Category: 2051-95-8

Pitchumani, Venkatachalam published the artcileStudies on Thiourea Catalysed Bromocycloetherification and Bromolactonisations*, Formula: C10H10O3, the publication is Australian Journal of Chemistry (2020), 73(12), 1292-1295, database is CAplus.

Lewis base catalyzed halofunctionalisation reactions of alkenes are well established and allow access to, among others, various oxygen containing heterocycles. By exploiting the known conversion of N-heterocyclic carbenes into the corresponding thioureas it has been possible to prepare and study a range of chiral and non-chiral Lewis base catalysts for such reactions. Although all thiourea catalysts were found to mediate bromocycloetherification and bromolactonisation reactions, they could not be achieved with enantioselectivity.

Australian Journal of Chemistry published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C10H10O3, Formula: C10H10O3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Pan, Yixiao published the artcileCobalt-Catalyzed Selective Transformation of Levulinic Acid and Amines into Pyrrolidines and Pyrrolidinones using Hydrogen, Computed Properties of 2051-95-8, the publication is Advanced Synthesis & Catalysis (2022), 364(16), 2830-2836, database is CAplus.

Cobalt-catalyzed selective transformation of levulinic acid and primary amines into pyrrolidines and pyrrolidinones under H₂ was developed. The catalyst system consisting of Co(NTf₂)₂, 1,1,1-tris(di(4-methoxyphenyl)phosphinomethyl) ethane ((p-anisyl)triphos) and Me₃SiOTf works well for the synthesis of pyrrolidines via reductive amination/cyclization/deoxygenative reduction of amide, and using Co(NTf₂)₂/1,1,1-tris(diphenylphosphinomethyl) ethane (triphos) as the catalyst under reduced hydrogen pressure results in exclusive formation of pyrrolidinones. Both aryl and alkyl primary amines are suitable substrates, and a variety of functional groups are tolerated. Meanwhile, 4-oxo-4-arylbutanoic acids, 5-oxohexanoic acid, 6-oxoheptanoic acid, 2-formylbenzoic acid, 2-acetylbenzoic acid and 2¡ä-acetyl-[1,1¡ä-biphenyl]-2-carboxylic acid are also applicable, allowing for convenient access to cyclic amines and lactams with different ring size.

Advanced Synthesis & Catalysis published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C10H10O3, Computed Properties of 2051-95-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Bergamaschi, Enrico published the artcileControlling Chemoselectivity of Catalytic Hydroboration with Light, HPLC of Formula: 2051-95-8, the publication is Angewandte Chemie, International Edition (2022), 61(8), e202114482, database is CAplus and MEDLINE.

The ability to selectively react one functional group in the presence of another underpins efficient reaction sequences. Despite many designer catalytic systems being reported for hydroboration reactions, which allow introduction of a functional handle for cross-coupling or act as mild method for reducing polar functionality, these platforms rarely deal with more complex systems where multiple potentially reactive sites exist. Here authors demonstrate, for the first time, the ability to use light to distinguish between ketones and carboxylic acids in more complex mols. By taking advantage of different activation modes, a single catalytic system can be used for hydroboration, with the chemoselectivity dictated only by the presence or absence of visible light.

Angewandte Chemie, International Edition published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C10H10O3, HPLC of Formula: 2051-95-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Badir, Shorouk O. published the artcilePhotoredox-mediated hydroalkylation and hydroarylation of functionalized olefins for DNA-encoded library synthesis, SDS of cas: 2051-95-8, the publication is Chemical Science (2021), 12(36), 12036-12045, database is CAplus and MEDLINE.

DNA-encoded library (DEL) technol. features a time- and cost-effective interrogation format for the discovery of therapeutic candidates in the pharmaceutical industry. To develop DEL platforms, the implementation of water-compatible transformations that facilitate the incorporation of multifunctional building blocks (BBs) with high C(sp³) carbon counts is integral for success. In this report, a decarboxylative-based hydroalkylation of DNA-conjugated trifluoromethyl-substituted alkenes enabled by single-electron transfer (SET) and subsequent hydrogen atom termination through electron donor-acceptor (EDA) complex activation was detailed. In a further photoredox-catalyzed hydroarylation protocol, the coupling of functionalized, electronically unbiased olefins was achieved under air and within minutes of blue light irradiation through the intermediacy of reactive (hetero)aryl radical species with full retention of the DNA tag integrity. Notably, these processes operate under mild reaction conditions, furnishing complex structural scaffolds with a high d. of pendant functional groups.

Chemical Science published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C10H10O3, SDS of cas: 2051-95-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Grinev, Vyacheslav S. published the artcileCrystal structures, packing features, Hirshfeld surface analyses and DFT calculations of hydrogen-bond energy of two homologous 8a-aryl-2,3,4,7,8,8a-hexahydropyrrolo[1,2-a]pyrimidin-6(1H)-ones, SDS of cas: 2051-95-8, the publication is Acta Crystallographica, Section C: Structural Chemistry (2020), 76(5), 483-489, database is CAplus and MEDLINE.

The crystal structures and packing features of two homologous Meyer’s bicyclic lactams with fused pyrrolidone and medium-sized perhydropyrimidine rings, namely, 8a-phenyl-2,3,4,7,8,8a-hexahydropyrrolo[1,2-a]pyrimidin-6(1H)-one, C₁₃H₁₆N₂O (1), and 8a-(4-methylphenyl)-2,3,4,7,8,8a-hexahydropyrrolo[1,2-a]pyrimidin-6(1H)-one, C₁₄H₁₈N₂O (2), were elucidated, and Hirshfeld surface plots were calculated and drawn for visualization and a deeper anal. of the intermol. noncovalent interactions. Mols. of 1 and 2 are weakly linked by intermol. C=O¡¤¡¤¡¤H-N hydrogen bonds into chains, which are in turn weakly linked by other C=O¡¤¡¤¡¤H-C_ar interactions. The steric volume of the substituent significantly affects the crystal packing pattern.

Acta Crystallographica, Section C: Structural Chemistry published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C10H10O3, SDS of cas: 2051-95-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Xu, Xiao-Long published the artcileCatalytic Redox Chain Ring Opening of Lactones with Quinones To Synthesize Quinone-Containing Carboxylic Acids, Formula: C10H10O3, the publication is Organic Letters (2019), 21(13), 5078-5081, database is CAplus and MEDLINE.

Catalytic ring opening of five- to eight-membered lactones with quinones is achieved through a redox chain mechanism. With low loading of a simple metal triflate Lewis acid catalyst and a chain initiator, C-H bonds of many quinones were efficiently functionalized with carboxylic acid-containing side chains. This method also features 100% atom economy and wide substrate scope. A novel route to the anti-asthma drug Seratrodast was developed. Mechanism study suggests that the redox chain reaction likely undergoes a carbocation intermediate.

Organic Letters published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C14H31NO2, Formula: C10H10O3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Xie, Wen-Bin published the artcileBis(¦Ì-oxo)-Dititanium(IV)-Chiral Binaphthyldisulfonate Complexes for Highly Enantioselective Intramolecular Hydroalkoxylation of Nonactivated Alkenes, Synthetic Route of 2051-95-8, the publication is ACS Catalysis (2021), 11(10), 6270-6275, database is CAplus.

A series of chiral 1,1′-binaphthyl-2,2′-disulfonic acids was designed, synthesized, and applied in a highly enantioselective Ti-catalyzed intramol. hydroalkoxylation of nonactivated alkenes. The catalyst is probably a complex between two chiral binaphthyldisulfonate ligands and a bis(¦Ì-oxo)-dititanium(IV) core structure. The sulfonamide groups of the ligands and water are necessary for the catalysis, as they may stabilize the catalytically active complex through hydrogen bonding. Various 2-methylcoumarans were obtained in up to greater than 99% yields and up to 97% enantiomeric excess under mild conditions.

ACS Catalysis published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C5H12O2, Synthetic Route of 2051-95-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Li, Mao-Lin published the artcileCarboxyl Group-Directed Iridium-Catalyzed Enantioselective Hydrogenation of Aliphatic ¦Ã-Ketoacids, HPLC of Formula: 2051-95-8, the publication is ACS Catalysis (2020), 10(17), 10032-10039, database is CAplus.

Although the transition metal-catalyzed asym. hydrogenation of aromatic ketones has been extensively explored, the enantioselective hydrogenation of aliphatic ketones remains a challenge because chiral catalysts cannot readily discriminate between the re and si faces of these ketones. Herein, we report a carboxyl-directing strategy for the asym. hydrogenation of aliphatic ¦Ã-ketoacids. With catalysis by iridium complexes bearing chiral spiro phosphino-oxazoline ligands, hydrogenation of aliphatic ¦Ã-ketoacids afforded chiral ¦Ã-hydroxylacids with high enantioselectivity (up to 99% ee). Mechanistic studies revealed that the carboxyl group of the substrate directs hydrogen transfer and ensures high enantioselectivity. D. functional theory calculations suggested the occurrence of chiral induction involving a hydrogen-hydrogen interaction between a hydride on the iridium atom and the substituent on the oxazoline ring of the ligand, and on the basis of the calculations, we proposed a catalytic cycle involving only Ir(III), which differs from the Ir(III)/Ir(V) catalytic cycle that operates in the hydrogenation of ¦Á,¦Â-unsaturated carboxylic acids.

ACS Catalysis published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C10H10O3, HPLC of Formula: 2051-95-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Xie, Jianing published the artcilePd-catalyzed stereoselective tandem ring-opening amination/cyclization of vinyl ¦Ã-lactones: access to caprolactam diversity, Synthetic Route of 2051-95-8, the publication is Chemical Science (2020), 11(33), 8839-8845, database is CAplus and MEDLINE.

A stereoselective amination/cyclization cascade process was developed that allowed for the preparation of a series of unsaturated and substituted caprolactam derivatives I [R = Ph, 3,5-di-MeC₆H₃, 2-naphthyl, etc.; R¹ = Ph, Bn, CH(Ph)₂, etc.; R² = H, Me, R³ = CH₂, C=CH₂, CHPh] in good yields. This conceptually novel protocol took advantage of the easy access and modular character of vinyl ¦Ã-lactones that could be prepared from simple precursors. Activation of the lactone substrate in the presence of a suitable Pd precursor and newly developed phosphoramidite ligand offers a stereocontrolled ring-opening/allylic amination manifold under ambient conditions. The intermediate (E)-configured ¦Å-amino acid could be cyclized using a suitable dehydrating agent in an efficient one-pot, two-step sequence. This overall highly chemo-, stereo- and regio-selective transformation streamlined the production of a wide variety of modifiable and valuable caprolactam building blocks in an operationally attractive way.

Chemical Science published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C9H5ClO4S, Synthetic Route of 2051-95-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Lu, Yufei published the artcileSynthesis of chiral ¦Ã-lactones via a RuPHOX-Ru catalyzed asymmetric hydrogenation of aroylacrylic acids, Related Products of catalysis-chemistry, the publication is Tetrahedron (2019), 75(26), 3643-3649, database is CAplus.

An asym. hydrogenation of aroylacrylic acids RCOCH:CHCO₂H (R = Ph, 2-MeOC₆H₄, 4-FC₆H₄, 3,4-F₂C₆H₃, etc.) catalyzed by RuPHOX-Ru catalyst has been developed, affording the corresponding chiral ¦Ã-lactones I in high yields and with up to 93% ee. The methodol. has the advantage of utilizing easily accessible substrates and has therefore expanded the scope of the resulting chiral ¦Ã-lactones. Furthermore, high catalytic efficiency was achieved in that the reduction of both the C=C and C=O double bonds was achieved in one step. The current work provides an alternative and convenient pathway for the synthesis of a wide range of chiral ¦Ã-lactones.

Tetrahedron published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C10H10O3, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia