Category: 1949-41-3

Braun, J. V. published the artcileSyntheses in the aliphatic-aromatic series. XII, COA of Formula: C11H14O2, the publication is Berichte der Deutschen Chemischen Gesellschaft (1914), 262-9, database is CAplus.

cf. C. A., 7, 2567. The following compounds were prepared to determine whether the introduction of a Me group in the CH₂ adjacent to CH₂OH or CHO in the side chain of aliphatic-aromatic alcs. and aldehydes has in general a greater influence on the odor than when it is introduced nearer to the aromatic radical, as was found in the case of PhCH₂CH₂CH₃OH and PhCH₂CH₃CHO: It was found that the methylation does change the odor but at the same time it weakens it so extraordinarily that shades cannot be distinguished. Diethyl phenethylmethylmalonate, in 77% yield from Ph(CH₂)₂CH(CO₂Et)₂ and MeI, b₂₀ 192¡ã, hydrolyzed by aqueous alc. KOH to the acid, m. 160¡ã, which at 165¡ã, gives ¦Á-methyl-¦Ã-phenylbutyric acid, b₁₉ 180¡ã (different from Willgerodt and Merck’s compound (C. A., 4,903)); its ethyl ester, b₁₇ 143-4¡ã, with Na and alc. gives 60% of ¦Â-methyl-¦Ã-phenylbutyl alcohol, viscous oil, b₁₈ 145-8¡ã, d₄²⁰ 0.9719, has a faint odor somewhat more pleasant than that of Ph(CH₂)₄OH.Di-ethyl ¦Ä-phenylpropylmethylmalonate, in 80% yield from Ph(CH₂)₂CH(CO₂Et)₂, b₁₈, 194¡ã; with 2 mols. of hot aqueous alc.KOH, even after 2.5. hrs., it gives chiefly the monoethyl ester, oil which loses CO₂ on distillation, with formation of ethyl ¦Á-methyl-¦Ä-phenyl. valerate, b₁₇ 158¡ã, hydrolyzed by alks. to the acid, b₁₉, 190¡ã, and reduced by Na and alc. to ¦Â-methyl-l¦Ä-phenylamyl alcohol, b₂₀ 159-60¡ã, d₄²⁰ 0.9642, has an odor much fainter but similar to that of Ph(CH₂)₄OH. Its chloride, obtained by heating the alc. with 2 parts fuming HCl at 120¡ã b₁₂ 140-2¡ã, has not as pleasant an odor as that of Ph(CH₂)₂₁Cl, gives quant. with NaI the iodide, b₂₀ 160-6¡ã, which with AgNO₂ gives approx. equal amounts of nitrite, b₁₆, about 130¡ã, and of nitro compound, yellow, b. 172-8¡ã; when the latter is reduced with SnCl₂ and the resulting oxime is b. 0.5 hr. with 15 % H₂SO₄ there is obtained ¦Á-methyl-¦Ä-phenylvaleraldehyde, b₂₁ 148-52¡ã (50% yield); its odor is much fainter and not so characteristically lemon-like as that of Ph(CH₂)₄CHO. Diethyl ¦Ã-phenylisobutylmalonate, in 80% yield from CH₂(CO₂Et)₂ and PhCH₂CHMeCH₂Br, b₁₁ 189¡ã, gives 80% of diethyl phenylisobutylmethylmalonate, b₁₂ 192-4¡ã. Free acid, oil, gives phenylisobutylmethylacetic acid, b. 282-4¡ã; ethyl ester, b₂₅ 154¡ã. ¦Â,¦Ã-Dimethyl- ¦Ò-phenylamyl alcohol (55-60% yield), b₁₇ 156-8¡ã, d₄²⁰ 0.9549, has a fainter odor even than the ¦Â-monomethyl compound Chloride, b₂₀ 146-8¡ã, has an even less pleasant odor than the mono-Me compound Iodide, b₂₀ 163-6¡ã. Nitro compound, b₂₀ 176-81¡ã. ¦Á,¦Ã-Di- methyl-¦Ä-valeraldehyde, b₂₀ 151-6¡ã.

Berichte der Deutschen Chemischen Gesellschaft published new progress about 1949-41-3. 1949-41-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene, name is 2-Methyl-4-phenylbutanoic acid, and the molecular formula is C11H14O2, COA of Formula: C11H14O2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

He, Jian published the artcileLigand-Promoted Borylation of C(sp³)-H Bonds with Palladium(II) Catalysts, Category: catalysis-chemistry, the publication is Angewandte Chemie, International Edition (2016), 55(2), 785-789, database is CAplus and MEDLINE.

A quinoline-based ligand effectively promotes the Pd-catalyzed borylation of C(sp³)-H bonds. Primary ¦Â-C(sp³)-H bonds in carboxylic acid derivatives as well as secondary C(sp³)-H bonds in a variety of carbocyclic rings, including cyclopropanes, cyclobutanes, cyclopentanes, cyclohexanes, and cycloheptanes, can thus be borylated. This directed borylation method complements existing Ir(I)- and Rh(I)-catalyzed C-H borylation reactions in terms of scope and operational conditions. The borylated products were converted into various organic synthons through C-C and C-heteroatom bond formation.

Angewandte Chemie, International Edition published new progress about 1949-41-3. 1949-41-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene, name is 2-Methyl-4-phenylbutanoic acid, and the molecular formula is C11H14O2, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
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Jensen, Arne published the artcileCarbamates. VIII. The carbamates of benzylamine, piperidine, and alanine, Application In Synthesis of 1949-41-3, the publication is Acta Chemica Scandinavica (1952), 1073-85, database is CAplus.

cf. C.A. 47, 5230e. The investigation deals with the equilibrium conditions and reaction mechanism of the formation and decomposition in aqueous medium of the carbamates formed by PhCH₂NH₂, piperidine, and PhNH₂. The exptl. conditions were the same as previously used (cf. C.A. 47, 5230c). All the experiments were done at 15¡ã and the velocity constants were calculated with Briggs logarithms, the unit of time being the min. The activity coefficient f for a univalent ion was calculated from the expression of Bjerrum: log f = 0.5³¡Ìc ion. The velocity constants of the reaction amine + CO₂ = carbamic acid and the equilibrium constant for the reaction carbamate + H₂O = HCO₃^– + amine were determined The velocity of the decomposition of the carbamate ion in basic medium was investigated and is explained for piperidine and PhCH₂NH₂ by assuming that the decomposition is a 2-stage reaction, i.e. carbamate = amine + CO₂; CO₂ = carbonate. In the case of PhNH₂ there was a relatively great difference between the exptl. and calculated velocity constants, not excluding that the decomposition also here was the same 2-stage reaction, because the experiments on which the calculations were based in this case may be subject to particularly great errors.

Acta Chemica Scandinavica published new progress about 1949-41-3. 1949-41-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene, name is 2-Methyl-4-phenylbutanoic acid, and the molecular formula is C11H14O2, Application In Synthesis of 1949-41-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Buu-Hoi, N. P. published the artcileChemistry of carbazoles. IV. Synthesis and rearrangement of benzo- and dibenzocarbazolenines, Synthetic Route of 1949-41-3, the publication is Bulletin de la Societe Chimique de France (1970), 628-31, database is CAplus and MEDLINE.

2-Methyl-1-tetralone ¦Á-naphthylhydrazone was cyclized by heating with HCl-saturated AcOH to give 6a-methyl-5,6-dihydrodibenzo[a,i]carbazole (I). Similarly were prepared 13a-methyl-5,6-dihydrodibenzo[a,g]carbazole (II) and 6a-methyl-5,6-dihydrobenzo[a]carbazole (III). The dehydrogenation of I-III over Pd/C gave 13H-dibenzo-[a,i]carba zole, 7H-dibenzo[a,g]carbazole and 11H-benzo[a]-carbazole, resp.

Bulletin de la Societe Chimique de France published new progress about 1949-41-3. 1949-41-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene, name is 2-Methyl-4-phenylbutanoic acid, and the molecular formula is C11H14O2, Synthetic Route of 1949-41-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Morin, Frederick G. published the artcileCarbon-13 magnetic resonance of hydroaromatics. II. Conformation of Tetralin and tetrahydroanthracene and their methyl derivatives, Related Products of catalysis-chemistry, the publication is Journal of the American Chemical Society (1983), 105(12), 3992-8, database is CAplus.

¹³C NMR chem. shifts are determined for 36 methylated tetralins and tetrahydroanthracenes. A least-squares regression anal. of the ring C atoms in compounds of unequivocal conformation is used to estimate Me substituent parameters for the 2 distinct aliphatic positions, and the results are used to estimate the position of equilibrium of conformationally mobile compounds 1-Methyltetralin exists in essentially equally populated conformers at room temperature; the 2-Me derivative is dominated by the conformation with an equatorial Me group. Substituent parameters are compared with those previously determined for methylated cyclohexanes. A similar anal. of the Me chem. shifts was unsuccessful due, in part, to the highly flexible nature of the saturated ring.

Journal of the American Chemical Society published new progress about 1949-41-3. 1949-41-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene, name is 2-Methyl-4-phenylbutanoic acid, and the molecular formula is C11H14O2, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Huh, Soohee published the artcileSynthetic Utility of N-Benzoyloxyamides as an Alternative Precursor of Acylnitrenoids for ¦Ã-Lactam Formation, Name: 2-Methyl-4-phenylbutanoic acid, the publication is Organic Letters (2019), 21(8), 2808-2812, database is CAplus and MEDLINE.

Described herein is the development of a new entry of acylnitrenoid precursors for ¦Ã-lactam synthesis via an intramol. C-H amidation reaction. Upon Ir catalysis, N-benzoyloxyamides serve as efficient substrates to afford 5-membered amides. Mechanistic studies revealed that the generation of a putative Ir-carbonylnitrenoid via N-O bond cleavage is facilitated by the chelation of countercations. This protocol offers a convenient and step-economic route to ¦Ã-lactams starting from the corresponding carboxylic acids.

Organic Letters published new progress about 1949-41-3. 1949-41-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene, name is 2-Methyl-4-phenylbutanoic acid, and the molecular formula is C11H14O2, Name: 2-Methyl-4-phenylbutanoic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zhuang, Zhe published the artcileRapid Construction of Tetralin, Chromane, and Indane Motifs via Cyclative C-H/C-H Coupling: Four-Step Total Synthesis of (¡À)-Russujaponol F, Name: 2-Methyl-4-phenylbutanoic acid, the publication is Journal of the American Chemical Society (2021), 143(2), 687-692, database is CAplus and MEDLINE.

The development of practical C-H/C-H coupling reactions remains a challenging yet appealing synthetic venture because it circumvents the need to prefunctionalize both coupling partners for the generation of C-C bonds. Herein we report a cyclative C(sp³)-H/C(sp²)-H coupling reaction of free aliphatic acids enabled by a cyclopentane-based mono-N-protected ¦Â-amino acid ligand. This reaction uses inexpensive sodium percarbonate (Na₂CO₃¡¤1.5H₂O₂) as the sole oxidant and generates water as the only byproduct. A range of biol. important scaffolds, including tetralins, chromans, and indanes, can be easily prepared by this protocol. Finally, the synthetic application of this methodol. is demonstrated by the concise total synthesis of (¡À)-russujaponol F in a four-step sequence starting from readily available phenylacetic acid and pivalic acid through sequential functionalizations of four C-H bonds.

Journal of the American Chemical Society published new progress about 1949-41-3. 1949-41-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene, name is 2-Methyl-4-phenylbutanoic acid, and the molecular formula is C7H8BFO2, Name: 2-Methyl-4-phenylbutanoic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zhu, Ru-Yi published the artcileLigand-Promoted Alkylation of C(sp³)-H and C(sp²)-H Bonds, HPLC of Formula: 1949-41-3, the publication is Journal of the American Chemical Society (2014), 136(38), 13194-13197, database is CAplus and MEDLINE.

9-Methylacridine was identified as a generally effective ligand to promote a Pd(II)-catalyzed C(sp³)-H and C(sp²)-H alkylation of simple amides with various alkyl iodides. This alkylation reaction was applied to the preparation of unnatural amino acids and geometrically controlled tri- and tetrasubstituted acrylic acids.

Journal of the American Chemical Society published new progress about 1949-41-3. 1949-41-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene, name is 2-Methyl-4-phenylbutanoic acid, and the molecular formula is C17H14N2O2, HPLC of Formula: 1949-41-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Levene, P. A. published the artcileMaximum rotations of carboxylic acids containing a phenethyl group, COA of Formula: C11H14O2, the publication is Journal of Biological Chemistry (1935), 725-33, database is CAplus.

Ph(CH₂)₂CHMeEt (I) can be prepared from active AmOH without racemization and, on the basis of the maximum rotation of I, the maximum rotations of other members of the phenethyl series can be calculated Using this data as a basis, substances of the type Me(PhCH₂CH₂)CH(CH₂)_nCO₂H, where n = 0 or an integer, were prepared Periodic fluctuations of the rotatory values as n increased were noted, thus parallelling the observations with the analogous Ph series and with carboxylic acids of the normal series. Ph(CH₂)₂CHMeCO₂H, [M]_D²⁰ -51.20¡ã, was prepared by the CH₂(CO₂Et)₂ (II) method and resolved by the cinchonidine salt from Me₂CO. Ph(CH₂)₂CHMe(CH₂)₂OH and anhydrous HI followed by reduction with Raney’s catalyst in alk. MeOH gave I, b₃ 66-7¡ã, b₁₃ 96¡ã, d₄²⁵ 0.8563, n_D²⁵ 1.4860, [M]_D²⁵ -17.72¡ã. I was also prepared from BzH and active AmMgBr via the intermediate PhCH(OH)CH₂CHMeEt, b₁ 90¡ã, d₄²⁵ 0.9628, n_D²⁵ 1.5097, [M]_D²⁵ -5.09¡ã, which with anhydrous HI overnight at -70¡ã and 48 hrs. at room temperature gave I, [M]_D²⁵ -35.1¡ã. The values for [M] of the following compounds are based on the parent AcOH, and values based on the parent hydrocarbon are found by using the factor 1.981 obtained from the above. Ph(CH₂)₂CHMe(CH₂)₂MgBr and CO₂ gave Ph(CH₂)₂CHMe(CH₂)₂CO₂H (III), b₁ 152-4¡ã. III was also prepared from Ph(CH₂)₂CHMeCH₂CH₂Br and II via the intermediate Ph(CH₂)₂CHMeCH₂CH(CO₂H)₂, m. 96-8¡ã, which on heating at 180¡ã gave III, b₁ 162¡ã, d₄^21.5 1.018, n_D²⁵ 1.5066, [M]_D^21.5 -3.29¡ã, Et ester (IV), b₂ 122¡ã, d₄²⁵ 0.965, n_D²⁵ 1.4872, [M]_D²⁵ -17.20¡ã. IV with Na and EtOH gave Ph(CH₂)₂CHMe(CH₂)₃OH, b₁₀ 155¡ã, d₄²⁵ 0.9477, n_D²⁵ 1.5080, [M]_D²⁵ -10.13¡ã. Similarly Ph(CH₂)₂CHMe(CH₂)₃CO₂H (V), b_2.5 172¡ã, d₄²⁵ 1.0014, n_D²⁵ 1.5039, [M]_D²⁵ -7.20¡ã, was prepared III reduced with PtO₂ in AcOH gave C₆H₁₁(CH₂)₂CHMe(CH₂)₂CO₂H, b₁₀ 180¡ã, d₄²³ 0.9528, n_D²⁵ 1.4657, [M]_D²³ -2.51¡ã and V gave C₆H₁₁(CH₂)₂CHMe(CH₂)₃CO₂H, b_0.3 136-40¡ã, d₄²⁵ 0.9455, n_D²⁵ 1.4685, [M]_D²⁵ -3.18¡ã. All values for [M] are maximum and for the homogeneous substance.

Journal of Biological Chemistry published new progress about 1949-41-3. 1949-41-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene, name is 2-Methyl-4-phenylbutanoic acid, and the molecular formula is C11H14O2, COA of Formula: C11H14O2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Amici, Giuseppe published the artcileEffect of hypocholesterolemic substances on lipid content in organs of rats on a high fat diet, Recommanded Product: 2-Methyl-4-phenylbutanoic acid, the publication is Minerva Medica (1966), 57(96), 4056-64, database is CAplus and MEDLINE.

Groups of 10 rats were fed the following diets: (1) standard pellets and H2O; (2) diet 1 with phenylethylacetic acid or ¦Á-phenylbutyric acid (I) (700 mg./kg./24 hrs.); (3) excess lipid-containing diet; (4) diet 3 with I; (5) diet 3 with ¦Â-benzal butyramide (II) (260 mg./kg./24 hrs.); (6) diet 3 with ¦Á-methyl-¦Ã-phenylbutyric acid (III) (260 mg./kg./24 hrs.). Five rats in each group were examined after 20 days and 5 after 40 days on the diets. Body weight, total blood cholesterol (TBC); wet and dry weight of liver, lungs, testes, adrenals, and aorta, and their content of total fatty acids (TFA), total cholesterol (TC), esterified cholesterol (EC), free cholesterol (FC), and phospholipids (PL) was determined Cholesterol-lowering compounds decreased TC and EC in all examined organs under the conditions of diet 2. An initial increase in TFA was followed by a decrease below control levels. PL increased in the liver, lungs, and testes and decreased in the adrenals and aorta. Diets 4, 5, and 6 inhibited the increase in TFA, TC, EC, and PL levels in the liver, lungs, and the aorta. TBC, body weight, and wet and dry weight increases induced by diet 3 were also inhibited by diets, 4, 5, and 6. The effects were particularly marked with diet 5, where TFA, TC, and EC levels lower than control values under diet 1 were observed. Response to diet 3 was different in the testes and adrenals than in other organs: dry and wet weight did not increase, TC and EC decreased and TFA increased less than elsewhere. PL decreased in the adrenals and increased slightly in the testes. I, II, and III inhibited the increase in TFA levels of testes and adrenals, but did not decrease the TC and EC levels, which were found instead to be relatively higher. It is suggested that I, II, and III (II being the more potent) are particularly effective in decreasing the TFA, TC, and EC content of the liver, lungs, and aorta, i.e. the organs where the deposition of exogenous lipids selectively occurs. 57 references.

Minerva Medica published new progress about 1949-41-3. 1949-41-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene, name is 2-Methyl-4-phenylbutanoic acid, and the molecular formula is C11H14O2, Recommanded Product: 2-Methyl-4-phenylbutanoic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia