Category: 215297-17-9

Moore, Whylder published the artcileSpin-spin interaction and relaxation in two trityl-nitroxide diradicals, Product Details of C10H25NO2Si, the publication is Journal of Magnetic Resonance (2021), 107078, database is CAplus and MEDLINE.

Trityl-nitroxides show substantial promise as polarizing agents in solid state dynamic nuclear polarization. To optimize performance it is important to understand the impact of spin-spin interactions on relaxation times of the diradicals. CW spectra and electron spin relaxation were measured for two trityl-nitroxides that differ in the substituents on the amide linker and have different strengths of the exchange interaction J. Anal. of the EPR spectra in terms of overlapping AB spin-spin splitting patterns explains the impact of J on various regions of the spectra. Even modest values of J are large relative to the separation between trityl and nitroxide resonances for some nitrogen nuclear spin state. Two conformations for each diradical were observed in CW spectra in fluid solution at X-band and Q-band. For one diradical J = 15 G (83%) and 5 G (17%) at 293 K, and J = 27 G (67%) and 3 G (33%) with interspin distances of 16 ? and 12 ?, resp., at 80 K. For the second diradical the exchange interaction is stronger: the two conformations in fluid solution at 293 K had J = 113 G (67%) and 59 G (33%) and at 80 K the value of J was 43 G and there were two conformations with interspin distances of 13 and 11.5 ?. The observation of two conformations for each diradical, with different values of J, demonstrates the dependence of their exchange interactions on through-bond orbital interactions. X-band values of spin relaxation rates 1/T1 and 1/Tm at 80 to 120 K for the trityl-nitroxides are similar to values for nitroxide mono-radicals, and faster than for trityl radicals. These observations show that even for a relatively small value of J, the nitroxide is very effective in enhancing the relaxation of the more slowly relaxing trityl.

Journal of Magnetic Resonance published new progress about 215297-17-9. 215297-17-9 belongs to catalysis-chemistry, auxiliary class Linker,PROTAC Linker, name is 2-(2-((tert-Butyldimethylsilyl)oxy)ethoxy)ethan-1-amine, and the molecular formula is C10H25NO2Si, Product Details of C10H25NO2Si.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Stoll, Emma L. published the artcileA practical catalytic reductive amination of carboxylic acids, Safety of 2-(2-((tert-Butyldimethylsilyl)oxy)ethoxy)ethan-1-amine, the publication is Chemical Science (2020), 11(35), 9494-9500, database is CAplus and MEDLINE.

Reductive alkylation reactions of amines using carboxylic acids as nominal electrophiles was reported. The two-step reaction exploits the dual reactivity of phenylsilane and involves a silane-mediated amidation followed by a Zn(OAc)₂-catalyzed amide reduction The reaction is applicable to a wide range of amines and carboxylic acids and has been demonstrated on a large scale (305 mmol of amine). The rate differential between the reduction of tertiary and secondary amide intermediates is exemplified in a convergent synthesis of the antiretroviral medicine maraviroc. Mechanistic studies demonstrate that a residual 0.5 equiv of carboxylic acid from the amidation step is responsible for the generation of silane reductants with augmented reactivity, which allow secondary amides, previously unreactive in zinc/phenylsilane systems, to be reduced.

Chemical Science published new progress about 215297-17-9. 215297-17-9 belongs to catalysis-chemistry, auxiliary class Linker,PROTAC Linker, name is 2-(2-((tert-Butyldimethylsilyl)oxy)ethoxy)ethan-1-amine, and the molecular formula is C8H15BrO2, Safety of 2-(2-((tert-Butyldimethylsilyl)oxy)ethoxy)ethan-1-amine.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Andrews, Keith G. published the artcileCatalytic reductive N-alkylation of amines using carboxylic acids, Recommanded Product: 2-(2-((tert-Butyldimethylsilyl)oxy)ethoxy)ethan-1-amine, the publication is Chemical Communications (Cambridge, United Kingdom) (2016), 52(9), 1855-1858, database is CAplus and MEDLINE.

A catalytic reductive alkylation reaction of primary or secondary amines with carboxylic acids is reported. The two-phase process involved silane mediated direct amidation followed by catalytic reduction

Chemical Communications (Cambridge, United Kingdom) published new progress about 215297-17-9. 215297-17-9 belongs to catalysis-chemistry, auxiliary class Linker,PROTAC Linker, name is 2-(2-((tert-Butyldimethylsilyl)oxy)ethoxy)ethan-1-amine, and the molecular formula is C10H25NO2Si, Recommanded Product: 2-(2-((tert-Butyldimethylsilyl)oxy)ethoxy)ethan-1-amine.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Bevers, Susan published the artcileNaphthalene- and Perylene-Based Linkers for the Stabilization of Hairpin Triplexes, COA of Formula: C10H25NO2Si, the publication is Journal of the American Chemical Society (2000), 122(25), 5905-5915, database is CAplus.

Planar perylene- and naphthalene-based diimide linkers can be employed to tether the Watson-Crick and the Hoogsteen strands of a DNA triplex, thus providing conjugates capable of targeting single-stranded nucleic acids with the formation of hairpin triplexes. The planar linkers are designed to bridge the terminal base triplet of the three-stranded complex and provide base-stacking interactions with all three residues. Sixteen complexes have been prepared, eight with each linker, half with RNA (R) targets and half with DNA (D) targets. The conjugate sequences are composed of two strands of DNA, two of 2′-O-Me RNA (M), or one of each. In comparison to similar complexes formed with a hexa(ethylene glycol) linker, the planar linkers enhance the T_M values for the complexes by as much as 28 ¡ãC with ¦¤G values indicating as much as 12.3 kcal/mol of stabilization relative to the simple glycol linker. All sixteen complexes have been characterized by T_M measurements and ¦¤G determinations That ¦Ð-stacking interactions are present between the linkers, and the nucleobases can be inferred from the quenching of the perylene fluorescence upon complex formation, and the observation of an absorbance vs temperature transition for the naphthalene-based linker at 383 nm and for the perylene-based linker monitored at 537 nm.

Journal of the American Chemical Society published new progress about 215297-17-9. 215297-17-9 belongs to catalysis-chemistry, auxiliary class Linker,PROTAC Linker, name is 2-(2-((tert-Butyldimethylsilyl)oxy)ethoxy)ethan-1-amine, and the molecular formula is C10H25NO2Si, COA of Formula: C10H25NO2Si.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Heathcote, Dean A. published the artcileA Novel Pyrazolo[1,5-a]pyrimidine is a Potent Inhibitor of Cyclin-Dependent Protein Kinases 1, 2, and 9, Which Demonstrates Antitumor Effects in Human Tumor Xenografts Following Oral Administration, Name: 2-(2-((tert-Butyldimethylsilyl)oxy)ethoxy)ethan-1-amine, the publication is Journal of Medicinal Chemistry (2010), 53(24), 8508-8522, database is CAplus and MEDLINE.

Cyclin-dependent protein kinases (CDKs) are central to the appropriate regulation of cell proliferation, apoptosis, and gene expression. Abnormalities in CDK activity and regulation are common features of cancer, making CDK family members attractive targets for the development of anticancer drugs. Here, we report the identification of a pyrazolo[1,5-a]pyrimidine derived compound, 4k (BS-194, I), as a selective and potent CDK inhibitor, which inhibits CDK2, CDK1, CDK5, CDK7, and CDK9 (IC₅₀ = 3, 30, 30, 250, and 90 nmol/L, resp.). Cell-based studies showed inhibition of the phosphorylation of CDK substrates, Rb and the RNA polymerase II C-terminal domain, down-regulation of cyclins A, E, and D1, and cell cycle block in the S and G₂/M phases. Consistent with these findings, 4k demonstrated potent antiproliferative activity in 60 cancer cell lines tested (mean GI₅₀ = 280 nmol/L). Pharmacokinetic studies showed that 4k is orally bioavailable, with an elimination half-life of 178 min following oral dosing in mice. When administered at a concentration of 25 mg/kg orally, 4k inhibited human tumor xenografts and suppressed CDK substrate phosphorylation. These findings identify 4k as a novel, potent CDK selective inhibitor with potential for oral delivery in cancer patients.

Journal of Medicinal Chemistry published new progress about 215297-17-9. 215297-17-9 belongs to catalysis-chemistry, auxiliary class Linker,PROTAC Linker, name is 2-(2-((tert-Butyldimethylsilyl)oxy)ethoxy)ethan-1-amine, and the molecular formula is C10H25NO2Si, Name: 2-(2-((tert-Butyldimethylsilyl)oxy)ethoxy)ethan-1-amine.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Bevers, Susan published the artcilePerylene- and Naphthalene-Based Linkers for Duplex and Triplex Stabilization, Application In Synthesis of 215297-17-9, the publication is Journal of the American Chemical Society (1998), 120(42), 11004-11005, database is CAplus.

Perylene and naphthalene were chosen for development into planar ¦Ð-stacking linkers in DNA duplex or triplex preparations Linkers were prepared by reaction of the corresponding tetra-carboxylic acid dianhydride with 2-aminoethoxyethanol or its tBDMS derivative Thermal stabilities of DNA duplex (5′-TCTTTTCTT-linker-AAGAAAAGA) or triplex (5′-TCTTTTCTT-linker-TTCTTTTCT/9-mer or 19-mer) systems. Both the perylene and naphthalene-based duplex linkers showed increased T_M values, compared to a duplex tethered by hexa(ethylene glycol), but the perylene linker showed only a small increase over naphthalene, perhaps because it is significantly larger than necessary to bridge the phosphate residues at the terminus of a B-form helix, while the naphthalene-based linker can be more optimally positioned at the end of a duplex. In triplex formation, the most significant T_M enhancements were those that occurred with the 19-mer complex, where the perylene-based linker showed a 19¡ã increase at pH 5.5; for both linkers, this is perhaps due to their potential to provide stacking interactions with all three residues, and possibly with the first base residue of the target strand that extends beyond the triplex region.

Journal of the American Chemical Society published new progress about 215297-17-9. 215297-17-9 belongs to catalysis-chemistry, auxiliary class Linker,PROTAC Linker, name is 2-(2-((tert-Butyldimethylsilyl)oxy)ethoxy)ethan-1-amine, and the molecular formula is C10H25NO2Si, Application In Synthesis of 215297-17-9.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Goess, Brian C. published the artcileSynthesis of a 10,000-Membered Library of Molecules Resembling Carpanone and Discovery of Vesicular Traffic Inhibitors, Formula: C10H25NO2Si, the publication is Journal of the American Chemical Society (2006), 128(16), 5391-5403, database is CAplus and MEDLINE.

Split-and-pool synthesis of a 10,000-membered library of mols. resembling the natural product carpanone has been achieved. The synthesis features development of solid-phase multicomponent reactions between nitrogen nucleophiles, enones, and hydroxylamines, and a solid-phase application of the Huisgen cycloaddition affording substituted triazoles. The synthesis was performed in high-capacity (500 ¦Ìm) polystyrene beads using a one bead-one stock solution strategy that enabled phenotypic screens of the resulting library. Using whole-cell fluorescence imaging, we discovered a series of mols. from the carpanone-based library that inhibit exocytosis from the Golgi apparatus The most potent member of this series (I; CLL-19) has an IC₅₀ of 14 ¦ÌM. We also report structure-activity relationships for the mols. exhibiting this interesting phenotype. These inhibitors of exocytosis may be useful reagents for the study of vesicular traffic.

Journal of the American Chemical Society published new progress about 215297-17-9. 215297-17-9 belongs to catalysis-chemistry, auxiliary class Linker,PROTAC Linker, name is 2-(2-((tert-Butyldimethylsilyl)oxy)ethoxy)ethan-1-amine, and the molecular formula is C10H25NO2Si, Formula: C10H25NO2Si.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

van der Cruijsen, Elwin A. W. published the artcileBiomolecular DNP-Supported NMR Spectroscopy using Site-Directed Spin Labeling, Computed Properties of 215297-17-9, the publication is Chemistry – A European Journal (2015), 21(37), 12971-12977, database is CAplus and MEDLINE.

Dynamic nuclear polarization (DNP) has been shown to greatly enhance spectroscopic sensitivity, creating novel opportunities for NMR studies on complex and large mol. assemblies in life and material sciences. In such applications, however, site-specificity and spectroscopic resolution become critical factors that are usually difficult to control by current DNP-based approaches. We have examined in detail the effect of directly attaching mono- or biradicals to induce local paramagnetic relaxation effects and, at the same time, to produce sizable DNP enhancements. Using a membrane-embedded ion channel as an example, we varied the degree of paramagnetic labeling and the location of the DNP probes. Our results show that the creation of local spin clusters can generate sizable DNP enhancements while preserving the intrinsic benefits of paramagnetic relaxation enhancement (PRE)-based NMR approaches. DNP using chem. labeling may hence provide an attractive route to introduce mol. specificity into DNP studies in life science applications and beyond.

Chemistry – A European Journal published new progress about 215297-17-9. 215297-17-9 belongs to catalysis-chemistry, auxiliary class Linker,PROTAC Linker, name is 2-(2-((tert-Butyldimethylsilyl)oxy)ethoxy)ethan-1-amine, and the molecular formula is C11H15NO2, Computed Properties of 215297-17-9.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Sauvee, Claire published the artcileTailoring of Polarizing Agents in the bTurea Series for Cross-Effect Dynamic Nuclear Polarization in Aqueous Media, Application of 2-(2-((tert-Butyldimethylsilyl)oxy)ethoxy)ethan-1-amine, the publication is Chemistry – A European Journal (2016), 22(16), 5598-5606, database is CAplus and MEDLINE.

A series of 18 nitroxide biradicals derived from bTurea has been prepared, and their enhancement factors ¦Å (¹H) in cross-effect dynamic nuclear polarization (CE DNP) NMR experiments at 9.4 and 14.1 T and 100 K in a DNP-optimized glycerol/water matrix (“DNP juice”) have been studied. We observe that ¦Å (¹H) is strongly correlated with the substituents on the polarizing agents, and its trend is discussed in terms of different mol. parameters: solubility, average e-e distance, relative orientation of the nitroxide moieties, and electron spin relaxation times. We show that too short an e-e distance or too long a T_1e can dramatically limit ¦Å (¹H). Our study also shows that the mol. structure of AMUPol is not optimal and its ¦Å (¹H) could be further improved through stronger interaction with the glassy matrix and a better orientation of the TEMPO moieties. A new AMUPol derivative introduced here provides a better ¦Å (¹H) than AMUPol itself (by a factor of ca. 1.2).

Chemistry – A European Journal published new progress about 215297-17-9. 215297-17-9 belongs to catalysis-chemistry, auxiliary class Linker,PROTAC Linker, name is 2-(2-((tert-Butyldimethylsilyl)oxy)ethoxy)ethan-1-amine, and the molecular formula is C10H25NO2Si, Application of 2-(2-((tert-Butyldimethylsilyl)oxy)ethoxy)ethan-1-amine.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Stevanato, Gabriele published the artcileOpen and Closed Radicals: Local Geometry around Unpaired Electrons Governs Magic-Angle Spinning Dynamic Nuclear Polarization Performance, COA of Formula: C10H25NO2Si, the publication is Journal of the American Chemical Society (2020), 142(39), 16587-16599, database is CAplus and MEDLINE.

The development of magic-angle spinning dynamic nuclear polarization (MAS DNP) has allowed at.-level characterization of materials for which conventional solid-state NMR is impractical due to the lack of sensitivity. The rapid progress of MAS DNP has been largely enabled through the understanding of rational design concepts for more efficient polarizing agents (PAs). Here, we identify a new design principle which has so far been overlooked. We find that the local geometry around the unpaired electron can change the DNP enhancement by an order of magnitude for two otherwise identical conformers. We present a set of 13 new stable mono- and dinitroxide PAs for MAS DNP NMR where this principle is demonstrated. The radicals are divided into two groups of isomers, named open (O-) and closed (C-), based on the ring conformations in the vicinity of the N-O bond. In all cases, the open conformers exhibit dramatically improved DNP performance as compared to the closed counterparts. In particular, a new urea-based biradical named HydrOPol and a mononitroxide O-MbPyTol yield enhancements of 330 ¡À 60 and 119 ¡À 25, resp., at 9.4 T and 100 K, which are the highest enhancements reported so far in the aqueous solvents used here. We find that while the conformational changes do not significantly affect electron spin-spin distances, they do affect the distribution of the exchange couplings in these biradicals. Electron spin echo envelope modulation (ESEEM) experiments suggest that the improved performance of the open conformers is correlated with higher solvent accessibility.

Journal of the American Chemical Society published new progress about 215297-17-9. 215297-17-9 belongs to catalysis-chemistry, auxiliary class Linker,PROTAC Linker, name is 2-(2-((tert-Butyldimethylsilyl)oxy)ethoxy)ethan-1-amine, and the molecular formula is C4H6BrFO2, COA of Formula: C10H25NO2Si.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia