Category: 4230-93-7

Nageswara Rao, N. published the artcileMicrowave promoted catalyst-free benzylic C-H functionalization of methyl quinoline and Michael addition to beta-nitro styrene, Category: catalysis-chemistry, the publication is Tetrahedron Letters (2013), 54(10), 1315-1317, database is CAplus.

A catalyst-free aqueous mediated C-H activation of Me quinolines and addition to various ¦Â-nitro styrenes were executed under microwave irradiation providing 2-(2-aryl-3-nitropropyl)quinolines, e.g., I. Catalyst-free, additive free, simple workup, clean reaction conditions, easy isolation and environmentally benign medium are the best features of the present protocol.

Tetrahedron Letters published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Mallepalli, Raghu published the artcilePolyethylene glycol (PEG-400) as an efficient and recyclable reaction medium for catalyst-free benzyl C-H functionalization of methyl quinoline and Michael addition to beta-nitro styrene, Synthetic Route of 4230-93-7, the publication is Pharmacia Lettre (2013), 5(3), 201-205, database is CAplus.

Polyethylene glycol (PEG-400) was found to be an effective reaction medium for C-H activation of Me quinolines and additions to various ¦Â-nitro styrenes were executed in PEG-400 under mild reaction conditions. PEG-400 is a recyclable and eco-friendly solvent.

Pharmacia Lettre published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, Synthetic Route of 4230-93-7.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Lopez-Garcia, M. Angeles published the artcile1-alkoxyamino-2-nitroalkanes as key building blocks for a chemo- and diastereoselective synthesis of a new type of polyfunctionalized N-alkoxypiperidine, Application of 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, the publication is European Journal of Organic Chemistry (2010), 5482-5488, S5482/1-S5482/13, database is CAplus.

A highly efficient conversion of ¦Â-nitrostyrenes into a new kind of functionalized N-alkoxy-2-hydroxypiperidine, e.g. I, in two steps was developed, giving excellent yields and diastereoselectivity. The prepared compounds are the first examples of N-alkoxy-2-hydroxypiperidines. The synthetic approach involved the conjugate addition of alkoxyamines to ¦Â-nitrostyrenes, followed by Michael addition of the isolated nitro-alkoxyamines to ¦Á,¦Â-unsaturated carbonyl compounds, and intramol. addition of the alkoxyamino group to the carbonyl functionality of the (non-isolated) adducts. Although three stereogenic centers are formed, only one diastereoisomer was detected. This unprecedented sequence of reactions can also be performed in a one-pot fashion.

European Journal of Organic Chemistry published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, Application of 1,2-Dimethoxy-4-(2-nitrovinyl)benzene.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Kumar, Tarun published the artcileSynthesis of Aminophenanthrenes and Benzoquinolines via Hauser-Kraus Annulation of Sulfonyl Phthalide with Rauhut-Currier Adducts of Nitroalkenes, Formula: C10H11NO4, the publication is Organic Letters (2017), 19(16), 4283-4286, database is CAplus and MEDLINE.

The Hauser-Kraus reaction of sulfonyl phthalide with nitroalkene derivatives provides access to aminophenanthrenes, including phenanthrene-substituted amino acids and benzoquinolines. The intermediate quinones bearing a key ketoalkyl moiety undergoes facile intramol. enamine cyclization. Interestingly, enamines derived from primary and secondary amines undergo cyclization via C-centered nucleophilic attack to provide aminophenanthrenes I [R¹R² = (CH₂)₄, (CH₂)₂O(CH₂)₂, etc.; Ar = 4-FC₆H₄, 3-MeOC₆H₄, etc.] whereas those derived from ammonia undergo cyclization via N-centered nucleophilic attack leading to benzoquinolines II (Ar = 4-FC₆H₄, 4-MeOC₆H₄, Ph, etc.). A one-pot protocol for the direct transformation of phthalides and nitroalkene derivatives to aminophenanthrenes and benzoquinolines has also been developed.

Organic Letters published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, Formula: C10H11NO4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Karishma, Pidiyara published the artcileReducing-Agent-Free Convergent Synthesis of Hydroxyimino-Decorated Tetracyclic Fused Cinnolines via Rh^III-Catalyzed Annulation Using Nitroolefins, Recommanded Product: 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, the publication is Journal of Organic Chemistry (2021), 86(3), 2734-2747, database is CAplus and MEDLINE.

A mild Rh-catalyzed method was developed for the synthesis of hydroxyimino functionalized indazolo[1,2-a]cinnolines and phthalazino[2,3-a]cinnolines by reductive [4 + 2] annulation between 1-arylindazolones and 2-aryl-2,3-dihydrophthalazine-1,4-diones with varied nitroolefins. The targeted oxime decorated tetracyclic fused cinnolines were synthesized via sequential C-H activation/olefin insertion/reduction under reducing-agent-free conditions.

Journal of Organic Chemistry published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, Recommanded Product: 1,2-Dimethoxy-4-(2-nitrovinyl)benzene.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Qian, Wangke published the artcileDesign, synthesis, and pharmacological evaluation of novel tetrahydroprotoberberine derivatives: Selective inhibitors of dopamine D₁ receptor, Quality Control of 4230-93-7, the publication is Bioorganic & Medicinal Chemistry (2012), 20(15), 4862-4871, database is CAplus and MEDLINE.

A series of new tetrahydroprotoberberine (THPB) derivatives were designed, synthesized, and tested for their binding affinity towards dopamine (D₁ and D₂) and serotonin (5-HT_1A and 5-HT_2A) receptors. Many of the THPB compounds exhibited high binding affinity and activity at the dopamine D₁ receptor, as well as high selectivity for the D₁ receptor over the D₂, 5-HT_1A, and 5-HT_2A receptors. Among these, compound I exhibited a promising D₁ receptor binding affinity (K_i = 2.53 nM) and remarkable selectivity vs. D₂R (inhibition = 81.87%), 5-HT_1AR (inhibition = 61.70%), and 5-HT_2AR (inhibition = 24.96%). Compared with l-(S)-stepholidine (l-SPD) (D₁K_i = 6.23 nM, D₂K_i = 56.17 nM), compound I showed better binding affinity for the D₁ receptor (2.5-fold higher) and excellent D₂/D₁ selectivity. Functional assays found compounds II, III, and I are pure D₁ receptor antagonists. These results indicate that removing the C10 hydroxy group and introducing a methoxy group at C11 of the pharmacophore of l-SPD can reverse the function of THPB compounds at the D₁ receptor. These results are in accord with mol. docking studies.

Bioorganic & Medicinal Chemistry published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, Quality Control of 4230-93-7.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Lee, David Y. W. published the artcileAsymmetric total synthesis of tetrahydroprotoberberine derivatives and evaluation of their binding affinities at dopamine receptors, Recommanded Product: 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, the publication is Bioorganic & Medicinal Chemistry Letters (2017), 27(6), 1437-1440, database is CAplus and MEDLINE.

Cocaine addiction remains a serious challenge for clin. and medical research because there is no effective pharmacol. treatment. L-THP I, a natural product isolated from Corydalis yanhusuo W. T. Wang, is one of the most frequently used traditional herbs to treat drug addiction in China. Our laboratory first reported that its demethylated metabolites had high affinity at dopamine D1, D2, and D5 receptors. Here we report the chem. synthesis of these metabolites and other derivatives and their binding affinities at dopamine receptors. The synthesis of these bioactive metabolites will allow further in vivo study of their potential in treating cocaine addiction.

Bioorganic & Medicinal Chemistry Letters published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, Recommanded Product: 1,2-Dimethoxy-4-(2-nitrovinyl)benzene.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Song, Liping published the artcileFluorine-containing furan derivatives from the Michael addition of ethyl 4,4,4-trifluoro-3-oxobutanoate with ¦Â-nitrostyrenes, Product Details of C10H11NO4, the publication is Synlett (2010), 830-834, database is CAplus.

Et 4,4,4-trifluoro-3-oxobutanoate reacted with nitrostyrenes in the presence of Et₃N to afford Et 5-(hydroxyimino)-4-aryl-2-(trifluoromethyl)-2,5-dihydrofuran-3-carboxylates along with a small amount of Et 2-hydroxy-5-imino-4-aryl-2-(trifluoromethyl)-2,5-dihydrofuran-3-carboxylates, e.g., I. Treatment of Et 5-(hydroxyimino)-4-aryl-2-(trifluoromethyl)-2,5-dihydrofuran-3-carboxylates with 1.2 equiv of TsOH in t-BuOH, afforded Et 2-hydroxy-5-imino-4-aryl-2-(trifluoromethyl)-2,5-dihydrofuran-3-carboxylates in good yields. However, Et 2-ethoxy or 2-methoxy-5-oxo-4-aryl-2-(trifluoromethyl)-2,5-dihydrofuran-3-carboxylates were obtained as major products in EtOH or MeOH along with a small amount of Et 2-hydroxy-5-imino-4-aryl-2-(trifluoromethyl)-2,5-dihydrofuran-3-carboxylates.

Synlett published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C14H31NO2, Product Details of C10H11NO4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Li, Jiu-ling published the artcilePalladium(II)-catalyzed C-C and C-O bond formation for the synthesis of C₁-benzoyl isoquinolines from isoquinoline N-oxides and nitroalkenes, Computed Properties of 4230-93-7, the publication is Chemical Communications (Cambridge, United Kingdom) (2016), 52(65), 10028-10031, database is CAplus and MEDLINE.

C₁-Benzoyl isoquinolines I [R = H, CH₃; R¹ = 6-CH₃, 5-Cl, 5-NO₂, etc.; R² = 4-H₃COC₆H₄, 4-(CH₃)₂CHC₆H₄, naphthalen-2-yl, etc.] can be generated via a palladium(II)-catalyzed C-C and C-O coupling of isoquinoline N-oxides II with aromatic nitroalkenes R²C=CHNO₂. The reaction proceeds through remote C-H bond activation and subsequent intramol. oxygen atom transfer (OAT). In this reaction, the N-O bond was designed as a directing group in the C-H bond activation as well as the source of an oxygen atom.

Chemical Communications (Cambridge, United Kingdom) published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, Computed Properties of 4230-93-7.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wu, Lei published the artcileOrganocatalytic asymmetric Michael reaction with acylsilane donors, Recommanded Product: 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, the publication is Organic & Biomolecular Chemistry (2013), 11(3), 443-447, database is CAplus and MEDLINE.

Authors have developed an organocatalytic asym. Michael reaction of acylsilane through the selection of acylsilane substrates and organocatalysts, thus creating a rare example of acylsilane ¦Á-alkylation with a chiral guanidine catalyst, which afforded products in good yields and high stereoselectivity. The corresponding adducts described here have also been demonstrated to be useful in the synthesis of unnatural amino acids and biol. active compounds

Organic & Biomolecular Chemistry published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C18H24N6O6S4, Recommanded Product: 1,2-Dimethoxy-4-(2-nitrovinyl)benzene.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia