Category: 1949-41-3

Zhang, Xiang published the artcileMechanism for Ag (I)-catalyzed decarboxylative chlorination: a DFT study, Quality Control of 1949-41-3, the publication is Theoretical Chemistry Accounts (2016), 135(6), 1-9, database is CAplus.

Ag(I)-catalyzed decarboxylative chlorination of the carboxylic acid with t-BuOCl has been given a systematic theor. study. According to the calculations, the catalytic cycle was assumed to include four steps: proton-coupled two-electron transfer, oxidative decarboxylation, formation of Ag(II)-Cl (chlorine source) and chlorine abstraction. It was first suggested that this kind of reaction is driven by the proton-coupled two-electron transfer, which leads to the formation of Ag(II) species, carboxylate, chloridion and t-BuOH. Then the oxidative decarboxylation and formation of Ag(II)-Cl take place at the same time. The resultant alkyl radical from the former abstracts the chlorine atom of Ag(II)-Cl to give the final product. Based on a comparison of the reactivities among different carboxylic acids, the oxidative decarboxylation was established as the rate-determining step. Moreover, it proceeds preferentially in a concerted dissociative electron transfer pathway.

Theoretical Chemistry Accounts published new progress about 1949-41-3. 1949-41-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene, name is 2-Methyl-4-phenylbutanoic acid, and the molecular formula is C8H5IO, Quality Control of 1949-41-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
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Sjoberg, Berndt published the artcileStereochemical studies. IV. The enantiomers of ¦Á-(2-thianaphthenyl)propionic acid, Quality Control of 1949-41-3, the publication is Arkiv foer Kemi (1958), 565-71, database is CAplus.

cf. C.A. 52, 20124h. To study the synthetic plant growth regulants, ¦Á-hydroxy-¦Á-(2-thianaphthenyl)propionic acid was prepared and reduced to the title compound After resolving it into the optical antipodes employing morphine and (+)-¦Á-2-naphthyl)ethylamine, the rotary power measured was [¦Á]²⁵_D 31.2¡ã and [¦Á]²⁵_D -31.4¡ã (absolute EtOH), resp. The configuration was determined by desulfurization of the (+)-form to (+)-¦Á-methyl-¦Ã-phenylbutyric acid which was ozonized to (+)-¦Á-methylglutaric acid.

Arkiv foer Kemi published new progress about 1949-41-3. 1949-41-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene, name is 2-Methyl-4-phenylbutanoic acid, and the molecular formula is C16H24BF4Ir, Quality Control of 1949-41-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
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Khalaf, Ali Ali published the artcileModern Friedel-Crafts chemistry. VII. Group participation in the rate-determining ionization step during inter- and intramolecular Friedel-Crafts alkylations and the mechanism of formation of 1-methyltetralin during the aluminum chloride-catalyzed reaction of 1-chloro-2-methyl-4-phenylbutane, Recommanded Product: 2-Methyl-4-phenylbutanoic acid, the publication is Revue Roumaine de Chimie (1974), 19(8), 1361-72, database is CAplus.

Aryl group participation in the rate-determining ionization step during intramol. Friedel-Crafts alkylation of benzene with Me2CBrCH2Br and Me2CPhCH2Cl and intramol. alkylation of Ph(CH2)4Cl, Ph(CH2)2CHMeCH2Cl (I), and p-MeC6H4CMe2CH2CH2Cl over AlCl3/MeNO2 was affected by the relative positions of the aryl and halogen groups. The formation of 1-methyltetralin from I, in addition to 1,1-dimethylindene, involved an AlCl3-induced hydride ion abstraction mechanism.

Revue Roumaine de Chimie published new progress about 1949-41-3. 1949-41-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene, name is 2-Methyl-4-phenylbutanoic acid, and the molecular formula is C11H14O2, Recommanded Product: 2-Methyl-4-phenylbutanoic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wang, Zhentao published the artcileSilver-catalyzed decarboxylative chlorination of aliphatic carboxylic acids, Computed Properties of 1949-41-3, the publication is Journal of the American Chemical Society (2012), 134(9), 4258-4263, database is CAplus and MEDLINE.

Decarboxylative halogenation of carboxylic acids, the Hunsdiecker reaction, is one of the fundamental functional group transformations in organic chem. As the initial method requires the preparations of strictly anhydrous silver carboxylates, several modifications have been developed to simplify the procedures. However, these methods suffer from the use of highly toxic reagents, harsh reaction conditions, or limited scope of application. In addition, none is catalytic for aliphatic carboxylic acids. In this Article, we report the first catalytic Hunsdiecker reaction of aliphatic carboxylic acids. Thus, with the catalysis of Ag(Phen)₂OTf, the reactions of carboxylic acids with t-Bu hypochlorite afforded the corresponding chlorodecarboxylation products in high yields under mild conditions. This method is not only efficient and general, but also chemoselective. Moreover, it exhibits remarkable functional group compatibility, making it of more practical value in organic synthesis. The mechanism of single electron transfer followed by chlorine atom transfer is proposed for the catalytic chlorodecarboxylation.

Journal of the American Chemical Society published new progress about 1949-41-3. 1949-41-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene, name is 2-Methyl-4-phenylbutanoic acid, and the molecular formula is C8H10S, Computed Properties of 1949-41-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
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Liao, Yang published the artcileIntramolecular Oxidative Coupling between Unactivated Aliphatic C-H and Aryl C-H Bonds, Application In Synthesis of 1949-41-3, the publication is Organic Letters (2021), 23(4), 1251-1257, database is CAplus and MEDLINE.

In this article, a Pd-catalyzed intramol. oxidative coupling between unactivated aliphatic and aryl C-H compounds ROCH₂C(CH₃)₂CO₂H (R = C₆H₅, 4-ClC₆H₄, 2-naphthyl, etc.) has been described. This chem. showed great potential to build up fused cyclic scaffolds I (R¹ = H, Me, OMe; R² = Me, Ph, F, etc.; R³ = H, Me; R⁴ = H, Me; R¹R² = R³R⁴ = -CH=CHCH=CH-) and 3-methyl-3,4-dihydro-2H-benzofuro[2,3-h]chromene-3-carboxylic acid from linear substrates through oxidative couplings. Privileged chromane and tetralin scaffolds were constructed from readily available linear starting materials in the absence of any organohalides and organometallic partners.

Organic Letters published new progress about 1949-41-3. 1949-41-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene, name is 2-Methyl-4-phenylbutanoic acid, and the molecular formula is C11H14O2, Application In Synthesis of 1949-41-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Yi, Ji-Tao published the artcileCopper-catalyzed direct decarboxylative fluorosulfonylation of aliphatic carboxylic acids, Category: catalysis-chemistry, the publication is Chemical Communications (Cambridge, United Kingdom) (2022), 58(67), 9409-9412, database is CAplus and MEDLINE.

Two efficient and complementary methods for direct decarboxylative fluorosulfonylation of carboxylic acids by the merging of copper catalysis with different N-centered HAT regents were reported. A wide range of structurally diverse sulfonyl fluorides was readily accessed from primary, secondary, and tertiary carboxylic acids in a single step under mild conditions.

Chemical Communications (Cambridge, United Kingdom) published new progress about 1949-41-3. 1949-41-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene, name is 2-Methyl-4-phenylbutanoic acid, and the molecular formula is C2H3N3, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Chen, Zhi-Da published the artcileCatalytic Decarboxylative Fluorosulfonylation Enabled by Energy-Transfer-Mediated Photocatalysis, SDS of cas: 1949-41-3, the publication is Organic Letters (2022), 24(13), 2474-2478, database is CAplus and MEDLINE.

Sulfonyl fluorides are useful building blocks in a wide array of fields. Herein, authors report a catalytic decarboxylative fluorosulfonylation approach for converting abundant aliphatic carboxylic acids to the corresponding sulfonyl fluorides. This transformation is enabled by simple preactivation as aldoxime esters and energy-transfer-mediated photocatalysis. This operationally simple method proceeds with high functional-group tolerance under mild and redox-neutral conditions.

Organic Letters published new progress about 1949-41-3. 1949-41-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene, name is 2-Methyl-4-phenylbutanoic acid, and the molecular formula is C11H14O2, SDS of cas: 1949-41-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zhuang, Zhe published the artcileLigand-Enabled ¦Â-C(sp³)-H Olefination of Free Carboxylic Acids, Application of 2-Methyl-4-phenylbutanoic acid, the publication is Journal of the American Chemical Society (2018), 140(32), 10363-10367, database is CAplus and MEDLINE.

An acetyl-protected aminoethyl Ph thioether has been developed to promote C(sp³)-H activation. Significant ligand enhancement is demonstrated by the realization of the first Pd(II)-catalyzed olefination of C(sp³)-H bonds of free carboxylic acids without using an auxiliary. Subsequent lactonization of the olefinated product via 1,4 addition provided exclusively monoselectivity in the presence of multiple ¦Â-C-H bonds. The product ¦Ã-lactone can be readily opened to give either the highly valuable ¦Â-olefinated or ¦Ã-hydroxylated aliphatic acids. Considering the challenges in developing Heck couplings using alkyl halides, this reaction offers a useful alternative.

Journal of the American Chemical Society published new progress about 1949-41-3. 1949-41-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene, name is 2-Methyl-4-phenylbutanoic acid, and the molecular formula is C7H8BFO2, Application of 2-Methyl-4-phenylbutanoic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Inouye, Yoshinobu published the artcileConformation of (S,S)-methyl (2-methyl-4-phenylbutanamido)(phenyl)acetate, Safety of 2-Methyl-4-phenylbutanoic acid, the publication is Acta Crystallographica, Section C: Crystal Structure Communications (1997), C53(10), x, database is CAplus.

Crystals of the title compound are monoclinic, space group C2, with a 22.874(6), b 5.1010(10), c 18.261(4) ?, ¦Â 122.870(10)¡ã; Z = 4, d_c = 1.208; R = 0.047, R_w(F²) = 0.111 for 2876 reflections. The planes of the amide group and the ester group in the Me phenylglycinate (PGME) moiety make an angle of 34.9(1)¡ã. The benzene ring on PGME faces to the Me group of (S)-2-methyl-4-phenylbutanoic acid.

Acta Crystallographica, Section C: Crystal Structure Communications published new progress about 1949-41-3. 1949-41-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene, name is 2-Methyl-4-phenylbutanoic acid, and the molecular formula is C11H14O2, Safety of 2-Methyl-4-phenylbutanoic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zhu, Yuchao published the artcileSilver-Catalyzed Radical Transformation of Aliphatic Carboxylic Acids to Oxime Ethers, Related Products of catalysis-chemistry, the publication is ACS Catalysis (2016), 6(10), 6465-6472, database is CAplus.

Oximes and oxime ethers are privileged building blocks and can be conveniently converted to ketones, amines, hydroxylamines, and nitriles. The authors describe the catalytic decarboxylation of aliphatic carboxylic acids to oxime ethers. With AgNO₃ as the catalyst, valuable oxime ethers bearing various substituents could be easily obtained. The broad substrate scope, easy accessibility of aliphatic carboxylic acids, and mild reaction conditions make this strategy immediately applicable to the synthesis, late-stage functionalization, and modification of biol. active compounds Exptl. studies show the reaction undergoes a radical process.

ACS Catalysis published new progress about 1949-41-3. 1949-41-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene, name is 2-Methyl-4-phenylbutanoic acid, and the molecular formula is C8H11BO2, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia