Category: 2051-95-8

Cong, Yikang published the artcileNano Cu-CuFe₂O₄-catalyzed selective reduction of ¦Á,¦Â,¦Ã,¦Ä-unsaturated carbonyls in alcohol medium, Recommanded Product: 3-Benzoylpropionicacid, the publication is Youji Huaxue (2020), 40(8), 2411-2418, database is CAplus.

An efficient Cu-CuFe₂O₄ nanoparticle-catalyzed protodeboronation strategy has been developed for the chemoselective 1,4-reduction of ¦Á,¦Â,¦Ã,¦Ä-unsaturated ketones, carboxylic ester and cyano-ester e.g., I. This protocol has the advantageous of the use of alc. as hydrogen source and solvent, low catalyst loading (0.5 mol%), and excellent catalyst recyclability. Addnl., the Cu-CuFe₂O₄ catalyst has shown excellent performance in gram-scale reactions. Furthermore, the catalytic mechanism has also been discussed. The reactivity of (E)-¦Ã,¦Ä-unsaturated carbonyl products , an important class of ¦Ã,¦Ä-unsaturated alkenes e.g., II, enables easy access to (E)-1,5-diphenylpent-4-en-1-ol, 3-buten-1-amines III, 4-oxo-4-phenylbutanoic acid, cyclic ethers such as 2-benzyl-5-phenyloxolane, 2,6-diphenyloxane, and cyclic nitrones IV.

Youji Huaxue published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C10H10O3, Recommanded Product: 3-Benzoylpropionicacid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wu, Hongguo published the artcileHot water-promoted catalyst-free reductive cycloamination of (bio-)keto acids with HCOONH₄ toward cyclic amides, Formula: C10H10O3, the publication is Journal of Supercritical Fluids (2020), 104698, database is CAplus.

HCOONH₄ was demonstrated to be capable of acting as both hydrogen and nitrogen source in the absence of any catalyst and additive for the reductive cycloamination of bio-based levulinic acid (LA) to 5-methyl-2-pyrrolidone (MPL) with more than 90% in just 60 min at 180¡ã. Pressurized hot water remarkably enabled the reaction efficiency and rate by promoting the hydrolysis of HCOONH₄ to liberated ammonia and formic acid for the cascade reactions and this catalyst-free protocol was also applicable to the efficient synthesis of various cyclic amides from relevant keto acids. Moreover, the reaction pathways were investigated by conducting deuterium-labeling experiments and kinetic studies of selected reactions.

Journal of Supercritical Fluids published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C16H19BO3, Formula: C10H10O3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zhao, Haoqiang published the artcileRh(I)-Catalyzed C6-Selective Decarbonylative Alkylation of 2-Pyridones with Alkyl Carboxylic Acids and Anhydrides, Application of 3-Benzoylpropionicacid, the publication is Organic Letters (2020), 22(11), 4228-4234, database is CAplus and MEDLINE.

A Rh-catalyzed chelation-assisted C6-selective C-H activation/alkylation of 2-pyridones e.g., 1-(pyridin-2-yl)-1,2-dihydropyridin-2-one with readily available anhydrides RC(O)OC(O)R (R = Me, Et, 2-methylpropyl, etc.) or alkyl carboxylic acids R¹C(O)OH (R¹ = nonyl, cyanoethyl, cyclohexyl, etc.) is introduced. The reaction proceeds via substrate decarbonylation. This approach merges C-H functionalization with readily available anhydrides, allowing for the efficient synthesis of various C6-alkylated 2-pyridones e.g., 6-methyl-2H-[1,2′-bipyridin]-2-one with good functional group tolerance.

Organic Letters published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C14H26O2, Application of 3-Benzoylpropionicacid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Jiang, Liang published the artcileA nitrogen-doped carbon modified nickel catalyst for the hydrogenation of levulinic acid under mild conditions, Related Products of catalysis-chemistry, the publication is Green Chemistry (2021), 23(18), 7065-7073, database is CAplus.

The conversion of levulinic acid (LA) to ¦Ã-valerolactone (GVL) is 1 of the most important reactions from biomass-derived platform chems. to value-added chems. N-doped C was introduced into a Ni/Al₂O₃ catalyst and was employed for the hydrogenation of LA to GVL with a full conversion and equivalent yield under mild conditions, at as low as ambient H pressure and 130¡ã for 6 h. The doping of N introduced NiNx species and the imperfection of modified N-doped C were beneficial for the selective hydrogenation of carbonyl groups. This catalyst showed excellent activity and selectivity in various solvents and could be recycled for at least 6 runs with little deactivation. In addition to LA, various substrates with both carbonyl and carboxyl groups could also be selectively hydrogenated to the corresponding lactones. This study offers both theor. foundation and practical instructions for the high-efficiency conversion of LA to GVL over nonnoble metal catalysts under mild conditions, especially ambient H₂ pressure.

Green Chemistry published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C10H10O3, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Xiao, Guiying published the artcileNickel-Catalyzed Asymmetric Hydrogenation of ¦Ã-Keto Acids, Esters, and Amides to Chiral ¦Ã-Lactones and ¦Ã-Hydroxy Acid Derivatives, Recommanded Product: 3-Benzoylpropionicacid, the publication is Organic Letters (2022), 24(14), 2722-2727, database is CAplus and MEDLINE.

A highly efficient asym. hydrogenation of a series of ¦Ã-keto acid derivatives, including ¦Ã-keto acids RC(O)CH₂CH₂C(O)OH (R = Me, Ph, cyclopentyl, 3,4-dimethylphenyl, etc.), esters RC(O)CH₂CH₂C(O)OR¹ (R¹ = Me, Et, t-Bu), and amides RC(O)CH₂CH₂C(O)NR²R³ (R² = H, Bn, iPr; R³ = H, iPr), using a Ni-(R,R)-QuinoxP* complex as the catalyst has been developed to afford chiral ¦Ã-hydroxy acid derivatives RCH(OH)CH₂CH₂C(O)OR¹ and RCH(OH)CH₂CH₂C(O)NR²R³ with excellent enantioselectivities, up to 99.9% ee. This method provides not only an economical one-pot approach for the synthesis of chiral ¦Ã-lactones I but also access to (S)-norfluoxetine, an inhibitor of neural serotonin reuptake and an essential intermediate for pharmaceutical synthesis.

Organic Letters published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C6H3BrFNO, Recommanded Product: 3-Benzoylpropionicacid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Sherwood, Trevor C. published the artcileDecarboxylative Intramolecular Arene Alkylation Using N-(Acyloxy)phthalimides, an Organic Photocatalyst, and Visible Light, COA of Formula: C10H10O3, the publication is Journal of Organic Chemistry (2019), 84(13), 8360-8379, database is CAplus and MEDLINE.

An intramol. arene alkylation reaction was developed using the organic photocatalyst 4CzIPN, visible light, and N-(acyloxy)phthalimides as radical precursors. Reaction conditions were optimized via high-throughput experimentation, and electron-rich and electron-deficient arenes and heteroarenes are viable reaction substrates. This reaction enables access to a diverse set of fused, partially saturated cores which are of high interest in synthetic and medicinal chem.

Journal of Organic Chemistry published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C12H17NS2, COA of Formula: C10H10O3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Chandrachud, Preeti P. published the artcileDecarboxylative Amination: Diazirines as Single and Double Electrophilic Nitrogen Transfer Reagents, SDS of cas: 2051-95-8, the publication is Journal of the American Chemical Society (2020), 142(52), 21743-21750, database is CAplus and MEDLINE.

The ubiquity of nitrogen-containing small mols. in medicine necessitates the continued search for improved methods for C-N bond formation. Electrophilic amination often requires a disparate toolkit of reagents whose selection depends on the specific structure and functionality of the substrate to be aminated. Further, many of these reagents are challenging to handle, engage in undesired side reactions, and function only within a narrow scope. Here, we report the use of diazirines as practical reagents for the decarboxylative amination of simple and complex redox-active esters. The diaziridines thus produced are readily diversifiable to amines, hydrazines, and nitrogen-containing heterocycles in one step. The reaction has also been applied in fluorous phase synthesis with a perfluorinated diazirine.

Journal of the American Chemical Society published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C10H10O3, SDS of cas: 2051-95-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Lam, Ying-Pong published the artcileAmide/Iminium Zwitterionic Catalysts for (Trans)esterification: Application in Biodiesel Synthesis, Product Details of C10H10O3, the publication is ACS Catalysis (2019), 9(9), 8083-8092, database is CAplus.

A class of zwitterionic organocatalysts based on an amide anion/iminium cation charge pair has been developed. The zwitterions are easily prepared by reacting aziridines with aminopyridines. They are catalytically applicable to transesterifications and dehydrative esterifications. Mechanistic studies reveal that the amide anion and iminium cation work synergistically in activating the reaction partners, with the iminium cationic moiety interacting with the carbonyl substrates through nonclassical hydrogen bonding. The reaction can be applied to large-scale synthesis of biodiesel under mild conditions.

ACS Catalysis published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C10H10O3, Product Details of C10H10O3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Tierno, Anthony F. published the artcileHeterocyclic group transfer reactions with I(III) N-HVI reagents: access to N-alkyl(heteroaryl)onium salts via olefin aminolactonization, COA of Formula: C10H10O3, the publication is Chemical Science (2021), 12(18), 6385-6392, database is CAplus and MEDLINE.

Herein, leverage (bis)cationic nitrogen-ligated I(III) hypervalent iodine reagents, or N-HVIs, as “heterocyclic group transfer reagents” to provide access to a broad scope of N-alkyl(heteroaryl)onium salts e.g., I via the aminolactonization of alkenoic acids e.g., 2,2-diphenylpent-4-enoic acid, the first example of engaging an olefin to directly generate these salts. The reactions proceed in excellent yields, under mild conditions, and are capable of incorporating a broad scope of sterically and electronically diverse aromatic heterocycles such as pyridine, 4-piperidinylpyridine, 1-methylimidazole, etc.. The N-HVI reagents can be generated in situ, the products are isolated via simple trituration, and subsequent derivatizations demonstrate the power of this platform for diversity-oriented synthesis of 6-membered nitrogen heterocycles e.g., I.

Chemical Science published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C38H24F4O4P2, COA of Formula: C10H10O3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Stavytskyi, Viktor published the artcileTandem heterocyclization of 2-(azolyl-(azinyl-))anilines as an efficient method for preparation of substituted pyrrolo[1,2-a]azolo-(azino-)[c]quinazolines, Formula: C10H10O3, the publication is Journal of Heterocyclic Chemistry (2020), 57(3), 1249-1260, database is CAplus.

The synthesis of novel pyrrolo[1,2-a]azolo(azino)[c]quinazolines I (R¹ = Me, Ph, HO₂C, HO₂CCH₂CH₂; R² = Me, Ph, 4-i-PrC₆H₄, 2-thienyl) and II (R¹ as above; X = N, CHMe, CHPh, etc.) by tandem reaction of the corresponding o-aminophenyl-substituted azines and azoles with oxocarboxylic acids R¹C(O)CH₂CH₂CO₂H is described. The mechanism of formation of the compounds I and II was proposed, and the intermediate of the heterocyclization has been isolated and characterized. The IR-, ¹H and ¹³C NMR-, chromato-mass spectra of synthesized compounds were studied for estimation of their structure and spectral patterns features. The mol. structure of the obtained compounds was addnl. proved by X-ray diffraction method.

Journal of Heterocyclic Chemistry published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C7H7ClN2S, Formula: C10H10O3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia