Category: 6084-58-8

Bargigia, Gianangelo published the artcileSynthesis of O-substituted hydroxylamines (RONH₂) from alcohols and isohydroxylamine monosulfonic acid, Safety of O-Isobutylhydroxylamine hydrochloride, the publication is Atti della Accademia Nazionale dei Lincei, Classe di Scienze Fisiche, Matematiche e Naturali, Rendiconti (1965), 39(1-2), 83-6, database is CAplus.

The process already described for the synthesis of RON₂ (CA 62, 8649h) was, studied in regard to several side and concomitant products. The alcs. used were Et, Pr, Bu, iso-Bu, sec-Bu, and benzyl alcs., and the products prepared were RONH₂ with R = EtO; PrO; iso-PrO; BuO; iso-BuO, sec-BuO, PhCH₂O. In each case, 12.5 g. dry H₂NOSO₃Na was suspended into 30 cc. absolute alc. and a cold solution of 3.2 g. Na in 40 cc. absolute alc. was added. The reaction mixture grew warm spontaneously after 15 min. under agitation until boiling occurred. After a 12-h. rest, the solid residue was removed and the salts were precipitated by acidification with concentrated HCl; the hydroxylamine-HCl was isolated in 27-49% yields by concentration to a small volume, filtration, and precipitation with ether. The purity of the products was controlled by gas chromatog.

Atti della Accademia Nazionale dei Lincei, Classe di Scienze Fisiche, Matematiche e Naturali, Rendiconti published new progress about 6084-58-8. 6084-58-8 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is O-Isobutylhydroxylamine hydrochloride, and the molecular formula is C4H12ClNO, Safety of O-Isobutylhydroxylamine hydrochloride.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Dandu, Reddeppareddy published the artcileDesign and synthesis of dihydroindazolo[5,4-a]pyrrolo[3,4-c]carbazole oximes as potent dual inhibitors of TIE-2 and VEGF-R2 receptor tyrosine kinases, Recommanded Product: O-Isobutylhydroxylamine hydrochloride, the publication is Bioorganic & Medicinal Chemistry Letters (2008), 18(6), 1916-1921, database is CAplus and MEDLINE.

Fused dihydroindazolopyrrolocarbazole oximes have been identified as low nanomolar, potent dual TIE-2 and VEGF-R2 receptor tyrosine kinase inhibitors with excellent cellular potency. Development of the structure-activity relationships (SAR) led to identification of compounds I and II as potent, selective dual TIE-2/VEGF-R2 inhibitors with favorable pharmacokinetic properties. Compound I was orally active in tumor models with no observed toxicity.

Bioorganic & Medicinal Chemistry Letters published new progress about 6084-58-8. 6084-58-8 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is O-Isobutylhydroxylamine hydrochloride, and the molecular formula is C4H12ClNO, Recommanded Product: O-Isobutylhydroxylamine hydrochloride.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wu, Yong-Jin published the artcileSynthesis and SAR of hydroxyethylamine based phenylcarboxyamides as inhibitors of BACE, Related Products of catalysis-chemistry, the publication is Bioorganic & Medicinal Chemistry Letters (2009), 19(10), 2654-2660, database is CAplus and MEDLINE.

A series of N-((2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-(3-methoxybenzylamino)-butan-2-yl)benzamides, i.e. I, has been synthesized as BACE inhibitors. A variety of P2 and P3 substituents has been explored, and these efforts have culminated in the identification of several 1,3,5-trisubstituted phenylcarboxyamides with potent BACE inhibitory activity.

Bioorganic & Medicinal Chemistry Letters published new progress about 6084-58-8. 6084-58-8 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is O-Isobutylhydroxylamine hydrochloride, and the molecular formula is C25H23NO4, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Xiao, Yan-shuang published the artcileDesign, synthesis and fungicidal activity of 11-alkoxyimino-5,6-dihydro-dibenzo[b,e] azepine-6-one derivatives, HPLC of Formula: 6084-58-8, the publication is Pest Management Science (2013), 69(7), 814-826, database is CAplus and MEDLINE.

Background: Macrocyclic compounds with an oxime ether side chain are known to show good fungicidal activity. However, the long synthetic route makes the cost too high for them to be developed further as practical fungicides. Alternative compounds with good fungicidal activity and an easier synthesis than these macrolactams were sought, and a series of 11-alkoxyimino-5,6-dihydro-dibenzo[b,e]azepine-6-one derivatives (I; R = alkyl, etc.; X = H, Cl, Br, or I) were designed and bioassayed. Results: The structures were confirmed by ¹H NMR, ¹³C NMR and LC-MS. The bioassay showed that about half of the 11-alkoxyimino-5,6-dihydro-dibenzo[b,e]azepine-6-one derivatives displayed good fungicidal activity against Sclerotinia sclerotiorum, with EC₅₀ values <15 ¦Ìg mL^-1. 11-(N-Butyloxyimino)-5,6-dihydro-dibenzo[b,e]azepine-6-one, 11-(4-nitrobenzyloxyimino)-5,6-dihydro-dibenzo[b,e]azepine-6-one, and 11-(2-chloro-6-fluorobenzyloxyimino)-5,6-dihydro-dibenzo[b,e]azepine-6-one displayed excellent fungicidal activity, with EC₅₀ values of <2.5 ¦Ìg mL^-1, much better than the com. fungicide chlorothalonil with an EC₅₀ value of 7.16 ¦Ìg mL^-1. In addition, about half of the 11-alkoxyimino-5,6-dihydro-dibenzo[b,e]azepine-6-one derivatives had good fungicidal activity against Botrytis cinerea, with EC₅₀ values of <10 ¦Ìg mL^-1. 11-(2-Fluorobenzyloxyimino)-5,6-dihydro-dibenzo[b,e]azepine-6-one, 11-(3-fluorobenzyloxyimino)-5,6-dihydro-dibenzo[b,e]azepine-6-one, and 11-(2-chloro-6-fluorobenzyloxyimino)-5,6-dihydro-dibenzo[b,e]azepine-6-one displayed excellent fungicidal activity, with EC₅₀ values of 3.73, 2.54 and 3.20 ¦Ìg mL^-1 resp., comparable with the com. fungicide procymidone with an EC₅₀ value of 2.45 ¦Ìg mL^-1. Their structure-activity relationship is discussed. ? 2013 Society of Chem. Industry.

Pest Management Science published new progress about 6084-58-8. 6084-58-8 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is O-Isobutylhydroxylamine hydrochloride, and the molecular formula is C13H18BClO3, HPLC of Formula: 6084-58-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Xiao, Yanshuang published the artcileSynthesis and fungicidal activity of 4-alkyloxyiminohexanolactone derivatives, Name: O-Isobutylhydroxylamine hydrochloride, the publication is Nongyaoxue Xuebao (2009), 11(1), 55-58, database is CAplus.

The title compounds [i.e., 4-[(alkoxy)imino]hexanolactone derivatives] were obtained by a reaction of cyclohexanedione, formation of 2,5-oxepanedione and subsequent oximation and the product structures were confirmed by NMR and elemental anal., MS. A preliminary bioassay indicated that some compounds possess fungicidal activity against Phytophthora parasitica (Phytophthora nicotianae), Rhizoctonia solani, Botrytis cinerea, Sclerotinia sclerotiorum (Whetzelinia sclerotiorum), Puccinia asparagi.

Nongyaoxue Xuebao published new progress about 6084-58-8. 6084-58-8 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is O-Isobutylhydroxylamine hydrochloride, and the molecular formula is C14H31NO2, Name: O-Isobutylhydroxylamine hydrochloride.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Mott, Bryan T. published the artcileSynthesis and Antimalarial Efficacy of Two-Carbon-Linked, Artemisinin-Derived Trioxane Dimers in Combination with Known Antimalarial Drugs, Synthetic Route of 6084-58-8, the publication is Journal of Medicinal Chemistry (2013), 56(6), 2630-2641, database is CAplus and MEDLINE.

Malaria continues to be a difficult disease to eradicate largely because of the widespread populations it affects and the resistance that malaria parasites have developed against once very potent therapies. The natural product artemisinin has been a boon for antimalarial chemotherapy, as artemisinin combination therapy (ACT) has become the first line of chemotherapy. Because the threat of resistance is always on the horizon, it is imperative to continually identify new treatments, comprising both advanced analogs of all antimalarial drugs, especially artemisinin, and the exploration of novel combinations, ideally with distinct mechanisms of action. Here we report for the first time the synthesis of a series of two-carbon-linked artemisinin-derived dimers (I and oxime derivatives), their unique structural features, and demonstration of their antimalarial efficacy via single oral dose administration in two 60-day survival studies of Plasmodium berghei infected mice. Several of the new endoperoxide chem. entities consistently demonstrated excellent antimalarial efficacy, and combinations with two non-peroxide antimalarial drugs have been studied.

Journal of Medicinal Chemistry published new progress about 6084-58-8. 6084-58-8 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is O-Isobutylhydroxylamine hydrochloride, and the molecular formula is C4H12ClNO, Synthetic Route of 6084-58-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Futamura-Takahashi, Junko published the artcileStructure-based design, synthesis, and binding mode analysis of novel and potent chymase inhibitors, Name: O-Isobutylhydroxylamine hydrochloride, the publication is Bioorganic & Medicinal Chemistry Letters (2018), 28(2), 188-192, database is CAplus and MEDLINE.

Based on insight from the x-ray crystal structure of human chymase in complex with compound 1, a lactam carbonyl of the diazepane core was exchanged with O-substituted oxyimino group, leading to amidoxime derivatives This modification resulted in highly potent chymase inhibitors, such as O-phenylamidoxime I. X-ray crystal structure anal. indicated that compound I induced movement of the Leu99 and Tyr94 side chains at the S2 site, and the increase in inhibitory activity of O-Ph amidoxime derivatives suggested that the O-Ph moiety interacted with the Tyr94 residue. Surface plasmon resonance experiments showed that compound I had slower association and dissociation kinetics and the calculated residence time of compound I to human chymase was extended compared to that of amide compound 1.

Bioorganic & Medicinal Chemistry Letters published new progress about 6084-58-8. 6084-58-8 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is O-Isobutylhydroxylamine hydrochloride, and the molecular formula is C4H12ClNO, Name: O-Isobutylhydroxylamine hydrochloride.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Mangion, Ian published the artcileDynamic kinetic asymmetric allylation of hydrazines and hydroxylamines, Synthetic Route of 6084-58-8, the publication is Organic Letters (2009), 11(15), 3258-3260, database is CAplus and MEDLINE.

Hydrazines and hydroxylamines have been found to be excellent nucleophiles for the palladium-catalyzed dynamic asym. allylic amination of vinyl epoxide, with good yields and enantioselectivities of up to 97% ee. This method is applicable to acyclic and heterocyclic amines and was applied toward a five-step synthesis of (R)-piperazic acid.

Organic Letters published new progress about 6084-58-8. 6084-58-8 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is O-Isobutylhydroxylamine hydrochloride, and the molecular formula is C4H12ClNO, Synthetic Route of 6084-58-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Cao, Xiaosong published the artcileTandem Functionalization in a Highly Branched Polymer with Layered Structure, Category: catalysis-chemistry, the publication is Chemistry – A European Journal (2018), 24(22), 5974-5981, database is CAplus and MEDLINE.

A hyperbranched polymer with multilayer structure was developed to demonstrate the possibility of highly efficient tandem functionalization reactions at different domains within one nanostructured platform. The polymer scaffold was constructed by chain-growth copper-catalyzed azide-alkyne cycloaddition polymerization of three functional monomers with sequential monomer addition in one pot. Subsequent reactions with different monomer units resulted in efficient functionalization of each segment with construction of a highly sophisticated polymer structure by a robust procedure. As a proof of concept, the ability of this polymer structure to quant. load six species of guest mols. through three different types of conjugation reactions was demonstrated.

Chemistry – A European Journal published new progress about 6084-58-8. 6084-58-8 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is O-Isobutylhydroxylamine hydrochloride, and the molecular formula is C4H12ClNO, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Khomutov, R. M. published the artcileHydroxylamine derivatives. IX. Synthesis of some O-substituted hydroxylamines, Computed Properties of 6084-58-8, the publication is Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya (1967), 1820-3, database is CAplus.

Saturation of 150 g. dry MeCN in 170 ml. EtOH with HCl at 0-5¡ã and keeping 2 days in the cold gave a precipitate of Et acetimidoacetate-HCl, which was separated and treated with aqueous NaOH at -10¡ã, then with 275 g. NH2OH.HCl in C6H6-H2O and stirred 1 hr. at room temperature to yield 45-50% MeC(:NOH)OEt (I), m. 32¡ã, b12 62¡ã. I was converted to the Na salt by MeONa in MeOH and treated with an alkyl halide to give the following MeC(:NOR)OEt (II): (R, % yield, b.p., and n20D given): Et, 70, b55 60¡ã, 1.4141; iso-Pr 84, 134-6¡ã, 1.4155; iso-Bu, 81, 160¡ã, 1.4240; MeSCH2CH2, 34, b7 85-7¡ã, -; PhCH2, 75, b12 122¡ã, 1.5030. II in Et2O was treated with 1 mole H2O and HCl in Et2O to yield on standing the following RONH2.Hcl (R and m.p. given): Et, 128¡ã; iso-Pr, 85-6.5¡ã; iso-Bu 129.5-30.5¡ã; MeSCH2CH2, 96¡ã (decomposition); PhCH2, 224-6¡ã (free base b3 64-4.5¡ã). BrCH2CO2K (0.32 mole) in H2O treated with 0.32 mole KOH and 0.32 mole I 0.5 hr. at 35¡ã, then diluted at -10¡ã with (CH2Cl)2 and acidifying with HCl, then evaporating in vacuo, gave a residue that on reevapn. with HCl gave 65-70% aminoxyacetic acid-HCl, m. 150-1¡ã (iso-PrOH); heating with EtOH-HCl gave the Et ester HCl salt, m. 115-16¡ã, while heating with benzyl alc. in the presence of p-MeC6H4SO3H in C6H6 gave, after azeotropic removal of H2O, 77% benzyl aminoxyacetate, m. 135-7¡ã. Heating Me N-(ethylidenethoxy)aminoxypropionate in concentrated HCl 2.5 hrs. gave on evaporation 80% free acid-HCl, m. 151¡ã, which with benzyl alc. as above gave the benzyl ester of ¦Â-aminoxypropionic acid, m. 112-14¡ã. I and CF2:CFCl kept in an autoclave with alc. EtONa several days gave 85% MeC(OEt):NOCF2CHFCl, b12 61-2.5¡ã. CCl3CH2OH and ClNH2 in the presence of EtONa in Et2O at -10¡ã, then at room temperature 1 day, gave CCl3CH2ONH2.HCl, m. 196-7¡ã (iso-PrOH), after saturation of the crude product with dry HCl in Et2O.

Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya published new progress about 6084-58-8. 6084-58-8 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is O-Isobutylhydroxylamine hydrochloride, and the molecular formula is C4H12ClNO, Computed Properties of 6084-58-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia