Category: 1772-76-5

Rong, Guangwei published the artcileIron-catalyzed decarboxylative methylation of ¦Á,¦Â-unsaturated acids under ligand-free conditions, SDS of cas: 1772-76-5, the publication is Tetrahedron (2014), 70(34), 5033-5037, database is CAplus.

It is the first time to find that iron-catalyzed decarboxylative methylation of ¦Á,¦Â-unsaturated acids could be performed in the absence of any ligands. During the reaction, the configuration of the double bond could be retained. It is noteworthy that di-tert-Bu peroxide (DTBP) was employed not only as the oxidant, but also as the Me source.

Tetrahedron published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C9H7NO4, SDS of cas: 1772-76-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Collins, Karl D. published the artcilePreparation of conjugated 1,3-enynes by Rh(III)-catalysed alkynylation of alkenes via C-H activation, Application of (E)-3-(3-Nitrophenyl)acrylic acid, the publication is Chemical Communications (Cambridge, United Kingdom) (2014), 50(34), 4459-4461, database is CAplus and MEDLINE.

An exptl. simple additive-free Rh(III)-catalyzed direct alkynylation of alkenes has been developed. This protocol employs com. available 1-[(triisopropylsilyl)ethynyl]-1,2-benziodoxol-3(1H)-one (TIPS-EBX) as the alkyne source, giving access to conjugated terminal enynes following a simple silyl-deprotection. This method has also been applied to arenes.

Chemical Communications (Cambridge, United Kingdom) published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C9H7NO4, Application of (E)-3-(3-Nitrophenyl)acrylic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zhang, Jun-Rong published the artcileDABCO-Promoted Decarboxylative Acylation: Synthesis of ¦Á-Keto and ¦Á,¦Â-Unsaturated Amides or Esters, Product Details of C9H7NO4, the publication is Asian Journal of Organic Chemistry (2017), 6(3), 305-312, database is CAplus.

A metal-free protocol was reported for the synthesis of aryl ¦Á-ketoamides e.g., N,N-dimethyl-2-oxo-2-phenylacetamide and ¦Á,¦Â-unsaturated amides e.g., N,N-dimethylcinnamamide through decarboxylative acylation of various carboxylic acids with carbamic chlorides in good to excellent yields. Further, this method was used for the synthesis of aryl ¦Á-ketoesters e.g., propyl-2-oxo-2-phenylacetate and ¦Á,¦Â-unsaturated esters e.g., Pr cinnamate from corresponding carbonochloridates. 1,4-Diazabicyclo[2.2.2]octane (DABCO) was found to be an effective reagent for decarboxylative acylation of carboxylic acids with carbamic chlorides or carbonochloridates. This protocol offered several advantages such as metal-free and mild conditions, simple operation, a broad substrate scope and high yields.

Asian Journal of Organic Chemistry published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C6H10O7, Product Details of C9H7NO4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Xu, Hongjiao published the artcileSynthesis and preliminary antitumor activity evaluation of 17-(5-(substituted cinnamamido)pentylamino)-17-demethoxygeldanamycin derivatives as potent Hsp90 Inhibitors, Recommanded Product: (E)-3-(3-Nitrophenyl)acrylic acid, the publication is Youji Huaxue (2015), 35(10), 2125-2134, database is CAplus.

Geldanamcyin (GA) was the first potent inhibitor of heat shock protein 90 (Hsp90) from natural products. However, its clin. application was limited by the unwanted hepatotoxicity. Our previous studies on the structure-activity relationships of GA derivatives indicated that the introduction of hepatoprotective cinnamoyl group via an alkyldiamino linker decreased the hepatotoxicity evidently. In this study, using pentyldiamine as the linker, twenty-six 17-(5-(substituted cinnamamido)pentylamino)-17-demethoxygeldanamycins were designed and synthesized as the inhibitors of Hsp90. All the compounds showed potent antitumor activities against human breast cancer cell line MDA-MB-231 with IC₅₀ ranging from 0.12 to 1 ¦Ìmol¡¤L^-1. Particularly, 17-(5-(cinnamamido)pentylamino)-17-demethoxygeldanamycin and 17-(5-(2,5-methoxycinn-amamido)pentylamino)-17-demethoxygeldanamycin were proved to be the most potent compounds (IC₅₀ = 0.12 ¦Ìmol¡¤L^-1), more active than the pos. control 17-N-allylamino-17-demethoxygeldanamycin (17-AAG) (IC₅₀ = 0.27 ¦Ìmol¡¤L^-1) and showed lower hepatotoxicity. Addnl., the preliminary structure-activity relationships among these newly synthesized congeners were briefly discussed, which should provide valuable basis for the structure optimization of GA-type Hsp90 inhibitors and antitumor lead compounds

Youji Huaxue published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C8H10S, Recommanded Product: (E)-3-(3-Nitrophenyl)acrylic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wu, Yunfei published the artcileSynthesis of novel 17-[3,6-dioxa-8-N-(substituted cinnamoyl)-octanediamino]-17-demethoxygeldanamycin derivatives, Related Products of catalysis-chemistry, the publication is Youji Huaxue (2014), 34(9), 1870-1874, database is CAplus.

Twenty six new 17-[3,6-dioxa-8-N-(substituted cinnamoyl)octanediamino]-17-demethoxygeldanamycins were designed, synthesized and evaluated for their cytotoxicities against growth of human breast cancer cell line MDA-MB-231 and binding affinities to heat shock protein 90 (Hsp90). Among these derivatives, 17-(3,6-dioxa-8-N-((E)-3-(3,5-dimethoxyphenyl)acrylamido)octanediamino)-17-demethoxygeldanamycin, was identified as the most potent one (IC₅₀=1.5 ¦Ìmol/L, K_d=1.14 ¦Ìmol/L). Addnl., influence of substitutions at the cinnamoyl group on the bioactivities of this type of Geldanamycin (GA) derivatives was discussed. This study was anticipated to provide reference for the further structure modifications of GA for developing antitumor agents.

Youji Huaxue published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C8H10BNO3, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Hong, Huanliang published the artcileElectrochemical Synthesis Strategy for C_vinyl-CF₃ Compounds through Decarboxylative Trifluoromethylation, Quality Control of 1772-76-5, the publication is Journal of Organic Chemistry (2019), 84(9), 5980-5986, database is CAplus and MEDLINE.

An efficient decarboxylative trifluoromethylation of ¦Á,¦Â-unsaturated carboxylic acids using the Langlois reagent as a trifluoromethyl precursor has been achieved by an electro-oxidative strategy. Under catalyst-free and external oxidant-free electrolysis conditions, a series of C_vinyl-CF₃ compounds are obtained with a high regioselectivity in good yields. The successful trapping of the CF₃ radical by a scavenger has confirmed that radical processes are involved in this system.

Journal of Organic Chemistry published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C9H7NO4, Quality Control of 1772-76-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Lu, Guo-qing published the artcileDesign, synthesis and biological evaluation of novel uracil derivatives bearing 1, 2, 3-triazole moiety as thymidylate synthase (TS) inhibitors and as potential antitumor drugs, Name: (E)-3-(3-Nitrophenyl)acrylic acid, the publication is European Journal of Medicinal Chemistry (2019), 282-296, database is CAplus and MEDLINE.

Aryltriazolylphenylaminosulfonyl uracils such as I (R = Ph, 2-MeC₆H₄, 3-MeC₆H₄, 4-MeC₆H₄, 2-FC₆H₄, 3-FC₆H₄, 4-FC₆H₄, 2-ClC₆H₄, 3-ClC₆H₄, 4-ClC₆H₄) were prepared as thymidylate synthase inhibitors for potential use as antitumor agents. The aryltriazolylphenylaminosulfonyl uracils were tested for their inhibition of human cancer cell lines and for their toxicities in normal human cell lines; selected compounds were tested for their inhibition of human thymidylate synthase (hTS). I (R = 4-ClC₆H₄) was the most effective antitumor agent of the compounds tested, inhibiting the growth of A549 cells with an IC₅₀ value of 1.18 ¦ÌM and inhibiting hTS with an IC₅₀ value of 0.13 ¦ÌM, superior to comparable data for the known antitumor agent pemetrexed. I (R = 4-ClC₆H₄) inhibited cell cycle advancement in G1/S phase and induced apoptosis. I (R = 4-ClC₆H₄) likely down-regulates the cycle checkpoint proteins cyclin D1 and cyclin E to inhibit cell cycle progression, and induced intrinsic apoptosis by activating caspase-3 and reducing the ratio of bcl-2 to bax.

European Journal of Medicinal Chemistry published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C9H7NO4, Name: (E)-3-(3-Nitrophenyl)acrylic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zhang, Jun published the artcileSynthesis of m-aminophenyl acetylene, Name: (E)-3-(3-Nitrophenyl)acrylic acid, the publication is Zhongguo Yiyao Gongye Zazhi (2012), 43(10), 812-814, database is CAplus.

M-Aminophenyl acetylene, the key intermediate of antitumor agent erlotinib hydrochloride, was synthesized from m-nitrobenzaldehyde by Perkin reaction, bromine addition, elimination of hydrogen bromide and decarboxylation to give (Z)-1-bromo-2-(3-nitrophenyl)ethylene, followed by reaction with NaH and reduction with Fe/HCl. The overall yield was about 45%.

Zhongguo Yiyao Gongye Zazhi published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C9H9BrO2, Name: (E)-3-(3-Nitrophenyl)acrylic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wang, Rong published the artcileOxime-derived palladacycle Immobilized in an Ionic Liquid Brush as an Efficient and Reusable Catalyst for Mizoroki-Heck Reaction in Neat Water, Recommanded Product: (E)-3-(3-Nitrophenyl)acrylic acid, the publication is Applied Organometallic Chemistry (2019), 33(11), e5226, database is CAplus.

An efficient and reusable heterogeneous catalyst with oxime-derived palladacycle immobilized in an ionic liquid brush was synthesized and an environmentally-friendly procedure was developed for coupling aryl iodides and bromides with acrylic acid to get corresponding cinnamic acid derivatives I [R = H, 2-Me, 4-OMe, etc.]. These reactions were conducted in neat water under aerobic conditions with water-insoluble or even solid aryl halides and they proceeded smoothly and cleanly without any organic co-solvent or other additives. The ionic liquid brush could be easily recovered and reused at least five times without significant loss of activity. The protocol was the advantages of excellent yields, environmental friendliness and catalyst recyclability.

Applied Organometallic Chemistry published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C18H28B2O4, Recommanded Product: (E)-3-(3-Nitrophenyl)acrylic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Sun, Juan published the artcileSynthesis and antitumor activity of 1,3,4-oxadiazole possessing 1,4-benzodioxane moiety as a novel class of potent methionine aminopeptidase type II inhibitors, Application In Synthesis of 1772-76-5, the publication is Bioorganic & Medicinal Chemistry Letters (2013), 23(10), 2876-2879, database is CAplus and MEDLINE.

A series of 1,3,4-oxadiazole derivatives containing 1,4-benzodioxane moiety have been designed, synthesized and evaluated for their antitumor activity. Most of the synthesized compounds were proved to have potent antitumor activity and low toxicity. Among them, compound I showed the most potent biol. activity against Human Umbilical Vein Endothelial cells, which was comparable to the pos. control. The results of apoptosis and flow cytometry (FCM) demonstrated that compound I induce cell apoptosis by the inhibition of MetAP2 pathway. Mol. docking was performed to position compound I into MetAP2 binding site in order to explore the potential target.

Bioorganic & Medicinal Chemistry Letters published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C10H9NO, Application In Synthesis of 1772-76-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia