Category: 6084-58-8

Xu, Guozhang published the artcileDiscovery of novel 4-amino-6-arylaminopyrimidine-5-carbaldehyde oximes as dual inhibitors of EGFR and ErbB-2 protein tyrosine kinases, Recommanded Product: O-Isobutylhydroxylamine hydrochloride, the publication is Bioorganic & Medicinal Chemistry Letters (2008), 18(12), 3495-3499, database is CAplus and MEDLINE.

We herein disclose a novel series of 4-aminopyrimidine-5-carboxaldehyde oximes that are potent and selective inhibitors of both EGFR and ErbB-2 tyrosine kinases, with IC₅₀ values in the nanomolar range. Structure-activity relationship (SAR) studies elucidated a critical role for the 4-amino and C-6 arylamino moieties. The X-ray co-crystal structure of EGFR with a (fluorobenzylindazolylamino)aminopyrimidine carboxaldehyde O-(2-methoxyethyl) oxime was determined and validated our design rationale.

Bioorganic & Medicinal Chemistry Letters published new progress about 6084-58-8. 6084-58-8 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is O-Isobutylhydroxylamine hydrochloride, and the molecular formula is Al2H32O28S3, Recommanded Product: O-Isobutylhydroxylamine hydrochloride.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Murafuji, Hidenobu published the artcileDiscovery and structure-activity relationship study of 1,3,6-trisubstituted 1,4-diazepane-7-ones as novel human kallikrein 7 inhibitors, Application In Synthesis of 6084-58-8, the publication is Bioorganic & Medicinal Chemistry Letters (2017), 27(23), 5272-5276, database is CAplus and MEDLINE.

Compound I, composed of a 1,3,6-trisubstituted 1,4-diazepane-7-one, was discovered as a novel human kallikrein 7 (KLK7, stratum corneum chymotryptic enzyme, SCCE) inhibitor, and its derivatives were synthesized and evaluated. Structure-activity relationship studies of the amidoxime unit and benzoic acid part of this new scaffold led to the identification of compounds II (R = CO₂H and R = Ms), which were more potent than the hit compound, I. The X-ray co-crystal structure of compound II (R = CO₂H) and human KLK7 revealed the characteristic interactions and enabled explanations of the structure-activity relationship.

Bioorganic & Medicinal Chemistry Letters published new progress about 6084-58-8. 6084-58-8 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is O-Isobutylhydroxylamine hydrochloride, and the molecular formula is C4H12ClNO, Application In Synthesis of 6084-58-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Plate, Ralf published the artcileSynthesis, and in vitro and in vivo muscarinic pharmacological properties of a series of 1,6-dihydro-5-(4H)-pyrimidinone oximes, Recommanded Product: O-Isobutylhydroxylamine hydrochloride, the publication is Bioorganic & Medicinal Chemistry (1998), 6(9), 1403-1420, database is CAplus and MEDLINE.

A series of 1,6-dihydro-5-(4H)-pyrimidinone oximes I [R = alkyl, alkenyl, alkynyl, aralkyl] and some of the derived hydroxylamines were synthesized and tested for muscarinic activity in receptor binding assays using [³H]-oxotremorine-M (Oxo-M) and [³H]-pirenzepine (Pz) as ligands. Potential muscarinic agonistic or antagonistic properties of the compounds were determined using binding studies that measured their potencies to inhibit the binding of Oxo-M and Pz. Preferential inhibition of Oxo-M binding was used as an indicator for potential muscarinic agonistic properties; this potential was confirmed in functional studies on isolated organs. The series produced a wide range of active compounds with differing degrees of selectivity in M₁, M₂, and M₃ functional models. Several compounds that have mixed agonist/antagonist profiles were able to reduce cholinergic-related cognitive impairments in models of mnemonic function. Substitutions (I, e.g. R² or R³ = Me) at the 1,6-dihydro-5-(4H)pyrimidine ring disrupted binding and efficacy, whereas systematic variation of the oximes substituent R¹ resulted in various degrees of potency and selectivity dependent on the nature of the substitution.

Bioorganic & Medicinal Chemistry published new progress about 6084-58-8. 6084-58-8 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is O-Isobutylhydroxylamine hydrochloride, and the molecular formula is C4H12ClNO, Recommanded Product: O-Isobutylhydroxylamine hydrochloride.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Kim, Hyunwoo published the artcileA Facile Access to Primary Alkylamines and Anilines via Ir(III)-Catalyzed C-H Amination Using Azidoformates, Formula: C4H12ClNO, the publication is ACS Catalysis (2016), 6(9), 5922-5929, database is CAplus.

Described herein is the development of Ir(III)-catalyzed direct C-H amination using azidoformates as a readily deprotectable amino source. Substrates with unactivated Me C(sp³)-H and aromatic or olefinic C(sp²)-H bonds were smoothly reacted by the iridium-based catalyst system to provide the corresponding primary alkylamines and anilines upon the subsequent removal of N-protecting groups, such as Boc, Fmoc, Cbz, pNZ, or Troc. A brief mechanistic study and synthetic applications are also presented.

ACS Catalysis published new progress about 6084-58-8. 6084-58-8 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is O-Isobutylhydroxylamine hydrochloride, and the molecular formula is C4H12ClNO, Formula: C4H12ClNO.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Mamalis, P. published the artcileAmino?xy derivatives. II. Some derivatives of N-hydroxybiguanide, Category: catalysis-chemistry, the publication is Journal of the Chemical Society (1960), 229-38, database is CAplus.

The preparation of some amino?xyalkanes and their corresponding biguanides, together with certain arylmethyl analogs, was described. A summary of bacteriostatic activities was included. Benzohydroxamates (I) were prepared by reaction of Na benzohydroxamate with an alkyl or arylmethyl halide. The following new I were obtained (substituent and m.p. or b.p. given): hexyl, 138-40¡ã/0.3 mm.; 4-methylbenzyl, 107-8¡ã; 4-chlorobenzyl, 162¡ã; 4-bromobenzyl, 176¡ã; 2-nitrobenzyl, 121¡ã; 3,4-dichlorobenzyl, 134¡ã; cinnamyl, 118-20¡ã; 1-naphthylmethyl, 140¡ã; 2-naphthylmethyl, 131¡ã; 2-methyl-1-naphthylmethyl, 150¡ã; 1-bromo-2-naphthylmethyl, 144¡ã; 8-quinolylmethyl, 133-4¡ã; 6-chloro-8-(1,3-benzodioxanylmethyl), 131-2¡ã. The required arylmethyl bromides were prepared by side chain bromination of toluenes and methylnaphthalenes with N-bromosuccinimide (II) in CCl₄ in the presence of Bz₂O₂. 4-BrC₆H₄CH₂Br, 1-(bromomethyl)naphthalene, and 1-bromo-(2-bromomethyl)naphthalene did not appear to have been prepared by this method. Bromination of 2-methylnaphthalene with II afforded 2-(bromomethyl)naphthalene, m. 48¡ã; in one run a substance, m. 128¡ã, was also obtained in low yield and shown to be 1-(dibromomethyl)naphthalene, since with refluxing H₂O it yielded 2-naphthaldehyde, leaflets, m. 57-8¡ã; semicarbazone m. 245¡ã (Me₂CO). The following I were prepared with properties in agreement with those in the literature: Me, Et, allyl, Bu, PhCH₂, and 4-nitrobenzyl. Cinnamyl benzohydroxamate (1 g.) in 15 ml. alc. and 15 ml. EtOAc shaken 3 min. with H and 10% Pd-C gave 0.88 g. crude product and distillation at 120-40¡ã 33 ¡Á 10^-5 mm. gave 3-phenylpropyl benzohydroxamate, m. 45-6¡ã. Benzohydroxamic acid (6.9 g.) and 2 g. NaOH in 50 ml. alc. refluxed 4 hrs. with 9-(chloromethyl)phenanthrene yielded 2.1 g. N-benzoyl-O,N-bis(9-phenanthrylmethyl)hydroxylamine, m. 209-10¡ã (aqueous HCONMe₂). Addition of H₂O to the original mother liquors precipitated 8.6 g. 9-phenanthrylmethyl benzohydroxamate, m. 160-1¡ã (EtOAc). K salt of hydroxyurethan and the alkyl bromides yielded alkyloxyurethans (III), colorless oils or low melting solids, purified by distillation or crystallization: (alkyl group and b.p./mm. or m.p. given): allyl, 123¡ã/28; isobutyl, 55¡ã/0.2; pentyl, 76¡ã/0.08; hexyl, 86¡ã/0.35; heptyl, 93¡ã/0.3; octyl, 98¡ã/0.04; nonyl, 103-4¡ã/0.3; decyl, 112¡ã/0.05; undecyl, 130¡ã/0.3; 2-methyldecyl, 128¡ã/0.2; tetradecyl, 39-40¡ã; hexadecyl, 40.5-1.5¡ã; octadecyl, 45-6¡ã. N-Decyl-N-decyloxyurethan was isolated as a by-product from the reaction of hydroxyurethan with decyl bromide, b_0.1 154¡ã, n_D¹⁸ 1.4490. A mixture of 5.6 g. NH₂OH.HCl, 12.5 g. anhydrous Na₂CO₃, and 37 ml. H₂O added dropwise at 15-20¡ã to 13.4 g. benzyl chloroformate, the mixture stirred 4 hrs., acidified, and the liberated oil extracted with Et₂O yielded 10.2 g. N-benzyloxycarbonylhydroxylamine (IV), m. 68-9¡ã (Et₂O-ligroine). NaOH (0.96 g.) in 25 ml. alc. treated with 4 g. IV, the Na salt separated, after addition of 3.4 g. MeI the mixture refluxed 4 hrs., H₂O added, the oily product isolated with Et₂O, and the solvent removed gave 3.3 g. oil. The oil left overnight at room temperature with 10 ml. 20% solution HBr in AcOH, evaporated, and the residual solid crystallized from alc.-Et₂O gave 1.5 g. amino?xymethane-HBr, plates, m. 102¡ã. Me benzohydroxamate (3 g.), 15 ml. concentrated HCl, and 15 ml. H₂O refluxed 2 hrs., 2.1 g. BzOH collected, and the filtrate evaporated gave 1.4 g. amino?xy methane-HCl, plates, m. 148-9¡ã (EtOAc-alc.). Aminooxyethane-HCl obtained from III (allyl) crystallized as plates, m. 172-4¡ã. The above HCl salt (5.0 g.) in 50 ml. alc. shaken with H and 10% Pd-C gave 4.8 g. 1-amino?xypropane-HCl (V), m. 150-1¡ã (EtOAc). III (Pr) (11.5 g.) and 60 ml. 6% alc.-HCl refluxed 1 hr. gave 6.4 g. V. III (Pr) (11.1 g.) and 100 ml. 17% HCl refluxed 2 hrs. (black oil separated), cooled, extracted with Et₂O, the aqueous layer evaporated, and the residual solid triturated with EtOAc-alc. gave 2.35 g. NH₄Cl; the Et₂O layer extracted with aqueous NaHCO₃ gave 4.8 g. BzOH. Evaporation of the Et₂O layer gave 2.95 g. material which on hydrolysis gave 2 g. BzOH and a little low boiling oil. III (Bu) (17 g.) and 80 ml. 6% alc.-HCl refluxed 2 hrs. gave 7.8 g. 1-amino?xybutane-HCl, plates, m. 155-6¡ã (EtOAc-alc.). 1-Amino?xypentane-HCl was similarly prepared as plates, m. 148¡ã. Amino?xyisobutane-HCl was prepared by alk. hydrolysis of the urethan as leaflets, m. 134-5¡ã (EtOAc). Amino?xyhexane-HCl similarly prepared, m. 151¡ã. 1-Amino?xyheptane-HCl separated as leaflets, m. 151-2¡ã (EtOAc-alc.). 1-Amino?xyoctane-HCl formed as plates, m. 147-9¡ã. 1-Amino?xynonane-HCl failed to crystallize and the crude material was used for the preparation of the biguanide. 1-Amino?xydecane-HCl crystallized as plates, m. 145.5-6.5¡ã (EtOAc-alc.), the HBr salt as plates, m. 135-6¡ã; the hydrochloride (2.1 g.) 1.25 g. salicylaldehyde, 0.4 g. NaOH in 2 ml. H₂O, and 15 ml. alc. refluxed 1 hr. gave 1.9 g. 1-salicylideneamino?xydecane, lemon-yellow oil, b_0.3 132¡ã. 1-Furfurylideneamino?xydecane was similarly prepared as a yellow oil, b_0.08 114¡ã. 1-Aminooxyundecane-HCl crystallized similarly, m. 145-6¡ã. 1-Aminooxytetradecane-HCl separated as leaflets, m. 137-8¡ã. The base crystallized as leaflets, m. 68-70¡ã (EtOAc-ligroine). 1-Amino?xyhexadecane-HCl was obtained as leaflets, m. 133-4¡ã; free base, leaflets, m. 45-7¡ã (ligroine). 1-Aminooxyoctadecane crystallized as needles, m. 50-2¡ã. I (PhCH₂) (4.3 g.) and 30 ml. 6% alc.-HCl refluxed 20 min. gave 2.7 g. amino?xymethylbenzene-HCl, m. 230-2¡ã. Similar preparations gave 88% p-amino?xymethyltoluene-HCl, leaflets, m. 233¡ã (alc.-H₂O);-chlorobenzene-HCl, leaflets, m. 243¡ã; -bromobenzene-HCl, plates, m. 246-7¡ã (alc.-Et₂0); and -nitrobenzene-HCl, leaflets, m. 216¡ã; o-amino?xymethylnitrobenzene-HCl, needles, m. 165-6¡ã; 4-amino?xymethyl-1,2-dichlorobenzene-HCl, leaflets, m. 197¡ã (EtOAc-alc.); 3-amino?xypropylbenzene-HCl, plates, m. 168-9¡ã (alc.-Et₂O); 1-amino?xymethylnaphthalene-HCl, needles, m. 198¡ã (EtOAc); 2-amino?xymethyl isomer, leaflets, m. 247¡ã (aqueous alc.) (N-benzyloxycarbonyl derivative, leaflets, m. 93-4¡ã); 1-amino?xymethyl-2-methylnaphthalene-HCl.H₂O, needles, m. 192-3¡ã (alc.-Et₂O); 2-amino?xymethyl-1-bromonaphthalene-HCl, needles, m. 199¡ã (alc.-H₂0); 9-amino?xymethylphenanthrene-HCl, needles, m. 216-17¡ã (alc.); and the 1-isomer, needles, m. 184-6¡ã. Chloromethylation of Tetralin gave a mixture, b₁₅ 142-8¡ã, of some 5- with 6-chloromethyl derivative of Tetralin. The mixture with Na benzhydroxamate gave mixed benzamido?xymethyl derivatives of Tetralin as a thick yellow oil. This (18 g.) refluxed 3 hrs. with 150 ml. 6% alc. HCl gave 6.8 g. 6-amino?xymethyl derivative -HCl of Tetralin, m. 190-1¡ã (alc.). 8-Amino?xymethyl-6-chloro-1,3-benzodioxan-HCl was prepared by alcoholysis of the benzohydroxamate as needles, m. 204-5¡ã (alc.-Et₂O). Benzohydroxamate (3.2 g.) with alc. HCl gave 2.3 g. 8-amino?xymethylquinoline-2HCl, m. 193¡ã. The amino?xy HCl salt (0.1 mole), 0.1 mole dicyandiamide, and 70 ml. alc. refluxed 2-4 hrs., filtered, the mixture evaporated, and treated with alc.-HCl and Et₂O gave the RONHC(:NH)(NHC(:NH)NH₂ (VI).2HCl, which usually crystallized and was collected and recrystallized VI.2HCl were often deliquescent and this precluded anal. results. These compounds were characterized by their picrates. The following results were thus obtained (substituent and derivative of VI, and m.p. given): Me, 2HCl, 183-4¡ã; Et, 2HCl, 180-1¡ã; Et, picrate, 235-6¡ã; Pr, 2HCl, 142-7¡ã; Pr, picrate, 219-20¡ã; Bu, 2HCl, 135-6¡ã; iso-Bu, 2HCl, 142-4¡ã; iso-Bu, picrate, 225¡ã; pentyl, 2HCl, 129-33¡ã;pentyl, 95-6¡ã; pentyl, picrate, 204-5¡ã; hexyl, 2HCl, 138-41¡ã; hexyl, picrate, 204-5¡ã; hexyl, -, 102-3¡ã; heptyl, 2HCl, 135-7¡ã; heptyl, picrate, 210¡ã; octyl, -, 99-100¡ã; octyl, picrate, 209¡ã; nonyl, 2HCl, 148-52¡ã; decyl, 2HCl, 123-30¡ã; decyl, -, 100-1¡ã; decyl, picrate, 204-5¡ã; undecyl, 2HCl, 145-8¡ã 2-methyldecyl, 2HCl, 108-11¡ã; dodecyl, 2HCl, 162-4¡ã; dodecyl, picrate, 207-8¡ã; tetradecyl, HCl, 140¡ã; tetradecyl, picrate, 210-12¡ã; hexadecyl, -, 101-3¡ã. Benzyloxybiguanide-2HCl (VII) crystallized as needles, m. 150-1¡ã (alc.-EtOAc); the base-formed as plates, m. 111¡ã (H₂O) [picrate, leaflets, m. 226-7¡ã (alc.-Me₂CO)]. VII (1.4 g.) in 15 ml. alc. shaken 15 min. with H and 10% Pd-C, the filtered solution evaporated, the gum triturated with Et₂O, and the product crystallized gave hydroxybiguanide-2HCl (VIII), m. 139-40¡ã (alc.-Et₂O). In a 2nd experiment the filtered hydrogenation solution seeded yielded the pure material directly. The aqueous solution of VIII with aqueous Li picrate gave the picrate, yellow prisms, m. above 300¡ã, which appeared to be guanylurea picrate. On prolonged storage VIII decomposed to guanylurea-HCl, m. 173-4¡ã. p-Amino?xymethyltoluene-HCl (8.5 g.), 4.1 g. dicyandiamide (IX), and 50 ml. alc. refluxed 2 hrs.. evaporated, treated with alc.-HCl, Et₂O, the 8 g. di-HCl salt dissolved in the min. amount of hot H₂O, and basified gave the base as leaflets, m. 177¡ã (EtOAc-alc.). Isonicotinonoylhydrazine (X) (1.35 g.), 0.84 g. IX, and 15 ml. MeOH refluxed 24 hrs. gave 1.92 g. prisms, m. 138-42¡ã. This substance with picric acid gave isonicotinoylhydrazine dipicrate-H₂O, m. 204-5¡ã. X (1.35 g.), 0.84 g. IX, 15 ml. MeOH, and 1 ml. concentrated HCl refluxed 1 hr. gave 1.86 g. isonicotinamidobiguanide-2HCl, m. 200¡ã (H₂O). The following RONHC(:NH)NHC(:NH)NH₂ were prepared (substituent, and derivative and m.p. given): p-ClC₆H₄CH₂, -; 175¡ã; o-BrC₆H₄CH₂, -, 188¡ã; p-O₂NC₆H₄CH₂, HCl, 216¡ã; o-O₂NC₆H₄CH₂. HCl, 179¡ã; 3,4-Cl₂C₆H₃CH₂, 2HCl, 171¡ã; 3-phenylpropyl, 2HCl.EtOH, 153-5¡ã; 1-naphthylmethyl, -, 145¡ã; 2-naphthylmethyl, -, 213¡ã; 1-methyl-2-naphthylmethyl, -, 1658¡ã; 1-bromo-2-naphthylmethyl, -, 158-60¡ã; 9-phenanthrylmethyl, H₂O, 107-8¡ã; 9-phenanthrylmethyl, -, 95-8¡ã; 1-phenanthrylmethyl, H₂O, 190¡ã; 6-tetrahydronaphthylmethyl, 2HCl, 138-41¡ã; 6-tetrahydronaphthylmethyl, -, 157-8¡ã; 6-chloro-8-(1,3-benzodioxanyl)methyl, -, 191-2¡ã. Benzohydrazide (20 g.), 12.5 g. IX, and 100 ml. alc. containing 5.1 g. dry HCl refluxed 3 hrs. gave 26.9 g. benzamidobiguanide-2HCl, m. 169-70¡ã (alc.-H₂O). 1-Amino?xydecane (XI) (1.32 g.), 0.64 g. IX, and 10 ml. alc. refluxed 20 hrs. gave 0.60 g. unchanged IX and 1.2 g. XI. 8-Amino?xymethyl-6-chloro-1,3-benzodioxan (1.24 g.), 0.48 g. IX, and 10 ml. MeOH refluxed 20 hrs. gave only unchanged materials. IX was recovered when refluxed 24 hrs. in MeOH. ¦Á-Amino?xyheptanoic acid-HCl (2 g.) refluxed 1 hr. with 20 ml. 5% MeOH-HCl and evaporated gave a gum, which refluxed 2 hrs. with 0.84 g. IX and 20 ml. alc., then 2 hrs. with 25 ml. N NaOH, the solvent removed, the product taken up in H₂O, brought to pH 6, and the solid collected gave 1.5 g. monohydrate, m. 127-8¡ã. Distillation with xylene gave 1-carboxyhexyloxybiguanide, m. 194¡ã. ¦Á-Amino?xyoctanoic acid (1 g.) in 20 ml. MeOH saturated with HCl refluxed 2 hrs., evaporated, the gum refluxed 2 hrs. with 0.48 g. IX, and 10 ml. alc., and hydrolyzed gave 0.5 g. 1-carboxyheptyloxybiguanide-H₂O, m. 129-31¡ã (aqueous alc.). ¦Á-Amino?xynonanoic acid (0.8 g.) treated as above gave 0.3. g. 1-carboxyoctyloxybiguanide-H₂O, m. 128-9¡ã. ¦Á-Amino?xydecanoic acid (1 g.) similarly gave 1.1 g. 1-carboxynonyloxybiguanide. H₂O, m. 122-5¡ã (aqueous alc.), and thence by use of xylene 1-carboxynonyloxy-biguanide, m. 187-8¡ã.

Journal of the Chemical Society published new progress about 6084-58-8. 6084-58-8 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is O-Isobutylhydroxylamine hydrochloride, and the molecular formula is C4H12ClNO, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Cornea, Felicia published the artcileSynthesis and characterization of some new derivatives of (+)- and (-)- carvone, Category: catalysis-chemistry, the publication is Revistade Chimie (Bucharest, Romania) (1987), 38(7), 570-3, database is CAplus.

Carvone was treated with R¹ONH₂.HCl (R¹ = PhCH₂, methylbenzyl, CHPh₂, CPh₃, alkyl) and H₂NO(CH₂)_nONH₂.2HCl (n = 1, 2) to give oximes I and II. II (n = 1) was also prepared from carvone oxime and CH₂Cl₂.

Revistade Chimie (Bucharest, Romania) published new progress about 6084-58-8. 6084-58-8 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is O-Isobutylhydroxylamine hydrochloride, and the molecular formula is C4H12ClNO, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Kim, Kyeojin published the artcileGlucal-conjugated sterols as novel vascular leakage blocker: Structure-activity relationship focusing on the C₁₇-side chain, Related Products of catalysis-chemistry, the publication is European Journal of Medicinal Chemistry (2014), 184-194, database is CAplus and MEDLINE.

A series of glucal-conjugated sterols as novel vascular leakage blocker were identified through design, synthesis and biol. evaluation. In addition, the structure-activity relationship (SAR) of the glucal-conjugated sterols focusing on the C₁₇-side chain was also established. The sterol analogs linked with the rigid C₁₇-side chain side chains exhibited potent cell survival activities. In particular, ((2R,3S)-3-Acetoxy-6-((3S,10R,13S,17S)-17-((E)-1-(cyclopentyloxyimino)ethyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yloxy)3,6-dihydro-2H-pyran-2-yl)methyl acetate, which possesses a cyclopentyl oxime moiety, was shown to have excellent pharmacol. effects on retinal vascular leakage in a diabetic mouse model.

European Journal of Medicinal Chemistry published new progress about 6084-58-8. 6084-58-8 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is O-Isobutylhydroxylamine hydrochloride, and the molecular formula is C4H12ClNO, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Lee, Hyo Won published the artcileSequential Post-Polymerization Modification of Aldehyde Polymers to Ketone and Oxime Polymers, Recommanded Product: O-Isobutylhydroxylamine hydrochloride, the publication is Macromolecular Rapid Communications (2021), 42(22), 2100478, database is CAplus and MEDLINE.

A new sequential post-polymerization modification route has been developed for the synthesis of multifunctional polymers from a simple aldehyde polymer. In the first modification step, a template polymer derived from the radical polymerization of 4-vinylbenzaldehyde undergoes Rh-catalyzed hydroacylation with alkenes to furnish a group of ketone polymers. In the second modification step, Schiff base formation with alkoxy ammonium salts introduces a second group-an oxime functionality. Both the steps are highly efficient, introducing evenly distributed dual functionalities at the same position.

Macromolecular Rapid Communications published new progress about 6084-58-8. 6084-58-8 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is O-Isobutylhydroxylamine hydrochloride, and the molecular formula is C4H12ClNO, Recommanded Product: O-Isobutylhydroxylamine hydrochloride.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Chimiak, A. published the artcileO-alkylhydroxylamines, Name: O-Isobutylhydroxylamine hydrochloride, the publication is Bulletin de l’Academie Polonaise des Sciences, Serie des Sciences Chimiques (1974), 22(3), 195-9, database is CAplus.

Thirteen RONH2 (R = C1-15 alkyl, PhCH2, p-O2NC6H4CH2) were prepared by alkylating N-hydroxyphthalimide to give N-alkoxyphthalimides, followed by hydrazinolysis. The alkylations were carried out with RI containing Na2CO3 or Et3N, with CH2N2, or with AcOCMe3-HCiO4.

Bulletin de l’Academie Polonaise des Sciences, Serie des Sciences Chimiques published new progress about 6084-58-8. 6084-58-8 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is O-Isobutylhydroxylamine hydrochloride, and the molecular formula is C4H12ClNO, Name: O-Isobutylhydroxylamine hydrochloride.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Kang, Taek published the artcileIridium-Catalyzed Intermolecular Amidation of sp³ C-H Bonds: Late-Stage Functionalization of an Unactivated Methyl Group, HPLC of Formula: 6084-58-8, the publication is Journal of the American Chemical Society (2014), 136(11), 4141-4144, database is CAplus and MEDLINE.

Reported herein is the iridium-catalyzed direct amidation of unactivated sp³ C-H bonds. With sulfonyl and acyl azides as the amino source, the amidation occurs efficiently under mild conditions over a wide range of unactivated Me groups with high functional group tolerance. This procedure can be successfully applied for the direct introduction of an amino group into complex compounds and thus can serve as a powerful synthetic tool for late-stage C-H functionalization. Thus, e.g., [IrCp*Cl₂]₂/AgNTf₂-catalyzed amidation of ketoxime I with TsN₃ in 1,2-DCE in presence of catalytic AgOAc afforded sulfonamide II (90%).

Journal of the American Chemical Society published new progress about 6084-58-8. 6084-58-8 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is O-Isobutylhydroxylamine hydrochloride, and the molecular formula is C4H12ClNO, HPLC of Formula: 6084-58-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia