Category: 4230-93-7

Irshad Ahamed, J. published the artcileSynthesis and computational studies of 2-nitro-3-phenyl-3- (phenylthio)propan-1-ol and their derivatives, Name: 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, the publication is DJ Journal of Engineering Chemistry and Fuel (2017), 2(2), 9-24, database is CAplus.

Michael addition of thiols to nitro-olefins was performed in Lewis base DABCO (1,4-diazabicyclo[2.2.2]octane) with THF (THF) at room temperature 2-Nitro-3- phenyl-3-(phenylthio)propan-1-ols, compounds I [R = H, 4-Et, 3-Cl, etc.] were obtained at appreciable purity of compounds which was ascertained by m.p. and thin-layer chromatog. and was characterized by ¹H and ¹³C NMR. The synthesized compounds were subjected to mol. docking studies through com. software using Discovery Studio 4.0. Further the pharmacokinetics properties were studied by ADMET. DMol³ properties and B3LYP functions were also studied. Among the six derivative compound I [R = 4-Et] showed the higher docking energy of the score -88.1382 and promising mol. interaction against the target protein cytochrome P 450 17A1 (steroid 17 alpha – hydroxylase/17,20 lyase) which is primarily involved in the steroid biosynthesis pathway. Compounds I were explored against the target 3SWZ (CYP17A1). Compounds I [R = 4-Et] exhibited desirable pharmacokinetic and higher reactivity, hence could be proposed for further in-vitro anticancer activity.

DJ Journal of Engineering Chemistry and Fuel published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, Name: 1,2-Dimethoxy-4-(2-nitrovinyl)benzene.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Jadhav, Nikhil C. published the artcileDesign, synthesis and molecular docking study of novel pyrrole-based ¦Á-amylase and ¦Á-glucosidase inhibitors, Product Details of C10H11NO4, the publication is Medicinal Chemistry Research (2017), 26(10), 2675-2691, database is CAplus.

In an effort to design and synthesize a new class of ¦Á-glucosidase and ¦Á-amylase inhibitors, we have synthesized novel pyrrole based mols. using mol. hybridization approach. These novel analogs were synthesized by the novel methodol. developed in our lab which comprises of the multi-component direct synthesis route using hypervalent iodine reagent. The compounds were characterized by IR, ¹H NMR (NMR), ¹³C NMR and Mass Spectroscopy. These compounds were screened for their ¦Á-amylase and ¦Á- glucosidase activity. They showed a varying degree of inhibition with IC₅₀ values ranging between 0.4 to 4.14 ¦Ìmol/mL and 0.8 to 4.14 ¦Ìmol/mL for ¦Á-amylase and ¦Á-glucosidase resp. Compounds 3, 7, 12, and 18 showed excellent activity as compared to standard acarbose. This has identified a new class of ¦Á-amylase and ¦Á-glucosidase inhibitor which can be further developed as antihyperglycemic agents. The mol. docking anal. was carried out to better understand of interaction between ¦Á-amylase and ¦Á-glucosidase target and inhibitors in this series. We also generated a homol. model for human ¦Á-glucosidase enzyme and identified the key residues at the binding site. The outcome of the study could be used for the rational design of potent and selective ¦Á-amylase and ¦Á-glucosidase inhibitors, resp.

Medicinal Chemistry Research published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, Product Details of C10H11NO4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Reis, Joana published the artcileExploring nitrostyrene as a scaffold for a new class a of monoamine oxidase inhibitors, Related Products of catalysis-chemistry, the publication is Letters in Drug Design & Discovery (2012), 9(10), 958-961, database is CAplus.

To find the structural features that are relevant for MAO inhibitory activity and selectivity towards MAO-B isoform, a series of compounds encompassing a ¦Â-nitrostyrene moiety was designed and the in vitro inhibitory activity was evaluated. The synthesis and pharmacol. evaluation of a series of functionalized derivatives of ¦Â-methyl-¦Â-nitrostyrene with distinct substitution patterns in the Ph ring, namely HO, MeO, PhCH₂O, and H₂CO₂ was reported. All the studied compounds were substituted in meta and para positions of the Ph ring related to the nitrovinyl side-chain. The synthesized compounds were evaluated for activity towards both human MAO isoforms, and some of them displayed activities in the low micromolar range. Particularly a methylenedioxy derivative exhibited high potency and selectivity towards MAO-B.

Letters in Drug Design & Discovery published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Naganaboina, Ram Tilak published the artcileTrifluoroacetic acid-promoted Michael addition-cyclization reactions of vinylogous carbamates, Formula: C10H11NO4, the publication is Organic & Biomolecular Chemistry (2014), 12(21), 3366-3370, database is CAplus and MEDLINE.

A simple and efficient methodol. was developed for the synthesis of pyrrolobenzoxazine and 3-arylamino coumarin derivatives promoted by trifluoroacetic acid. The initial step in the current protocol involves a Michael addition of the 1,4-benzoxazinone derivatives, a novel class of vinylogous carbamates to the Michael acceptors and subsequent cyclization.

Organic & Biomolecular Chemistry published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, Formula: C10H11NO4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Shanbhag, Pramod published the artcileRauhut-Currier type homo- and heterocouplings involving nitroalkenes and nitrodienes, HPLC of Formula: 4230-93-7, the publication is Organic & Biomolecular Chemistry (2010), 8(21), 4867-4873, database is CAplus and MEDLINE.

Reaction of nitroalkenes R¹CH:CHNO₂ (R¹ = 2-furyl, 2-thienyl, Ph, etc.) or nitrodienes, e.g. R²CH:CHCH:CHNO₂ (R² = Ph, 2-furyl, etc.), with Me vinyl ketone or acrylate in the presence of the imidazole-LiCl catalyst system provides Rauhut-Currier (vinylogous Morita-Baylis-Hillman) adducts R¹CH:CH(NO₂)CH₂CH₂COX (X = Me, EtO) or R²CH:CHCH:C(NO₂)CH₂CH₂COMe in moderate yields. Under similar conditions (imidazole-hydroquinone), nitroalkenes and nitrodienes undergo self-dimerization to afford the Rauhut-Currier adducts in varying yields. An alternative self-dimerization-nitro group elimination pathway in the presence of tricyclohexylphosphine was observed with heteroaromatic nitroalkenes. A synthetically useful one-pot two step transformation of Rauhut-Currier adducts of nitroalkenes with Me vinyl ketone to 2,3-disubstituted cyclopentenones is also described.

Organic & Biomolecular Chemistry published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C8H14O4, HPLC of Formula: 4230-93-7.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Paplal, Banoth published the artcileRegioselective synthesis of functionalized 1,2,3-triazoles via oxidative [3+2]-cycloaddition using Zn(OAc)₂ – ^tBuOOH or ZnO nanoparticle as catalyst system in aqueous medium, Synthetic Route of 4230-93-7, the publication is Catalysis Communications (2017), 115-120, database is CAplus.

The regioselective synthesis of functionalized pyrazole-1,2,3-triazoles is reported via oxidative [3 + 2]-cycloaddition reactions of azides with ¦Â-nitrostyrenes and chalcone derivatives using Zn(OAc)₂ – ^tBuOOH or ZnO nanoparticles as catalyst system in aqueous medium. The catalyst dependent product selectivity was observed with ¦Â-nitrostyrenes to give the triazoles with and without -NO₂ group Zn(OAc)₂ and ZnO nanoparticles. The chalcones gave the triazoles selectively as sole products with good regioselectivity. The resulting products were further converted into sulfonamides and oxazoles resp.

Catalysis Communications published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, Synthetic Route of 4230-93-7.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Ceban, Victor published the artcileThree-component diastereoselective cascade synthesis of thiohydantoins, Recommanded Product: 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, the publication is Tetrahedron Letters (2013), 54(52), 7183-7187, database is CAplus.

A new three-component cascade reaction for the synthesis of thiohydantoins is reported. The reaction between ¦Á-amino esters, nitrostyrenes, and aromatic isothiocyanates is efficiently promoted by organic bases to afford highly substituted thiohydantoins e. g., I in moderate to good yields and diastereoselectivities.

Tetrahedron Letters published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, Recommanded Product: 1,2-Dimethoxy-4-(2-nitrovinyl)benzene.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Sun, Hao published the artcileApproach to Vicinal t-Boc-amino Dibromides via Catalytic Aminobromination of Nitrostyrenes without Using Chromatography and Recrystallization, Application In Synthesis of 4230-93-7, the publication is Journal of Organic Chemistry (2013), 78(3), 1171-1175, database is CAplus and MEDLINE.

In the presence of tripotassium phosphate trihydrate, tert-Bu N,N-dibromocarbamate (prepared from tert-Bu carbamate) added regioselectively to ¦Â-nitrostyrenes RCH:CHNO₂ [R = Ph, 4-ClC₆H₄, 4-MeOC₆H₄, 2-ClC₆H₄, 4-MeC₆H₄, 4-F₃CC₆H₄, 4-NCC₆H₄, 2-naphthyl, 1-naphthyl, 2-PhCH₂OC₆H₄, 2,6-Cl₂C₆H₃, 3,4-Cl₂C₆H₃, 4-FC₆H₄, 4-BrC₆H₄, 3-FC₆H₄, 3-Br-4-MeOC₆H₃, 2-MeOC₆H₄, 3,4-(MeO)₂C₆H₃, 4-Me₃CC₆H₄] in 1,2-dichloroethane to give tert-Bu ¦Á-(dibromonitromethyl)benzylcarbamates RCH(NHBoc)C(NO₂)Br₂ [R = Ph, 4-ClC₆H₄, 4-MeOC₆H₄, 2-ClC₆H₄, 4-MeC₆H₄, 4-F₃CC₆H₄, 4-NCC₆H₄, 2-naphthyl, 1-naphthyl, 2-PhCH₂OC₆H₄, 2,6-Cl₂C₆H₃, 3,4-Cl₂C₆H₃, 4-FC₆H₄, 4-BrC₆H₄, 3-FC₆H₄, 3-Br-4-MeOC₆H₃, 2-MeOC₆H₄, 3,4-(MeO)₂C₆H₃, 4-Me₃CC₆H₄] in 82-99% yields. The solubility of the products allowed them to be isolated in pure form by extraction with hexanes rather than requiring chromatog. or recrystallization for purification

Journal of Organic Chemistry published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C15H14O, Application In Synthesis of 4230-93-7.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Reddy, Golipalli Ramana published the artcileUnusual Reactivity of Nitronates with an Aryl Alkyl Carbonate: Synthesis of ¦Á-Amino Esters, HPLC of Formula: 4230-93-7, the publication is Organic Letters (2014), 16(22), 5874-5877, database is CAplus and MEDLINE.

The monoanions of nitroalkanes are ambident nucleophiles that react with carbonate electrophiles through the oxygen atom. Products arising from reactivity at the carbon atom will yield ¦Á-nitro esters, which are precursors for ¦Á-amino esters. We demonstrate this in the reactions of nitroalkanes with benzyl Ph carbonate and DABCO where ¦Á-nitro esters are obtained instead of nitrile oxides. The products are readily reduced to ¦Á-amino esters. This pathway could be a safe alternative to the Strecker reaction.

Organic Letters published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, HPLC of Formula: 4230-93-7.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Adib, Mehdi published the artcileA novel synthesis of 3-aryl-2,6-dicyano-5-methylanilines via reaction between nitrostyrenes and malononitrile, COA of Formula: C10H11NO4, the publication is Synthesis (2010), 1526-1530, database is CAplus.

A novel and simple synthesis of 3-aryl-2,6-dicyano-5-methylanilines is described. Reactions between nitrostyrenes and excess malononitrile in the presence of sodium carbonate in 80% ethanol proceeded at room temperature to afford the aromatic products in good yields. A mechanism for the formation of the products is proposed.

Synthesis published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, COA of Formula: C10H11NO4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia