Category: 1772-76-5

Zheng, Yang published the artcileA NCS mediated oxidative C-H bond functionalization: direct esterification between a C(sp³)-H bond and carboxylic acids, HPLC of Formula: 1772-76-5, the publication is Chemical Communications (Cambridge, United Kingdom) (2015), 51(42), 8837-8840, database is CAplus and MEDLINE.

A transition metal free oxidative C-H bond functionalization/esterification of ¦Á-alkoxy alkanes with acids is described. This method is effectively mediated by NCS instead of traditional oxidants, like TBHP or its derivatives, and directly generates the esterification products in moderate to high yield under mild conditions. This tranformation constitutes a practical and general approach toward various ¦Á-acyloxy ethers with broad substrate generality; alkyl-, aryl-, alkenyl- and alkynyl-carboxylic acids are all well tolerated.

Chemical Communications (Cambridge, United Kingdom) published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C7H16ClNO2, HPLC of Formula: 1772-76-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Gushchin, A. V. published the artcileSynthesis of Ph₃Bi(O₂CR)₂ Compounds with Unsaturated Carboxylic Acids and Use of Triphenylbismuth Dicrotonate in the Synthesis of Bismuth-Containing Polymers, Related Products of catalysis-chemistry, the publication is Russian Journal of General Chemistry (2022), 92(1), 85-94, database is CAplus.

Triphenylbismuth dicarboxylates Ph₃Bi(O₂CCH:CHMe)₂, Ph₃Bi(O₂CCH:CHPh)₂, Ph₃Bi(O₂CCH:CHC₆H₄NO₂-m)₂, Ph₃Bi(O₂CCH:CHC₄H₃O)₂, Ph₃Bi(O₂CCH:CHC₆H₄OMe-p)₂, Ph₃Bi(O₂CCH:CHCH:CHMe)₂, Ph₃Bi(O₂CCH₂CH:CH₂)₂ were obtained by the reaction of triphenylbismuth with ^tBuOOH and unsaturated carboxylic acids in yields of 43-90%. According to the X-ray data for Ph₃Bi(O₂CCH:CHMe)₂, Ph₃Bi(O₂CCH:CHPh)₂, Ph₃Bi(O₂CCH:CHC₆H₄NO₂-m)₂, and Ph₃Bi(O₂CCH:CHC₄H₃O)₂, the coordination of the bismuth atom is intermediate between trigonal bipyramidal and tetragonal pyramidal. Close intermol. contacts (3.648 ?) in the triphenylbismuth dicrotonate crystal, involving the C:C bonds of the crotonate fragments were revealed. Triphenylbismuth dicrotonate was used to synthesize transparent bismuth-containing poly(Me methacrylate) and polystyrene (1-5%). The mol. weight and X-ray and UV absorption characteristics of the polymers were determined

Russian Journal of General Chemistry published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C9H7NO4, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Bedane, Kibrom Gebreheiwot published the artcileFast and efficient synthesis of flavanones from cinnamic acids, SDS of cas: 1772-76-5, the publication is Synthetic Communications (2016), 46(22), 1803-1809, database is CAplus.

A fast and efficient synthesis of flavanones from cinnamic acids in three steps was developed. First, the cinnamic acids were converted to cinnamoyl chlorides using SOCl₂. The acid chlorides were then treated with substituted phenols in BF₃¡¤OEt₂ to furnish the corresponding chalcones in 42-75% yields. Base-catalyzed cyclization of the chalcones at room temperature afforded the corresponding flavanones in 85-95% yields. The conversion of the cinnamic acid derivatives to corresponding chalcones was found to be sensitive to the position and nature of the substituents on the aromatic rings.

Synthetic Communications published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C9H7NO4, SDS of cas: 1772-76-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Saeed, Aamer published the artcileSynthesis, cytotoxicity and molecular modelling studies of new phenylcinnamide derivatives as potent inhibitors of cholinesterases, Application of (E)-3-(3-Nitrophenyl)acrylic acid, the publication is European Journal of Medicinal Chemistry (2014), 43-53, database is CAplus and MEDLINE.

The present study reports the synthesis of cinnamides I [R = 4-ClC₆H₄, 3-O₂NC₆H₄, 2-F-6-ClC₆H₃, etc.] and their biol. activity as inhibitors of both cholinesterases and anticancer agents. Controlled inhibition of brain acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) may slow neurodegeneration in Alzheimer’s diseases (AD). The anticholinesterase activity of phenylcinnamide derivatives was determined against Elec. Eel acetylcholinesterase (EeAChE) and horse serum butyrylcholinesterase (hBChE) and some of the compounds appeared as moderately potent inhibitors of EeAChE and hBChE. Compound I [R = 2-(PhCH₂O)C₆H₄] showed maximum activity against EeAChE with an IC₅₀ 0.29¡À0.21 ¦ÌM whereas I [R = 2-Cl-6-NO₂C₆H₃] was proved to be the most potent inhibitor of hBChE having IC₅₀ 1.18¡À1.31 ¦ÌM. To better understand the enzyme-inhibitor interaction of the most active compounds toward cholinesterases, mol. modeling studies were carried out on high-resolution crystallog. structures. The anticancer effects of synthesized compounds were also evaluated against cancer cell line (lung carcinoma). The compounds may be useful leads for the design of a new class of anticancer drugs for the treatment of cancer and cholinesterase inhibitors for Alzheimer’s disease.

European Journal of Medicinal Chemistry published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C9H7NO4, Application of (E)-3-(3-Nitrophenyl)acrylic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Sun, Juan published the artcileAromatic diacylhydrazine derivatives as a new class of polo-like kinase 1 (PLK1) inhibitors, Application of (E)-3-(3-Nitrophenyl)acrylic acid, the publication is European Journal of Medicinal Chemistry (2014), 420-426, database is CAplus and MEDLINE.

A novel class of aromatic diacylhydrazine derivatives was designed as PLK1 inhibitors. All the 19 new synthesized compounds were assayed for antitumor activity against the resp. cervical cancer cells. In which, nine compounds with better antitumor activities were further tested for their PLK1 inhibitory activity. Last, we have successfully found that compound 7k showed both the promising antitumor activity with IC₅₀ of 0.17 ¦ÌM against the cervical cancer cells, and also processed the most potent PLK1 inhibitory activity with IC₅₀ of 0.03 ¦ÌM. In addition, docking simulation also carried out in this study to give a potent prediction binding mode between the small mol. and PKL1 (PDB code: 1umw) protein.

European Journal of Medicinal Chemistry published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C12H19BF2O3Si, Application of (E)-3-(3-Nitrophenyl)acrylic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zhao, Haoqiang published the artcileLigand-Promoted Rh^I-Catalyzed C2-Selective C-H Alkenylation and Polyenylation of Imidazoles with Alkenyl Carboxylic Acids, Product Details of C9H7NO4, the publication is Chemistry – A European Journal (2022), 28(36), e202200441, database is CAplus and MEDLINE.

The first RhI-catalyzed, directed decarbonylative C2-H alkenylation of imidazoles with readily available alkenyl carboxylic acids is reported. The reaction proceeds in a highly regio- and stereoselective manner, providing efficient access to C2-alkenylated imidazoles that are generally inaccessible by known C-H alkenylation methods. This transformation accommodates a wide range of alkenyl carboxylic acids, including challenging conjugated polyene carboxylic acids, and diversely decorated imidazoles with high functional group compatibility. The presence of a removable pyrimidine directing group and the use of a bidentate phosphine ligand are pivotal to the success of the catalytic reaction. This process is also suitable for benzimidazoles. Importantly, the scalability and diversification of the products highlight the potential of this protocol in practical applications. Detailed exptl. and computational studies provide important insights into the underlying reaction mechanism.

Chemistry – A European Journal published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C18H20N2O12, Product Details of C9H7NO4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Xu, Xuemei published the artcileSynthesis of (E)-vinyl Isobutyronitriles via Fe(III)-catalyzed Decarboxylative Cross-coupling of Cinnamic Acids and AIBN under Additive-free Conditions, SDS of cas: 1772-76-5, the publication is Letters in Organic Chemistry (2019), 16(8), 656-661, database is CAplus.

A facile, efficient, additive-free and eco-friendly protocol for the synthesis of (E)-vinyl isobutyronitriles via Fe(III)-catalyzed decarboxylative cross-coupling of cinnamic acids and AIBN (azodiisobutyronitrile) has been developed. The presented methodol. offers several advantages such as easy accessibility and stability of substrates, inexpensive catalyst and simple post-treatment procedure.

Letters in Organic Chemistry published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C6H12O2, SDS of cas: 1772-76-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Parmeggiani, Fabio published the artcileSynthesis of D– and L-Phenylalanine Derivatives by Phenylalanine Ammonia Lyases: A Multienzymatic Cascade Process, COA of Formula: C9H7NO4, the publication is Angewandte Chemie, International Edition (2015), 54(15), 4608-4611, database is CAplus and MEDLINE.

The synthesis of substituted D-phenylalanines in high yield and excellent optical purity, starting from inexpensive cinnamic acids, has been achieved with a novel one-pot approach by coupling phenylalanine ammonia lyase (PAL) amination with a chemoenzymic deracemization (based on stereoselective oxidation and nonselective reduction). A simple high-throughput solid-phase screening method has also been developed to identify PALs with higher rates of formation of non-natural D-phenylalanines. The best variants were exploited in the chemoenzymic cascade, thus increasing the yield and ee value of the D-configured product. Furthermore, the system was extended to the preparation of those L-phenylalanines which are obtained with a low ee value using PAL amination.

Angewandte Chemie, International Edition published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C9H7NO4, COA of Formula: C9H7NO4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Lovelock, Sarah L. published the artcilePhenylalanine ammonia lyase catalyzed synthesis of amino acids by an MIO-cofactor independent pathway, COA of Formula: C9H7NO4, the publication is Angewandte Chemie, International Edition (2014), 53(18), 4652-4656, database is CAplus and MEDLINE.

Phenylalanine ammonia-lyases (PALs) belong to a family of 4-methylideneimidazole-5-one (MIO) cofactor-dependent enzymes which are responsible for the conversion of L-phenylalanine into trans-cinnamic acid in eukaryotic and prokaryotic organisms. Under conditions of high NH₃ concentration, this deamination reaction is reversible and hence there is considerable interest in the development of PALs as biocatalysts for the enantioselective synthesis of non-natural amino acids. Here, the discovery of a previously unobserved competing MIO-independent reaction pathway, which proceeds in a non-stereoselective manner and results in the generation of both L– and D-phenylalanine derivatives, is described. The mechanism of the MIO-independent pathway is explored through isotopic-labeling studies and mutagenesis of key active site residues. The results obtained were consistent with amino acid deamination occurring by a stepwise E₁cB elimination mechanism.

Angewandte Chemie, International Edition published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C9H7NO4, COA of Formula: C9H7NO4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wang, Dongfang published the artcileMagnetic polymer nanocomposite-supported Pd: an efficient and reusable catalyst for the Heck and Suzuki reactions in water, Name: (E)-3-(3-Nitrophenyl)acrylic acid, the publication is New Journal of Chemistry (2015), 39(3), 2052-2059, database is CAplus.

A novel type of magnetically responsive polymer nanocomposite Fe₃O₄@poly(undecylenic acid-co-4-vinyl pyridine-co-sodium acrylate) (Fe₃O₄@PUVS) was synthesized by the free radical polymerization of 4-vinyl pyridine (4-VP) with sodium acrylate (SAA) and Fe₃O₄@undecylenic acid. Pd²⁺ was then immobilized on this magnetic nanocomposite to form the magnetic Fe₃O₄@PUVS-Pd catalyst. This catalyst exhibited excellent catalytic activity for the Heck and Suzuki coupling reactions in water, and could be simply separated by using a permanent magnet. The supported catalyst could be used consecutively for six runs without significant loss of catalytic activity.

New Journal of Chemistry published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C7H16ClNO2, Name: (E)-3-(3-Nitrophenyl)acrylic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia