Category: 4230-93-7

Li, Xiang published the artcileOrganocatalytic tandem Morita-Baylis-Hillman-Michael reaction for asymmetric synthesis of a drug-like oxa-spirocyclic indanone scaffold, SDS of cas: 4230-93-7, the publication is Chemical Communications (Cambridge, United Kingdom) (2013), 49(77), 8692-8694, database is CAplus and MEDLINE.

A novel multicatalytic MBH-Michael tandem reaction has been developed for the asym. assembly of ninhydrin, nitroolefins and aldehydes into a structurally complex oxa-spirocyclic indanone backbone, e.g., I. Successive iodocyclization allowed us to convert these multifunctional allylic products into fused chiral natural product mimics,e.g.,II.

Chemical Communications (Cambridge, United Kingdom) published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, SDS of cas: 4230-93-7.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Shen, Li published the artcileNovel hybrids from lamellarin D and combretastatin A4 as cytotoxic agents, Safety of 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, the publication is European Journal of Medicinal Chemistry (2010), 45(1), 11-18, database is CAplus and MEDLINE.

A new series of hybrids of lamellarin D and combretastatin A4, 1,2-diphenyl-5,6-dihydropyrrolo[2,1-a]isoquinolines, was designed as cytotoxic agents based on principles of combination in medicinal chem. and taking the parent compounds’ different anti-proliferative mechanisms into consideration. Twenty-two novel hybrids, e.g. I, were synthesized through a convenient route, with a key step of core pyrrole formation and evaluated for their anti-proliferative activities in vitro against K-562, A-549, SMMC-7721, SGC-7901 and HCT-116 cancer cell lines. The results showed that some hybrids had good anti-proliferative activities in low IC₅₀ ranges.

European Journal of Medicinal Chemistry published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C15H14BNO4S, Safety of 1,2-Dimethoxy-4-(2-nitrovinyl)benzene.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Jiang, Ling published the artcileCatalyst-free one-pot three-component rapid synthesis of polysubstituted pyrroles by liquid-assisted grinding, HPLC of Formula: 4230-93-7, the publication is Journal of Heterocyclic Chemistry, database is CAplus.

A series of polysubstituted pyrroles were rapidly synthesized in moderate to good yields via catalyst-free one-pot three-component reaction of 1,3-dicarbonyl compounds with primary amines and nitrostyrenes by using liquid-assisted grinding. This protocol provided several advantages over the conventional chem. synthesis, such as simple work-up procedure, wide substrate scope, short reaction time and environmental friendliness. Structures of polysubstituted pyrroles were confirmed by ¹H NMR, ¹³C NMR and ESI-MS studies.

Journal of Heterocyclic Chemistry published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, HPLC of Formula: 4230-93-7.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Yu, Fuchao published the artcileThree-component solvent-free synthesis of highly substituted tetrahydroimidazo[1,2-a]pyridines, Recommanded Product: 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, the publication is RSC Advances (2011), 1(4), 596-601, database is CAplus.

An efficient and green method was developed for the synthesis of tetrahydroimidazo[1,2-a]pyridines by three-component reactions of heterocyclic ketene aminals, triethoxymethane, and nitro alkenes in one-pot in the absence of catalyst and solvent. This protocol has advantages of environmental friendliness, high yields (73-93%), short reaction time and convenient operation.

RSC Advances published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C7H5ClN2S, Recommanded Product: 1,2-Dimethoxy-4-(2-nitrovinyl)benzene.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Mei, Ren-Qiang published the artcileAsymmetric Michael/cyclization tandem reaction of 4-hydroxycoumarin with ¦Â-nitroalkenes catalyzed by chiral bifunctional thioureas, Application of 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, the publication is Organic & Biomolecular Chemistry (2013), 11(8), 1286-1289, database is CAplus and MEDLINE.

The first asym. Michael/cyclization tandem reaction of 4-hydroxycoumarin with nitroolefins catalyzed by chiral bifunctional thioureas was reported and 2,3-dihydrofuro[3,2-c]coumarin adducts have been obtained in moderate yields (53-75%) and good enantioselectivities (64-90% ee).

Organic & Biomolecular Chemistry published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, Application of 1,2-Dimethoxy-4-(2-nitrovinyl)benzene.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Han, Bo published the artcileOrganocatalytic Morita-Baylis-Hillman/Michael/Acetalization Cascade: Procedure-Controlled Diastereodivergence in the Asymmetric Synthesis of Fully Substituted Tetrahydropyrans, Related Products of catalysis-chemistry, the publication is Advanced Synthesis & Catalysis (2014), 356(17), 3676-3682, database is CAplus.

The authors accomplished a controlled diastereodivergence in the asym. synthesis of fully functionalized tetrahydropyrans I (R¹ = C₆H₅, 2-ClC₆H₄, 2,4-Cl₂C₆H₃, 2-thienyl, etc., R² = OC₂H₅, CH₃, R³ = CH₃, C₂H₅, n-Pr) by adjusting the sequence of an organocatalytic cascade reaction. The one-pot operation provides two synthetically important architectures with excellent stereocontrol. This is the first published kinetic resolution of MBH alcs. in an organocascade.

Advanced Synthesis & Catalysis published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Huang, Yongkang published the artcileFirst total syntheses of 1-benzoyl-3,4-dihydroisoquinoline alkaloids Nelumstemine and Longifolonine based on the photo-oxidation, Name: 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, the publication is Youji Huaxue (2020), 40(5), 1281-1289, database is CAplus.

A novel synthetic route for the total syntheses of 1-benzoyl-3,4-dihydroisoquinoline alkaloids was developed. Nelumstemine was synthesized for the first time via 6 steps in 50% overall yield starting from 3,4-dimethoxybenzaldehyde, and Longifolonine was also synthesized for the first time via 9 steps in 35% overall yield starting from vanillin. The key step of these total syntheses is photo-oxidation of 1-benzyl-3,4-dihydroisoquinolines to 1-benzoyl-3,4-dihydroisoquinolines by air under visible-light irradiation at room temperature The unique mild photo-oxidation of 1-benzyl-3,4-dihydro-isoquinolines has been studied in detail.

Youji Huaxue published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, Name: 1,2-Dimethoxy-4-(2-nitrovinyl)benzene.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Tangdenpaisal, Kassrin published the artcileDesigning New Analogs for Streamlining the Structure of Cytotoxic Lamellarin Natural Products, Synthetic Route of 4230-93-7, the publication is Chemistry – An Asian Journal (2015), 10(4), 925-937, database is CAplus and MEDLINE.

Despite the therapeutic potential of marine-derived lamellarin natural products, their preclin. development has been hampered by their lipophilic nature, causing very poor aqueous solubility In order to develop more drug-like analogs, their structure was streamlined in this study from both the cytotoxic activity and lipophilicity standpoints. First, a modified total synthetic route was successfully devised to construct a library of 59 systematically designed lamellarin analogs, which were then subjected to cytotoxicity and log P determinations [e.g., I with single or double bond as indicated by dotted line; R = H, Me; X = H, OH; Y = H, OMe; A, B = H, OH]. Along with the 25 first-generation lamellarins previously synthesized in our laboratory, the structure-activity and structure-lipophilicity relationships were extensively evaluated. Our results clearly indicated the addnl. structural requirements around the lamellarin skeleton which, when combined with those reported previously, can provide invaluable guidance for further modifications to increase the aqueous solubility of these compounds

Chemistry – An Asian Journal published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C15H10O2, Synthetic Route of 4230-93-7.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Yan, Li-Jun published the artcileChemically Sustainable and Green One-Pot Multicomponent Synthesis of Highly Functionalized Polycyclic N-Fused-Pyrrolidine Heterocycles, Category: catalysis-chemistry, the publication is ChemistrySelect (2018), 3(2), 662-665, database is CAplus.

An eco-friendly, highly-efficient, atom-economical three-component cascade reaction of acenaphthenequinone, ¦Â-nitroolefins RCH=CHNO₂ (R = 2,4-dichlorophenyl, furan-2-yl, 1-methylindol-3-yl, etc.) and ¦Á-amino acids I (X = CH₂, CH₂CH₂, S; n = 1, 2) in MeOH/H₂O is developed for the synthesis of novel functionalized polycyclic N-fused-pyrrolidine derivatives II. All products are obtained by filtration in the absence of column chromatog. and recrystallization Due to its operational simplicity, this green and chem. sustainable reaction can be easily applied toward the design and synthesis of target mols. for the discovery of novel biol. active compounds

ChemistrySelect published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C14H26O2, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Li, Ying-Zi published the artcileEnantioselective synthesis of bicyclo[2.2.2]octane-1-carboxylates under metal free conditions, HPLC of Formula: 4230-93-7, the publication is Organic Chemistry Frontiers (2015), 2(3), 274-278, database is CAplus.

A new tandem reaction was realized that permits rapid access to a wide range of bicyclo[2.2.2]octane-1-carboxylates in good to excellent yields with excellent enantioselectivities under metal free, mild, and operationally simple conditions. An open transition state was deemed operative in this highly enantioselective process mediated by an organic base.

Organic Chemistry Frontiers published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, HPLC of Formula: 4230-93-7.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia