Category: 1772-76-5

Lanigan, Rachel M. published the artcileDirect Synthesis of Amides from Carboxylic Acids and Amines Using B(OCH₂CF₃)₃, HPLC of Formula: 1772-76-5, the publication is Journal of Organic Chemistry (2013), 78(9), 4512-4523, database is CAplus and MEDLINE.

B(OCH₂CF₃)₃, prepared from readily available B₂O₃ and 2,2,2-trifluoroethanol, is as an effective reagent for the direct amidation of a variety of carboxylic acids with a broad range of amines. In most cases, the amide products can be purified by a simple filtration procedure using com. available resins, with no need for aqueous workup or chromatog. The amidation of N-protected amino acids with both primary and secondary amines proceeds effectively, with very low levels of racemization. B(OCH₂CF₃)₃ can also be used for the formylation of a range of amines in good to excellent yield, via transamidation of DMF.

Journal of Organic Chemistry published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C9H7NO4, HPLC of Formula: 1772-76-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Raghavendra, Gutala Jeevan published the artcileDesign and synthesis of 3-ethyl 5-methyl 2-((2-substituted aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate analogues as antitubercular and anti-bacterial agents, Recommanded Product: (E)-3-(3-Nitrophenyl)acrylic acid, the publication is Heterocyclic Letters (2019), 9(1), 79-83, database is CAplus.

A series of eleven novel 3-Et 5-Me 2-((2-substituted aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate analogs, e.g., I [R = 2-(3-nitrophenyl)ethenyl], was synthesized, characterized and screened for their in vitro anti-tubercular activity against MTBH37Rv strain and anti-bacterial activity against Pseudomonas aeruginosa (gram-neg.), Escherichia coli(gram-neg.), Bacillus subtilis (gram-pos.), Staphylococcus aureus (gram-pos.). Many of these compounds exhibited MIC values in the range 12.5-50¦Ìg/mL against Mycobacterium tuberculosis H37RV. Some compounds exhibited good anti-bacterial activity against Pseudomonas aeruginosa with 8 mm, Bacillus subtilis with 9 mm of inhibition.

Heterocyclic Letters published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C9H7NO4, Recommanded Product: (E)-3-(3-Nitrophenyl)acrylic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Kooner, Anoopjit Singh published the artcileSynthesis and microbial activity of acrylamides with heteroatoms, Computed Properties of 1772-76-5, the publication is Journal of the Indian Chemical Society (2014), 91(2), 293-298, database is CAplus.

The modified condensation reaction of benzaldehyde, 2-chlorobenzaldehyde, 3-nitrobenzaldehyde, and 4-chlorobenzaldehyde with ¦Á-proton containing acids viz. acetic acid and similar reaction of propionic acid with 3-nitrobenzaldehyde and 4-chlorobenzaldehyde in the presence of sodium borohydride to afford corresponding acrylic acids I (R¹ = H, 3-O₂N, 4-Cl, 2-Cl; R² = H, CH₃) which on further reaction with amines like morpholine and 4-aminophenazone in the presence of base and thionylchloride yielded series of acrylamides II (R¹ = H, 3-O₂N, 4-Cl, 2-Cl; R² = H, CH₃) and III (R¹ = H, 3-O₂N, 4-Cl, 2-Cl; R² = H, CH₃). Phys. data (yield, m.p., state and color) of synthesized acids and amides were determined Amide derivative were tested for their microbial activity on Rhizobium sp. (LMR 07), Bradyrhizobium sp. (BJP), Pseudomonas sp. (LK 791) and Bacillus sp. (BSY 101) at different concentration Amides with morpholine moiety showed promising results.

Journal of the Indian Chemical Society published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C9H7NO4, Computed Properties of 1772-76-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Kaur, Sandeep published the artcileConventional as well as microwave assisted synthesis and microbial effect of some new acrylamides, Related Products of catalysis-chemistry, the publication is Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry (2013), 52B(12), 1513-1520, database is CAplus.

Knoevenagel condensation of a variety of aromatic aldehydes with acetic acid in the presence of sodium borohydride gave the corresponding cinnamic acids R¹CH:CHCO₂H (R¹ = Ph, 2-ClC₆H₄, 4-ClC₆H₄, 3-O₂NC₆H₄, 2-MeOC₆H₄, 4-MeOC₆H₄) which further reacted with furfurylamine or 2-aminopyridine either by conventional method in the presence of a catalytic amount of boric acid or using microwave irradiation to form the corresponding cinnamides R¹CH:CHC(O)NHR² (R² = 2-furylmethyl, 2-pyridyl) (I). For all the compounds, the amidation under microwave irradiation conditions gave higher yields and took less time than the reactions under conventional heating conditions. The resulting amides were screened for their antimicrobial activity against bacteria [Bacillus sp. (BSY 101), Pseudomonas sp. (LK 791) and Ensifer sp. (IND 2)], fungus (Ascochyta blight) and yeast (Sacchromyces cerevisiae). The majority of the synthesized amides showed poor inhibition against Bacillus sp., Pseudomonas sp. and Ensifer sp. The compounds I (R¹ = 4-ClC₆H₄, 4-MeOC₆H₄; R² = 2-furylmethyl) and I (R¹ = 2-ClC₆H₄, 4-MeOC₆H₄; R² = 2-pyridyl) showed the best activity against Ensifer sp. The products containing a pyridine moiety were found to be more effective against bacteria than those based on furfurylamine. All the amides were ineffective against fungus and yeast.

Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C9H7NO4, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Giessel, Josephine M. published the artcileSubstituted cinnamic anhydrides act as selective inhibitors of acetylcholinesterase, Formula: C9H7NO4, the publication is Bioorganic Chemistry (2019), 103058, database is CAplus and MEDLINE.

Cinnamic anhydrides have been shown to be more than reactive reagents, but they also act as inhibitors of the enzyme acetylcholinesterease (AChE). Thus, out of a set of 33 synthesized derivatives, several of them were mixed type inhibitors for AChE (from elec. eel). Thus, (E)-3-(2,4-dimethoxyphenyl)acrylic anhydride (2c) showed K_i = 8.30 ¡À 0.94 ¦ÌM and K_i‘ = 9.54 ¡À 0.38 ¦ÌM, and for (E)-3-(3-chlorophenyl)acrylic anhydride (2u) K_i = 8.23 ¡À 0.93 ¦ÌM and K_i‘ = 13.07 ¡À 0.46 ¦ÌM were measured. While being not cytotoxic to many human cell lines, these compounds showed an unprecedented and noteworthy inhibitory effect for AChE but not for butyrylcholinesterase (BChE).

Bioorganic Chemistry published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C9H7NO4, Formula: C9H7NO4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Timelthaler, Daniel published the artcileSelective and Additive-Free Hydrogenation of Nitroarenes Mediated by a DMSO-Tagged Molecular Cobalt Corrole Catalyst, Application In Synthesis of 1772-76-5, the publication is European Journal of Organic Chemistry (2021), 2021(14), 2114-2120, database is CAplus and MEDLINE.

We report on the first cobalt corrole that effectively mediates the homogeneous hydrogenation of structurally diverse nitroarenes to afford the corresponding amines. The given catalyst is easily assembled prior to use from 4-tert-butylbenzaldehyde and pyrrole followed by metalation of the resulting corrole macrocycle with cobalt(II) acetate. The thus-prepared complex is self-contained in that the hydrogenation protocol is free from the requirement for adding any auxiliary reagent to elicit the catalytic activity of the applied metal complex. Moreover, a containment system is not required for the assembly of the hydrogenation reaction set-up as both the autoclave and the reaction vessels are readily charged under a regular laboratory atm.

European Journal of Organic Chemistry published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C6H8O3, Application In Synthesis of 1772-76-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Ghafari, Shahrzad published the artcileNovel morpholine containing cinnamoyl amides as potent tyrosinase inhibitors, Synthetic Route of 1772-76-5, the publication is International Journal of Biological Macromolecules (2019), 978-985, database is CAplus and MEDLINE.

Tyrosinase enzyme plays a crucial role in melanin biosynthesis and enzymic browning process of vegetables and fruits. Hence, tyrosinase inhibitors are important in the fields of medicine, cosmetics and agriculture. In this study, novel N-(2-morpholinoethyl)cinnamamide derivatives bearing different substituents on Ph ring were designed, synthesized and evaluated for their tyrosinase diphenolase inhibitory activity. The compounds were found to be better tyrosinase inhibitors (IC₅₀s were in micro molar range) than cinnamic acid. (E)-3-(3-chlorophenyl)-N-(2-morpholinoethyl)acrylamide (B6) exhibited the highest inhibition with IC₅₀ value of 15.2 ¡À 0.6¦ÌM which was comparable to that of kojic acid. The inhibition kinetic anal. of B6 indicated that the compound was a mixed-type tyrosinase inhibitor. In silico ADME prediction indicated that B6 might show more skin penetration than kojic acid. Mol. docking anal. confirmed that the active inhibitors well accommodated in the mushroom tyrosinase active site and it was also revealed that B6 formed the most stable drug-receptor complex with the target protein. Therefore, cinnamamide B6 could be introduced as a potent tyrosinase inhibitor that might be a promising lead in cosmetics, medicine and food industry.

International Journal of Biological Macromolecules published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C9H7NO4, Synthetic Route of 1772-76-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Selvakumar, Kodirajan published the artcileDevelopment of a mild and efficient protocol for the protection and O-alkylation of allyl alcohols, Related Products of catalysis-chemistry, the publication is RSC Advances (2014), 4(69), 36538-36543, database is CAplus.

An efficient, pyridine-free protocol has been developed for the protection of the tertiary allyl alc. of oxindole using a mild base, such as potassium carbonate, under microwave irradiation conditions. The methodol. has been tested with a variety of substrates and protecting group reagents, which provides a clean and good yield of the desired products within a short reaction time.

RSC Advances published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C14H28O5S, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Li, Huamin published the artcileCopper-catalyzed oxidative coupling of carboxylic acids with formamides for the synthesis of ¦Á,¦Â-unsaturated amides, SDS of cas: 1772-76-5, the publication is Tetrahedron Letters (2013), 54(49), 6679-6681, database is CAplus.

A novel and efficient protocol for the synthesis of ¦Á,¦Â-unsaturated amides was developed using catalytic amounts of Cu(OAc)₂ and TBHP as oxidant. Oxidative coupling of various unsaturated carboxylic acids with N,N-disubstituted formamides furnished the desired products in good yields.

Tetrahedron Letters published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C9H7NO4, SDS of cas: 1772-76-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Kadari, Lingaswamy published the artcileIodine-Catalyzed Facile Approach to Sulfones Employing TosMIC as a Sulfonylating Agent, Name: (E)-3-(3-Nitrophenyl)acrylic acid, the publication is Organic Letters (2017), 19(10), 2580-2583, database is CAplus and MEDLINE.

A novel iodine-catalyzed functionalization of a variety of olefins and alkynes and direct decarboxylative functionalization of cinnamic and propiolic acids with TosMIC to provide access to various vinylic and allylic sulfones is described. This simple, efficient, and environmentally benign approach employing inexpensive mol. iodine as a catalyst demonstrates a versatile protocol for the synthesis of highly valuable sulfones, rendering it attractive to both synthetic and medicinal chem.

Organic Letters published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C9H7NO4, Name: (E)-3-(3-Nitrophenyl)acrylic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia