Category: 1772-76-5

Seyedi, Neda published the artcileMicrowave-assisted eco-friendly method for the synthesis of cinnamic acids, Related Products of catalysis-chemistry, the publication is Heterocyclic Letters (2014), 4(1), 13-16, 4 pp., database is CAplus.

Condensation of acylals RCH(OAc)₂ (R = Ph, 2-ClC₆H₄, 2,4-Cl₂C₆H₃, etc.) with malonic acid in the presence of ammonium acetate under microwave irradiation conditions allowed for the green synthesis of cinnamic acids RCH:CHCO₂H in 70-90% yields.

Heterocyclic Letters published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C18H23N3O4S, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Kaminska, Katarzyna published the artcile(2-Arylethenyl)-1,3,5-triazin-2-amines as a novel histamine H₄ receptor ligands, COA of Formula: C9H7NO4, the publication is European Journal of Medicinal Chemistry (2015), 238-251, database is CAplus and MEDLINE.

Within the constantly growing number of histamine H₄ (H₄R) receptor ligands there is a large group of azine derivatives A series of novel compounds in the group of 4-methylpiperazinyl-1,3,5-triazin-2-amines were designed and obtained. Structures were modified at the triazine 6-position by introduction of variously substituted arylethenyl moieties. Their affinities to histamine H₄ receptors were evaluated in radioligand binding assays with use of Sf9 cells, transiently expressing human H₄R. Pharmacol. studies identified 4-[(E)-2-(3-chlorophenyl)ethenyl]-6-(4-methylpiperazin-1-yl)-1,3,5-triazin-2-amine (K_i = 253 nM) as the most potent compound in the present series.

European Journal of Medicinal Chemistry published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C9H7NO4, COA of Formula: C9H7NO4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Chen, Yao published the artcileSynthesis and bioevaluation of new tacrine-cinnamic acid hybrids as cholinesterase inhibitors against Alzheimer’s disease, Recommanded Product: (E)-3-(3-Nitrophenyl)acrylic acid, the publication is Journal of Enzyme Inhibition and Medicinal Chemistry (2018), 33(1), 290-302, database is CAplus and MEDLINE.

Small mol. cholinesterases inhibitor (ChEI) provides an effective therapeutic strategy to treat Alzheimer’s disease (AD). Currently, the discovery of new ChEI with multi-target effect is still of great importance. Herein, we report the synthesis, structure-activity relationship study and biol. evaluation of a series of tacrine-cinnamic acid hybrids as new ChEIs. All target compounds are evaluated for their in vitro cholinesterase inhibitory activities. The representatives which show potent activity on cholinesterase, are evaluated for the amyloid ¦Â-protein self-aggregation inhibition and in vivo assays. The optimal compound , , and (human AChE IC₅₀ = 10.2 ¡À 1.2, 16.5 ¡À 1.7, and 15.3 ¡À 1.8 nM, resp.) show good performance in ameliorating the scopolamine-induced cognition impairment and preliminary safety in hepatotoxicity evaluation. These compounds deserve further evaluation for the development of new therapeutic agents against AD.

Journal of Enzyme Inhibition and Medicinal Chemistry published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C9H7NO4, Recommanded Product: (E)-3-(3-Nitrophenyl)acrylic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Garreau, Alyssa L. published the artcileA Protocol for the Ortho-Deuteration of Acidic Aromatic Compounds in D₂O Catalyzed by Cationic Rh^III, Related Products of catalysis-chemistry, the publication is Organic Letters (2019), 21(17), 7044-7048, database is CAplus and MEDLINE.

Methods to catalytically introduce deuterium in synthetically useful yields ortho to a carboxylic acid directing group on arenes typically requires D₂ or high catalyst loadings, which makes using these approaches cost prohibitive for large-scale synthesis (equipment and reagent costs resp.). Herein, we present a simplified approach using low catalyst loadings of cationic Rh^III and D₂O as both deuterium source and solvent and show its application to H/D exchange on various carboxylic acid substrates.

Organic Letters published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C9H7NO4, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Xu, Shengtao published the artcileA Novel Potent Anticancer Compound Optimized from a Natural Oridonin Scaffold Induces Apoptosis and Cell Cycle Arrest through the Mitochondrial Pathway, Recommanded Product: (E)-3-(3-Nitrophenyl)acrylic acid, the publication is Journal of Medicinal Chemistry (2017), 60(4), 1449-1468, database is CAplus and MEDLINE.

The cytotoxicity of the natural ent-kaurene diterpenoid, oridonin, has been extensively studied. However, the application of oridonin for cancer therapy was hampered primarily by its moderate potency. In this study, a series of oridonin A-ring modified analogs, and their derivatives bearing various substituents on 14-OH position, were designed, synthesized and evaluated for anticancer efficacy. Some of the derivatives were significantly more potent than oridonin against both drug-sensitive and drug-resistant cancer cells. The most potent compound, I, was 200-fold more efficacious than oridonin in MCF-7 cancer cells. Furthermore, I induced apoptosis and cell cycle arrest at the G2/M phase. A decrease in mitochondrial membrane potential and increased Bax/Bcl-2 ratio, accompanied by activated caspase-3 cleavage, were observed in MCF-7 cells after treatment with I, suggesting that the mitochondrial pathway was involved in the I-mediated apoptosis. Moreover, I significantly inhibited tumor growth in mouse xenograft models and had no observable toxic effect.

Journal of Medicinal Chemistry published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C20H18BrN3, Recommanded Product: (E)-3-(3-Nitrophenyl)acrylic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Yang, Hailong published the artcileIron-catalyzed direct alkenylation of sp³(C-H) bonds via decarboxylation of cinnamic acids under ligand-free conditions, Computed Properties of 1772-76-5, the publication is Green Chemistry (2013), 15(4), 976-981, database is CAplus.

An example of highly efficient low-cost ferrocene-catalyzed decarboxylative C(sp²)-C(sp³) coupling reactions via C-H functionalization has been developed successfully. It is noteworthy that nanoparticles of Fe₃O₄ could be used as a reusable catalyst for 7 times in the absence of ligand.

Green Chemistry published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C7H7ClN2, Computed Properties of 1772-76-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Cai, Shunyou published the artcileVisible-light-enabled decarboxylative sulfonylation of cinnamic acids with sulfonylhydrazides under transition-metal-free conditions, Computed Properties of 1772-76-5, the publication is Organic Letters (2016), 18(12), 2990-2993, database is CAplus and MEDLINE.

Decarboxylative cross-coupling reactions of cinnamic acids with sulfonylhydrazides were explored using oxygen as the sole terminal oxidant, realizing a conceptually novel technol. for vinyl sulfone synthesis under the synergistic interactions of visible light irradiation, organic dye-type photocatalyst eosin Y, KI, and Cs₂CO₃ at room temperature

Organic Letters published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C9H7NO4, Computed Properties of 1772-76-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Luo, Zai-Gang published the artcileCu(NO₃)₂-catalyzed nitrodecarboxylation of ¦Á,¦Â-unsaturated acids: facile synthesis of (E)-nitroolefins under additive-free conditions, Name: (E)-3-(3-Nitrophenyl)acrylic acid, the publication is Research on Chemical Intermediates (2016), 42(6), 6079-6087, database is CAplus.

An additive-free, facile, efficient, and ecofriendly protocol for synthesis of (E)-nitroolefins via nitrodecarboxylation of ¦Á,¦Â-unsaturated acids was developed. Cu(NO₃)₂ was used as both nitrating agent and catalyst. Furthermore, the presented methodol. offers several advantages such as easily accessible and stable substrates, inexpensive catalyst, high to excellent yield, short reaction time, and simple posttreatment procedure.

Research on Chemical Intermediates published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C9H7NO4, Name: (E)-3-(3-Nitrophenyl)acrylic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Gong, Pei-Xue published the artcileIron-catalyzed domino decarboxylation-oxidation of ¦Á,¦Â-unsaturated carboxylic acids enabled aldehyde C-H methylation, HPLC of Formula: 1772-76-5, the publication is Chemical Communications (Cambridge, United Kingdom) (2021), 57(48), 5905-5908, database is CAplus and MEDLINE.

A practical and general iron-catalyzed domino decarboxylation-oxidation of ¦Á,¦Â-unsaturated carboxylic acids enabling aldehyde C-H methylation for the synthesis of Me ketones has been developed. This mild, operationally simple method uses ambient air as the sole oxidant and tolerates sensitive functional groups for the late-stage functionalization of complex natural-product-derived and polyfunctionalized mols.

Chemical Communications (Cambridge, United Kingdom) published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C9H7NO4, HPLC of Formula: 1772-76-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Jiang, Qing published the artcileCopper-Catalyzed Aerobic Decarboxylative Sulfonylation of Cinnamic Acids with Sodium Sulfinates: Stereospecific Synthesis of (E)-Alkenyl Sulfones, HPLC of Formula: 1772-76-5, the publication is Journal of Organic Chemistry (2014), 79(16), 7372-7379, database is CAplus and MEDLINE.

A copper-catalyzed aerobic decarboxylative sulfonylation of alkenyl carboxylic acids with sodium sulfinates is developed. This study offers a new and expedient strategy for stereoselective synthesis of (E)-alkenyl sulfones that are widely present in biol. active natural products and therapeutic agents. Moreover, the transformation is proposed to proceed via a radical process and exhibits a broad substrate scope and good functional group tolerance.

Journal of Organic Chemistry published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C9H7NO4, HPLC of Formula: 1772-76-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia