Category: 4230-93-7

Rostami, Hedieh published the artcileOne-Pot Multicomponent Synthesis of Pyrrolo[1,2-a]pyrazines in Water Catalyzed by Fe₃O₄@SiO₂-OSO₃H, SDS of cas: 4230-93-7, the publication is ChemistrySelect (2018), 3(47), 13487-13492, database is CAplus.

An effective and green one-pot multicomponent reaction for the synthesis of pyrrolo[1,2-a]pyrazine derivatives I [R¹ = Ph, 2-thiazolyl, 4-ClC₆H₄, etc.; R² = Me, Et] using Fe₃O₄@SiO₂-OSO₃H as a reusable magnetic nanocatalyst was reported. Compounds I were achieved via reaction among ethylenediamine, dialkyl acetylenedicarboxylates and ¦Â-nitrostyrene derivatives in water as a green solvent with high to excellent yields.

ChemistrySelect published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, SDS of cas: 4230-93-7.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Kupriyanova, Olga V. published the artcileSynthesis and determination of analytical characteristics and differentiation of positional isomers in the series of N-(2-methoxybenzyl)-2-(dimethoxyphenyl)ethanamine using chromatography-mass spectrometry, Category: catalysis-chemistry, the publication is Drug Testing and Analysis (2020), 12(8), 1154-1170, database is CAplus and MEDLINE.

N-(2-Methoxybenzyl)-2,5-dimethoxyphenethylamines (NBOMes) are synthetic phenethylamine derivatives emerging on the global drug market and reported to be associated with untoward effects in people who use drugs. Its action involves agonism at serotonin 5-HT_2A receptors, affecting cognitive and behavioral processes. However, certain isomers of NBOMes may not show any psychoactive effects. They are not controlled by legislation and can be tested as pharmaceutical drugs. This study deals with the differentiation among positional isomers of 25H-NBOMe differing in the position of the two methoxy groups in the phenylethyl moiety of the mol., using chromatog.-mass spectrometry methods. The gas chromatog. anal. showed that the isothermal mode was more efficient than the usually applied temperature-programming mode for the separation of the mentioned isomers. Electron ionization mass spectra of 25H-NBOMe isomers were highly similar, often resulting in a high probability of erroneous identification. However, mass spectra of their trifluoroacetyl or pentafluoropropanoyl derivatives were easily identified as they contained fragments with many significant differences. The proposed anal. using liquid chromatog.-tandem mass spectrometry could distinguish the isomers of 25H-NBOMe without the need for any derivatization.

Drug Testing and Analysis published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Kupriyanova, Olga V. published the artcilePotential of chromatography and mass spectrometry for the differentiation of three series of positional isomers of 2-(dimethoxyphenyl)-N-(2-halogenobenzyl)ethanamines, Name: 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, the publication is Drug Testing and Analysis (2022), 14(6), 1102-1115, database is CAplus and MEDLINE.

N-(2-substituted benzyl)-2,5-dimethoxyphenethylamines often cause severe poisonings which has led to their legal prohibition in many countries. At the same time, their positional isomers can be studied as potential therapeutic drugs. In this regard, the search for various approaches to differentiate these isomers is an important practical task, the solution of which would guarantee from identification errors during laboratory anal. In this paper, the possibilities of differentiation of isomers varying in the position of two methoxy groups in the phenylethyl part of the mol. are considered on the example of compounds of NBF, NBCl, and NBBr series by chromatog.-mass spectrometry methods. Gas or liquid reverse-phase chromatog. in the proposed chromatog. separation modes has demonstrated their ability to resolve this problem reliably. Data on retention indexes of isomeric compounds and their derivatives can serve as an addnl. identification criterion for gas chromatog.-mass spectrometry (GC-MS) anal. Differentiation of NBF and NBCl isomers using electron ionization (EI) mass spectra is feasible only if both the spectrum of the compound and its N-trifluoroacetyl derivative are registered; differentiation of NBBr positional isomers under these conditions does not require obtaining the derivatives Using electrospray ion source, the compounds can easily be differentiated based on the distinctive features of their collision induced dissociation (CID) spectra recorded at low energy values, which also does not require the synthesis of derivatives The data presented in current paper will be useful for anal. in laboratories providing the determination of narcotic drugs.

Drug Testing and Analysis published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, Name: 1,2-Dimethoxy-4-(2-nitrovinyl)benzene.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Balachandra, Biguvu published the artcileIodine catalyzed one-pot synthesis of highly substituted N-methyl pyrroles via [3 + 2] annulation and their in vitro evaluation as antibacterial agents, Safety of 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, the publication is RSC Advances (2015), 5(79), 64781-64789, database is CAplus.

A class of highly substituted pyrroles I [R = 2-F, 3-Cl, 4-OCH₃, etc.] have been synthesized via a simple, fast, and efficient method using environmentally friendly iodine catalyzed [3 + 2] annulation. N-Methyl-N-[(E)-1-(methylsulfanyl)-2-nitro-1-ethenyl]amine (NMSM) and U+03B2-nitrostyrenes underwent cycloaddition to afford the desired products I in excellent yields under solvent and metal free conditions. All the pyrrole derivatives I were evaluated for their in vitro anti-bacterial activity. Among the synthesized pyrrole derivatives I [R = H, 3-OCH₃, 3,4,5-(OCH₃)₃, 4-F, 4-Cl, 2-Br, 3-OH, 4-NO₂, 1,2-C₄H₄] displayed good inhibitory properties against a panel of Gram pos. and neg. infectious pathogens.

RSC Advances published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, Safety of 1,2-Dimethoxy-4-(2-nitrovinyl)benzene.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Reddy, Raju Jannapu published the artcileMetal-free, highly regioselective sulfonylation of NH-1,2,3-triazoles with sodium sulfinates and thiosulfonates, Recommanded Product: 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, the publication is Tetrahedron Letters (2018), 59(21), 2014-2017, database is CAplus.

A convenient and metal-free protocol for the highly regioselective sulfonylation of NH-1,2,3-triazoles such as 4-methyl-5-phenyl-2H-1,2,3-triazole, 4-furan-2-yl-5-methyl-2H-[1,2,3]triazole, 4-phenyl-2H-1,2,3-triazole, etc. was described. A range of readily accessible NH-1,2,3-triazoles was sulfonylated with various aryl sulfinates such as sodium p-toluenesulfinate, sodium 4-bromobenzenesulfinate, sodium benzenesulfinate, sodium 4-chlorobenzenesulfinate in the presence of mol. iodine. The scope was extended to thiosulfonates such as S-Ph 4-Me benzenesulfonothioate, S-Ph benzenesulfonothioate as an efficient sulfonylating agent and nitrochromene derived triazoles which were also explored for selective N-sulfonylation. A variety of synthetically viable N2-sulfonyl triazoles e.g., I was obtained in moderate to high yields with excellent regioselectivities via N-S bond construction under mild reaction conditions.

Tetrahedron Letters published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, Recommanded Product: 1,2-Dimethoxy-4-(2-nitrovinyl)benzene.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Saha, Satyajit published the artcileFunctionalized proline with double hydrogen bonding potential: highly enantioselective Michael addition of carbonyl compounds to ¦Â-nitrostyrenes in brine, Category: catalysis-chemistry, the publication is Tetrahedron Letters (2010), 51(40), 5281-5286, database is CAplus.

Simple synthetic manipulation of S-proline allows access to prolinamides as catalysts capable of double hydrogen bonding for enantioselective Michael addition reactions of carbonyl compounds to ¦Â-nitrostyrenes. It is shown that prolinamide catalyst I leads to addition products with a high diastereo- as well as enantioselectivity. The transition state structure involving the binding of electrophilic nitrostyrene via two H-bonds is believed to be further stabilized by ¦Ð,¦Ð stacking interactions mediated by the tosyl ring.

Tetrahedron Letters published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Yasukawa, Tomohiro published the artcileHomologation of Aryl Aldehydes Using Nitromethane as a C1 Source Enabled by Nitrogen-Doped Carbon-Supported Palladium Catalysts, Safety of 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, the publication is ACS Catalysis (2022), 12(10), 5887-5893, database is CAplus.

Homologation of aryl aldehydes provides useful synthetic intermediates, but it requires multistep reactions and generates significant amounts of waste. Herein, such reactions using nitromethane as a C1 source through nitroolefin formation, partial hydrogenation to oximes, and hydration of oximes were considered; however, the control of selectivity in the second reaction was challenging. To achieve this pathway, nitrogen-doped carbon-incarcerated palladium nanoparticle catalysts were developed for selective hydrogenation. The presence of nitrogen dopants effectively tuned the catalytic activity to show almost perfect selectivity, high activity, and reusability under ambient pressure. Then a three-step homologation reaction was performed in both batch and flow systems with only one purification step. The sequential continuous-flow system worked efficiently for more than 2 days to afforded the product in a high yield.

ACS Catalysis published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C11H10ClNO, Safety of 1,2-Dimethoxy-4-(2-nitrovinyl)benzene.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Rahmani-Nezhad, Samira published the artcileSynthesis, in vitro cytotoxicity and apoptosis inducing study of 2-aryl-3-nitro-2H-chromene derivatives as potent anti-breast cancer agents, Recommanded Product: 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, the publication is European Journal of Medicinal Chemistry (2014), 562-569, database is CAplus and MEDLINE.

A series of 2-aryl-3-nitro-2H-chromenes I [R¹ = H, OMe; R² = H, OMe; R³ = H, OMe; R⁴ = 4-OMe, 3,4-dimethyoxy, 4-Cl, etc.] were designed as hybrid analogs of flavanone, ¦Â-nitrostyrene and nitrovinylstilbene scaffolds. They were synthesized from the reaction of appropriate ¦Â-nitrostyrenes and salicylaldehydes in good yields. In vitro cytotoxic activities of compounds I were tested against breast cancer cell lines including MCF-7, T-47D and MDA-MB-231. Most compounds exhibited good cytotoxic activity against selected cell lines, being more potent than standard drug etoposide. Representatively, 8-methoxy-3-nitro-2-(4-chlorophenyl)-2H-chromene I (R¹=R²=H, R³=OMe, R⁴= 4-Cl) with IC₅₀ = 0.2 ¦ÌM against MCF-7 cells, was 36-times more potent than etoposide. Apoptosis as a mechanism of cell death for selected compounds I (R¹=R²=H, R³=R⁴=OMe) and I (R¹=R²=H, R³=OMe, R⁴= 4-Cl) was confirmed morphol. by acridine orange/ethidium bromide double staining and TUNEL anal., as well as caspase-3 activation assay.

European Journal of Medicinal Chemistry published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, Recommanded Product: 1,2-Dimethoxy-4-(2-nitrovinyl)benzene.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Moorthy, Jarugu Narasimha published the artcileC₃-Symmetric Proline-Functionalized Organocatalysts: Enantioselective Michael Addition Reactions, Name: 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, the publication is European Journal of Organic Chemistry (2010), 6359-6365, S6359/1-S6359/55, database is CAplus.

C₃-Sym., tripodal catalyst I based on 1,3,5-triethylbenzene, which incorporates the features of a mol. receptor, is shown to catalyze Michael addition reactions ofcarbonyl compounds to ¦Â-nitrostyrenes in a high stereoselectivity (up to 99:1 dr and up to 98 % ee).

European Journal of Organic Chemistry published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, Name: 1,2-Dimethoxy-4-(2-nitrovinyl)benzene.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Disadee, Wannaporn published the artcileOne-pot cascade synthesis of azabicycles via the nitro-Mannich reaction and N-alkylation, Category: catalysis-chemistry, the publication is Organic & Biomolecular Chemistry (2018), 16(5), 707-711, database is CAplus and MEDLINE.

A one-pot, metal-free process for the synthesis of azabicycles is developed. The key transformations involved a cascade of double intramol. cyclizations via the nitro-Mannich reaction and N-alkylation, providing various ring systems of azabicycles in yields up to 81% and an isomeric ratio of 62 : 1. This approach offers considerable advantages in terms of the handling of small mols., the flexibility to introduce a functionalized side chain, and gives direct access to various azabicycles.

Organic & Biomolecular Chemistry published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia