Category: 2051-95-8

Deng, Chen-Qiang published the artcileNi-Catalyzed Asymmetric Hydrogenation of Aromatic Ketoacids for the Synthesis of Chiral Lactones, Related Products of catalysis-chemistry, the publication is Organic Letters (2022), 24(13), 2494-2498, database is CAplus and MEDLINE.

A highly efficient Ni-catalyzed asym. hydrogenation of aromatic ¦Ã- and ¦Ä-ketoacids has been developed, affording a series of ¦Ã- and ¦Ä-aryl lactones in high yields and excellent enantioselectivities (¡Ü98% ee). The hydrogenation could occur smoothly on a gram scale with 0.05 mol % catalyst loading (S/C = 2000). This protocol provides an efficient and practical approach for accessing chiral lactones with important potential applications in organic synthesis and the pharmaceutical industry.

Organic Letters published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C10H10O3, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Trujillo, Cristina published the artcileMechanistic Insights into the Organocatalytic Kinetic Resolution of Oxazinones through Alcoholysis, Product Details of C10H10O3, the publication is European Journal of Organic Chemistry (2022), 2022(3), e202100818, database is CAplus.

A complete computational study has been performed in order to rationalise the results of a new organocatalytic approach to the kinetic resolution of 4-substituted oxazinones which results in highly enantioenriched and orthogonally-protected ¦Â-amino acids. DFT-anal. elucidated the preferable binding orientation of the 4-oxazinone under study, predicted the formation of the observed major R product with a calculated ee in good agreement with the exptl. data and allowed a complete mechanistic and stereochem. understanding of the catalysis. The alcoholytic kinetic resolution of a 7-memebered ring analog to generate enantioenriched ¦Ã-amino acids was exptl. and computationally investigated for the first time.

European Journal of Organic Chemistry published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C6H12N2O, Product Details of C10H10O3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Singhania, Vani published the artcileLipase-catalyzed esterification in water enabled by nanomicelles. Applications to 1-pot multi-step sequences, Recommanded Product: 3-Benzoylpropionicacid, the publication is Chemical Science (2022), 13(5), 1440-1445, database is CAplus and MEDLINE.

Esterification in an aqueous micellar medium is catalyzed by a com. available lipase in the absence of any co-factors. The presence of only 2 wt% designer surfactant, TPGS-750-M, assisted in a 100% selective enzymic process in which only primary alcs. participated (in a 1:1 ratio with carboxylic acid). An unexpected finding was also disclosed where the simple additive, PhCF₃ (1 equivalent vs. substrate), appeared to significantly extend the scope of usable acid/alc. combinations. Taken together, several chemo- and bio-catalyzed 1-pot, multi-step reactions was performed in water.

Chemical Science published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C10H16O2, Recommanded Product: 3-Benzoylpropionicacid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Page, Claire G. published the artcileQuaternary Charge-Transfer Complex Enables Photoenzymatic Intermolecular Hydroalkylation of Olefins, Recommanded Product: 3-Benzoylpropionicacid, the publication is Journal of the American Chemical Society (2021), 143(1), 97-102, database is CAplus and MEDLINE.

Intermol. C-C bond-forming reactions are underdeveloped transformations in the field of biocatalysis. Here we report a photoenzymic intermol. hydroalkylation of olefins catalyzed by flavin-dependent ‘ene’-reductases. Radical initiation occurs via photoexcitation of a rare high-order enzyme-templated charge-transfer complex that forms between an alkene, ¦Á-chloroamide, and flavin hydroquinone. This unique mechanism ensures that radical formation only occurs when both substrates are present within the protein active site. This active site can control the radical terminating hydrogen atom transfer, enabling the synthesis of enantioenriched ¦Ã-stereogenic amides. This work highlights the potential for photoenzymic catalysis to enable new biocatalytic transformations via previously unknown electron transfer mechanisms.

Journal of the American Chemical Society published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C10H10O3, Recommanded Product: 3-Benzoylpropionicacid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Go, Su Yong published the artcileA Unified Synthetic Strategy to Introduce Heteroatoms via Electrochemical Functionalization of Alkyl Organoboron Reagents, Recommanded Product: 3-Benzoylpropionicacid, the publication is Journal of the American Chemical Society (2022), 144(20), 9149-9160, database is CAplus and MEDLINE.

Based on systematic electrochem. anal., an integrated synthetic platform of C(sp³)-based organoboron compounds was established for the introduction of heteroatoms. The electrochem. mediated bond-forming strategy is highly effective for the functionalization of sp³-hybridized C atoms with significant steric hindrance. Also, virtually all the nonmetallic heteroatoms could be used as reaction partners using one unified protocol. The observed reactivity stems from the two consecutive single-electron oxidations of the substrate, which eventually generates an extremely reactive carbocation as the key intermediate. The detailed reaction profile could be elucidated through multifaceted electrochem. studies. Ultimately, a new dimension in the activation strategies for organoboron compounds was accomplished through the electrochem. driven reaction development.

Journal of the American Chemical Society published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C10H10O3, Recommanded Product: 3-Benzoylpropionicacid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wen, Tingyu published the artcileDiscovery, semisynthesis and neurite outgrowth-promoting activity of novel merrillianone/cycloparvifloralone based esters as neurotrophic agents, Application of 3-Benzoylpropionicacid, the publication is Bioorganic & Medicinal Chemistry Letters (2021), 127832, database is CAplus and MEDLINE.

Natural products (NPs) are very important sources for the development of new drugs. Merrillianone and cycloparvifloralone, isolated from the roots, stems, and fruits of Illicium henryi Diels, are two natural sesquiterpene compounds In continuation of our effort to discover more effective neurotrophic compounds from NPs, a series of novel merrillianone/cycloparvifloralone based esters I (R = MeCH:CHCH:CH, CH₂CH₂Ph, CH₂CH₂COPh, etc.) and II (R = 4-BrC₆H₄CH₂, 2-naphthylmethyl, CH:CHPh, etc.) were prepared and their structures were characterized by ¹H NMR, ¹³C NMR and IR spectral analyses. Furthermore, the spatial structure of compound I (R = CH₂CH₂Ph) was unambiguously confirmed by X-ray crystallog. The neurite outgrowth-promoting activity results indicated that most of the target derivatives exhibited more potent neurite outgrowth-promoting activity than merrillianone and cycloparviforalone. Among all target derivatives, the neurite outgrowth-promoting activity of compounds I (R = MeCH:CHCH:CH) and II (R = MeCH:CHCH:CHMe, 4-FC₆H₄CH₂CH₂) was about 2-fold stronger than that of their precursors merrillianone and cycloparvifloralone, resp. Besides, compounds I (R = MeCH:CHCH:CH) and II (R = MeCH:CHCH:CH) displayed relatively low cytotoxicity to normal GES-1 cells. Moreover, these derivatives had good hydrolytic stability. Finally, some interesting results of the structure-activity relationships (SARs) were also discussed. This work will pave the way for the development of merrillianone/cycloparvifloralone derivatives as potential neurotrophic agents.

Bioorganic & Medicinal Chemistry Letters published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C8H8O2, Application of 3-Benzoylpropionicacid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wang, Rui published the artcileAuCl₃-Catalyzed Ring-Closing Carbonyl-Olefin Metathesis, Computed Properties of 2051-95-8, the publication is Chemistry – A European Journal (2020), 26(9), 1941-1946, database is CAplus and MEDLINE.

A highly efficient AuCl₃-catalyzed intramol. ring-closing carbonyl-olefin metathesis reaction is described. This method features easily accessible starting materials, simple operation, good functional-group tolerance and short reaction times, and provides the target cyclopentenes I (R = C(O)OEt, Ph, COPh, CONHPh; Ar = Ph, 3-methoxyphenyl, furan-2-yl, etc.), polycycles e.g., II, benzocarbocycles e.g., III, and N-heterocycle derivatives IV (R¹ = Ph, 4-fluorophenyl, naphthalen-2-yl, etc.) in good to excellent yields.

Chemistry – A European Journal published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C18H34N4O5S, Computed Properties of 2051-95-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

He, Jiayan published the artcileCatalytic Decarboxylative Radical Sulfonylation, Synthetic Route of 2051-95-8, the publication is Chem (2020), 6(5), 1149-1159, database is CAplus.

The decarboxylative radical sulfonylation with sulfinates were reported, with the merger of 4CzIPN and Cu(OTf)₂ as catalysts, the visible-light-induced reaction of redox-active esters of aliphatic carboxylic acids with organosulfinates at room temperature provided the corresponding sulfones in satisfactory yields. This redox-neutral protocol exhibited broad substrate scope and wide functional group compatibility, enabling the late-stage modification of complex natural products and bioactive pharmaceuticals. The synthetic utility of the method was further demonstrated by the improved synthesis of anti-prostate cancer drug bicalutamide.

Chem published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C10H10O3, Synthetic Route of 2051-95-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zhang, Qingyu published the artcileHypervalent Chalcogenonium…¦Ð Bonding Catalysis, Related Products of catalysis-chemistry, the publication is Angewandte Chemie, International Edition, database is CAplus and MEDLINE.

A proof-of-concept study of hypervalent chalcogenonium…¦Ð bonding catalysis was performed. A new catalytic strategy using 1,2-oxaselenolium salts as chalcogen bond donors and alkenes as chalcogen bond acceptors is described. The feasibility of this concept is demonstrated by the use of trisubstituted selenonium salts in the metal-free catalytic hydrofunctionalization and polymerization of alkenes via unconventional seleniranium ion-like intermediates. The results indicate that counter anions have a significant effect on the catalysis based on hypervalent chalcogenonium…¦Ð bonding interactions.

Angewandte Chemie, International Edition published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C8H10S, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Watile, Rahul A. published the artcileIntramolecular substitutions of secondary and tertiary alcohols with chirality transfer by an iron(III) catalyst, Formula: C10H10O3, the publication is Nature Communications (2019), 10(1), 1-9, database is CAplus and MEDLINE.

A simple, inexpensive, and environmentally benign iron(III) catalyst promotes the direct intramol. substitution of enantiomerically enriched secondary and tertiary alcs. with O-, N-, and S-centered nucleophiles, e.g., (1S)-3-[2-[(4-methoxyphenyl)amino]phenyl]-1-phenylpropan-1-ol to generate valuable 5-membered, 6-membered and aryl-fused 6-membered heterocyclic compounds, e.g., I with chirality transfer and water as the only byproduct has been demonstrated. The power of the methodol. is demonstrated in the total synthesis of (+)-lentiginosine from D-glucose where iron-catalysis is used in a key step. Adoption of this methodol. will contribute towards the transition to sustainable and bio-based processes in the pharmaceutical and agrochem. industries.

Nature Communications published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C8H5F3N4, Formula: C10H10O3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia