Category: 4230-93-7

Thangaraj, Baskaran published the artcileDiaminosilane-functionalized on silicate-stabilised hydrotalcite (MA-HTSi-DA): As potential catalyst for nitro-aldol condensation, Name: 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, the publication is Journal of Molecular Catalysis A: Chemical (2015), 11-18, database is CAplus.

Diaminosilane was introduced into silicate-anion-intercalated hydrotalcite (HT-Si) using a post-synthesis method. The resulting functionalized materials possess surface basicity. The textural properties of the functionalized materials were systematically investigated through powder XRD, FTIR and MAS-NMR studies. The diamine-functionalized materials showed very good catalytic activity for the nitro-aldol condensation of benzaldehyde and nitromethane under solvent-free conditions. The materials showed comparable catalytic activity upon recycling.

Journal of Molecular Catalysis A: Chemical published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C30H24BrCuN2P, Name: 1,2-Dimethoxy-4-(2-nitrovinyl)benzene.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zhang, Zhiguo published the artcileEnantioselective synthesis of 2-aryl-3-nitro-2H-chromenes catalyzed by a bifunctional thiourea, Formula: C10H11NO4, the publication is Synlett (2011), 1262-1264, database is CAplus.

A bifunctional thiourea-catalyzed tandem approach of oxa-Michael-aza-Henry-desulfonamidation was used to synthesize chiral 2-aryl-3-nitro-2H-chromenes. This method provides direct access to the corresponding products in moderate to good yields and enantioselectivities.

Synlett published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C15H12O6, Formula: C10H11NO4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Du, Manfei published the artcileRegiospecific amino bromine addition of ¦Â-nitrostyrene derivatives with acrylamide and N-bromobutanimide, Related Products of catalysis-chemistry, the publication is Gaodeng Xuexiao Huaxue Xuebao (2016), 37(5), 902-911, database is CAplus.

A new protocol for the high regioselective aminobromination of ¦Â-nitrostyrene derivatives with acrylamide and N-Bromobutanimide (NBS) as nitrogen/bromine sources was developed. ¦Â-Nitrostyrene derivatives reacted with acrylamide and NBS promoted by CH₃CH₂ONa at room temperature (without the protection of an inert gaseous atm.) in CH₂Cl₂, offered vicinal haloamine products in good yields (up to 83%). For the ¦Â-methyl-¦Â-nitrostyrene, the good yields (up to 98%) were also achieved in CH₃OH promoted by Na₂CO₃. Although the strong electron-donating substituents (e.g., OCH₃) on the 4-position of benzene ring could deactivated the reaction activity of ¦Â-nitrostyrene derivatives, the vicinal haloamines were also afforded as the sole addition product. Whereas strong electron-withdrawing substituents (e.g., NO₂) could activated reaction activity remarkably and the vicinal haloamines were afforded as the sole addition product, too. The result revealed that the addition reaction had a nucleophilic addition feature. The aminobromination of 25 examples of ¦Â-nitrostyrenes were investigated and the structure of all products were confirmed by the corresponding NMR (NMR) spectra and high resolution mass spectrometer (HRMS). A possible mechanism involving a nucleophilic conjugate addition was proposed.

Gaodeng Xuexiao Huaxue Xuebao published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Weng, Jian-Quan published the artcileEnantioselective Friedel-Crafts Alkylation Reactions of 3-Substituted Indoles with Electron-Deficient Alkenes, Synthetic Route of 4230-93-7, the publication is Journal of Organic Chemistry (2016), 81(7), 3023-3030, database is CAplus and MEDLINE.

Highly enantioselective Friedel-Crafts C2-alkylation reactions of 3-substituted indoles with ¦Á,¦Â-unsaturated esters and nitroalkenes were developed using chiral Lewis acids as catalysts, which afforded chiral indole derivatives bearing C2-benzylic stereogenic centers in good to excellent yields (up to 99%) and enantioselectivities (up to 96% ee).

Journal of Organic Chemistry published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H10CoF6P, Synthetic Route of 4230-93-7.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Lobe, Maloba M. M. published the artcile3′,4′-Dihydro-2’H-spiro[indoline-3,1′-isoquinolin]-2-ones as potential anti-cancer agents: synthesis and preliminary screening, Safety of 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, the publication is Royal Society Open Science (2020), 7(1), 191316, database is CAplus and MEDLINE.

In the present study, 3′,4′-dihydro-2’H-spiro[indoline-3,1′-isoquinolin]-2-ones, designed as mol. hybrids of THIQ and OX, were synthesized and screened in-vitro against 59 cell lines in the NCI-60 screen. Twenty compounds displayed weak to moderate inhibition of cell proliferation; among them, three compounds displayed at least 50% inhibition of cell proliferation. The compounds appeared to target primarily renal cell cancer lines; however, leukemia, melanoma, non-small cell lung cancer, prostate, ovarian and even breast cancer cell lines were also affected. Therefore, this class of spirooxindoles may provide useful leads in the search for new anti-cancer agents.

Royal Society Open Science published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, Safety of 1,2-Dimethoxy-4-(2-nitrovinyl)benzene.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Yang, Wen published the artcileChiral Squaramide-Catalyzed Highly Enantioselective Michael Addition of 2-Hydroxy-1,4-naphthoquinones to Nitroalkenes, Product Details of C10H11NO4, the publication is Advanced Synthesis & Catalysis (2011), 353(8), 1241-1246, database is CAplus.

A chiral squaramide-organocatalyzed, highly enantioselective Michael addition of 2-hydroxy-1,4-naphthoquinones to nitroalkenes has been developed. This reaction afforded the chiral naphthoquinones in excellent yields (up to 99%) and excellent enantioselectivity (up to 98% ee) under very low catalyst loading (0.25 mol%). This organocatalytic asym. Michael addition provides an efficient alternative route toward the synthesis of chiral functionalized naphthoquinones.

Advanced Synthesis & Catalysis published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C18H17NO8, Product Details of C10H11NO4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Yang, Wen published the artcileChiral squaramide-catalyzed highly diastereo- and enantioselective direct Michael addition of nitroalkanes to nitroalkenes, Safety of 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, the publication is Chemical Communications (Cambridge, United Kingdom) (2011), 47(47), 12706-12708, database is CAplus and MEDLINE.

An efficient highly diastereo- and enantioselective direct Michael addition of nitroalkanes to nitroalkenes catalyzed by chiral squaramide catalyst has been developed. This organocatalytic reaction with a low catalyst loading (2 mol%) proceeded well to afford synthetically useful 1,3-dinitro compounds in high yields with high diastereoselectivities (up to 95:5 dr) and excellent enantioselectivities (up to 97% ee).

Chemical Communications (Cambridge, United Kingdom) published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C3H6BrNaO3S, Safety of 1,2-Dimethoxy-4-(2-nitrovinyl)benzene.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Karki, Bhupal S. published the artcileVisible Light-Induced, Metal-Free Denitrative [3+2] Cycloaddition for Trisubstituted Pyrrole Synthesis, Application In Synthesis of 4230-93-7, the publication is Chemistry – An Asian Journal (2019), 14(24), 4793-4797, database is CAplus and MEDLINE.

A metal-free, regioselective synthesis of trisubstituted pyrroles has been developed through a formal [3+2] cycloaddition reaction between 2H-azirines and nitroalkenes under visible light/photoredox-catalyzed conditions. The reaction proceeds through 2H-azaallenyl radical addition on ¦Â-nitrostyrenes in a Michael fashion followed by a base-mediated denitration reaction. The directive group influence of the nitro group controls the regiochem. of the reaction.

Chemistry – An Asian Journal published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, Application In Synthesis of 4230-93-7.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Neves, Bruno J. published the artcileDiscovery of New Anti-Schistosomal Hits by Integration of QSAR-Based Virtual Screening and High Content Screening, Safety of 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, the publication is Journal of Medicinal Chemistry (2016), 59(15), 7075-7088, database is CAplus and MEDLINE.

Schistosomiasis is a debilitating neglected tropical disease, caused by flatworms of Schistosoma genus. The treatment relies on a single drug, praziquantel (PZQ), making the discovery of new compounds extremely urgent. In this work, we integrated QSAR-based virtual screening (VS) of Schistosoma mansoni thioredoxin glutathione reductase (SmTGR) inhibitors and high content screening (HCS) aiming to discover new antischistosomal agents. Initially, binary QSAR models for inhibition of SmTGR were developed and validated using the Organization for Economic Co-operation and Development (OECD) guidance. Using these models, we prioritized 29 compounds for further testing in two HCS platforms based on image anal. of assay plates. Among them, 2-[2-(3-methyl-4-nitro-5-isoxazolyl)vinyl]pyridine and 2-(benzylsulfonyl)-1,3-benzothiazole, two compounds representing new chem. scaffolds have activity against schistosomula and adult worms at low micromolar concentrations and therefore represent promising antischistosomal hits for further hit-to-lead optimization.

Journal of Medicinal Chemistry published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, Safety of 1,2-Dimethoxy-4-(2-nitrovinyl)benzene.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Liao, Yu-Hua published the artcileOrganocatalytic asymmetric Michael addition of pyrazolin-5-ones to nitroolefins with bifunctional thiourea: stereocontrolled construction of contiguous quaternary and tertiary stereocenters, Related Products of catalysis-chemistry, the publication is Advanced Synthesis & Catalysis (2010), 352(5), 827-832, database is CAplus.

The first organocatalytic diastereo- and enantioselective Michael addition reaction of 4-substituted-pyrazolin-5-ones to nitroolefins was developed with a chiral bifunctional thiourea as organocatalyst. A wide variety of desired multi-substituted pyrazolin-5-one derivatives, e.g., I, with contiguous quaternary and tertiary stereocenters were smoothly obtained in good yields (up to 98%) with excellent enantioselectivities (up to >99% ee) and acceptable diastereoselectivities (up to 80:20). This exptl. simple process facilitated the access to various enantioenriched, multiply substituted pyrazolin-5-one derivatives, potential biol. active mols., starting from readily available starting materials.

Advanced Synthesis & Catalysis published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia