Category: 1772-76-5

Gao, Bao published the artcileCopper-catalyzed decarboxylative cross-coupling of cinnamic acids and ACCN via single electron transfer, Category: catalysis-chemistry, the publication is Organic & Biomolecular Chemistry (2016), 14(8), 2399-2402, database is CAplus and MEDLINE.

A novel and convenient method for the synthesis of ¦Â,¦Ã-unsaturated nitriles using ACCN (1,1′-azobis(cyclohexane-1-carbonitrile)) as a cyano source was described. This reaction was amenable to a broad range of substrates and provided the desired ¦Â,¦Ã-unsaturated nitriles containing an all-carbon quaternary carbon center in moderate yields with high selectivity via single electron transfer and decarboxylation.

Organic & Biomolecular Chemistry published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C9H7NO4, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Tang, Lin published the artcileSolvent-Controlled Copper-Catalyzed Radical Decarboxylative Coupling for Alkenyl C(sp²)-P Bond Formation, Formula: C9H7NO4, the publication is Asian Journal of Organic Chemistry (2017), 6(11), 1683-1692, database is CAplus.

The first solvent-controlled copper-catalyzed oxidative decarboxylative coupling of alkenyl acids with P(O)H compounds for alkenyl C(sp²)-P bond formation by a free-radical process is reported. The reaction enables the highly chemo- and stereoselective synthesis of various (E)-alkenylphosphonates and (E)-alkenylphosphine oxides in moderate to good yields. On the basis of this catalytic system, styrenes and ¦Â-nitrostyrene as well as alkenyl acids can also give the corresponding products by cross-dehydrogenative coupling and denitration, resp. By altering the oxidant, the oxyphosphorylation of styrenes with P(O)H compounds readily yields ¦Â-ketophosphonates. The reaction described here enables a versatile and practical avenue for the formation of valuable C-P bonds.

Asian Journal of Organic Chemistry published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C6H12N2O, Formula: C9H7NO4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Han, Jianlei published the artcileDecarboxylative bromination of cinnamic acids by 2-iodoxybenzoic acid with tetrabutylammonium bromide, Recommanded Product: (E)-3-(3-Nitrophenyl)acrylic acid, the publication is Journal of Chemical Research (2012), 36(5), 247-248, database is CAplus.

The decarboxylative bromination of cinnamic acids using the hypervalent iodine reagent 2-iodoxybenzoic acid with tetrabutylammonium bromide was described, providing good to excellent yields of bromostyrenes.

Journal of Chemical Research published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C9H7NO4, Recommanded Product: (E)-3-(3-Nitrophenyl)acrylic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Xiao, Chengqian published the artcilePd(II)-catalyzed cascade Heck/intramolecular C(sp²)-H amidation reaction: An efficient route to 4-aryl-2-quinolinones, Computed Properties of 1772-76-5, the publication is Tetrahedron (2017), 73(2), 204-211, database is CAplus.

A Pd(II)-catalyzed cascade Heck/intramol. C(sp²)-H amidation reaction is described for the synthesis of 4-aryl-2-quinolinone derivatives Substituted cinnamamides containing 2-(pyridin-2-yl)ethanamine units reacts with aryl iodides to form intermediates by Heck reaction. Then, the intermediate undergoes intramol. amidation via a C(sp²)-H activated process promoted by an orientation group.

Tetrahedron published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C7H5ClN2S, Computed Properties of 1772-76-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Gatzenmeier, Tim published the artcileAsymmetric Lewis acid organocatalysis of the Diels-Alder reaction by a silylated C-H acid, HPLC of Formula: 1772-76-5, the publication is Science (Washington, DC, United States) (2016), 351(6276), 949-952, database is CAplus and MEDLINE.

Silylium ion equivalent have shown promise as Lewis acid catalysts for a range of important C-C bond-forming reactions. Here we describe chiral C-H acids that upon in situ silylation, generate silylium-carbanion pairs, which are extremely active Lewis acid catalysts for enantioselective Diels-Alder reactions of cinnamates with cyclopentadiene. Enantiomeric ratios of up to 97:3 and diastereomeric ratios of more than 20:1 are observed across a diverse set of substitution patterns with 1 mol percent (mol%) of C-H acid catalyst and 10 mol% of a silylating reagent. The results show promise for broad applications of such C-H acid-derived silylium ion equivalent in asym. Lewis acid catalysis.

Science (Washington, DC, United States) published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C9H7NO4, HPLC of Formula: 1772-76-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Perez, Bianca C. published the artcileN-Cinnamoylated Chloroquine Analogues as Dual-Stage Antimalarial Leads, Application of (E)-3-(3-Nitrophenyl)acrylic acid, the publication is Journal of Medicinal Chemistry (2013), 56(2), 556-567, database is CAplus and MEDLINE.

The control of malaria is challenged by drug resistance, and new antimalarial drugs are needed. New drug discovery efforts include consideration of hybrid compounds as potential multitarget antimalarials. Previous work from our group has demonstrated that hybrid structures resulting from cinnamic acid conjugation with heterocyclic moieties from well-known antimalarials present improved antimalarial activity. Now, we report the synthesis and SAR anal. of an expanded series of cinnamic acid derivatives displaying remarkably high activities against both blood- and liver-stage malaria parasites. Two compounds judged most promising, based on their in vitro activity and druglikeness according to the Lipinski rules and Veber filter, were active in vivo against blood-stage rodent malaria parasites. Therefore, the compounds reported represent a new entry as promising dual-stage antimalarial leads.

Journal of Medicinal Chemistry published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C9H7NO4, Application of (E)-3-(3-Nitrophenyl)acrylic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Sidneva, Vera V. published the artcileOne-pot synthesis of 3,5-disubstituted 1,2,4-oxadiazoles containing an alkenyl moiety, Product Details of C9H7NO4, the publication is Chemistry of Heterocyclic Compounds (New York, NY, United States) (2022), 58(6-7), 349-353, database is CAplus.

A one-pot method was developed for the preparation of 3,5-disubstituted 1,2,4-oxadiazoles containing an alkenyl fragment I (R = Ph, 3-O₂NC₆H₄, 3-pyridyl, etc.; R¹ = Ph, 3-ClC₆H₄, 2-thienyl, etc.), which entails the preparation of O-acylamidoximes and their subsequent cyclization using N,N¡ä-dimethylacetamide as a solvent. The proposed method allows to significantly reduce the overall synthesis time by carrying out all steps sequentially in a single reactor, avoiding the step of isolation of the intermediate O-acylamidoxime, leading to the production of 5-alkenyl-1,2,4-oxadiazoles in high yields.

Chemistry of Heterocyclic Compounds (New York, NY, United States) published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C15H10O2, Product Details of C9H7NO4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Deng, Yu published the artcileSemi-synthesis, antibacterial activity, and molecular docking study of novel pleuromutilin derivatives bearing cinnamic acids moieties, Application of (E)-3-(3-Nitrophenyl)acrylic acid, the publication is Archiv der Pharmazie (Weinheim, Germany) (2019), 352(1), n/a, database is CAplus and MEDLINE.

To develop new antibiotics owning a special mechanism, we used the mol. assembly method to synthesize a series of novel pleuromutilin derivatives containing a cinnamic acid scaffold at the C-14 side chain. We evaluated their antibacterial activity and used in silico mol. docking to study their binding mode with the target. The structure-activity relationship (SAR) study suggested that compounds with NO₂ (13e), OH (13u), and NH₂ (13y) appeared more active (0.0625-2 ¦Ìg/mL) in vitro against several penicillin-resistant Gram-pos. bacteria and the position of the substituent on the benzene ring would affect the activity. The in vivo efficacy investigation of 13e, 13u, and 13y with once daily intragastric (i.g.) administration at 40 mg/kg for 3 consecutive days in a mouse systemic infection model showed that 13u had equal activity as valnemulin providing the mice with 60% survival, while 13e and 13y gave 30 and 40% survival, resp. The mol. docking studies indicated that ¦Ð-¦Ð stacking and hydrogen bond formation played important roles in improving the antibacterial activity.

Archiv der Pharmazie (Weinheim, Germany) published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C9H7NO4, Application of (E)-3-(3-Nitrophenyl)acrylic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Promkatkaew, Malinee published the artcilePhotophysical properties and photochemistry of substituted cinnamates and cinnamic acids for UVB blocking: effect of hydroxy, nitro and fluoro substitutions at ortho, meta and para positions, Application In Synthesis of 1772-76-5, the publication is Photochemical & Photobiological Sciences (2014), 13(3), 583-594, database is CAplus and MEDLINE.

Photophys. properties and photochem. of various substituted cinnamates and cinnamic acids for UV B blocking were investigated exptl. and theor. This series includes monohydroxy, -nitro and -fluoro derivatives The absorption spectra were satisfactorily reproduced by the direct SAC-CI method with respect to the peak position and intensity. The transition character of the low-lying two ¦Ð¦Ð^* and ¦Ò¦Ð^* states for these 18 derivatives was analyzed. The para derivatives have a different transition character of the ¦Ð¦Ð^* transitions compared with those of the ortho and meta derivatives To elucidate the relaxation mechanism, the emission spectra were observed with oxygen quenching and the photostability was examined exptl. The calculated radiative lifetimes indicate that the ortho- and meta-substituted derivatives have longer lifetimes for emission than the para derivatives The potential energy curves of the first and second singlet excited states of the hydroxy derivatives as well as the vertical singlet and triplet transitions were examined to investigate the relaxation qual. The ortho and meta derivatives have an energy barrier or flat surface in S₁ resulting in fluorescence, whereas the para derivatives show nonradiative decay without an energy barrier. The para-hydroxy derivative was found to be an excellent UV absorber based on its broad absorption in the UVB/UVA regions, less emission and higher photostability.

Photochemical & Photobiological Sciences published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C9H7NO4, Application In Synthesis of 1772-76-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Liao, Daohong published the artcileNecrosulfonamide inhibits necroptosis by selectively targeting the mixed lineage kinase domain-like protein, Safety of (E)-3-(3-Nitrophenyl)acrylic acid, the publication is MedChemComm (2014), 5(3), 333-337, database is CAplus.

Through high-throughput screening of 200 000 compounds and subsequent structure-activity relationship (SAR) studies we identified necrosulfonamide (NSA) as a potent small mol. inhibitor for necroptosis, induced by a combination of TNF-a, Smac mimetic, and z-VAD-fmk (T/S/Z). Applying a forward chem. genetic approach, we utilized an NSA based chem. probe to further reveal that NSA selectively targeted the Mixed Lineage Kinase Domain-like Protein (MLKL) to block the necrosome formation.

MedChemComm published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C9H7NO4, Safety of (E)-3-(3-Nitrophenyl)acrylic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia