Category: 1949-41-3

Buchta, Emil published the artcilePolycyclic compounds. IX. 20-Methylcholanthrene and cholanthrene, Related Products of catalysis-chemistry, the publication is Chemische Berichte (1962), 213-21, database is CAplus.

cf. CA 54, 457b. -Methyl-3-(2-bromoethyl)acenaphthene (I) was converted by a modification of the previously described method (loc. cit.) to 20-methylcholanthrene (II). 3-(2-Bromoethyl)acenaphthene (III) was prepared in 8 steps from naphthalene-1,2-dicarboxylic acid anhydride (IV) and converted in an analogous manner to cholanthrene (V). Granulated K (4 g.) in 100 cc. PhMe refluxed 1 hr. with 16 g. CH₂(CO₂Et)₂ in 20 cc. dry PhMe, cooled slightly, treated with stirring dropwise during 0.5 hr. with 16 g. I in 100 cc. PhMe, refluxed 40 hrs., cooled, and poured into H₂O, the aqueous phase extracted with Et₂O, the combined organic phase and Et₂O extract worked up, the resulting viscous brown oil refluxed 3 hrs. with 18 g. KOH in 300 cc. MeOH, concentrated, and filtered, the residue refluxed 2 hrs. with 400 cc. H₂O, filtered, and added dropwise to dilute H₂SO₄, and the product isolated with Et₂O and heated 1 hr. at 180¡ã gave 10.5 g. 4-(8-methyl-3-acenaphthenyl)butyric acid (VI), yellow, m. 116-17¡ã (ligroine). VI (8 g.) and 80 cc. anhydrous HF kept 2 hrs. at room temperature and evaporated with a stream of air, and the residue neutralized with 30% aqueous K₂CO₃ and extracted with C₆H₆ yielded 6 g. 6-methyl-1-oxo-1,2,3,4-tetrahydro-5,10-aceanthrene (VII), m. 118¡ã (sublimed at 180-90¡ã/0.2 mm.). Com. NaOMe (5 g.) in 20 cc. C₆H₆ stirred 15 min., treated dropwise during 15 min. with 5 g. HCO₂Et in 50 cc. dry C₆H₆ with cooling under N, the mixture treated dropwise during 45 min. with cooling and stirring with 5 g. VII in 100 cc. dry C₆H₆, stirred 5 hrs. with cooling, diluted with 50 cc. H₂O, and treated with 100 cc. dilute H₂SO₄, and the C₆H₆ layer worked up gave 5.3 g. 2-hydroxymethylene derivative (VIII) of VII, yellow needles, m. 127-8¡ã (EtOH). VIII (4 g.) in 30 cc. dry C₆H₆, 3 g. AcCH:CH₂, and 10 drops Et₃N kept 5 days and evaporated in vacuo, and the residue chromatographed on Al₂O₃ yielded 2.5 g. 2-formyl-2-(3-oxobutyl) derivative (IX) of VII, yellow, m. 123-4¡ã (EtOH). IX (2 g.) in 25 cc. dioxane refluxed 3 hrs. with 130 cc. 3% aqueous KOH, cooled, poured into H₂O, and extracted with C₆H₆, and the extract filtered through Al₂O₃ and evaporated gave 1.5 g. 20-methyl-2-oxo-2,3,-4,5,6,7-hexahydrocholanthrene (X), light yellow, m. 174-5¡ã (EtOH). X (1 g.) in 100 cc. dry tetrahydrofuran added dropwise with stirring during 0.5 hr. to 1.5 g. powd. LiAlH₄ in 50 cc. tetrahydrofuran, refluxed 2 hrs. with stirring, and worked up, and the viscous, red-brown product heated during 3 hrs. with 0.5 g. 30% Pd-C under N gradually to 300-20¡ã, cooled, diluted with C₆H₆, filtered, and evaporated, and the viscous brown residue sublimed at 180-200¡ã/0.01 mm. yielded 18 mg. II, pale yellow, m. 175-6.5¡ã (PrOH). IV (45 g.) in 400 cc. dry tetrahydrofuran added dropwise during 1 hr. to 15 g. powd. LiAlH₄ in 200 cc. dry tetrahydrofuran, refluxed 1.5 hrs., and worked up yielded 29 g. 1,2-C₁₀H₆(CH₂OH)₂ (XI), m. 122-3¡ã (EtOAc). XI (28 g.) in 250 cc. 1:1 C₆H₆-PhMe stirred about 15 min. at room temperature, treated with stirring with 45 g. PBr₃ in 150 cc. C₆H₆, stirred 2 hrs. at room temperature and 2 hrs. at 50¡ã, cooled, and poured into iced H₂O, and the product isolated with 1:1 PhMe-C₆H₆ yielded 38.5 g. 1,2-C₁₀H₆(CH₂Br)₂ (XII), leaflets, m. 148.5-9.5¡ã (CHCl₃). KCN (15 g.) in 35 cc. H₂O and 125 cc. 96% EtOH treated with stirring during 1 hr. with 28 g. XII in portions, stirred 3 hrs., refluxed 1 hr. with stirring, concentrated in vacuo, added hot to 225 cc. H₂O, cooled, and filtered yielded 14.5 g. 1,2-C₁₀H₆(CH₂CN)₂ (XIII), needles, m. 188¡ã (EtOAc). XIII (18 g.), 200 cc. 40% H₂SO₄, and 20 cc. AcOH refluxed 2 hrs., cooled, diluted with 100 cc. H₂O, and filtered, and the residue reprecipitated from 20% aqueous Na₂CO₃ with dilute H₂SO₄ yielded 14 g. 1,2-C₁₀H₆CH₂CO₂H)₂ (XIV), m. 214¡ã (30% AcOH). XIV (15 g.), 60 g. SOCl₂, 75 cc. Et₂O, and a few drops C₅H₅N kept 0.5 hr. at room temperature, concentrated, diluted with CS₂, evaporated again, dissolved in 300 cc. dry CS₂, treated with stirring during 1 hr. with 30 g. powd. AlCl₃, stirred 3 hrs. with cooling, and worked up gave 7.5 g. acenaphthen-1-one-3-acetic acid (XV), leaflets, m. 168¡ã (hot H₂O). XV (12 g.) and 120 g. amalgamated Zn, 50 cc. H₂O, 75 cc. concentrated HCl, and 40 cc. PhMe refluxed 34 hrs. while adding at 8-hr. intervals four 25-cc. portions concentrated HCl and cooled, the PhMe layer and Zn residues extracted with 20% aqueous Na₂CO₃, and the extract acidified gave 12 g. acenaphthene-3-acetic acid (XVI), leaflets, m. 164¡ã. XVI (10 g.) in 50 cc. dry tetrahydrofuran added dropwise during 0.5 hr. to 2 g. powd. LiAlH₄ in 100 cc. refluxing dry tetrahydrofuran, refluxed 2 hrs. with stirring, and worked up gave 8 g. 3-(2-hydroxyethyl)acenaphthene (XVII), needles, m. 96¡ã (ligroine). XVII (10 g.) in 50 cc. dry CCl₄ treated dropwise during 0.5 hr. at 60¡ã with 10 g. PBr₃ in 10 cc. CCl₄, heated 0.5 hr. at 70¡ã, and worked up gave 7 g. III, leaflets, m. 66¡ã (ligroine). CH₂(CO₂Et)₂ (20 g.) in 50 cc. drytetrahydrofuran added dropwise with stirring to 3 g. powd. Na in 100 cc. dry PhMe, refluxed 1 hr., cooled to about 50¡ã, treated dropwise with stirring during 0.5 hr. with 20 g. III in 50 cc. dry PhMe, refluxed 36 hrs., and worked up gave 19 g. di-Et 2-(3-acenaphthyl)ethylmalonate (XVIII), b_0.03 180¡ã. XVIII (6 g.) and 6 g. KOH in 100 cc. MeOH refluxed 6 hrs. gave 4.8 g. 2-(3-acenaphthenyl)ethylmalonic acid (XIX), leaflets, m. 180¡ã (decomposition). XIX (7 g.) heated 1.5 hrs. at 180-90¡ã yielded 5.2 g. 4-(3-acenaphthenyl)butyric acid (XX), leaflets, m. 154¡ã, b_0.1 212¡ã. XX (5 g.) treated with 50 cc. anhydrous HF during 36 hrs. yielded 3.8 g. 1-oxo-1,2,3,4-tetrahydro-5,10-aceanthrene (XXI), needles, m. 145¡ã (EtOH). XXI (1 g.) in 50 cc. dry tetra hydrofuran added dropwise with stirring to 1.5 g. powd. Li-AlH₄ in 100 cc. dry tetrahydrofuran, the mixture worked up, and the resulting viscous, yellow oil heated with 150 mg. 10% Pd-C at 320-30¡ã and then sublimed at 120¡ã/0.2 mm. yielded 0.48 g. aceanthrene (XXII), pale yellow leaflets, m. 117¡ã. Com. NaOMe (7 g.) in 20 cc. dry C₆H₆ treated during 15 min. with stirring with 7 g. HCO₂Et in 50 cc. dry C₆H₆ and then during 45 min. with 7 g. XXI gave 7.5 g. 2-hydroxymethylene derivative (XXIII) of XXI, yellow needles, m. 120¡ã (EtOH). XXIII (6 g.) in 60 cc. dry C₆H₆ treated with 10 drops Et₃N and 4 g. AcCH:CH₂ and kept 4 days yielded 4 g. 2-formyl-2-(3-oxobutyl) derivative (XXIV) of XXI, needles, m. 146 7¡ã (EtOH). XXIV (4 g.) in 50 cc. dioxane refluxed 2 hrs. with 250 cc. 2% aqueous KOH yielded 3.1 g. 2-oxo-2,3,4,5,6,7-hexahydrocholanthrene (XXV), yellow leaflets, m. 180¡ã (EtOH). XXV (1 g.) in 50 cc. dry tetrahydrofuran reduced in the usual manner with 1.5 g. LiAlH₄ in 50 cc. tetrahydrofuran, and the crude product heated 5 hrs. with 0.5 g. 10% Pd.C at 320-30¡ã gave 80 mg. V, pale yellow leaflets, m. 169-70¡ã (PrOH). MeCH(CO₂Et)₂ (40 g.) added dropwise with stirring to 4 g. powd. Na in 150 cc. dry PhMe, refluxed 1 hr., cooled, treated dropwise with 40 g. PhCH₂CH₂Br, refluxed 7 hrs., and worked up yielded 37.3 g. PhCH₂CH₂CMe(CO₂Et)₂ (XXVI), b₁₀ 176-9¡ã. XXVI (67 g.) and 40 g. KOH in 200 cc. MeOH refluxed 4 hrs. yielded 53 g. PhCH₂-CH₂CMe(CO₂H)₂, m. 166-7¡ã (decomposition); the acid heated 0.5 hr. at 180-90¡ã and then fractionated yielded 34 g. PhCH₂CH₂CHMeCO₂H (XXVII), b₉ 161-4¡ã. XXVII (105 g.) cyclized by the method of Alexander and Mudrak (J. Am. Chem. Soc. 72, 3194(1950)) gave 89 g. 2-methyl-1-tetralone (XXVIII), b₉ 126-7¡ã. MeMgI from 6.25 g. Mg and 35.5 g. MeI in 100 cc. dry Et₂O treated dropwise with stirring with 32.5 g. XXVIII in 50 cc. Et₂O, refluxed 1 hr., and worked up, and the resulting oil refluxed 0.5 hr. with 20 g. AcCl gave 23 g. 1,2-dimethyl-3,4-dihydronaphthalene (XXIX), b₁₂ 123-6¡ã. XXIX (10.6 g.) and 2.1 g. powd. S heated 0.5 hr. at 180¡ã and 15 min. at 220-30¡ã and distilled yielded 9.5 g. 1,2-C₁₀H₆Me₂, b₁₂ 132-3¡ã.

Chemische Berichte published new progress about 1949-41-3. 1949-41-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene, name is 2-Methyl-4-phenylbutanoic acid, and the molecular formula is C11H14O2, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Levene, P. A. published the artcileConfigurational relationships of acids of the phenethyl series to those of the normal series, HPLC of Formula: 1949-41-3, the publication is Journal of Biological Chemistry (1935), 311-21, database is CAplus.

Substances of the type Ph(CH₂)_m.CHMe(CH₂)_nCO₂H offer an opportunity to study the effect of the distance of the CO₂H group from the asym. center when the distance of the Ph group is kept constant or varied. d-Ph(CH₂)₂CHMeCO₂H has been configurationally correlated with l-Ph(CH₂)₂CHMeEt. Configurationally related 2-octyl- and 2-phenethylpropionic acids rotate polarized light in the same direction and, when m is 2, substitution of a hexyl by a Ph group does not change the direction of rotation of the EtCO₂H substituted in position 2. In the phenethyl series change from n = 0 to n = 1 brings about the same change in the direction of rotation as in the octyl series. Exhaustive hydrogenation of the phenethyl group has no effect on the direction of rotation except in the case of Ph(CH₂)₂CHMe(CH₂)₂Br in which the direction is reversed in the hexahydro derivative The following compounds were prepared by methods given in the preceding abstract All rotations are for the homogeneous substances. l-Ph(CH₂)₂CHMeCO₂H, b₂ 155¡ã, d₄³² 1.042, [M]_D³² -48.3¡ã, by CH₂(CO₂Et)₂ synthesis and resolved by the cinchonidine salt; d-Et ester, b₂ 120¡ã, d₄²⁸ 0.979, [M]_D²⁸ 7.6¡ã; l-Ph(CH₂)₂CHMeCH₂OH, b₁₇, 157¡ã, d₄²⁸ 0.968, [M]_D²⁸ -2.7¡ã; l-Ph(CH₂)₂CHMeCH₂Br, b₁₇ 151¡ã, d₄²⁷ 1.235, [M]_D²⁷ -5.8¡ã; l-Ph(CH₂)₂CHMeCH₂CO₂H, b₂ 162¡ã, d₄²⁷, 1.033, [M]_D²⁷ -6.04¡ã; l-Et ester, b₂ 131¡ã, d₄²⁷ 0.973, [M]_D²⁷ -4.9¡ã; l-Ph(CH₂)₂CHMe(CH₂)₂OH, b₁₇, 157¡ã, d₄²⁷ 0.959, [M]_D²⁷; -3.99¡ã; l-Ph(CH₂)₂CHMe(CH₂)₂Br, b₁₇ 160¡ã, d₄²⁷ 1.201, [M]_D²⁷ -2.29¡ã; l-Ph(CH₂)₂CHMeEt, b₁₅ 112¡ã, d₄²⁵ 0.855, [M]_D²⁷ -4.76¡ã; d-C₆H₁₁CH₂)₂CHMeCO₂H, b₂ 156¡ã, d₄²⁷ 0.968, [M]_D²⁷ 3.4¡ã; d-Et ester, b₁ 101¡ã d₄²⁸ 0.919, [M]_D²⁸ 4.92¡ã; l-C₆H₁₁(CH₂)₂CHMeCH₂OH, b₁₇ 141¡ã, d₄²⁷ 0.898, [M]_D²⁷ -2.09¡ã; C₆H₁₁(CH₂)₂CHMeCH₂Br, b₁₅ 142¡ã, [M] 0¡ã. l-C₆H₁₁(CH₂)₂CHMeCH₂CO₂H, b₂ 158¡ã, d₄²⁷ 0.959, [M]_D²⁷ -2.36¡ã; l-Et ester, b₁₇ 162¡ã, d₄²⁵ 0.918, [M]_D²⁵ -1.85¡ã; l-C₆H₁₁(CH₂)₂CHMe(CH₂)₂OH, b₁₇ 157¡ã, d₄²⁷ 0.893, [M]₄²⁷ -1.84¡ã; d-C₆H₁₁(CH₂)₂ CHMe(CH₂)₂Br, b₁₅ 151¡ã, d₄²⁷ 1.122, [M]₄²⁷ 1.12¡ã; l-C₆H₁₁(CH₂)₂CHMeEt, b₁₅ 110¡ã, d₄²⁷ 0.806, [M]_D²⁷ -2.82¡ã.

Journal of Biological Chemistry published new progress about 1949-41-3. 1949-41-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene, name is 2-Methyl-4-phenylbutanoic acid, and the molecular formula is C11H14O2, HPLC of Formula: 1949-41-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Levene, P. A. published the artcileMaximum rotations of configurationally related carboxylic acids containing a phenyl or a cyclohexyl group, Computed Properties of 1949-41-3, the publication is Journal of Biological Chemistry (1935), 329-42, database is CAplus.

Maximum rotations of acids of the types RPhCH(CH₂)_nCO₂H (Type I), RC₆H₁₁CH(CH₂)_nCO₂H (Type II) and RMeCH(CH₂)_nCO₂H (Type III) are discussed for cases where n varies from 0 to 3. With compounds of Type I the direction of rotation shifts to the left on passing from n = 0 to 1, to the right from n = 1 to 2, to the left from n = 2 to 3. This shift also holds in the cases of the esters, carbinols and halides. In acids of Type III the CO₂H group when n = 0 owes its activity to a band located further in the ultraviolet than the Ist band of the CO₂H group which is responsible for the activity of the CO₂H groups of the acids when n = 1. On passing from the acids to esters when n is constant the shift is to the left in the disubstituted acetic, to the right in the propionic, to the left in the butyric: and to the right in the valeric acids. This type of acid therefore does not follow Freudenberg’s rule of shift. By the use of methods given in the preceding abstracts the following compounds were prepared All values for [M]_D are maximum and for the homogeneous substances. EtPhCHCH₂CO₂H, prepared from EtPhCHCH₂Br by the Grignard reagent and resolved by quinine; l-Et ester, b₁ 105¡ã,[M]_D²⁵ -49.8¡ã l-EtPhCH(CH₂)₂OH, b₁ 118¡ã, [M]_D²⁵ -24.7¡ã; l-EtPhCH(CH²)₂Br, b₁ 102¡ã, [M]_D²⁵-165¡ã; l-EtPhCH(CH₂)₂CO₂H, b₄ 156¡ã, [M]_D²⁵ -6.54¡ã; l-Et ester, b₁ 121¡ã, [M]_D²⁵ -22.9¡ã; d-EtPhCH(CH₂)₃OH, b₅ 125¡ã, [M]_D²⁵ 2.07¡ã; l-EtPhCH(CH₂)₃Br, b₃ 125¡ã, [M]_D²⁵-18.2¡ã; l-EtPhCH(CH₂)₃ CO₂H, b₁, 161¡ã d_D²⁵ 0.998,[M]_D²⁵ -22.2¡ã; l-Et ester, b₁ 135¡ã, [M]_D²⁵ -14.7¡ã; l-EtPhCH(CH₂)₄OH, b₁ 123¡ã, [M]_D²⁵ -18.2¡ã; l-EtPhCH(CH₂)₄Br, b₁ 125¡ã, [M]_D²⁵ -42.6¡ã; MePhCHCH₂CO₂H by the Grignard reaction from MePhCHCH₂Br and resolved by quinine; l-Et ester, b₄ 111¡ã, [M]_D²⁵ -56.9¡ã; l-MePhCH(CH₂)₂OH, b₈ 117¡ã, [M]_D²⁵ -54.8¡ã; l-MePhCH(CH₂)₂Br, b₁₁ 120¡ã, [M]_D²⁵ -148¡ã; l-MePhCH(CH₂)₂CO₂H, b₁ 137¡ã, [M]_D²⁵ -39.4¡ã; l-Et ester, b₁ 112¡ã, [M]_D²⁵ -52.9¡ã; l-MePhCH(CH₂)₃OH, b₁ 109¡ã, [M]_D²⁵ -30.8¡ã; l-MePhCH(CH₂)₃Br, b₁₅ 125¡ã, [M]_D²⁵ -38.3¡ã; d-Me(C₆H₁₁CHCO₂H, b₁ 105¡ã, [M]_D²⁵ 25.8¡ã; l-Me(C₆H₁₁) CH-CO₂H, b_0.2 95¡ã, [¦Á]_D²⁵ -7.14¡ã (in dry Et₂O); d-Me(C₆H₁₁)CHCO₂Et, b₁₅ 100¡ã, d_D²⁵ 0.938, [M]_D²⁵ 36.9¡ã; l-Me(C₆H₁₁)CHCH₂OH, b₁₅ 110¡ã, d_D²⁵ 0.923, [M]_D²⁵ -1.74¡ã; d-Me-(C₆H₁₁)CHCH₂Br, b₁₅ 110¡ã, d₄²⁵ 1.203, [M]_D²⁵ 12.0¡ã; d-Me(C₆H₁₁)CHCH₂CO₂H, b₄ 145¡ã, d₄²⁵ 1.018, [M]_D²⁵7.9¡ã. The maximum value calculated on the above reactions starting from the maximum value of MePhCHCO₂H, compares with a value of [M]_D²⁵ 7.8¡ã obtained by direct catalytic reduction of maximum MePhCHCH₂CO₂H. Thus there was no racemization in the experiments

Journal of Biological Chemistry published new progress about 1949-41-3. 1949-41-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene, name is 2-Methyl-4-phenylbutanoic acid, and the molecular formula is C11H14O2, Computed Properties of 1949-41-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Cong, Le Thi Nhi published the artcileTransformation of iso-pentylbenzene by a biofilm-forming strain of Candida viswanathii TH1 isolated from oil-polluted sediments collected in coastal zones in Vietnam, SDS of cas: 1949-41-3, the publication is Journal of Environmental Science and Health, Part A: Toxic/Hazardous Substances & Environmental Engineering (2014), 49(7), 777-786, database is CAplus and MEDLINE.

This work is aimed to assess the aerobic biotransformation of a branched side chain alkylbenzene, iso-pentylbenzene, by Candida viswanathii TH1. The yeast Candida viswanathii TH1 isolated from oil-polluted sediments collected in coastal zones in Vietnam exhibited as a strain that could better transform branched aromatic hydrocarbons in biofilm (pellicle) than in planktonic form. During incubation of TH1 as biofilm with iso-pentylbenzene, the seven intermediates produced were benzoic acid, phenylacetic acid, 2-methyl-4-phenyl-butan-1-ol, 2-hydroxy-phenylacetic acid, 2-methyl-4-phenylbutyric acid, succinic acid and iso-valerophenone as revealed by gas chromatog./mass spectra and high-performance liquid chromatog. analyses. The occurrence of these intermediates showed that iso-pentylbenzene could be oxidized not only via mono- but also by a sub-terminal oxidation pathway. This is the first study on iso-pentylbenzene transformation by a biofilm-forming Candida viswanathii strain. The catabolic versatility of the biofilm-forming strain TH1 and its use for mono and sub-terminal oxidation during the transformation of iso-pentylbenzene enhance our understanding of the degradation of branched side chain phenylalkanes and give new insight into the potential role of such species in the transformation of other recalcitrant aromatic compounds

Journal of Environmental Science and Health, Part A: Toxic/Hazardous Substances & Environmental Engineering published new progress about 1949-41-3. 1949-41-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene, name is 2-Methyl-4-phenylbutanoic acid, and the molecular formula is C11H14O2, SDS of cas: 1949-41-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Tan, Xinqiang published the artcileSilver-Catalyzed Decarboxylative Trifluoromethylation of Aliphatic Carboxylic Acids, Formula: C11H14O2, the publication is Journal of the American Chemical Society (2017), 139(36), 12430-12433, database is CAplus and MEDLINE.

The silver-catalyzed decarboxylative trifluoromethylation of aliphatic carboxylic acids is described. With AgNO₃ as the catalyst and K₂S₂O₈ as the oxidant, the reactions of aliphatic carboxylic acids with (bpy)Cu(CF₃)₃ (bpy = 2,2′-bipyridine) and ZnMe₂ in aqueous acetonitrile at 40 ¡ãC afford the corresponding decarboxylative trifluoromethylation products in good yield. The protocol is applicable to various primary and secondary alkyl carboxylic acids and exhibits wide functional group compatibility. Mechanistic studies reveal the intermediacy of ^–Cu(CF₃)₃Me, which undergoes reductive elimination and subsequent oxidation to give Cu(CF₃)₂ as the active species responsible for the trifluoromethylation of alkyl radicals.

Journal of the American Chemical Society published new progress about 1949-41-3. 1949-41-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene, name is 2-Methyl-4-phenylbutanoic acid, and the molecular formula is C9H7NO2, Formula: C11H14O2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wen, Kai-Ge published the artcileCatalytic Enantioselective Desymmetrization of Cyclobutane-1,3-diones by Carbonyl-Amine Condensation, Computed Properties of 1949-41-3, the publication is Organic Letters (2021), 23(3), 1118-1122, database is CAplus and MEDLINE.

A chiral phosphoric acid-catalyzed enantioselective condensation of 2,2-disubstituted cyclobutane-1,3-diones with a primary amine was described. This reaction offered a mild and efficient protocol for constructing quaternary carbon-containing cyclobutanes I [R¹ = Bn, (E)-PhCH=CHCH₂, 2-naphthylmethyl, etc.; Ar = Ph, C₆F₅, 2,4,6-Me₃-C₆H₂, etc.] in good to high yields and enantioselectivities. This reaction was first catalytic desymmetrizing carbonyl-amine condensation reaction and also represented first catalytic desymmetrizing reaction of prochiral cyclobutane-1,3-dione.

Organic Letters published new progress about 1949-41-3. 1949-41-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene, name is 2-Methyl-4-phenylbutanoic acid, and the molecular formula is C11H8F2, Computed Properties of 1949-41-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wu, Fu-Peng published the artcileCarbonylative Transformation of Allylarenes with CO Surrogates: Tunable Synthesis of 4-Arylbutanoic Acids, 2-Arylbutanoic Acids, and 4-Arylbutanals, Formula: C11H14O2, the publication is Organic Letters (2019), 21(14), 5699-5703, database is CAplus and MEDLINE.

In this communication, procedures for the selective synthesis of 4-arylbutanoic acids, 2-arylbutanoic acids, and 4-arylbutanals from the same allylbenzenes have been developed. With formic acid or TFBen as the CO surrogate, reactions proceed selectively and effectively under carbon monoxide gas-free conditions.

Organic Letters published new progress about 1949-41-3. 1949-41-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene, name is 2-Methyl-4-phenylbutanoic acid, and the molecular formula is C15H12O6, Formula: C11H14O2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Rothen, Alexandre published the artcileRotatory dispersion and absorption spectra of carboxylic acids and hydrocarbons containing a phenyl or a cyclohexyl group, Formula: C11H14O2, the publication is Journal of Chemical Physics (1939), 975-83, database is CAplus.

Maximum optical rotations are tabulated for (a) MeCHRCOOH, (b) MeCHRCH₂COOH, (c) EtCHRCOOH, (d) PrCHPhCH₂COOH, (e) EtCHPhBu, (f) RCH₂CHMeCOOH, (g) RCH₂CHMeCH₂COOH, (h) PhCH₂CHMeEt, (i) RCH₂CH₂CHMeCOOH, (j) RCH₂CH₂CHMeCH₂COOH, (k) PhCH₂CH₂CHMeCH₂CH₂COOH, (l) cyclo-C₆H₁₁CH₂CH₂CHMeCH₂CH₂COOH, (m) RCH₂CH₂CHMeCH₂CH₂CH₂COOH, (n) PhCH₂CH₂CHMeEt, where R = Ph, cyclo-C₆H₁₁ or C₆H₁₃. Calculated and observed rotatory dispersions are compared at 3-23 wave lengths between 2300 and 6700 A. for solutions in heptane of all the Ph compounds except a, and the cyclohexyl compounds a, b, c, f and g; and for the cyclohexyl compounds i, j, l and m and for e, h and n: rotatory dispersions are plotted (1/¦Á against ¦Ë²) for the Ph compounds b, f and m, and for cyclohexyl compounds a, f and i; the maximum mol. rotations are plotted against ¦Ë¦Ë (3900-6300) for cyclo-C₆H₁₁CHEtCOOH. Absorption spectra are plotted ¦Ë¦Ë (2200-2800) for the Ph compounds b, c, f, i, j, m and n; for the cyclohexyl compounds a, l and m; and for PhCHMeBu. Absorption bands (5-7 each) of PhCH₂CONH₂, Ph(CH₂)₆CONH₂, PhMeCHCOOH, PhCH₂CH₂CHMeCOOH and PhCH₂CH₂CHMeCH₂COOH are compared. Shifts in the absorption bands of these disubstituted carboxylic acids were studied as a function of the Phú´COOH distance. The first absorption region of the Ph group furnishes no detectable rotatory contribution in this type of acid. The first rotatory contribution is allocated to the COOH group. The Ph and cyclohexyl groups have a vicinal effect similar to that of the hexyl group with respect to the sign of rotation.

Journal of Chemical Physics published new progress about 1949-41-3. 1949-41-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene, name is 2-Methyl-4-phenylbutanoic acid, and the molecular formula is C11H14O2, Formula: C11H14O2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Hu, Jiantao published the artcileUnactivated C(sp³)-H hydroxylation through palladium catalysis with H₂O as the oxygen source, Formula: C11H14O2, the publication is Chemical Communications (Cambridge, United Kingdom) (2015), 51(80), 14929-14932, database is CAplus and MEDLINE.

A novel palladium catalyzed hydroxylation of unactivated aliphatic C(sp³)-H bonds was successfully developed. Different from conventional methods, water serves as the hydroxyl group source in the reaction. This new reaction demonstrates good reactivity and broad functional group tolerance. The C-H hydroxylated products can be readily transformed into various highly valuable chems. via known transformations. Based on exptl. and theor. studies, a mechanism involving the Pd(II)/(IV) pathway is proposed for this hydroxylation reaction.

Chemical Communications (Cambridge, United Kingdom) published new progress about 1949-41-3. 1949-41-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene, name is 2-Methyl-4-phenylbutanoic acid, and the molecular formula is C11H14O2, Formula: C11H14O2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Sang, Rui published the artcileSynthesis of Carboxylic Acids by Palladium-Catalyzed Hydroxycarbonylation, Application of 2-Methyl-4-phenylbutanoic acid, the publication is Angewandte Chemie, International Edition (2019), 58(40), 14365-14373, database is CAplus and MEDLINE.

The synthesis of carboxylic acids is of fundamental importance in the chem. industry and the corresponding products find numerous applications for polymers, cosmetics, pharmaceuticals, agrochems., and other manufactured chems. Although hydroxycarbonylations of olefins have been known for more than 60 years, currently known catalyst systems for this transformation do not fulfill industrial requirements, for example, stability. Presented herein for the first time is an aqueous-phase protocol that allows conversion of various olefins, including sterically hindered and demanding tetra-, tri-, and 1,1-disubstituted systems, as well as terminal alkenes, into the corresponding carboxylic acids in excellent yields. The outstanding stability of the catalyst system (26 recycling runs in 32 days without measurable loss of activity), is showcased in the preparation of an industrially relevant fatty acid. Key-to-success is the use of a built-in-base ligand under acidic aqueous conditions. This catalytic system is expected to provide a basis for new cost-competitive processes for the industrial production of carboxylic acids.

Angewandte Chemie, International Edition published new progress about 1949-41-3. 1949-41-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene, name is 2-Methyl-4-phenylbutanoic acid, and the molecular formula is C11H14O2, Application of 2-Methyl-4-phenylbutanoic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia