Category: 2051-95-8

Jakhmola, Vikash published the artcileSynthesis and in-vivo activity of some antihypertensive agent based on pyridazine scaffold design, Related Products of catalysis-chemistry, the publication is International Journal of Pharmaceutical Sciences and Research (2022), 13(2), 786-792, database is CAplus.

The main objective presents research work to synthesize, characterization, and in-vivo evaluation of Pyridazine derivatives To study the different synthesized derivatives by using different anal. parameters like IR, Mass, and NMR anal. And also find out the antihypertensive activity. The studies on the hydralazine group drugs led to the synthesis of many Pyridazine derivatives with a wide activity spectrum on the cardiovascular system. Pyridazine derivatives, a class of compounds containing the N-N bond, exhibit a wide range of pharmacol. activities such as antidepressant, antihypertensive and cardiotonic, etc. Some 7-phenyl-3, 4, 8, 9-tetrahydro-2H-pyridazino [1, 6-a] [1, 3, 5] triazin-2-imine were synthesized by reacting 6-Ph substituted 2, 3, 4, 5-Tetrahydro pyridazin-3-one with cyclic secondary amine under Mannich reaction conditions. The total seven compounds (vj1-vj7) were synthesized under Mannich reaction conditions. All the synthesized derivatives were selected for evaluation of antihypertensive activities by a noninvasive method using Tail Cuff method. Most of the compounds showed good antihypertensive activity. Few compounds like vj4, vj5, and vj6 were found to show a highly significant reduction in mean arterial blood pressure but at a higher dose in comparison to standard drugs like proponolol and hydralazine. The substituted pyridazine derivatives discovered in this study may provide valuable therapeutic intervention for the treatment of hypertension.

International Journal of Pharmaceutical Sciences and Research published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C10H10O3, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Atmaca, Ufuk published the artcileA novel approach for the synthesis of ¦Â-keto esters: one-pot reaction of carboxylic acids with chlorosulfonyl isocyanate, Recommanded Product: 3-Benzoylpropionicacid, the publication is ARKIVOC (Gainesville, FL, United States) (2020), 220-227, database is CAplus.

The ¦Â-Keto esters ArC(O)CH(COOCH₃)CH₂(CH₂)_nC(O)OCH₃ (Ar = Ph, 3,4-dimethylphenyl, 4-iodophenyl, etc.; n = 1,2) were synthesized by direct carboxylation of various 4- and 5-oxo-carboxylic acid derivatives ArC(O)CH₂(CH₂)_nC(O)OH. Addnl., optimization conditions were examined for synthesis ¦Â-keto esters. Finally, it has been found that trifluoroacetic acid is efficient in DCM under optimized conditions. This efficient one-pot novel method is very useful, fair price and easy to handle of ¦Â-keto esters.

ARKIVOC (Gainesville, FL, United States) published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C10H10O3, Recommanded Product: 3-Benzoylpropionicacid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Abu-Hashem, Ameen Ali published the artcileSynthesis and antimicrobial activity of new 1,2,4-triazole, 1,3,4-oxadiazole, 1,3,4-thiadiazole, thiopyran, thiazolidinone, and azepine derivatives, SDS of cas: 2051-95-8, the publication is Journal of Heterocyclic Chemistry (2021), 58(1), 74-92, database is CAplus.

The newly prepared heterocyclic compounds such as N-hydrazine-carbothioamides C₆H₅C(O)(CH₂)₂C(O)NHNHC(S)NHR (R = Ph, Bn, Et); 1,2,4-triazoles I; 1,3,4-oxadiazoles; 1,3,4-thiadiazoles II (X = O, S); 4-oxothiazolidines III [R¹ = H, Me; R² = 4-oxo-4-phenylbutanamidyl, (1-chloro-4-oxo-4-phenylbutylidene)azanyl, (1-hydrazinyl-4-oxo-4-phenylbutylidene)azanyl, 4-benzoyl-5-oxothian-2-iminyl]; pyridazine-hydrazono-thiazolidinones IV; oxothiazolidine-azepine-diones V were studied for their activities as antimicrobial. The above synthesized compounds were tested for their antimicrobial activity, and these compounds [pyridazin-hydrazono-thiazolidinones IV, oxothiazolidin-azepinediones V, N-thiazolidine-hydrazon-hydrazides III (R¹ = Me; R² = (1-hydrazinyl-4-oxo-4-phenylbutylidene)azanyl) and thiopyran-hydrazono-thiazolidinones III (R¹ = Me; R² = 4-benzoyl-5-oxothian-2-iminyl)] were considered as the most effective as antimicrobial activity.

Journal of Heterocyclic Chemistry published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C10H10O3, SDS of cas: 2051-95-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Abu-Hashem, Ameen Ali published the artcileSynthesis of new pyrazoles, oxadiazoles, triazoles, pyrrolotriazines, and pyrrolotriazepines as potential cytotoxic agents, Formula: C10H10O3, the publication is Journal of Heterocyclic Chemistry (2021), 58(3), 805-821, database is CAplus.

The 4-oxo-4-phenylbutanehydrazide reacted with many active methylene reagents such as acetylacetone, diethylmalonate, ethylacetoacetate, ethylcyanoacetate, benzoyl-acetonitrile, and malononitrile under neat conditions to afford the corresponding pyrazoles e.g., I, also, treatment of 4-oxo-4-phenylbutanehydrazide with electrophilic reagents as triethylorthoformate, dimethylformamide-dimethylacetal, acetic anhydride, and carbon disulfide to give 1,3,4-oxadiazoles e.g., II and N’-acetyl-4-oxo-4-phenylbutanehydrazide. Reaction of 4-oxo-4-phenylbutanehydrazide with potassium thiocyanate gave 1-phenyl-3-(5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)propan-1-one. Similarly, treatment of 4-oxo-4-phenylbutanehydrazide with chloroacetamide gave 3-(3-oxo-3-phenylpropyl)-1,6-dihydro-1,2,4-triazin-5(2H)-one. The 6-phenyl-3,4-dihydropyrrolo[1,2-b][1,2,4]triazin-2(8H)-one was obtained by cyclization of 3-(3-oxo-3-phenylpropyl)-1,6-dihydro-1,2,4-triazin-5(2H)-one. Also, 4-oxo-4-phenylbutanehydrazide was utilized as a starting material for the synthesis of new Schiff bases as N’-(4-sub-benzylidene)-phenylbutane-hydrazides C₆H₅C(O)(CH₂)₂C(O)NHN=CHAr (Ar = Ph, 4-chlorophenyl, 4-methoxyphenyl), which are used as an initiative to prepare new compounds such as 1,2,4-triazepinones III, pyrrolotriazepinones IV, 1,2,4-triazines V, and pyrrolotriazines VI by reaction of N’-(4-sub-benzylidene)-phenylbutane-hydrazides with each chloroacetamide or formamide. The prepared compounds were tested for their in vitro antitumor activities. The compounds III, IVand VI displayed activity against several types of cancer cell lines.

Journal of Heterocyclic Chemistry published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C10H10O3, Formula: C10H10O3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Yu, Haiyang published the artcileRhodium(I)-Catalyzed C2-Selective Decarbonylative C-H Alkylation of Indoles with Alkyl Carboxylic Acids and Anhydrides, Safety of 3-Benzoylpropionicacid, the publication is Asian Journal of Organic Chemistry (2021), 10(4), 879-885, database is CAplus.

A Rh(I)-catalyzed chelation-assisted C2-selective C-H decarbonylative alkylation of indoles with readily available, cheap, safe and structurally diverse alkyl carboxylic acids or anhydrides has been developed. A wide variety of primary and secondary alkyl carboxylic acids and differently substituted indoles are compatible with this transformation, allowing facile synthesis of various C2-alkylated indoles with high efficiency and broad tolerance of diverse functional groups. The reaction proceeds in the absence of any external oxidant, and the presence of readily installable and removable N-pyrimidyl directing group is critical for catalysis. The process is convenient and scalable, and avoids the use of a dried solvent and an inert atm. Moreover, selective C7-alkylation and C2, C7-dialkylation have also been achieved by slightly modifying the reaction conditions.

Asian Journal of Organic Chemistry published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C7H13NO2, Safety of 3-Benzoylpropionicacid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Sun, Peng-Wei published the artcileCobalt-Catalyzed Intermolecular Hydroamination of Unactivated Alkenes Using NFSI as Nitrogen Source, Computed Properties of 2051-95-8, the publication is Chinese Journal of Chemistry (2022), 40(9), 1066-1072, database is CAplus.

Comprehensive Summary : Cheap metal (Fe, Mn, and Co)-catalyzed hydroamination of alkenes has been an attractive method for synthesis of amines because of biocompatibility of metal, excellent Markovnikov selectivity and chemoselectivity. However, most reports are limited to unsaturated nitrogen sources (nitric oxide, azos, azides, cyano, etc.), for which aminated products are very limited. Notably, while used widely for fluorinating reaction, N-fluorobenzenesulfonimide (NFSI) as amine source for hydroamination has seldom been reported. Here authors developed a cobalt-catalyzed intermol. hydroamination of unactivated alkenes using NFSI as nitrogen source under mild conditions. The reaction exhibits excellent chemo- and regio-selectivity with no hydrofluorination or linear-selectivity products. Notably, the reaction proceeded with excellent yield even though the amount of Co(salen) catalyst was reduced to 0.2 mol%. Recently, a similar work was also reported by Zhang and coworkers (reference 19).

Chinese Journal of Chemistry published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C9H6N2O2, Computed Properties of 2051-95-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Dong, Xiao-Yang published the artcileA general asymmetric copper-catalysed Sonogashira C(sp³)-C(sp) coupling, Recommanded Product: 3-Benzoylpropionicacid, the publication is Nature Chemistry (2019), 11(12), 1158-1166, database is CAplus and MEDLINE.

Continued development of the Sonogashira coupling has made it a well established and versatile reaction for the straightforward formation of C-C bonds, forging the carbon skeletons of broadly useful functionalized mols. However, asym. Sonogashira coupling, particularly for C(sp³)-C(sp) bond formation, has remained largely unexplored. Here the authors demonstrate a general stereoconvergent Sonogashira C(sp³)-C(sp) cross-coupling of a broad range of terminal alkynes and racemic alkyl halides (>120 examples) that are enabled by copper-catalyzed radical-involved alkynylation using a chiral cinchona alkaloid-based P,N-ligand. Industrially relevant acetylene and propyne are successfully incorporated, laying the foundation for scalable and economic synthetic applications. The potential utility of this method is demonstrated in the facile synthesis of stereoenriched bioactive or functional mol. derivatives, medicinal compounds and natural products that feature a range of chiral C(sp³)-C(sp/sp²/sp³) bonds. This work emphasizes the importance of radical species for developing enantioconvergent transformations.

Nature Chemistry published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C10H10O3, Recommanded Product: 3-Benzoylpropionicacid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zhang, Keyang published the artcilePalladium/Zinc Co-Catalyzed Asymmetric Hydrogenation of ¦Ã-Keto Carboxylic Acids, Related Products of catalysis-chemistry, the publication is Chemistry – An Asian Journal (2021), 16(10), 1229-1232, database is CAplus and MEDLINE.

A palladium-catalyzed asym. hydrogenation of levulinic acid has been successful developed by using Zn(OTf)₂ as co-catalyst. The present method not only has provided a strategy in the palladium-catalyzed asym. hydrogenation of ketones RC(O)(CH₂)₂C(O)OH (R = C₆H₅, cyclohexyl, 2-naphthyl, etc.), but also allowed the preparation of a wide range of chiral ¦Ã-valerolactones (R/S)-I in good yields with excellent enantioselectivities.

Chemistry – An Asian Journal published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C10H2F12NiO4, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zheng, Suhua published the artcileMagnesium-Promoted Reductive Carboxylation of Aryl Vinyl Ketones: Synthesis of ¦Ã-Keto Carboxylic Acids, COA of Formula: C10H10O3, the publication is Journal of Organic Chemistry (2022), 87(11), 7342-7349, database is CAplus and MEDLINE.

Direct reductive carboxylation of aryl vinyl ketones under the atm. of carbon dioxide led to the selective formation of ¦Ã-keto carboxylic acids ArC(O)CH₂CHR¹C(O)OH [Ar = Ph, 2-MeC₆H₄,4-FC₆H₄, etc.; R¹ = Me, Et, ph] in 38-86% yields. The reaction was characterized by the carbon-carbon bond formation of carbon dioxide at the ¦Â-position of enone, with the use of magnesium turnings that can be easily handled as the reducing agent and the eco-friendly reaction conditions such as no pressuring, no lower or higher reaction temperature, and short reaction time. This protocol showed a wide substrate scope and provided a useful and convenient alternative to access biol. important ¦Ã-keto carboxylic acids which then converted to esters of ¦Ã-keto carboxylic acids under the typical esterification conditions.

Journal of Organic Chemistry published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C9H4F6O, COA of Formula: C10H10O3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zhan, Xiao-Yu published the artcileChemoselective Hydrosilylation of the ¦Á,¦Â-Site Double Bond in ¦Á,¦Â- and ¦Á,¦Â,¦Ã,¦Ä-Unsaturated Ketones Catalyzed by Macrosteric Borane Promoted by Hexafluoro-2-propanol, Quality Control of 2051-95-8, the publication is Journal of Organic Chemistry (2020), 85(10), 6578-6592, database is CAplus and MEDLINE.

The B(C₆F₅)₃-catalyzed chemoselective hydrosilylation of ¦Á,¦Â- and ¦Á,¦Â,¦Ã,¦Ä-unsaturated ketones into the corresponding asym. ketones in mild reaction conditions is developed. Nearly 50 substrates including those bearing reducible functional groups such as alkynyl, alkenyl, cyano, and aromatic heterocycles are chemoselectively hydrosilylation in good to excellent yields. Isotope-labeling studies revealed that HFIP also served as hydrogen source in the process.

Journal of Organic Chemistry published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C7H8BNO4, Quality Control of 2051-95-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia