Category: 1949-41-3

Gaiti, A. published the artcileEffects of butyric acid derivatives on membrane-bound and soluble hydroxymethylglutaryl coenzyme A reductase of rat liver, Product Details of C11H14O2, the publication is Archives Internationales de Physiologie et de Biochimie (1971), 79(3), 555-63, database is CAplus and MEDLINE.

The effect of ¦Â-benzylidenebutyric acid (3-methyl-4-phenyl-4-butenoic acid, I) on 3-hydroxy-3-methylglutaryl-CoA reductase (II) was studied in rat liver microsomes and a soluble preparation in order to identify the site of inhibition of cholesterol synthesis by I. 3-Hydroxy-3-methyl glutaric acid-3-14C was converted to the CoA derivative for assay of II; the product of II activity, mevalonic acid, was separated by Celite column chromatog. I inhibited the soluble form of II, as did 2-hydroxy-I, 2-methyl-4-phenylbutanoic acid and 3-phenylisopentanoic acid. The same compounds did not affect the membrane-bound enzyme, perhaps because of a nonspecific effect of drugs on the permeability of the membrane to substrate.

Archives Internationales de Physiologie et de Biochimie published new progress about 1949-41-3. 1949-41-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene, name is 2-Methyl-4-phenylbutanoic acid, and the molecular formula is C11H14O2, Product Details of C11H14O2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Duhamel, Thomas published the artcileCooperative iodine and photoredox catalysis for direct oxidative lactonization of carboxylic acids, Quality Control of 1949-41-3, the publication is Chemical Communications (Cambridge, United Kingdom) (2019), 55(7), 933-936, database is CAplus and MEDLINE.

A new method for the formation of ¦Ã- and ¦Ä-lactones from carboxylic acids through direct conversion of benzylic C-H to C-O bonds was described. The reaction was conveniently induced by visible light and relied on a mild cooperative catalysis by the combination of mol. iodine and an organic dye.

Chemical Communications (Cambridge, United Kingdom) published new progress about 1949-41-3. 1949-41-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene, name is 2-Methyl-4-phenylbutanoic acid, and the molecular formula is C11H14O2, Quality Control of 1949-41-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Li, Bo published the artcilePalladium-Catalyzed C(sp³)-H Nitrooxylation with tert-Butyl Nitrite and Molecular Oxygen, Category: catalysis-chemistry, the publication is Organic Letters (2020), 22(24), 9719-9723, database is CAplus and MEDLINE.

Herein, we report a Pd(II)-catalyzed nitrooxylation of unactivated Me C(sp³)-H bonds using com. available and easily manageable tert-Bu nitrite as the precursor of ONO₂ radical under aerobic conditions. Environmentally benign mol. oxygen is used to initiate the generation of active radical reactant; it is also used as the terminal oxidant. A broad range of nitrooxylated aliphatic carboxamides were prepared in moderate to good yields under mild conditions.

Organic Letters published new progress about 1949-41-3. 1949-41-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene, name is 2-Methyl-4-phenylbutanoic acid, and the molecular formula is C11H14O2, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Spino, Claude published the artcileA Chiral Cyclohexanone Linked to Polystyrene for Solid-Phase Synthesis of Chiral ¦Á-Carbonyls, Recommanded Product: 2-Methyl-4-phenylbutanoic acid, the publication is Journal of Combinatorial Chemistry (2005), 7(2), 345-352, database is CAplus and MEDLINE.

Two chiral cyclohexanones were linked to polystyrene resin. The polymer-bound auxiliaries were subjected to a sequence of four reactions, the last of which cleaves the desired ¦Á-chiral carbonyl compound off the resin, concurrently regenerating the resin-bound auxiliary in its original form. Thus, addition of vinyllithiums, derived from alkenyl iodides R¹CH₂CH₂CH:CHI (R¹ = n-Pr, Ph, Me₃CSiMe₂O), to the resin-bound cyclohexanone I (X = resin) followed by chloroformylation / cuprate addition gave the resin-bound alkylidenecyclohexanes II (R² = Me, Me₃C, Ph, 1-naphthyl, etc.), which were cleaved by ozonation to give, after reduction of oxidation if required, a set of non-racemic alcs., aldehydes and carboxylic acids ZCHR²CH₂CH₂R¹ (Z = HOCH₂, CHO, HO₂C). The resin can then be reused.

Journal of Combinatorial Chemistry published new progress about 1949-41-3. 1949-41-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene, name is 2-Methyl-4-phenylbutanoic acid, and the molecular formula is C13H9FO, Recommanded Product: 2-Methyl-4-phenylbutanoic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Brunner, Otto published the artcileSynthesis of 1-methyl-2-ethyl- and 1-ethyl-2-methylnaphthalene, Application of 2-Methyl-4-phenylbutanoic acid, the publication is Monatshefte fuer Chemie (1934), 76-9, database is CAplus.

PhCH₂CH₂Br and EtCH(CO₂H)₂ with Na in PhMe give di-Et (¦Â-phenylethyl)ethylmalonate, b₁₁ 186-7¡ã; hydrolysis and removal of CO₂ gives ¦Ã-phenyl-¦Á-ethylbutyric acid, b₁₁ 172-3¡ã; concentrated H₂SO₄ gives 2-ethyl-1-keto-1,2,3,4-tetrahydronaphthalene, b₁₁ 140-5¡ã; MeMgI gives 1-methyl-2-ethyl-¦¤¹-dihydronaphthalene, b₁₁ 135-45¡ã; heating with S at 260-90¡ã for 1 hr. gives 1-methyl-2-ethylnaphthalene, b₁₁ 140-5¡ã (picrate, orange, m. 97¡ã; styphnate, yellow, m. 114¡ã). ¦Ã-Phenyl-¦Á-methylbutyric acid, b₁₁ 155-65¡ã; concentrated H₂SO₄ gives 2-methyl-1-keto-1,2,3,4-tetrahydronaphthalene, b11 140-50¡ã, which yields with EtMgBr, as above, 1-ethyl-2-methylnaphthalene, b₁₁ 135-45¡ã (picrate, golden yellow, m. 110-1¡ã; styphnate, yellow, m. 141¡ã).

Monatshefte fuer Chemie published new progress about 1949-41-3. 1949-41-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene, name is 2-Methyl-4-phenylbutanoic acid, and the molecular formula is C11H14O2, Application of 2-Methyl-4-phenylbutanoic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Tlahuext-Aca, Adrian published the artcileMulticomponent Oxyalkylation of Styrenes Enabled by Hydrogen-Bond-Assisted Photoinduced Electron Transfer, Recommanded Product: 2-Methyl-4-phenylbutanoic acid, the publication is Angewandte Chemie, International Edition (2017), 56(13), 3708-3711, database is CAplus and MEDLINE.

Herein, authors disclose a strategy for the activation of N-(acyloxy)phthalimides towards photoinduced electron transfer through hydrogen bonding. This activation mode enables efficient access to C(sp³)-centered radicals upon decarboxylation from bench-stable and readily available substrates. Moreover, they demonstrate that the formed alkyl radicals can be successfully employed in a novel redox-neutral method for constructing sp³-sp³ bonds across styrene moieties that gives straightforward access to complex alc. and ether scaffolds.

Angewandte Chemie, International Edition published new progress about 1949-41-3. 1949-41-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene, name is 2-Methyl-4-phenylbutanoic acid, and the molecular formula is C5H10Cl3O3P, Recommanded Product: 2-Methyl-4-phenylbutanoic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zhang, Xuexin published the artcilePd(II)/Zn co-catalyzed chemo-selective hydrogenation of ¦Á-methylene-¦Ã-keto carboxylic acids, HPLC of Formula: 1949-41-3, the publication is Organic & Biomolecular Chemistry (2019), 17(8), 2174-2181, database is CAplus and MEDLINE.

An efficient Pd/Zn co-catalyzed chemo-selective hydrogenation of ¦Á-methylene-¦Ã-keto carboxylic acids was described. This methodol. offers a divergent synthesis of ¦Á-methyl-¦Ã-keto carboxylic acids, ¦Á-methylcarboxylic acids, and lactones starting from ¦Á-methylene-¦Ã-keto carboxylic acids via selective hydrogenation by varying the catalytic conditions avoiding the use of high pressure of hydrogen. The reaction also showed broad substrate tolerance to give the desired products in good to excellent yields.

Organic & Biomolecular Chemistry published new progress about 1949-41-3. 1949-41-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene, name is 2-Methyl-4-phenylbutanoic acid, and the molecular formula is C25H23NO4, HPLC of Formula: 1949-41-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Watanabe, Shoji published the artcileReaction of carboxylic acids with conjugated olefins, using sodium naphthalenide in the presence of N,N,N’,N’-tetramethylethylenediamine, Formula: C11H14O2, the publication is Yukagaku (1982), 31(5), 295-9, database is CAplus.

Alkylation of carboxylic acids at the 2-position with conjugated dienes such as isoprene, butadiene, myrcene, and styrene were carried out. For example, 2,2,5-trimethyl-4-hexenoic acid was obtained in 66% yield from the reaction of isobutyric acid (I) and isoprene using Na naphthalenide in the presence of Me₂NCH₂CH₂NMe₂. Similarly, from I and styrene, 2,2-dimethyl-4-phenylbutyric acid was obtained in 57% yield. Furthermore, conversion of these carboxylic acids to alcs., aldehydes, and lactones were examined

Yukagaku published new progress about 1949-41-3. 1949-41-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene, name is 2-Methyl-4-phenylbutanoic acid, and the molecular formula is C3H5BN2O2, Formula: C11H14O2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Alexander, Elliot R. published the artcileMechanism of Chugaev and acetate thermal decompositions. II. cis- and trans-2-Methyl-1-tetralol, Synthetic Route of 1949-41-3, the publication is Journal of the American Chemical Society (1950), 3194-8, database is CAplus.

cf. C.A. 44, 7254a. Details are given of the preparation of BzCH₂CHMeCO₂H (60%), PhCH₂CH₂CHMeCO₂H (85%), and 3, 4-dihydro-2-methyl-1(2H)-naphthalenone (I) (92%). Reduction of 10 g. I in 150 ml. 95% EtOH with 10 g. Na gives 2 g. crude trans-1,2,3,4-tetrahydro-2-methyl-1-naphthol (II), m. 74-5¡ã; if the filtrate from the recrystallization is added to another batch of I being reduced, the yield of II is 3-4 g.; 3,5-dinitrobenzoate, light yellow, m. 155-6¡ã. I (10 g.) in 40 ml. absolute EtOH, hydrogenated over 4 g. Raney Ni (9 hrs.) at room temperature and 45 lb./sq. in. and purified through the phenylurethan (m. 122-4¡ã, 67%), gives the cis isomer (III) of II, b_0.2-0.3 90-4¡ã, n_D²⁰ 1.5502. II yields 81% Me trans-1,2,3,4-tetrahydro-2-methyl-1-naphthylxanthate (IV), m. 58-9¡ã; cis isomer (V), m. 71-2¡ã, 17%. II acetate (VI), m. 61-2¡ã; III acetate (VII), b_0.2-0.3 86-92¡ã, n_D²⁰ 1.5192. Reduction of I over Cu chromite at 100¡ã and 1600 lb./sq. in. gives 2-methyl-3, 4-dihydronaphthalene (VIII), b_0.6 63-5¡ã, n_D²⁰ 1.5751, d₂₀²⁰ 0.9837 (picrate, unstable, m. 70-4¡ã). V is stable at 98-100¡ã, whereas IV is rapidly decomposed, forming VIII. VII is much more stable than VI; VI gives VIII, whereas VII at 650¡ã gives 2-C₁₀H₇Me. The results are given as curves. These results are in agreement with the point of view that the Chugaev reaction and the simple thermal decomposition of acetates involve the intermediate formation of a transitory 6-membered ring with a cis-¦Â-H atom.

Journal of the American Chemical Society published new progress about 1949-41-3. 1949-41-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene, name is 2-Methyl-4-phenylbutanoic acid, and the molecular formula is C11H14O2, Synthetic Route of 1949-41-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Gaydou, Morgane published the artcileSite-Selective Catalytic Carboxylation of Unsaturated Hydrocarbons with CO₂ and Water, Computed Properties of 1949-41-3, the publication is Journal of the American Chemical Society (2017), 139(35), 12161-12164, database is CAplus and MEDLINE.

A catalytic protocol that reliably predicts and controls the site-selective incorporation of CO₂ to a wide range of unsaturated hydrocarbons utilizing water as formal hydride source is described. This platform unlocks an opportunity to catalytically repurpose three abundant, orthogonal feedstocks under mild conditions.

Journal of the American Chemical Society published new progress about 1949-41-3. 1949-41-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene, name is 2-Methyl-4-phenylbutanoic acid, and the molecular formula is C11H14O2, Computed Properties of 1949-41-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia