Category: 2051-95-8

Nguyen, Dat P. published the artcileScope and limitations of reductive amination catalyzed by half-sandwich iridium complexes under mild reaction conditions, Formula: C10H10O3, the publication is Tetrahedron Letters (2020), 61(32), 152196, database is CAplus and MEDLINE.

The conversion of aldehydes and ketones RC(O)R¹ (R = Ph, thiophen-2-yl, 4-bromophenyl, etc.; R¹ = H, Me, CF₃, Ph), 9H-fluoren-9-one to 1¡ã amines RCH(NH₂)R¹ could be promoted by half-sandwich iridium complexes using ammonium formate as both the nitrogen and hydride source. To optimize this method for green chem. synthesis, various carbonyl substrates in common polar solvents at physiol. temperature (37¡ãC) and ambient pressure were tested. The excellent selectivity for the amine over alc./amide RCH(OH)R¹/RCH(R¹)NHCHO products could be achieved for a broad assortment of carbonyl-containing compounds in methanol. In aqueous media, selective reduction of carbonyls to 1¡ã amines was achieved in the absence of acids. Unfortunately, at Ir catalyst concentrations of <1 mM in water, reductive amination efficiency dropped significantly, which suggest that this catalytic methodol. might be not suitable for aqueous applications where very low catalyst concentration is required (e.g., inside living cells).

Tetrahedron Letters published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C10H10O3, Formula: C10H10O3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Vellaisamy, M. published the artcileMechanistic studies of oxidation of substituted oxo acids by IFC in the presence of 1,10-phenanthroline, Computed Properties of 2051-95-8, the publication is Journal of the Indian Chemical Society (2019), 96(6), 721-725, database is CAplus.

The catalytic activity of 1,10-phenanthroline (phen) in imidazolium fluorochromate (IFC) oxidation of 4-oxo-4-phenylbutanoic acid (4-oxo acids) has been studied in 50% acetic acid-50% water medium. The reaction is first order each in imidazolium fluorochromate, oxo acid and hydrogen ion concentration The rate of the reaction has been conducted at five different temperatures Thermodn. parameters have been calculated A good correlation is found to exist between log k₁(308 K) and Hammett constant (¦Ò). For substituted oxoacids, the electron withdrawing substituents retard the reaction rate, while the electron releasing substituents enhance the rate of the reaction. The order of reactivities with substituents is p-CH₃O > p-CH₃ > p-C₆H₅ > H > p-Cl > p-Br > m-NO₂ is due to the presence of +I and -I effect. The Exner plot k₂₍₃₁₃?_K) vs. k₂₍₃₁₈?_K) is linear and isokinetic temperature is obtained. This supports that all the reactions under this investigation follow a common mechanism. The constant ¦¤G values are obtained for all the substituted compounds It also indicates that the substituted compounds are oxidized by same mechanism. Benzoic acid has been identified as the corresponding product of oxidation Based on the kinetics results, a suitable mechanism has been proposed.

Journal of the Indian Chemical Society published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C8H15NO, Computed Properties of 2051-95-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Triandafillidi, Ierasia published the artcileSynthesis of ¦Ã-Lactones Utilizing Ketoacids and Trimethylsulfoxonium Iodide, Related Products of catalysis-chemistry, the publication is Organic Letters (2019), 21(14), 5533-5537, database is CAplus and MEDLINE.

¦Ã-Ketoacids, a ¦Ä-ketoacid, and a ¦Ã-ketoamide underwent Johnson-Corey-Chaykovsky epoxidation with trimethylsulfoxonium iodide and NaH in DMSO to yield ¦Ã-(hydroxymethyl)-¦Ã-lactones, a ¦Ä-(hydroxymethyl)-¦Ä-lactone, and a ¦Ã-(hydroxymethyl)-¦Ã-lactam in 22-76% yields. The method was used in an attempted synthesis of (+)-asperolide C; (-)-epi-asperolide C was obtained in two steps from (+)-podocarpic acid.

Organic Letters published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C23H43NP2, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Barut, Burak published the artcileAzole antifungal compounds could have dual cholinesterase inhibitory potential according to virtual screening, enzyme kinetics, and toxicity studies of an inhouse library, Related Products of catalysis-chemistry, the publication is Journal of Molecular Structure (2021), 130268, database is CAplus.

Recent advances in cholinesterase inhibitors opened new venues for the treatment of cognitive disorders like Alzheimer’s disease. Certain azole antifungals like miconazole were reported to have cholinesterase inhibitory effects and hence ameliorate cognitive deficits. In this study, we tested a set of azole antifungal derivatives selected through virtual screening of an inhouse library for their acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory effects. Compound 61 showed potent and selective AChE inhibition (IC50 = 8.77¦ÌM). The study also yielded dual AChE/BChE inhibitors in addition to a number of potent AChE inhibitors. Enzyme kinetics assays revealed that AChE inhibitors were competitive inhibitors. All the active compounds were imidazole derivatives and the modeling study showed that imidazole at protonated state contributed greatly to the binding interactions with some key residues of AChE and BChE active site. The active derivatives had negligible cytotoxic effects on murine fibroblast viability. According to our results, compounds featuring the classical scaffold of azole antifungal drugs could hold high potential for anticholinesterase drug design.

Journal of Molecular Structure published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C10H10O3, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Jorea, Alexandra published the artcilePhotocatalyzed Functionalization of Alkenoic Acids in 3D-Printed Reactors, Safety of 3-Benzoylpropionicacid, the publication is ChemSusChem, database is CAplus and MEDLINE.

The valorization of alkenoic acids possibly deriving from biomass (fumaric and citraconic acids) was carried out through conversion in important building blocks, such as ¦Ã-keto acids and succinic acid derivatives The functionalization was carried out by addition onto the C=C double bond of radicals generated under photocatalyzed conditions from suitable hydrogen donors (mainly aldehydes) and by adopting a decatungstate salt as the photocatalyst. Syntheses were performed under batch (in a glass vessel) and flow (by using 3D-printed reactors) conditions. The design of the latter reactors allowed for an improved yield and productivity.

ChemSusChem published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C10H10O3, Safety of 3-Benzoylpropionicacid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Bercher, Olivia P. published the artcileDeaminative Reductive Methylation of Alkylpyridinium Salts, Synthetic Route of 2051-95-8, the publication is Organic Letters (2021), 23(18), 7059-7063, database is CAplus and MEDLINE.

To enable efficient installation of Me groups on simple building blocks and in late-stage functionalization, a nickel-catalyzed reductive coupling of secondary Katritzky alkylpyridinium salts with Me iodide was developed. When coupled with formation of the pyridinium salt from an alkyl amine, this method allowed amino groups to be readily transformed to Me groups with broad functional group and heterocycle tolerance.

Organic Letters published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C10H10O3, Synthetic Route of 2051-95-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Siddiqui, Aness Ahmad published the artcileSynthesis, anti-convulsant activity and molecular docking study of novel thiazole pyridazinone hybrid analogues, Related Products of catalysis-chemistry, the publication is Bioorganic Chemistry (2020), 103584, database is CAplus and MEDLINE.

A series of hybrid pyridazinone-thiazoles (I)[R = Ph, p-tolyl, p-anisyl, etc.] connected through amide linkage were designed and synthesized. Among these, compound I [R = p-chlorophenyl] demonstrated significant anticonvulsant activity with median ED of 24.38 mg/kg (MES) and 88.23 mg/kg (scPTz). Results of GABA estimation showed a marked increase in the GABA level when compared with control. Mol. docking studies at the active site of GABA receptor, further confirmed the GABA modulatory effects of I [R = p-chlorophenyl].

Bioorganic Chemistry published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C31H25F2N5O7S, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Yan, Wenhao published the artcileLate-Stage Difluoromethylation of Aliphatic Carboxylic Acids with Copper Catalysis, Computed Properties of 2051-95-8, the publication is Synlett (2020), 31(8), 745-749, database is CAplus.

In this article, approaches towards difluoromethylation are discussed and the development of the first aliphatic decarboxylative difluoromethylation reaction is detailed. With a broad scope, the real-world utility of the protocol is demonstrated.

Synlett published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C4Br2N2O4S, Computed Properties of 2051-95-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Lindroth, Rickard published the artcileVisible-Light Mediated Oxidative Fragmentation of Ethers and Acetals by Means of Fe(III) Catalysis, Formula: C10H10O3, the publication is Organic Letters (2022), 24(8), 1662-1667, database is CAplus and MEDLINE.

A new method employing iron(III) acetylacetonate along with visible-light is described to effect oxidative ring-opening of cyclic ethers and acetals with unparalleled efficiency. The method allows for a photocatalytic radical chem. approach to functionalize relatively inert cyclic ethers into useful synthetic intermediates. The methodol. sheds further light on the use of under explored iron complexes in visible-light photochem. contexts and illustrates that simple Fe(III) complexes can initiate redox processes from 4LMCT excited states.

Organic Letters published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C10H10O3, Formula: C10H10O3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zaouri, Noor published the artcileInteractions between model organic compounds and metal oxides, COA of Formula: C10H10O3, the publication is Colloids and Surfaces, A: Physicochemical and Engineering Aspects (2021), 126858, database is CAplus.

Because of their mech., thermal, and chem. resistance, ceramic materials are suitable for challenging water treatments, where different metal oxides (MeO) have been tested as active layers. However, organic fouling is a major drawback impacting its performance. Organics adsorb onto the membrane surface and into their pores during long-term operation, resulting in irreversible fouling. This investigation focussed on the interfacial interactions between model organic acids and MeO to obtain a fundamental understanding of the adsorption phenomena. Batch adsorption experiments of a series of small mol. weight, oxygenated, aromatic organic acids were performed with Al₂O₃, TiO₂, and ZrO₂ particles, at pH 4.2 and 7.6. The adsorption of simple acids was described by the Langmuir model and exhibited a strong dependence on the relative abundance of carboxyl groups, aliphaticity/aromaticity, alkyl chain length, and presence of hydroxyl groups. The adsorption of model compounds was higher at low pH and decreased with increasing pH. The difference in Al₂O₃, TiO₂, and ZrO₂ surface characteristics, as evidenced by TEM, XRD, and BET, led to differences in the adsorption d. The results obtained with these well-defined organic structures will assist in better understanding the interfacial interactions between complex natural organic matter mols. and MeO of different characteristics.

Colloids and Surfaces, A: Physicochemical and Engineering Aspects published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C15H21BO3, COA of Formula: C10H10O3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia