Category: 1772-76-5

Yang, Zan published the artcileFe(III)/Pyridine-Mediated Decarboxylative Nitration of ¦Á,¦Â-Unsaturated Acids with Iron Nitrate, Recommanded Product: (E)-3-(3-Nitrophenyl)acrylic acid, the publication is Synlett (2017), 28(9), 1079-1082, database is CAplus.

A novel and efficient method for the synthesis of (E)-nitroolefins in moderate to excellent yields is developed by Fe(III)/pyridine-mediated decarboxylative nitration of ¦Á,¦Â-unsaturated acids with iron nitrate. A series of ¦Á,¦Â-unsaturated acids are well tolerated in this procedure.

Synlett published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C18H26ClN3O, Recommanded Product: (E)-3-(3-Nitrophenyl)acrylic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zhu, Lingjian published the artcile¦Â-Alanine-DBU: a highly efficient catalytic system for Knoevenagel-Doebner reaction under mild conditions, Recommanded Product: (E)-3-(3-Nitrophenyl)acrylic acid, the publication is Chinese Journal of Chemistry (2012), 30(1), 139-143, database is CAplus.

A mild and efficient Knoevenagel-Doebner reaction from malonic acid and a wide range of aldehydes was catalyzed by a catalytic system consisting of ¦Â-alanine and 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU), affording the corresponding (E)-¦Á,¦Â-unsaturated carboxylates in good to excellent yields and with high stereoselectivity. The advantage of the method is that the reaction could proceed smoothly at ambient temperature so that it can tolerate a variety of functional groups and avoid unnecessary side reactions.

Chinese Journal of Chemistry published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C11H15NOS, Recommanded Product: (E)-3-(3-Nitrophenyl)acrylic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Weise, Christian F. published the artcileOrganocatalytic Access to Enantioenriched Dihydropyran Phosphonates via an Inverse-Electron-Demand Hetero-Diels-Alder Reaction, Recommanded Product: (E)-3-(3-Nitrophenyl)acrylic acid, the publication is Journal of Organic Chemistry (2014), 79(8), 3537-3546, database is CAplus and MEDLINE.

The enantioselective inverse-electron-demand hetero-Diels-Alder reaction of the remote olefin functionality in dienamines was developed by the simultaneous activation of ¦Á,¦Â-unsaturated aldehydes and acyl phosphonates. The dual activation is based on an organocatalyst that activates both the ¦Á,¦Â-unsaturated aldehyde, through dienamine formation, and the acyl phosphonate by H-bonding. The enantioselective reaction gave dihydropyran frameworks with three contiguous stereogenic centers. Different substitution patterns are possible for both the heterodiene and the dienophile, and the target products were obtained in good yields and up to 92% ee. The potential of the reaction is demonstrated by transformation of the products into valuable and complex synthons.

Journal of Organic Chemistry published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C10H14O, Recommanded Product: (E)-3-(3-Nitrophenyl)acrylic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Kumar, Saurabh published the artcileDecarboxylative Arylation of ¦Á,¦Â-Unsaturated Carboxylic Acids Using Aryl Triazenes by Copper/Ionic Liquid Combination in PEG-400, Recommanded Product: (E)-3-(3-Nitrophenyl)acrylic acid, the publication is European Journal of Organic Chemistry (2018), 2018(43), 5942-5946, database is CAplus.

A practical method for the construction of stilbene derivatives has been developed via catalytic cross-coupling of cinnamic acids with aryl triazenes. The methodol. offers high stereoselectivity and is endowed with broad substrate scope, high yield, and significant functional group tolerance.

European Journal of Organic Chemistry published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C9H7NO4, Recommanded Product: (E)-3-(3-Nitrophenyl)acrylic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Priyadarshini, S. published the artcileCopper catalyzed cross-coupling reactions of carboxylic acids: an expedient route to amides, 5-substituted ¦Ã-lactams and ¦Á-acyloxy esters, HPLC of Formula: 1772-76-5, the publication is RSC Advances (2013), 3(40), 18283-18287, database is CAplus.

A convenient and recyclable catalytic protocol for the synthesis of N,N-di-Me substituted amides, 5-substituted ¦Ã-lactams, and ¦Á-acyloxy ethers from carboxylic acids using CuO nanoparticles and TBHP is described.

RSC Advances published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C9H7NO4, HPLC of Formula: 1772-76-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Jiang, Hejin published the artcileSymmetry Breaking and Amplification in a Self-Assembled Helix from Achiral trans-3-Nitrocinnamic Acid, Safety of (E)-3-(3-Nitrophenyl)acrylic acid, the publication is Journal of Physical Chemistry C (2018), 122(23), 12559-12565, database is CAplus.

Understanding the process of chiral symmetry breaking, amplification, and transfer to the macroscopic chirality in self-assembled systems has been a subject of essential challenge and immense interest. Here, we show that a simple trans-3-nitrocinnamic acid (3-NCA) self-assembles into a helix in solution with symmetry breaking. Upon casting on a solid substrate, the tiny chiral bias in solution was amplified into macroscopic chirality, which could be detected via CD measurements. Furthermore, the SEM observation revealed the unequal numbers of left- and right-handed helixes, which accounted for the net supramol. chirality. In comparison with the other isomers or related mols., it was found that only 3-NCA showed symmetry breaking. It was revealed that the H-bond and dipole-dipole interaction were responsible for the spontaneous symmetry breaking. This work provides a further insight into the emergence and amplification of supramol. chirality in self-assembly systems from achiral mols.

Journal of Physical Chemistry C published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C9H7NO4, Safety of (E)-3-(3-Nitrophenyl)acrylic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Li, Zhenyu published the artcileDiscovery of diamine-linked 17-aroylamido-17-demethoxygeldanamycins as potent Hsp90 inhibitors, Synthetic Route of 1772-76-5, the publication is European Journal of Medicinal Chemistry (2014), 346-363, database is CAplus and MEDLINE.

Heat shock protein 90 (Hsp90) is an attractive target for the development of antitumor agents. Geldanamycin (GA), the first Hsp90 inhibitor, has potent antitumor activity, but showed significant hepatotoxicity. To get rid of the hepatotoxicity of GA, in this study the authors incorporated aroyl groups via three types of linkers (4-aminomethylpiperidine, 1,4-butanediamine, and 1,6-hexanediamine) to the 17-position of GA and synthesized fifty-three 17-diamine-linked 17-aroylamido-17-demethoxygeldanamycins. All the derivatives were evaluated by MTT assay for their inhibitory activities against human breast cancer cell line MDA-MB-231. Among these compounds, I showed the most potent cytotoxicity against MDA-MB-231 (IC₅₀ = 0.19¡À0.02 ¦ÌM) with the lowest hepatotoxicity (AST = 181.0¡À23.6 U/L, ALT = 40.4¡À11.8 U/L). Compared to tanespimycin (17-AAG), I exhibited lower hepatotoxicity in mice, higher Hsp90 inhibitory activity in vitro and antitumor activity in human breast carcinoma (MDA-MB-231) xenograft nude mice.

European Journal of Medicinal Chemistry published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C9H7NO4, Synthetic Route of 1772-76-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Jiang, Qing published the artcileIron-Facilitated Oxidative Radical Decarboxylative Cross-Coupling between ¦Á-Oxocarboxylic Acids and Acrylic Acids: An Approach to ¦Á,¦Â-Unsaturated Carbonyls, Product Details of C9H7NO4, the publication is Journal of Organic Chemistry (2015), 80(7), 3586-3596, database is CAplus and MEDLINE.

The first Fe-facilitated decarboxylative cross-coupling reaction between ¦Á-oxocarboxylic acids and acrylic acids in aqueous solution has been developed. This transformation is characterized by its wide substrate scope and good functional group compatibility utilizing inexpensive and easily accessible reagents, thus providing an efficient and expeditious approach to an important class of ¦Á,¦Â-unsaturated carbonyls frequently found in bioactive compounds The synthetic potential of the coupled products is also demonstrated in subsequent functionalization reactions. Preliminary mechanism studies suggest that a free radical pathway is involved in this process: the generation of an acyl radical from ¦Á-oxocarboxylic acid via the excision of carbon dioxide followed by the addition of an acyl radical to the ¦Á-position of the double bond in acrylic acid then delivers the ¦Á,¦Â-unsaturated carbonyl adduct through the extrusion of another carbon dioxide.

Journal of Organic Chemistry published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C9H7NO4, Product Details of C9H7NO4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Manna, Srimanta published the artcileSynthesis of (E)-nitroolefins via decarboxylative nitration using t-butylnitrite (t-BuONO) and TEMPO, Recommanded Product: (E)-3-(3-Nitrophenyl)acrylic acid, the publication is Chemical Communications (Cambridge, United Kingdom) (2013), 49(46), 5286-5288, database is CAplus and MEDLINE.

Nitroolefins are usually synthesized using the Henry reaction. Here, the authors report an alternative metal-free decarboxylative nitration protocol for the preparation of the nitroolefins from ¦Á,¦Â-unsaturated carboxylic acids using tert-butylnitrite (t-BuONO) and TEMPO. ¦Á,¦Â-Unsaturated carboxylic acids bearing ¦Â-aromatic and ¦Â-heteroaromatic substituents gave (E)-nitroolefins exclusively under mild conditions. A radical based pathway has been proposed for this decarboxylative nitration reaction.

Chemical Communications (Cambridge, United Kingdom) published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C9H7NO4, Recommanded Product: (E)-3-(3-Nitrophenyl)acrylic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Kufs, Johann E. published the artcileRational Design of Flavonoid Production Routes Using Combinatorial and Precursor-Directed Biosynthesis, Application In Synthesis of 1772-76-5, the publication is ACS Synthetic Biology (2020), 9(7), 1823-1832, database is CAplus and MEDLINE.

Combinatorial biosynthesis has great potential for designing synthetic circuits and amplifying the production of new active compounds Studies on multienzyme cascades are extremely useful for improving our knowledge on enzymic catalysis. In particular, the elucidation of enzyme substrate promiscuity can be potentially used for bioretrosynthetic approaches, leading to the design of alternative and more convenient routes to produce relevant mols. In this perspective, plant-derived polyketides are extremely adaptable to those synthetic biol. applications. Here, we present a combination of an in vitro CoA ligase activity assay coupled with a bacterial multigene expression system that leads to precursor-directed biosynthesis of 21 flavonoid derivatives When the vast knowledge from protein databases is exploited, the herein presented procedure can be easily repeated with addnl. plant-derived polyketides. Lastly, we report an efficient in vivo expression system that can be further exploited to heterologously express pathways not necessarily related to plant polyketide synthases.

ACS Synthetic Biology published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C9H7NO4, Application In Synthesis of 1772-76-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia