Category: 2051-95-8

Du, Xuxin published the artcileRhodium(III)-Catalyzed Alkynylation of 4-Arylphthalazin-1(2H)-one Scaffolds via C-H Bond Activation, Category: catalysis-chemistry, the publication is European Journal of Organic Chemistry (2020), 2020(9), 1100-1107, database is CAplus.

A rhodium(III)-catalyzed selective C-H bond mono-/bialkynation of 4-aryl phthalazin-1(2H)-ones I (R¹ = 4-Me, 4-F, 3,4-di-Me, etc.) was developed. The silver salt AgSbF₆ is demonstrated to play a vital role in promoting the bialkynation reactions. The present alkynation strategy is simple and efficient and features high functional group tolerance and broad substrate scope under an air atm. Addnl., 6-aryl pyridazin-3(2H)-one scaffolds II (R² = H, OMe, Cl, etc.) are amenable to the selective monoalkynation and sequential bialkynation, resp.

European Journal of Organic Chemistry published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C10H10O3, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wang, Huamin published the artcileElectrochemical Oxidation Enables Regioselective and Scalable ¦Á-C(sp³)-H Acyloxylation of Sulfides, Application In Synthesis of 2051-95-8, the publication is Journal of the American Chemical Society (2021), 143(9), 3628-3637, database is CAplus and MEDLINE.

A highly selective, environmentally friendly, and scalable electrochem. protocol for the construction of ¦Á-acyloxy sulfides e.g., (p-tolylthio)methyl acetate, through the synergistic effect of self-assembly-induced C(sp³)-H/O-H cross-coupling, is reported. It features exceptionally broad substrate scope, high regioselectivity, gram-scale synthesis, construction of complex mols. e.g., I, and applicability to a variety of nucleophiles such as acetic acid, cyclohexanecarboxylic acid, benzoic acid, benzotriazole, etc. Moreover, the soft X-ray absorption technique and a series of control experiments have been utilized to demonstrate the pivotal role of the self-assembly of the substrates, which indeed is responsible for the excellent compatibility and precise control of high regioselectivity in electrochem. protocol.

Journal of the American Chemical Society published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C9H10O4, Application In Synthesis of 2051-95-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Seo, Jeong Moo published the artcileAn expeditious entry to rare tetrahydroimidazo[1,5-c]pyrrolo[1,2-a]pyrimidin-7(8H)-ones: A single-step gateway synthesis of glochidine congeners, Recommanded Product: 3-Benzoylpropionicacid, the publication is Tetrahedron (2019), 75(51), 130760pp., database is CAplus.

A single-step gateway synthesis of glochidine and its congeners that possessed the rare uncommon tetrahydroimidazo[1,5-c]pyrrolo[1,2-a]pyrimidine core I [R¹ = Me, (CH₂)₄CH₃, 4-MeC₆H₄, etc.; R² = R³ = H, Me] was developed employing histamine and readily available ¦Ã-ketoesters. Key features of the developed reaction involved tandem three C-N bonds formation and concomitant annulation of two rings in one pot to access this unique and complex tricyclic structure. Exploration of the unknown bioactivity of these compounds revealed that they elicit antiproliferative activity comparable to the anticancer drug imatinib against 6 cancer cell lines.

Tetrahedron published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C9H8BrF3, Recommanded Product: 3-Benzoylpropionicacid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Nguyen, Vu T. published the artcilePhotocatalytic decarboxylative amidosulfonation enables direct transformation of carboxylic acids to sulfonamides, Name: 3-Benzoylpropionicacid, the publication is Chemical Science (2021), 12(18), 6429-6436, database is CAplus and MEDLINE.

A visible light-induced, dual catalytic platform that for the first time allows for a one-step access to sulfonamides RS(O)₂R¹ (R = 4,4-dimethylcyclohexyl, heptadecyl, 4-oxo-4-phenylbutyl, etc.; R¹ = 2,3-dihydro-1H-indol-1-yl, (3,4,5-trimethylphenyl)aminyl, morpholin-4-yl, etc.) and sulfonyl azides R²S(O)₂N₃ (R² = 5-methoxy-5-oxopentyl, 4-(5-methylthiophen-2-yl)-4-oxobutyl, oxan-4-yl, etc.) directly from carboxylic acids R/R²COOH was reported. The broad scope of the direct decarboxylative amidosulfonation (DDAS) platform is enabled by the efficient direct conversion of carboxylic acids to sulfinic acids that are catalyzed by acridine photocatalysts and interfaced with copper-catalyzed sulfur-nitrogen bond-forming cross-couplings with both electrophilic and nucleophilic reagents.

Chemical Science published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C10H10O3, Name: 3-Benzoylpropionicacid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Mann, Mandeep K. published the artcileDiscovery of Small Molecule Antagonists of the USP5 Zinc Finger Ubiquitin-Binding Domain, Synthetic Route of 2051-95-8, the publication is Journal of Medicinal Chemistry (2019), 62(22), 10144-10155, database is CAplus and MEDLINE.

USP5 disassembles unanchored polyubiquitin chains to recycle free mono-ubiquitin, and is one of twelve ubiquitin-specific proteases featuring a zinc finger ubiquitin-binding domain (ZnF-UBD). This distinct structural module has been associated with substrate positioning or allosteric modulation of catalytic activity, but its cellular function remains unclear. We screened a chem. library focused on the ZnF-UBD of USP5, crystallized hits in complex with the protein, and generated a preliminary structure-activity relationship which enables the development of more potent and selective compounds This work serves as a framework for the discovery of a chem. probe to delineate the function of USP5 ZnF-UBD in proteasomal degradation and other ubiquitin signaling pathways in health and disease.

Journal of Medicinal Chemistry published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C10H10O3, Synthetic Route of 2051-95-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Nunes, Vanessa O. published the artcileChemical characterisation of sugarcane bagasse bio-oils from hydrothermal liquefaction: Effect of reaction conditions on products distribution and composition, SDS of cas: 2051-95-8, the publication is Journal of Environmental Chemical Engineering (2021), 9(6), 106513, database is CAplus.

The effects of temperature, residence time, catalyst use, and recycling on the composition of bio-oil as a result of the hydrothermal liquefaction (HTL) of sugarcane bagasse were investigated via comprehensive two-dimensional gas chromatog. with time-of-flight mass spectrometry (GCxGC-TOFMS) and high-resolution mass spectrometry (Orbitrap HRMS) with electrospray ionisation (ESI). HTL bio-oils from sugarcane bagasse contain linear and branched aliphatics, aromatics, phenolic derivatives, carboxylic acids, esters, and other heterocyclic oxygen-containing compounds The HHV from the HTL bio-oils are between 19.0 and 21.2 MJ/kg, lower than HHV of petroleum fuels. The operational parameters had different influences on the degrees of the decarboxylation and dehydration reactions. The processed water reuse has been shown to benefit deoxygenation and promoted decarboxylation reactions, while the residence time had less influence. The phenolic compounds formation was favored by the increase in temperature and the use of catalysts, and ketone and furan concentration showed opposite results. Higher temperature and catalyst use also increased the number of detectable polar compounds with high mol. weights

Journal of Environmental Chemical Engineering published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C10H10O3, SDS of cas: 2051-95-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Abu-Hashem, Ameen A. published the artcileSynthesis of 1,2,4-triazolopyridazines, isoxazolofuropyridazines, and tetrazolopyridazines as antimicrobial agents, COA of Formula: C10H10O3, the publication is Journal of Heterocyclic Chemistry (2020), 57(9), 3461-3474, database is CAplus.

Through current and previous researches, it was found that the derivatives of pyridazine, isoxazole, tetrazole, quinazoline, hydrazinyl, and 1,2,4-triazole had many pharmacol. activities. Thus, a series of novel furopyridazinones (7), isoxazolopyridazine (8), sub-benzylidene-furopyridazinones (9a-c), isoxazolofuropyridazines (10a-c), 3-chloro-(pyridin-4-ylmethylene)-dihydropyridazines (11), tetrazolopyridazines (12), pyridazinoquinazolinones (13), piperazinyl/morpholino-pyridazines (14a,b), hydrazinyl-pyridazines (15), and 1,2,4-triazolo-pyridazines (16a,b) in good yields (72%-90%) were synthesized from substituted Et 4-oxo-4-phenylbutanoate (2), 6-phenyl-4,5-dihydropyridazinone (3), and 6-phenyl-4-(pyridin-4-ylmethylene)-4,5-dihydropyridazinone (4) as beginning materials. All the chem. structures of the new compounds was demonstrated by different spectroscopy analyses such as IR, NMR, mass spectrum, and elemental anal. Also, the activities of the newly prepared compounds were tested against many types of bacteria and fungi in vitro. Hence, 1,2,4-triazolopyridazines (16a,b), isoxazolofuropyridazines (10a-c), tetrazolopyridazines (12), Piperazinyl/morpholinyl-pyridazines (14a,b) displayed the most efficient antimicrobial activities compared with the cefotaxime sodium and nystatin as standard drugs.

Journal of Heterocyclic Chemistry published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C10H10O3, COA of Formula: C10H10O3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Xin, Hong published the artcileVisible Light-Driven, Copper-Catalyzed Aerobic Oxidative Cleavage of Cycloalkanones, COA of Formula: C10H10O3, the publication is Journal of Organic Chemistry (2021), 86(12), 8263-8273, database is CAplus and MEDLINE.

A visible light-driven copper-catalyzed aerobic oxidative cleavage of cycloalkanones was presented. A variety of cycloalkanones with varying ring sizes and various ¦Á-substituents reacted well to give the distal keto acids or dicarboxylic acids with moderate to good yields.

Journal of Organic Chemistry published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C9H7NO4, COA of Formula: C10H10O3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Khan, Abida published the artcileSynthesis of novel N-substitutedphenyl-6-oxo-3-phenylpyridazine derivatives as cyclooxygenase-2 inhibitors, Name: 3-Benzoylpropionicacid, the publication is Drug Development Research (2020), 81(5), 573-584, database is CAplus and MEDLINE.

The novel non-ulcerogenic N-substituted-phenyl-6-oxo-3-phenylpyridazine derivatives such as I [X = NNHC(S)NH₂, NNHC(S)NHPh, NNHC(O)CH₂CN, NNHPh] and II [R¹ = NH₂, CH₂CN, CH₂C(O)NH₂, etc.] were synthesized by the reaction of 4-(6-oxo-3-phenylpyridazin-1[6H]-yl)benzaldehyde I [X = O] with different hydrazines or thiazolidin-4-ones. The novel aldehyde I [X = O] was prepared by reacting 6-phenylpyridazin-3(2H)-one with 4-fluorobenzaldehyde. Compounds I [X = NNHC(S)NH₂, NNHC(S)NHPh, NNHPh] and compound II [R¹ = NH₂] were assessed for their anti-inflammatory potential and gastric ulcerogenic effects. The mol. docking investigations of compounds I [X = NNHC(S)NH₂, NNHC(S)NHPh, NNHPh] and compound II [R¹ = NH₂] were also undertaken. The compounds I [X = NNHC(S)NH₂] (IC₅₀ = 17.45 nm; p < .05), I [X = NNHC(S)NHPh] (IC₅₀ = 17.40 nm; p < .05), I [X = NNHPh] (IC₅₀ = 16.76 nm; p < .05), and II [R¹ = NH₂] (IC₅₀ = 17.15 nm; p < .05) displayed better COX-2 inhibitory activity than celecoxib (IC₅₀ = 17.79 nm; p < .05). The compounds I [X = NNHC(S)NHPh, NNHPh] and II [R¹ = NH₂] revealed no gastric ulcerogenic effects, wherein the compound I [X = NNHC(S)NH₂] produced almost negligible gastric ulcerogenic effects than celecoxib and indomethacin. All synthesized compounds such as I and II were evaluated for COX-1/COX-2 inhibition assay, among which compounds I [X = NNHC(S)NH₂, NNHC(S)NHPh, NNHPh] and compound II [R¹ = NH₂] were identified as potent and safe non-ulcerogenic COX-2 inhibitors.

Drug Development Research published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C10H10O3, Name: 3-Benzoylpropionicacid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Khan, Abida published the artcileDiscovery of novel pyridazine-based cyclooxygenase-2 inhibitors with a promising gastric safety profile, COA of Formula: C10H10O3, the publication is Molecules (2020), 25(9), 2002, database is CAplus and MEDLINE.

Cyclooxygenase-2 (COX-2) is implicated in the development of chronic inflammatory diseases. Recently, pyridazine derivatives have emerged as a novel prototype to develop COX-2 inhibitors. Herein, some pyridazine-based COX-2 inhibitors I [R = H₂N, H₂NC(S)NH, (4-oxo-4,5-dihydro-1,3-thiazol-2-yl)amino, (4-phenyl-1,3-thiazol-2-yl)amino, (5-[(dimethylamino)methylidene]-4-oxo-4,5-dihydro-1,3-thiazol-2-yl)amino, etc.] were synthesized and assessed for COX-1 and COX-2 inhibitory action, gastric ulcerogenic effects, and lipid peroxidation properties. Mol. docking studies and determination of the physicochem. parameters were also carried out. The compounds I [R = (4-phenyl-1,3-thiazol-2-yl)amino] (IC₅₀ = 15.50 nM, 114.77%), I [R = (4-(4-bromophenyl)-1,3-thiazol-2-yl)amino] (IC₅₀ = 17.50 nM, 101.65%), I [R = (4-oxo-5-(2-oxo-2,3-dihydro-1H-indol-3-ylidene)-4,5-dihydro-1,3-thiazol-2-yl)amino] (IC₅₀ = 17.10 nM, 104.03%), I [R = ((5Z)-5-[(4-methoxyphenyl)methylidene]-4-oxo-4,5-dihydro-1,3-thiazol-2-yl)amino] (IC₅₀ = 16.90 nM, 105.26%), and I [R = (4-oxo-3-phenyl-1,3-thiazol-2-ylidene)imino] (IC₅₀ = 17.70 nM, 100.5%) displayed better COX-2 inhibition than celecoxib (IC₅₀ = 17.79 nM, 100%). These outcomes were harmonious with the mol. docking studies of these 5 compounds These compounds also displayed comparable onset and the duration of action concerning celecoxib and indomethacin in the in vivo studies. No ulcerogenic effects were observed for I [R = (4-phenyl-1,3-thiazol-2-yl)amino, (4-oxo-5-(2-oxo-2,3-dihydro-1H-indol-3-ylidene)-4,5-dihydro-1,3-thiazol-2-yl)amino], whereas I [R = (4-(4-bromophenyl)-1,3-thiazol-2-yl)amino, ((5Z)-5-[(4-methoxyphenyl)methylidene]-4-oxo-4,5-dihydro-1,3-thiazol-2-yl)amino, (4-oxo-3-phenyl-1,3-thiazol-2-ylidene)imino] showed an insignificant ulcerogenic effect compared to celecoxib. These 5 compounds displayed a better lipid peroxidation profile than celecoxib and indomethacin and appreciable calculated absorption compared to celecoxib, and have been recognized and postulated as non-ulcerogenic COX-2 inhibitors with promising physicochem. parameters and gastric safety profile. These compounds may be useful candidates to combat diseases caused by higher levels of COX-2.

Molecules published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C10H10O3, COA of Formula: C10H10O3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia