Category: 4230-93-7

Kumar, Tulam Vijaya published the artcilePolyethylene glycol (PEG-400) as an efficient and recyclable reaction medium for one-pot synthesis of substituted pyrroles under catalyst-free conditions, Application In Synthesis of 4230-93-7, the publication is Asian Journal of Chemistry (2015), 27(4), 1457-1461, database is CAplus.

Polyethylene glycol (PEG 400) was found to be an effective non-toxic reaction medium for multicomponent synthesis of substituted pyrroles I [R¹ = Ph, benzyl, 3-FC₆H₄, etc.; R² = 2-Br, 3,4-(OMe)₂, H, etc.] via tandem Michael addition-cyclization of amines, nitrostyrenes and acetylacetone. Environmental acceptability, low cost, high yields and recyclability of polyethylene glycol were important advantages of this protocol.

Asian Journal of Chemistry published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, Application In Synthesis of 4230-93-7.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Maresh, Justin J. published the artcileChemoselective Zinc/HCl Reduction of Halogenated ¦Â-Nitrostyrenes: Synthesis of Halogenated Dopamine Analogues, Name: 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, the publication is Synlett (2014), 25(20), 2891-2894, database is CAplus.

A detailed account regarding the synthesis of 2- and 5-halogenated dopamine is given. The key step is a chemoselective reduction of a nitrostyrene by Zn/HCl at 0 ¡ãC. These conditions represent a simple, low-cost alternative to reduction by water-sensitive hydride donors and two-step procedures. Under these conditions, aryl fluoride, chloride, and bromide groups are stable. However, iodine undergoes significant reductive dehalogenation.

Synlett published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, Name: 1,2-Dimethoxy-4-(2-nitrovinyl)benzene.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

de Silva, Nilamuni H. published the artcileMicrowave-assisted rapid synthesis of spirooxindole-pyrrolizidine analogues and their activity as anti-amyloidogenic agents, Synthetic Route of 4230-93-7, the publication is Bioorganic Chemistry (2021), 105128, database is CAplus and MEDLINE.

A library of Sox-pyrrolizidines was rapidly prepared by microwave-assisted, one-pot, three-component, 1,3-dipolar cycloaddition of azomethine ylides from L-proline and isatin, with various ¦Â-nitrostyrenes. Nitro-Sox compounds, I, 4d and 4e inhibit HEWL amyloid fibril formation by ThT studies with percentages of fluorescence intensity of 55.4, 42.9 and 40.3%, resp. Further studies with MTT assay, Raman spectroscopy, TEM and mol. docking supported these promising candidates for activity against amyloid misfolding, a phenomenon leading to Alzheimer’s disease pathol.

Bioorganic Chemistry published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, Synthetic Route of 4230-93-7.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Shumaila, Abdullah M. A. published the artcileSynthesis of tetrahydro-5-azaindoles and 5-azaindoles using Pictet-Spengler reaction-appreciable difference in products using different acid catalysts, Recommanded Product: 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, the publication is Tetrahedron (2011), 67(5), 936-942, database is CAplus.

Pictet-Spengler condensation of 2-(aryl)-2-(1H-pyrrol-2-yl)ethanamines using conventional acid catalysts like TMSCl or TFA resulted in the formation of substituted 5-azaindoles involving a tandem one pot four step reaction sequence. By contrast, use of glacial acetic acid furnished the targeted tetrahydro-5-azaindoles in diastereoselective manner. These were readily dehydrogenated to 5-azaindoles.

Tetrahedron published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C5H11NO2S, Recommanded Product: 1,2-Dimethoxy-4-(2-nitrovinyl)benzene.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Shumaila, Abdullah M. A. published the artcileDiastereoselective synthesis of tetrasubstituted-octahydro-3,6-diazacarbazoles and tetrasubstituted-3,6-diazacarbazoles via double Pictet-Spengler reaction, Category: catalysis-chemistry, the publication is Tetrahedron Letters (2011), 52(21), 2661-2663, database is CAplus.

Pictet-Spengler condensation of 2,5-bis(2-phenyl-1-aminoethyl)pyrrole using glacial acetic acid afforded only one diastereomer of unreported tetrasubstituted-octahydro-3,6-diazacarbazoles, e.g. I. These were readily dehydrogenated to tetrasubstituted-3,6-diazacarbazoles, e.g. II. The stereoselectivity in the Pictet-Spengler reaction has been demonstrated using single crystal X-ray anal.

Tetrahedron Letters published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C6H8O6, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Xie, Xin published the artcileAsymmetric synthesis of a structurally and stereochemically complex spirooxindole pyran scaffold through an organocatalytic multicomponent cascade reaction, SDS of cas: 4230-93-7, the publication is Chemical Communications (Cambridge, United Kingdom) (2012), 48(85), 10487-10489, database is CAplus and MEDLINE.

A novel and convenient organocatalytic tandem reaction has been developed for the asym. assembly of saturated aldehydes (or enals), nitroolefins and isatins to produce six-membered oxa-spirooxindole backbones bearing four contiguous stereogenic centers and multiple functional groups with high stereoselectivity, e.g. I.

Chemical Communications (Cambridge, United Kingdom) published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C6H5BN2O3, SDS of cas: 4230-93-7.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Xie, Xin published the artcileAsymmetric Synthesis of Oxa-spirocyclic Indanones with Structural Complexity via an Organocatalytic Michael-Henry-Acetalization Cascade, Formula: C10H11NO4, the publication is Synlett (2014), 25(1), 143-147, database is CAplus.

The highly enantioselective preparation of drug-like oxa-spirocyclic indanone derivatives employing a multicomponent cascade reaction of aldehydes, nitro alkenes, and ninhydrin is described. This approach utilizes an organocatalytic Michael reaction followed by a Henry-acetalization sequence that yields the desired chiral spirocyclic backbone, bearing four contiguous stereogenic centers and multiple functional groups, in good yields and high stereoselectivities (up to 99% ee and 95:5 dr).

Synlett published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C12H16O3, Formula: C10H11NO4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Lenin, Dandamudi V. published the artcile¦Â-Nitrostyrenes as a valuable precursor for the synthesis of ¦Â-aryl-¦Ã-lactam and 2-oxo-1,2-dihydroquinoline derivatives, Formula: C10H11NO4, the publication is Journal of Heterocyclic Chemistry (2022), 59(3), 588-596, database is CAplus.

Two different reaction pathways for the synthesis of ¦Â-aryl-¦Ã-lactam and 2-oxo-1,2-dihydroquinoline derivatives I (R = H, 2-Cl, 3,4-dimethoxy, 4-Et, etc.) and II (R¹ = H, Cl, Br) using ¦Â-nitrostyrenes R²CH=CHNO₂ (R² = Ph, 3,4-dimethoxyphenyl, 2-nitrophenyl, etc.) were successfully demonstrated. The reaction strategy involves the Michael addition followed by reduction and cyclization reactions. Michael adducts containing two different nitro group such as one on aryl ring and another on side chain, selectively take the path to involve nitro group on aryl to form 2-oxo-1,2-dihydroquinoline derivatives II as cyclized product. Michael adducts with nitro group on side chain alone forms ¦Â-aryl-¦Ã-lactam derivatives I as cyclized product. This methodol. is appealing with reliability and scalability with gram scale products that can be synthesized. These heterocyclic compounds can be exploited for their biol. activity.

Journal of Heterocyclic Chemistry published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, Formula: C10H11NO4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Bhagat, Ujjawal Kumar published the artcileRegiospecific Aza-Michael Addition of 4-Aryl-1H-1,2,3-triazoles to Chalcones: Synthesis of 2,4-Disubstituted 1,2,3-Triazoles in Basic Medium, Synthetic Route of 4230-93-7, the publication is Synlett (2018), 29(1), 99-105, database is CAplus.

A novel metal-free and base-mediated method to display the donor ability of 1,2,3-triazoles for the synthesis of 2,4-disubstituted 1,2,3-triazoles was developed. A DABCO-promoted aza-Michael addition of 4-aryl NH-1,2,3-triazoles to ¦Á,¦Â-unsaturated ketones (chalcones) is presented. The reactions proceeded with complete regiospecificity in a 3:1 mixture of acetonitrile and methanol at 85¡ã to provide 2,4-disubstituted 1,2,3-triazoles as Michael adducts, and the addition products 1,3-diaryl-(4-aryl-2 H-1,2,3-triazol-2-yl)propan-1-ones were isolated in high yields.

Synlett published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, Synthetic Route of 4230-93-7.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Tsirigotis-Maniecka, Marta published the artcileThe polyphenolic-polysaccharide complex of Agrimonia eupatoria L. as an indirect thrombin inhibitor – isolation and chemical characterization, Category: catalysis-chemistry, the publication is International Journal of Biological Macromolecules (2019), 124-132, database is CAplus and MEDLINE.

The polyphenolic-polysaccharide complex was isolated from the dried aerial parts of the medicinal plant Agrimonia eupatoria L. using a multi-step process involving the degreasing of the plant material by extraction with organic solvents, followed by extraction with hot alkali, neutralization, further separation with organic solvents and dialysis. The complex was homogeneous with a mol. weight of about 55 ¡Á 103 g/mol and consisted mainly of carbohydrates and polyphenols matrix, composed of lignin-related units, with the dominance of dimethoxyphenyl structures. The carbohydrate moiety consists mostly of arabinogalactan associated with highly esterified rhamnogalacturonan. In vitro anticoagulant studies revealed the ability of the A. eupatoria complex to inhibit plasma clot formation, mainly in the intrinsic pathway of the blood coagulation cascade. Further studies on the mechanisms of this anticoagulant activity revealed that the isolate was primarily an indirect inhibitor of thrombin, mediated by antithrombin or by heparin cofactor II. Such mechanism of action is characteristic for highly sulfated glycosaminoglycans.

International Journal of Biological Macromolecules published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C7H5Cl2NO, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia