress about 17351-62-1. 17351-62-1 belongs to catalysis-chemistry, auxiliary class Salt,Amine, name is Tetrabutylammonium hydrogencarbonate, and the molecular formula is C17H37NO3, Formula: C17H37NO3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Cunningham, Drew W. published the artcileReversible and Selective CO₂ to HCO₂^– Electrocatalysis near the Thermodynamic Potential, Quality Control of 17351-62-1, the publication is Angewandte Chemie, International Edition (2020), 59(11), 4443-4447, database is CAplus and MEDLINE.

Reversible catalysis is a hallmark of energy-efficient chem. transformations, but can only be achieved if the changes in free energy of intermediate steps are minimized and the catalytic cycle is devoid of high transition-state barriers. Using these criteria, the authors demonstrate reversible CO₂/HCO₂^– conversion catalyzed by [Pt(depe)₂]²⁺ (depe = 1,2-bis(diethylphosphino)ethane). Direct measurement of the free energies associated with each catalytic step correctly predicts a slight bias towards CO₂ reduction The exptl. measured free energy of each step directly contributes to the <50 mV overpotential. Also for CO₂ reduction, H₂ evolution is negligible and the faradaic efficiency for HCO₂^– production is nearly quant. A free-energy anal. reveals H₂ evolution is endergonic, providing a thermodn. basis for highly selective CO₂ reduction

Angewandte Chemie, International Edition published new progress about 17351-62-1. 17351-62-1 belongs to catalysis-chemistry, auxiliary class Salt,Amine, name is Tetrabutylammonium hydrogencarbonate, and the molecular formula is C17H37NO3, Quality Control of 17351-62-1.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Kim, Dong Wook published the artcileA New Class of S_N2 Reactions Catalyzed by Protic Solvents: Facile Fluorination for Isotopic Labeling of Diagnostic Molecules, HPLC of Formula: 17351-62-1, the publication is Journal of the American Chemical Society (2006), 128(50), 16394-16397, database is CAplus and MEDLINE.

Aprotic solvents are usually preferred for the S_N2 reactions, because nucleophilicity and hence S_N2 reactivity are severely retarded by the influence of the partial pos. charge of protic solvents. In this work, we introduce a remarkable effect of using tertiary alcs. as a reaction medium for nucleophilic fluorination with alkali metal fluorides. In this novel synthetic method, the nonpolar protic tert-alc. enhances the nucleophilicity of the fluoride ion dramatically in the absence of any kind of catalyst, greatly increasing the rate of the nucleophilic fluorination and reducing formation of byproducts (such as alkenes, alcs., or ethers) compared with conventional methods using dipolar aprotic solvents. The great efficacy of this method is a particular advantage in labeling radiopharmaceuticals with [¹⁸F]fluorine (t_1/2 = 110 min) for positron emission tomog. (PET) imaging, and it is illustrated by the synthesis of four [¹⁸F]fluoride-radiolabeled mol. imaging probes – [¹⁸F]FDG, [¹⁸F]FLT, [¹⁸F]FP-CIT, and [¹⁸F]FMISO – in high yield and purity and in shorter times compared to conventional syntheses.

Journal of the American Chemical Society published new progress about 17351-62-1. 17351-62-1 belongs to catalysis-chemistry, auxiliary class Salt,Amine, name is Tetrabutylammonium hydrogencarbonate, and the molecular formula is C17H37NO3, HPLC of Formula: 17351-62-1.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Sareen, Divya published the artcileHost-guest complexation behavior of emissive calix[3]naphthobipyrrole toward aromatic guests, Recommanded Product: Tetrabutylammonium hydrogencarbonate, the publication is Supramolecular Chemistry (2018), 30(11), 949-954, database is CAplus.

A new hexapyrrolic macrocycle composed of three naphthobipyrrole units has been synthesized which exhibited different emission changes with hydrogen pyrophosphate and benzoate ions. Phosphate ions caused red shifting of the fluorescence band of calixnaphthobipyrrole while benzoate ions resulted in quenching of the same. The fluorescence quenching was further utilized for investigating binding preferences of the probe with neutral aromatic guest mols. substituted with groups having varied electron withdrawing abilities. The extent of quenching with the neutral guests increased with the increasing electron deficiency on the aromatic ring of the guest. The fluorescence quenching has been ascribed to electron transfer from the host to the guest species.

Supramolecular Chemistry published new progress about 17351-62-1. 17351-62-1 belongs to catalysis-chemistry, auxiliary class Salt,Amine, name is Tetrabutylammonium hydrogencarbonate, and the molecular formula is C17H37NO3, Recommanded Product: Tetrabutylammonium hydrogencarbonate.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Culbert, P. A. published the artcileAutomated synthesis of [¹⁸F]FDG using tetrabutylammonium bicarbonate, Synthetic Route of 17351-62-1, the publication is Applied Radiation and Isotopes (1995), 46(9), 887-91, database is CAplus.

The synthesis of [¹⁸F]FDG using tetrabutylammonium bicarbonate has been successfully modified to accommodate automation using the Optomux control system. Noteworthy changes to the methods previously reported are the addition of a small ion exchange column which serves to quant. trap [¹⁸F]fluoride from the target water and the extensive use of thermocouple and radiation detector feedback for process control. The radiochem. yields observed over 30 runs are: 50.3 ± 9% decay corrected and 34.6 ± 6% decay uncorrected.

Applied Radiation and Isotopes published new progress about 17351-62-1. 17351-62-1 belongs to catalysis-chemistry, auxiliary class Salt,Amine, name is Tetrabutylammonium hydrogencarbonate, and the molecular formula is C17H37NO3, Synthetic Route of 17351-62-1.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Hassan, Hishar published the artcileImproving the ¹⁸F-fluoromethylcholine (¹⁸F-FCH) radiochemical yield via optimising the azeotropic drying of non-carrier-added ¹⁸F-fluorine, Related Products of catalysis-chemistry, the publication is Journal of Labelled Compounds and Radiopharmaceuticals (2015), 58(11-12), 458-459, database is CAplus and MEDLINE.

¹⁸F-Fluoromethylcholine (¹⁸F-FCH) has been suggested as one of the reputable imaging tracers for diagnosis of prostate tumor in PET/CT examination Nevertheless, it has never been synthesized in Malaysia. The authors acknowledge that the major problem with ¹⁸F-FCH is due to its relatively low radiochem. yield at the end of synthesis (EOS). Therefore, this tech. note presents improved ¹⁸F-FCH radiochem. yields after carrying out optimization on azeotropic drying of non-carrier-added ¹⁸F-fluorine.

Journal of Labelled Compounds and Radiopharmaceuticals published new progress about 17351-62-1. 17351-62-1 belongs to catalysis-chemistry, auxiliary class Salt,Amine, name is Tetrabutylammonium hydrogencarbonate, and the molecular formula is C17H37NO3, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia