Category: 1772-76-5

Horibe, Takahiro published the artcileEnantioselective 1,4-Addition Reaction of ¦Á,¦Â-Unsaturated Carboxylic Acids with Cycloalkanones Using Cooperative Chiral Amine-Boronic Acid Catalysts, Name: (E)-3-(3-Nitrophenyl)acrylic acid, the publication is Angewandte Chemie, International Edition (2020), 59(39), 17256-17260, database is CAplus and MEDLINE.

An enantioselective 1,4-addition of ¦Á,¦Â-unsaturated carboxylic acids with cycloalkanones has been developed by using chiral amine-boronic acid cooperative catalysts. In the presence of a chiral amine and boronic acid, cycloalkanones and carboxylic acids are activated as chiral enamines and mixed anhydrides, resp. The corresponding 1,4-adducts are obtained in high yield with high enantioselectivity. Furthermore, subsequent oxylactonization of the 1,4-adducts gives spirolactones with high diastereoselectivity.

Angewandte Chemie, International Edition published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C9H7NO4, Name: (E)-3-(3-Nitrophenyl)acrylic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Perez, Bianca C. published the artcileRecycling antimalarial leads for cancer: Antiproliferative properties of N-cinnamoyl chloroquine analogues, COA of Formula: C9H7NO4, the publication is Bioorganic & Medicinal Chemistry Letters (2013), 23(24), 6769-6772, database is CAplus and MEDLINE.

Cinnamic acids and quinolines are known as useful scaffolds in the discovery of antitumor agents. Therefore, N-cinnamoylated analogs of chloroquine, recently reported as potent dual-action antimalarials, were evaluated against three different cancer cell lines: MKN-28, Caco-2, and MCF-7. All compounds display anti-proliferative activity in the micromolar range against the three cell lines tested, and most of them were more active than their parent drug, chloroquine, against all cell lines tested. Hence, N-cinnamoyl-chloroquine analogs are a good start towards development of affordable antitumor leads.

Bioorganic & Medicinal Chemistry Letters published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C9H7NO4, COA of Formula: C9H7NO4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Leong, Sze Wei published the artcileSynthesis and SAR study of diarylpentanoid analogues as new anti-inflammatory agents, Application In Synthesis of 1772-76-5, the publication is Molecules (2014), 19(10), 16058-16081, 24 pp., database is CAplus and MEDLINE.

A series of ninety-seven diarylpentanoid derivatives I (R = H, 4-Cl, 4-Br, 5-OCH₃, 3,5-(OCH₃)₂, 4-OCH₃, 4,6-(Cl)₂; Ar = 3,4,5-trimethoxyphenyl, 2-chlorophenyl, 1-naphthyl, 2-furyl, 5-chloro-2-thienyl, etc.) were synthesized and evaluated for their anti-inflammatory activity through NO suppression assay using interferon gamma (IFN-¦Ã)/lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages. Some of the compounds I exhibited greater or similar NO inhibitory activity in comparison with curcumin (14.7 ¡À 0.2 ¦ÌM), notably compounds I (R = 4-Cl; Ar = 2,3-(OH)₂-C₆H₃) and I (R = H; Ar = 2,3-(OH)₂-C₆H₃), which demonstrated the most significant NO suppression activity with IC₅₀ values of 4.9 ¡À 0.3 ¦ÌM and 9.6 ¡À 0.5 ¦ÌM, resp. A structure-activity relationship (SAR) study revealed that the presence of a hydroxyl group in both aromatic rings is critical for bioactivity of these mols. With the exception of the polyphenolic derivatives, low electron d. in ring-A and high electron d. in ring-B are important for enhancing NO inhibition. The pharmacophore mapping showed that hydroxyl substituents at both meta- and para-positions of ring-B could be the marker for highly active diarylpentanoid derivatives

Molecules published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C9H7NO4, Application In Synthesis of 1772-76-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Jiang, Hejin published the artcileChiral nanostructures self-assembled from nitrocinnamic amide amphiphiles: substituent and solvent effects, Product Details of C9H7NO4, the publication is Beilstein Journal of Nanotechnology (2019), 1608-1617, database is CAplus and MEDLINE.

Chiral nanostructures, such as a-helical proteins and double helix DNA, are widely found in biol. systems and play a significant role in the biofunction of life. These structures are essentially fabricated through the covalent or noncovalent bonds between small chiral mols. It is thus an important issue to understand how small chiral mols. can form chiral nanostructures. Here, using a series of isomeric nitrocinnamic amide derivatives, we have investigated the self-assembly behavior and the effect of the substituent position as well as the solvent on the formation of chiral nanostructures. It was found that totally different chiral nanostructures were formed due to the different positions of the nitro group on the cinnamic amide. Moreover, it was found that the chiral sense of the self-assembled nanostructures can be regulated by the solvent whereby helicity inversion was observed This work provides a simple way to regulate the self-assembly pathway via mol. design and choice of solvent for the controlled creation of chiral nanostructures.

Beilstein Journal of Nanotechnology published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C9H7NO4, Product Details of C9H7NO4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zhang, Yun published the artcileCopper-catalyzed decarboxylative trifluoroethylation of cinnamic acids, Computed Properties of 1772-76-5, the publication is Tetrahedron Letters (2017), 58(9), 880-883, database is CAplus.

An efficient Cu-catalyzed stereoselective trifluoroethylation through the decarboxylative cross-coupling of cinnamic acid derivatives with CF₃CH₂I is described. The ready availability of the starting materials, the high level of functional group tolerance, and excellent E selectivity make this protocol a safe and operationally convenient strategy for the efficient synthesis of trifluoroethyl derivatives

Tetrahedron Letters published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C11H16BNO3, Computed Properties of 1772-76-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Liang, Jingwen published the artcileA series of organotin(IV) complexes based on (E)-3-(3-nitrophenyl) acrylic acid: Syntheses, crystal structures and biological activities, Formula: C9H7NO4, the publication is Inorganic Chemistry Communications (2014), 133-137, database is CAplus.

A series of organotin carboxylates based on (E)-3-(3-nitrophenyl) acrylic acid (HL), namely {[Ph₃SnL]¡¤0.5C₆H₆}_n (1), [(Ph₃Sn)₂O(L)(Ph₃Sn)(L)]_n (2) and [Bu₂LSnOSnLBu₂]₂ (3), have been synthesized. All the complexes have been characterized by elemental anal., IR, ¹H NMR spectroscopy and x-ray diffraction analyses. The structural analyses show that complexes 1–2 adopt 1D polymeric chain structures generated by the bridging carboxylate ligands and the five-coordinated tin centers. The structure of complex 3 is centro-sym. and features a central rhombus Sn₂O₂ unit with two addnl. tin atoms linked at the O atoms. In addition, the antitumor activity of complex 3 has been studied.

Inorganic Chemistry Communications published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C9H7NO4, Formula: C9H7NO4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Gao, Cheng-Zhi published the artcileSynthesis, preliminarily biological evaluation and molecular docking study of new Olaparib analogues as multifunctional PARP-1 and cholinesterase inhibitors, COA of Formula: C9H7NO4, the publication is Journal of Enzyme Inhibition and Medicinal Chemistry (2019), 34(1), 150-162, database is CAplus and MEDLINE.

A series of new Olaparib derivatives was designed and synthesized, and their inhibitory activities against poly (ADP-ribose) polymerases-1 (PARP-1) enzyme and cancer cell line MDA-MB-436 in vitro were evaluated. The results showed that compound exhibited the most potent inhibitory effects on PARP-1 enzyme (16.10 ¡À 1.25 nM) and MDA-MB-436 cancer cell (11.62 ¡À 2.15 ¦ÌM), which was close to that of Olaparib. As a PARP-1 inhibitor had been reported to be viable to neuroprotection, in order to search for new multitarget-directed ligands (MTDLs) for the treatment of Alzheimer’s disease (AD), the inhibitory activities of the synthesized compounds against the enzymes AChE (from elec. eel) and BChE (from equine serum) were also tested. Compound displayed moderate BChE inhibitory activity (9.16 ¡À 0.91 ¦ÌM) which was stronger than neostigmine (12.01 ¡À 0.45 ¦ÌM) and exhibited selectivity for BChE over AChE to some degree. Mol. docking studies indicated that could bind simultaneously to the catalytic active of PARP-1, but it could not interact well with huBChE. For pursuit of PARP-1 and BChE dual-targeted inhibitors against AD, small and flexible non-polar groups introduced to the compound seemed to be conducive to improving its inhibitory potency on huBChE, while keeping phthalazine-1-one moiety unchanged which was mainly responsible for PARP-1 inhibitory activity. Our research gave a clue to search for new agents based on AChE and PARP-1 dual-inhibited activities to treat Alzheimer’s disease.

Journal of Enzyme Inhibition and Medicinal Chemistry published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C9H7NO4, COA of Formula: C9H7NO4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Slavchev, Ivaylo published the artcileAntimycobacterial activity generated by the amide coupling of (-)-fenchone derived aminoalcohol with cinnamic acids and analogues, Recommanded Product: (E)-3-(3-Nitrophenyl)acrylic acid, the publication is Bioorganic & Medicinal Chemistry Letters (2014), 24(21), 5030-5033, database is CAplus and MEDLINE.

Aminoethyl substituted 2-endo-fenchol prepared from (-)-fenchone was used as scaffold for the synthesis of series of 31 amide structures by N-acylation applying cinnamic acids and analogs. The evaluation of their in vitro activity against Mycobacterium tuberculosis H₃₇Rv showed for some of them promising activity-up to 0.2 ¦Ìg/mL, combined with relatively low cytotoxicity of the selected active compounds

Bioorganic & Medicinal Chemistry Letters published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C9H9ClN2, Recommanded Product: (E)-3-(3-Nitrophenyl)acrylic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Nagalakshmi, K. published the artcileA simple and straightforward synthesis of cinnamic acids and ylidene malononitriles via Knoevenagel condensation employing DABCO as catalyst, Related Products of catalysis-chemistry, the publication is Asian Journal of Chemistry (2017), 29(7), 1561-1564, database is CAplus.

An efficient method for the synthesis of substituted cinnamic acids (E)-RHC:CHC(O)OH (R = 4-chlorophenyl, 2,6-dimethoxyphenyl, 3-nitrophenyl, furan-2-yl, etc.) and ylidene malanonitriles RC₆H₄HC:C(CN)₂ is developed via Knoevenagel condensation of aromatic aldehydes such as furan-2-carbaldehyde, 2,3,4-trimethoxybenzaldehyde, 4-hydroxybenzaldehyde with malonic acid and malononitrile in the presence of catalytic amounts of DABCO. This method has many advantages, such as mild reaction conditions, excellent yields, short reaction times and no further purification required.

Asian Journal of Chemistry published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C9H7NO4, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Agasti, Soumitra published the artcileTraceless directing group mediated branched selective alkenylation of unbiased arenes, Related Products of catalysis-chemistry, the publication is Chemical Communications (Cambridge, United Kingdom) (2016), 52(82), 12191-12194, database is CAplus and MEDLINE.

Synthesis of branched olefinated products RR¹C=CHR² [R = C₆H₅, 2-H₃CC₆H₄, 2,4,6-(CH₃)₃C₆H₂, etc.; R¹ = 4-ClC₆H₄, naphthalen-1-yl, 2H-1,3-benzodioxol-5-yl, etc.; R² = H, CN, C₆H₅], catalyzed via palladium, facilitated by a C-H activation has been reported. This involves selective insertion of olefins R¹CH=C(R²)C(O)OH and subsequent decarboxylation using a completely unbiased benzene ring as the starting precursor. The significance of the protocol has been further highlighted by exhibition of functionality tolerance along with a late-stage modification of the branched olefinated products leading to the formation of other functionalized mols.

Chemical Communications (Cambridge, United Kingdom) published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C9H7NO4, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia