Category: 2051-95-8

Pasha, Mohammed Anif published the artcileOrganocatalytic Reductive Propargylation: Scope and Applications, Category: catalysis-chemistry, the publication is Journal of Organic Chemistry (2019), 84(23), 15399-15416, database is CAplus and MEDLINE.

An amino acid-catalyzed three-component reductive coupling protocol has developed for the selective high-yielding synthesis of nearly fifty examples of propargylated cyclic/acyclic systems from the various propargyl aldehydes, cyclic/acyclic CH-acids, and Hantzsch ester at the ambient conditions. It is an economical, efficient, catalytic, metal-free protocol for the quick gram scale synthesis of propargylated cyclic/acyclic compounds and many of these coupling compounds were purified by simple precipitation-filtration technique instead of column chromatog. Functionally rich propargylated cyclic-1,3-diketones were specifically transformed into dihydropyrans found in natural products and drugs through an annulative etherification reaction by using Lewis-acid (AgOTf) catalysis. Further C-methylation reactions on propargylated cyclic-1,3-diketones, which are prolific synthons in natural products and medicinal chem are developed.

Journal of Organic Chemistry published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C10H10O3, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zubkov, Mikhail O. published the artcilePhotocatalyzed Decarboxylative Thiolation of Carboxylic Acids Enabled by Fluorinated Disulfide, SDS of cas: 2051-95-8, the publication is Organic Letters (2022), 24(12), 2354-2358, database is CAplus and MEDLINE.

Thiolation of carboxylic acids using a disulfide reagent having tetrafluoropyridinyl groups was described. The light-mediated process was performed using an acridine-type photocatalyst. Primary, secondary, tertiary and heteroatom-substituted carboxylic acids could be thiolated, and the method could be applied to the late-stage modification of a range of naturally occurring compounds and drugs. The fluorinated pyridine fragment was believed to enable the C-S bond formation. The resulting sulfides were used as redox-active radical precursors.

Organic Letters published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C6H8N2, SDS of cas: 2051-95-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wang, Jin published the artcileHydroboration Reaction and Mechanism of Carboxylic Acids using NaNH₂(BH₃)₂, a Hydroboration Reagent with Reducing Capability between NaBH₄ and LiAlH₄, Formula: C10H10O3, the publication is Journal of Organic Chemistry (2021), 86(7), 5305-5316, database is CAplus and MEDLINE.

Hydroboration reactions of carboxylic acids using sodium aminodiboranate (NaNH₂[BH₃]₂, NaADBH) to form primary alcs. were systematically investigated, and the reduction mechanism was elucidated exptl. and computationally. The transfer of hydride ions from B atoms to C atoms, the key step in the mechanism, was theor. illustrated and supported by exptl. results. The intermediates, NH₂B₂H₅, PhCH=CHCOOBH₂NH₂BH₃^–, PhCH=CHCH₂OBO, and the byproducts, BH₄^–, NH₂BH₂, and NH₂BH₃^–, were identified and characterized by ¹¹B and ¹H NMR. The reducing capacity of NaADBH was found between that of NaBH₄ and LiAlH₄. We have thus found that NaADBH is a promising reducing agent for hydroboration because of its stability and easy handling. These reactions exhibit excellent yields and good selectivity, therefore providing alternative synthetic approaches for the conversion of carboxylic acids to primary alcs. with a wide range of functional group tolerance.

Journal of Organic Chemistry published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C9H8BNO2, Formula: C10H10O3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Reynard, Guillaume published the artcileProtecting-group-free synthesis of hydroxyesters from amino alcohols, Category: catalysis-chemistry, the publication is Chemical Communications (Cambridge, United Kingdom) (2020), 56(74), 10938-10941, database is CAplus and MEDLINE.

The synthesis of hydroxyesters such as RCOOCH₂(CH)_nOH [R = MeC¡ÔC, 2-furyl, Ph, etc.; n = 1,2,3,4,7] from carboxylic acids RCOOH and unprotected amino alcs. H₂NCH₂(CH)_nOH in both continuous flow and batch processes was reported. The formation of a transient diazonium species with a dinitrite reagent was key in this transformation. The reaction conditions were compatible with a variety of functional groups.

Chemical Communications (Cambridge, United Kingdom) published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C10H10O3, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zhao, Feng published the artcileDeoxygenative alkylation of tertiary amides using alkyl iodides under visible light, Application In Synthesis of 2051-95-8, the publication is Science China: Chemistry, database is CAplus.

A deoxygenative alkylation strategy was demonstrated and combined amides R¹C(O)N(R²)R³ (R¹ = 2-phenylethyl, 3-(naphthalen-2-yl)propyl, 2-(adamantan-1-yl)ethyl, etc.; R² = Bn, Me, 2-(thiophen-2-yl)ethyl, etc.; R³ = Bn, Me, n-Pr, etc.) and alkyl iodides R⁴I (R⁴ = i-Pr, cyclopentyl, t-Bu, etc.) to build structurally diverse tertiary alkylamines R¹CH(R⁴)NR(²)R³in a single step. Compared with previous deoxygenative alkylation of amides using organometallic reagents as functional partner, this work uses stable and easily available alkyl halides as functionalization reagents. The versatile and flexible strategy plus structural and functional diversity of readily available amides and alkyl iodides renders it highly appealing for the streamlined synthesis of tertiary amines and would be of much interest in areas such as pharmaceutical and agrochem. research.

Science China: Chemistry published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C13H10F2, Application In Synthesis of 2051-95-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zhang, Yueteng published the artcileDeuteration of Formyl Groups via a Catalytic Radical H/D Exchange Approach, Application of 3-Benzoylpropionicacid, the publication is ACS Catalysis (2020), 10(3), 2226-2230, database is CAplus and MEDLINE.

H/D exchange at formyl groups represents the straightforward approach to C-1 deuterated aldehydes. This transformation has been recently realized by transition metal and NHC carbene catalysis. Mechanistically, all of these processes involve an ionic pathway. Herein, we report a distinct photoredox catalytic, visible light mediated neutral radical approach. Selective control of highly reactive acyl radical in the energy barrier surmountable, reversible reaction enables driving the formation of deuterated products when an excess of D₂O is employed. The power of the H/D exchange process has been demonstrated for not only aromatic aldehydes but also aliphatic substrates, which have been difficult in transitional metal catalyzed H/D exchange reactions, and for selective late-stage deuterium incorporation into complex structures with uniformly high deuteration level (>90%).

ACS Catalysis published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C18H23OP, Application of 3-Benzoylpropionicacid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Tan, Kathrin published the artcileHeteroaromatic Inhibitors of the Astacin Proteinases Meprin ¦Á, Meprin ¦Â and Ovastacin Discovered by a Scaffold-Hopping Approach, Recommanded Product: 3-Benzoylpropionicacid, the publication is ChemMedChem (2021), 16(6), 976-988, database is CAplus and MEDLINE.

Astacin metalloproteinases, in particular meprins ¦Á and ¦Â, as well as ovastacin, are emerging drug targets. Drug-discovery efforts have led to the development of the first potent and selective inhibitors in the last few years. However, the most recent compounds are based on a highly flexible tertiary amine scaffold that could cause metabolic liabilities or decreased potency due to the entropic penalty upon binding to the target. Thus, the aim of this study was to discover novel conformationally constrained scaffolds as starting points for further inhibitor optimization. Shifting from flexible tertiary amines to rigid heteroaromatic cores resulted in a boost in inhibitory activity. Moreover, some compounds already exhibited higher activity against individual astacin proteinases compared to recently reported inhibitors and also a favorable off-target selectivity profile, thus qualifying them as very suitable chem. probes for target validation.

ChemMedChem published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C5H5N3S, Recommanded Product: 3-Benzoylpropionicacid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Alghamdi, Saad published the artcileSynthesis, Characterization and Antimycobacterial Activity of Some Substituted Phenylpyridazinone Derivatives, Category: catalysis-chemistry, the publication is Pharmaceutical Chemistry Journal (2022), 55(12), 1367-1371, database is CAplus.

A series 6-phenyl-2-(substituted methyl)-dihydropyridazinone derivatives I [R = N-pyrrolidinyl, N-imidazolyl, N-morpholinyl, etc.] were synthesized using the interaction of 6-phenylpyridazinone with cyclic secondary amines such as pyrrolidine, 1H-Imidazole, morpholine, etc. by Mannich reaction and evaluated for their antimycobacterial activity against Mycobacterium tuberculosis H37Rv strain by Microplate Alamar Blue Assay (MABA) method. The results indicated that I [R = N-imidazolyl, N-Phenothiazinyl] exhibited highest antimycobacterial activity. Other compounds I [R = N-pyrrolidinyl, N-triazolyl, N-piperidinyl, N-morpholinyl] showed less significant antimycobacterial activity. The most effective compounds I [R = N-imidazolyl, N-Phenothiazinyl] possessed MIC of 6.25¦Ìg/mL that was equal to that of reference drugs Streptomycin and Ciprofloxacin.

Pharmaceutical Chemistry Journal published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C10H10O3, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Asif, Mohammad published the artcileBrine Shrimp (Artemia salina) lethality bioassay of some 2-(Alkyl/Aryl)-6-phenyl-4,5-dihydropyridazin-3(2H)-one derivatives, Computed Properties of 2051-95-8, the publication is Indian Journal of Heterocyclic Chemistry (2021), 31(1), 57-61, database is CAplus.

A series of pyridazinone derivatives, 2-(alkyl/aryl)-6-phenyl-4,5-dihydropyridazin-3(2H)-ones I [R = Me, Et, Ph, Bn, etc.], was synthesized from 6-phenyl-4,5-dihydropyridazin-3(2H)-one. The 6-phenyl-4,5-dihydropyridazin-3(2H)-one was synthesized from benzoylpropionic acid. All the synthesized compounds were studied for their brine shrimp (artemia salina) lethality bioassay. The compounds 6-phenyl-4,5-dihydropyridazin-3(2H)-on, I and potassium dichromate (as reference drug) were tested at the dose level of 10, 20, and 30¦Ìg/mL. Compounds I [R = Et, n-Bu] exhibited potent brine shrimp lethality with LC₅₀ values of 4.023¦Ìg and 4.20¦Ìg. Other compounds were also showed significant cytotoxic activity. The present study supported that brine shrimp bioassay was a simple, reliable, and suitable method for estimation of bioactivity of synthesized compounds and provided support for their use in medicine.

Indian Journal of Heterocyclic Chemistry published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C10H10O3, Computed Properties of 2051-95-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

DiRico, Kenneth J. published the artcileUltra-High-Throughput Acoustic Droplet Ejection-Open Port Interface-Mass Spectrometry for Parallel Medicinal Chemistry, Formula: C10H10O3, the publication is ACS Medicinal Chemistry Letters (2020), 11(6), 1101-1110, database is CAplus and MEDLINE.

High-throughput experimentation (HTE) has emerged as an important tool in drug discovery, providing a platform for preparing large compound libraries and enabling swift reaction screening over wide-ranging conditions. Recent advances in automated high-d., material-sparing HTE have necessitated the development of rapid analytics with sensitivity and resolution sufficient to identify products and/or assess reaction performance in a timely and data-rich manner. Combination of an ultra-throughput (UT) reader platform with Acoustic Droplet Ejection-Open Port Interface-Mass Spectrometry (ADE-OPI-MS) provides the requisite speed and sensitivity. Herein, the authors report the application of ADE-OPI-MS to HTE in the areas of parallel medicinal chem. and reaction screening.

ACS Medicinal Chemistry Letters published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C10H10O3, Formula: C10H10O3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia