Category: 6084-58-8

Han, Hee Oon published the artcileDesign and synthesis of oxime ethers of ¦Á-acyl-¦Â-phenylpropanoic acids as PPAR dual agonists, Safety of O-Isobutylhydroxylamine hydrochloride, the publication is Bioorganic & Medicinal Chemistry Letters (2007), 17(4), 937-941, database is CAplus and MEDLINE.

Oxime ethers of ¦Á-acyl-¦Â-phenylpropanoic acids, e.g., I, were prepared to apply as PPAR¦Á and ¦Ã dual agonists. Among them, I proved to exhibit potent in vitro activities with EC₅₀ of 19 and 13 nM in PPAR¦Á and ¦Ã, resp. It showed better glucose lowering effects than rosiglitazone and ameliorated the lipid profile like plasma triglyceride in db/db mice model.

Bioorganic & Medicinal Chemistry Letters published new progress about 6084-58-8. 6084-58-8 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is O-Isobutylhydroxylamine hydrochloride, and the molecular formula is C4H12ClNO, Safety of O-Isobutylhydroxylamine hydrochloride.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Kim, Taelim published the artcileIdentification of novel estrogen receptor (ER) agonists that have additional and complementary anti-cancer activities via ER-independent mechanism, Category: catalysis-chemistry, the publication is Bioorganic & Medicinal Chemistry Letters (2016), 26(7), 1844-1848, database is CAplus and MEDLINE.

In this study, a series of bis(4-hydroxy)benzophenone oxime ether derivatives such as 12c, 12e and 12h were identified as novel estrogen receptor (ER) agonists that have addnl. and complementary anti-proliferative activities via ER-independent mechanism in cancer cells. These compounds are expected to overcome the therapeutic limitation of existing ER agonists such as estradiol and tamoxifen, which have been known to induce the proliferation of cancer cells.

Bioorganic & Medicinal Chemistry Letters published new progress about 6084-58-8. 6084-58-8 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is O-Isobutylhydroxylamine hydrochloride, and the molecular formula is C4H12ClNO, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Cui, Shaoyu published the artcileDesign, synthesis and evaluation of wound healing activity for ¦Â-sitosterols derivatives as potent Na⁺/K⁺-ATPase inhibitors, Synthetic Route of 6084-58-8, the publication is Bioorganic Chemistry (2020), 103150, database is CAplus and MEDLINE.

¦Â-Sitosterols, is a common steroid that can be identified in a variety of plants and their efficacy in promoting wound healing has been demonstrated. Na⁺/K⁺-ATPase, more than a pump, its signal transduction function for involvement in cell growth regulation attracts widespread concern. The Na⁺/K⁺-ATPase/Src receptor complex can serve as a receptor involved in multiple signaling pathways including promoting wound healing pathways. To finding potent accelerating wound healing small mol., we choose the high inhibitory activity of Na⁺/K⁺-ATPase and non-cardiotoxic natural compound, ¦Â-sitosterol as the substrate. A series of ¦Â-sitosterol derivatives were designed, synthesized and evaluated as potential Na⁺/K⁺-ATPase inhibitors. Among them, some compounds showed improved inhibitory activity on Na⁺/K⁺-ATPase, with IC₅₀ value of 3.0¦ÌM, 3.4¦ÌM, 2.2¦ÌM, which are more potent than ¦Â-sitosterol with IC₅₀ 7.6¦ÌM. Especially, compound I can induce cell proliferation, migration and soluble collagen production in L929 fibroblasts. Compared to model, compound I can accelerate wound healing in SD rats. Further studies indicated that I can activate the sarcoma (Src), uptake the protein kinase B (Akt), extracellular signal-regulated kinase (ERK) proteins expression in a concentration dependent manner. Finally, binding mode of compound I with Na⁺/K⁺-ATPase was studied, which provides insights into the determinants of potency and selectivity. These results proved ¦Â-stitosterol derivative 49 can serve as an effective inhibitor of Na⁺/K⁺-ATPase and potential candidate for accelerating wound healing agents.

Bioorganic Chemistry published new progress about 6084-58-8. 6084-58-8 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is O-Isobutylhydroxylamine hydrochloride, and the molecular formula is C4H12ClNO, Synthetic Route of 6084-58-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Niwa, Atsushi published the artcileDevelopment of N,O-disubstituted hydroxylamines and N,N-disubstituted amines as insect juvenile hormone mimetics and the role of the nitrogenous function for activity, Computed Properties of 6084-58-8, the publication is Journal of Agricultural and Food Chemistry (1990), 38(2), 514-20, database is CAplus.

Insect juvenile hormone (JH) active N,O-disubstituted hydroxylamines were developed to examine the role of the nitrogenous function for high activity. They are O-alkyl-N-[(4-phenoxyphenoxy) and (4-benzylphenoxy)alkyl]hydroxylamines and reversely substituted N-alkyl-O-[(4-phenoxyphenoxy)alkyl]hydroxylamines. The activity against Culex?pipiens of the most potent member of each class was as high as that of the compounds known so far as the most active of JH mimics. When the overall length of the mols. is kept at the optimum, about 21 ?, suggested in earlier works, the compounds having a hydroxylamino N atom, rather than the O atom, at the ¦Ä-position from the central phenoxy O atom or at the 4-position (about 4.6 ?) from the alkyl end showed about 10 times higher activity than those having the N atom at position 1. The corresponding amine compounds showed this more clearly, but their activity was considerably lower than that of the hydroxylamines. The lower potency of the amines with pK_a ¡Ö10 was attributed to their quaternization at physiol. pH, preventing going to or binding with the action site.

Journal of Agricultural and Food Chemistry published new progress about 6084-58-8. 6084-58-8 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is O-Isobutylhydroxylamine hydrochloride, and the molecular formula is C4H12ClNO, Computed Properties of 6084-58-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Nakayama, Akira published the artcileDevelopment of insect juvenile hormone active oxime O-ethers and carbamates, Synthetic Route of 6084-58-8, the publication is Journal of Agricultural and Food Chemistry (1985), 33(6), 1034-41, database is CAplus.

Undecen-2-one oxime O-ethers and undecen-2-yl carbamates were prepared and their activities tested against Culex?pipiens (common mosquito), Chilo?suppressalis (rice stem borer), and Musca?domestica (housefly). Activities were comparable to that of naturally occurring juvenile?hormone?I??[13804-51-8]. To produce higher activities, the structures of the oxime O-ethers and the reportedly highly active 2-(4-phenoxyphenoxy)ethyl carbamates were hybridized to produce (4-phenoxyphenoxy)- and (4-benzylphenoxy)acetaldehyde oxime O-ethers and related compounds The activity of some of these substances against C. pipiens were comparable to the 90-100% inhibition of metamorphosis by methoprene??[40596-69-8], the most highly active of the juvenile hormone compounds

Journal of Agricultural and Food Chemistry published new progress about 6084-58-8. 6084-58-8 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is O-Isobutylhydroxylamine hydrochloride, and the molecular formula is C4H12ClNO, Synthetic Route of 6084-58-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Ishibashi, Masataka published the artcileDiethylhydrogensilyl-cyclic diethylsilylene derivatives in the gas chromatography-mass spectrometry of hydroxylated steroids. IV. Hydrocortisone, Related Products of catalysis-chemistry, the publication is Journal of Chromatography (1987), 197-206, database is CAplus.

The 3,20-bismethyloxime-11-diethylhydrogensilyl-17,21-cyclic diethylsilylene derivative of hydrocortisone (HC) was obtained by treating HC with O-methylhydroxylamine-HCl and then with N,O-bis(diethylhydrogensilyl)trifluoroacetamide. This derivative gave a single peak without resolution of its structural isomers. The electron-impact mass spectrum of the HC derivative was characterized by the appearance of an intense mol. ion peak and principal ion peak of [M – OCH₃]⁺ at m/z 559. The detection limit was 10 pg with a signal-to-noise ratio of >10 when gas chromatog. (GC)-selected ion monitoring was carried out at the mol. ion of m/z 590. On the other hand, GC-metastable peak monitoring, based on the metastable peak corresponding to the transition ions from m/z 590 to 559, showed a detection limit of ?10 pg with a signal-to-noise ratio of >5.

Journal of Chromatography published new progress about 6084-58-8. 6084-58-8 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is O-Isobutylhydroxylamine hydrochloride, and the molecular formula is C4H12ClNO, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Kuroda, Tokuyuki published the artcileSynthesis and biological activity of novel mitomycin C analogs derived from mitomycin A, Related Products of catalysis-chemistry, the publication is Journal of Heterocyclic Chemistry (1994), 31(1), 113-19, database is CAplus.

A variety of mitomycin C analogs were synthesized from mitomycin A and their biol. activities were studied. Mitomycin A (I) underwent nucleophilic displacement reactions involving intramol. hydrogen migrations upon treatment with nitrogen nucleophiles bearing mobile hydrogens, but the mode of hydrogen migration depended on the nature of the nucleophiles. The reaction with alkoxyamines gave oximes II (R = Me, CH₂CHMe₂). However, the reaction with hydroxylamine and benzohydrazine afforded imines III (R¹ = OH, NHBz). These products were converted into various types of mitomycin C derivatives by methylation with Me iodide or di-Me sulfate. The mechanistic features of these reactions are discussed. The in vitro and in vivo biol. activities were tested by using P388 leukemia and Sarcoma 180 tumor cells. Several of the synthesized compounds exhibited better activity than that of mitomycin C.

Journal of Heterocyclic Chemistry published new progress about 6084-58-8. 6084-58-8 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is O-Isobutylhydroxylamine hydrochloride, and the molecular formula is C4H12ClNO, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Theilacker, W. published the artcilePreparation of O-alkylhydroxylamines, Safety of O-Isobutylhydroxylamine hydrochloride, the publication is Angewandte Chemie (1956), 303, database is CAplus.

cf. Truitt, et al., C.A. 42, 8174a. To a dried (CaCl₂) solution of 10 g. ClNH₂ (I) in 500 cc. Et₂O is added a solution of 6 g. Na in 250-300 cc. of the required alc. and the mixture is allowed to stand 24 hrs.; or to a solution of 6 g. Na in 250-300 cc. of dry alc. (diluted with 200 cc. dioxane if necessary) heated to 80¡ã is added with vigorous stirring over 90 min. a solution of 10 g. I in 600 cc. Et₂O in a manner such as to prevent contact of the Et₂O solution with the walls of the reaction flask. The Et₂O is allowed to distil through a packed column during the addition, and stirring is continued 15 min. more. In each case the reaction mixture is then filtered, the filtrate distilled, HCl gas passed into the distillate to precipitate NH₄Cl, the mixture filtered, the filtrate saturated with HCl, and the HCl salt separated by filtration or evaporation of the solvent. Sirupy products are dried in vacuo over P₂O₅ and purified by recrystallization or sublimation. The following O-alkyl hydroxylamines are reported (temperature of preparation, m.p. of HCl salt, % yield, and b.p. of the base, resp., given): Me (20¡ã, 149-50¡ã, 32, 50¡ã), Et (20¡ã, 125-6¡ã, 29, 69¡ã), Pr (20¡ã, 155-7¡ã 38, 90-1¡ã), iso-Pr (20¡ã, 94-5¡ã, 38, 79-80¡ã), Bu (20¡ã, 159-60¡ã, 46, 115¡ã), iso-Bu (20¡ã, 129-30¡ã, 37, 95-7¡ã), sec-Bu (80¡ã, 68-70¡ã, 34, 103-4¡ã), tert-Bu (80¡ã, 150¡ã, 26, 200-3¡ã), (CH₂)₇CH₃ (80¡ã, 81-2¡ã, 26, 189-92¡ã), sec-octyl, (80¡ã, 71-2¡ã, 26, 189-92¡ã), PhCH₂ (80¡ã, 225-30¡ã, 51, 212-15¡ã), and cyclohexyl (80¡ã, 175¡ã, 25, 171-2¡ã).

Angewandte Chemie published new progress about 6084-58-8. 6084-58-8 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is O-Isobutylhydroxylamine hydrochloride, and the molecular formula is C4H6N2, Safety of O-Isobutylhydroxylamine hydrochloride.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Pratt, John K. published the artcileInhibitors of HCV NS5B polymerase: synthesis and structure-activity relationships of N-1-heteroalkyl-4-hydroxyquinolon-3-yl-benzothiadiazines, Formula: C4H12ClNO, the publication is Bioorganic & Medicinal Chemistry Letters (2005), 15(6), 1577-1582, database is CAplus and MEDLINE.

N-1-Alkylamino and N-1-alkyloxy-4-hydroxyquinolon-3-yl benzothiadiazines were synthesized and evaluated as inhibitors of genotype 1 HCV polymerase. The N-1-alkyloxy derivatives were not potent inhibitors, however N-1-alkylamino derivatives displayed comparable potency to carbon analogs. Analogs with aliphatic substituents were significantly more potent than those with benzylic substituents against genotype 1a polymerase. The most potent inhibitors contained small alkyl or carbocyclic substituents and exhibited IC₅₀‘s of 50-100 and 200-400 nM against genotype 1b and 1a HCV polymerase, resp.

Bioorganic & Medicinal Chemistry Letters published new progress about 6084-58-8. 6084-58-8 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is O-Isobutylhydroxylamine hydrochloride, and the molecular formula is C4H12ClNO, Formula: C4H12ClNO.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Nasier, Abudulajiang published the artcileElectrodimerization of N-Alkoxyamides for the Synthesis of Hydrazines, SDS of cas: 6084-58-8, the publication is Journal of Organic Chemistry (2021), 86(22), 16068-16076, database is CAplus and MEDLINE.

An efficient and valuable N-N dimerization reaction of N-alkoxyamides R¹C(O)NHOR² (R¹ = Ph, 2-naphthyl, 2-furyl, etc.; R² = Me, i-Pr, Bn, etc.) is reported under undivided electrolytic conditions. This electrochem. strategy provides a powerful way to access a wide range of advanced, highly functionalized hydrazines R¹C(O)N(OR²)N(OR²)C(O)R¹. Remarkably, an N-centered radical generated from the cleavage of the N-H bond under electrolytic conditions plays a crucial role in this transformation. Furthermore, various N-alkoxyamides bearing different substituents are suitable in this transformation, furnishing the corresponding hydrazines in up to 92% yield.

Journal of Organic Chemistry published new progress about 6084-58-8. 6084-58-8 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is O-Isobutylhydroxylamine hydrochloride, and the molecular formula is C4H12ClNO, SDS of cas: 6084-58-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia