Category: 6950-53-4

Chen, Chi-Tien published the artcileZinc complexes containing coumarin-derived anilido-aldimine ligands as catalysts for ring opening polymerization of L-lactide, Synthetic Route of 6950-53-4, the publication is Molecules (2015), 20(4), 5313-5328, database is CAplus and MEDLINE.

The coumarin-derived ligand precursors L¹H-L⁶H have been prepared Treatment of these ligand precursors with 1.2 equivalent of ZnEt₂ in toluene affords zinc Et complexes (LZnEt) 1-6 (where L = coumarin-derived ligands bearing different functional groups). Reaction of ligand precursor L³H with 1.5 equivalent of Zn[N(SiMe₃)₂]₂ in toluene affords the zinc amide complex, L³ZnN(SiMe₃)₂, 7. All these compounds were characterized by NMR spectroscopy and elemental anal. The mol. structures are reported for 1 and 7. The catalytic activities of complexes 1-7 towards the ring opening polymerization of L-lactide in the presence of 9-AnOH have been investigated.

Molecules published new progress about 6950-53-4. 6950-53-4 belongs to catalysis-chemistry, auxiliary class Salt,sulfides,Amine,Aliphatic hydrocarbon chain, name is 2-(Methylthio)ethanamine hydrochloride, and the molecular formula is C3H10ClNS, Synthetic Route of 6950-53-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Guvvala, Vinodh published the artcileDevelopment of a Novel and Scalable Process for the Synthesis of a Key Cangrelor Intermediate, Related Products of catalysis-chemistry, the publication is Organic Preparations and Procedures International (2019), 51(6), 530-536, database is CAplus.

An alternative synthetic route to the cangrelor key synthon, I, was developed with >99.5% purity without addnl. purifications. This improved method involves five steps starting from readily and cheaply available xanthine. Our process is scalable, cost effective, with simplified reaction workup, and avoids the use of costly metal catalysts or chromatog. Of note, this may be a com. viable large scale synthesis compared to previous methods.

Organic Preparations and Procedures International published new progress about 6950-53-4. 6950-53-4 belongs to catalysis-chemistry, auxiliary class Salt,sulfides,Amine,Aliphatic hydrocarbon chain, name is 2-(Methylthio)ethanamine hydrochloride, and the molecular formula is C3H10ClNS, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wang, Wei-Chi published the artcilePalladacycles bearing tridentate CNS-type benzamidinate ligands as catalysts for cross-coupling reactions, Name: 2-(Methylthio)ethanamine hydrochloride, the publication is Dalton Transactions (2012), 41(10), 3022-3029, database is CAplus and MEDLINE.

Three pendant benzamidines, [PhC(:NPh){NH(E)}] [E = (CH₂)₂SMe (1); (CH₂)₂S^tBu (2); o-C₆H₄SMe (3)], are described. Reactions of 1, 2 or 3 with one molar equiv Pd(OAc)₂ in CH₂Cl₂ give the palladacyclic complexes [PhC{NH(¦Ç¹-C₆H₄)}{:N(E)}]Pd(OAc) [E = (CH₂)₂SMe (4); (CH₂)₂S^tBu (5); o-C₆H₄SMe (6)], as mononuclear Pd complexes, resp. A minor product described as 5‘, {[PhC{NPh}{N(CH₂)₂S^tBu}]Pd(OAc)}₂, was isolated as a benzamidinate-bridged dinuclear Pd complex upon recrystallizing from Et₂O/hexane solution Treatment of 1, 2 or 3 with one molar equiv PdCl₂ in the presence of NEt₃ in CH₂Cl₂ gives the palladacyclic complexes [PhC{NH(¦Ç¹-C₆H₄)}{:N(E)}]PdCl [E = (CH₂)₂SMe (7); (CH₂)₂S^tBu (8); o-C₆H₄SMe (9)], as mononuclear Pd complexes, resp. The crystal and mol. structures are reported for compounds 5, 5‘ and 6–8. The application of these palladacyclic complexes to the Suzuki and Heck coupling reactions was examined

Dalton Transactions published new progress about 6950-53-4. 6950-53-4 belongs to catalysis-chemistry, auxiliary class Salt,sulfides,Amine,Aliphatic hydrocarbon chain, name is 2-(Methylthio)ethanamine hydrochloride, and the molecular formula is C12H10FeO4, Name: 2-(Methylthio)ethanamine hydrochloride.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Otsuka, Masami published the artcileSynthesis, structure of copper(II) complexes of S-containing pentadentate ligands, Application In Synthesis of 6950-53-4, the publication is Journal of Organometallic Chemistry (2000), 611(1-2), 577-585, database is CAplus.

Novel ligands containing a pyridine and methylsulfanyl groups, 2,6-bis[(2-methylsulfanylethylamino)methyl]pyridine (4) and 2,6-bis[(2-methylsulfanylethylamino)methyl]-4-dimethylaminopyridine (7) were prepared and the properties of their copper complexes were studied. Potentiometric titration, absorption and ESR spectral measurements, and x-ray crystallog. of copper complexes of 4 and 7 were carried out. The x-ray structures of [Cu(4)](ClO₄)₂ and [Cu(7)](ClO₄)₂ revealed an intermediate geometry between the regular trigonal bipyramid with two secondary amines being axial and the regular square pyramid with one of the thioethers being in the apical position.

Journal of Organometallic Chemistry published new progress about 6950-53-4. 6950-53-4 belongs to catalysis-chemistry, auxiliary class Salt,sulfides,Amine,Aliphatic hydrocarbon chain, name is 2-(Methylthio)ethanamine hydrochloride, and the molecular formula is C3H10ClNS, Application In Synthesis of 6950-53-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wieland, Theodor published the artcileAntagonists of the Lactobacillus bulgaricus factor and of pantothenic acid, Recommanded Product: 2-(Methylthio)ethanamine hydrochloride, the publication is Chemische Berichte (1952), 1035-42, database is CAplus.

According to the present concept of the mechanism of the action of pantothenic acid (I) in the living cell, I is incorporated into the coenzyme A (II) and is present there as the thioethanolamide (III), the SH group of which acts as acyl transcarrier in biol. acylation of amines and alcs. Certain lactic acid bacteria, e.g., Lactobacillus helveticus V 80 (IV), show a faster growth with a scission product of II, the so-called Lactobacillus bulgaricus factor (LBF), than with I, especially at the beginning. From this it may be concluded that during the II synthesis in these micro?rganisms I is converted into pantetheine (V) which is then, as a whole, built into II. To test this theory, derivatives of III are synthesized, differing only slightly from III but in such a way that the synthesis of II can be stopped by the competition with V. Adding CH₂.CH₂.NH to MeSH in 20 cc. EtOH at -15¡ã and keeping the mixture overnight at 20¡ã give MeSCH₂CH₂-NH₂ (VI), b₇₆₀ 146-8¡ã (HCl salt m. 120¡ã); EtSCH₂CH₂NH₂ b₇₆₀ 163¡ã (HCl salt m. 147¡ã). Keeping 1.2 g. absolute dry Na D-pantothenate (VII) in 5 cc. anhydrous HCONMe₂ and 0.5 g. ClCO₂Et several hrs. at 0¡ã, adding 0.46 g. VI, keeping the mixture several hrs., evaporating the filtered solution in vacuo, and purifying the residue in BuOH by the countercurrent extraction (CCE) method give 40% S-methylpantetheine (VIII), very viscous pale yellow oil; S-Et homolog (IX) and S-Ph analog (X) have similar properties. Adding 1.5 cc. liquid NH₃ at -60¡ã to the filtered reaction mixture of 2.4 g. VII, 1 g. ClCO₂Et, and 15 cc. HCONMe₂, evaporating the NH₃ and the solvent, finally at 40¡ã in vacuo, and purifying the residue by CCE in BuOH and H₂O give 40% D-pantothenamide (XI), oil, very soluble in H₂O and BuOH, slightly soluble in C₆H₆ and ether. Saturating 5 g. HOCH₂CMe₂CH(OH)CN in 50 cc. ether with dry HCl and keeping the mixture overnight give almost 100% [O.CH₂.CMe₂.CH(OH).C:NH₂]⁺Cl^– which failed to give XI on treatment with CH₂:CHCONH₂. At low concentrations VIII-X possess little growth activity with IV which, at higher concentrations, is annulled by LBF, V, and I. Whereas with VIII and IX this stoppage is overcome after a few days, with X it is stable because of a true competitive process whereby 30-70 mols. inhibitor per 1 mol. growth-promoting substance (XII) stops the growth by 50%. XI possesses no inhibitory action and can, at a higher concentration, completely substitute for XII. The results of the microbiol. tests are given in several curves.

Chemische Berichte published new progress about 6950-53-4. 6950-53-4 belongs to catalysis-chemistry, auxiliary class Salt,sulfides,Amine,Aliphatic hydrocarbon chain, name is 2-(Methylthio)ethanamine hydrochloride, and the molecular formula is C10H12F6N4O6PdS2, Recommanded Product: 2-(Methylthio)ethanamine hydrochloride.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Hua, Xuewen published the artcileNovel Anthranilic Diamide Insecticides: Design, Synthesis, and Insecticidal Evaluation, Quality Control of 6950-53-4, the publication is Australian Journal of Chemistry (2014), 67(10), 1491-1503, database is CAplus.

Three series of new anthranilic diamide derivatives containing sulfide, N-cyanomethylsulfilimine, and N-cyanomethylsulfoximine groups were designed and synthesized by coupling the active substructures of anthranilic diamides and sulfoxaflor. The structures of the synthesized compounds were confirmed by IR spectroscopy, ¹H and ¹³C NMR, and elemental anal. Several unique structural characteristics were revealed via the crystal structure anal. of compound N-(2-(2-methyl-2-(methylthio)propylcarbamoyl)-4-chloro-6-methylphenyl)-3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide I. Bioassay results indicated that most of the synthesized compounds showed superior insecticidal activities against Mythimna separata and Plutella xylostella when compared with the pos. control cyantraniliprole. In particular, N-(2-(2-methyl-2-(N-cyanomethylsulfideimino)propylcarbamoyl)-4-chloro-6-methylphenyl)-3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide II showed excellent insecticidal activity against Mythimna separata, with a mortality rate of 100% at a concentration of 1¦Ìg?mL^-1. These results indicated that sulfide, N-cyanomethylsulfilimine, and N-cyanomethylsulfoximine moieties, as important active substructures, could improve or maintain the activity of the anthranilic diamide and promote novel pesticide development.

Australian Journal of Chemistry published new progress about 6950-53-4. 6950-53-4 belongs to catalysis-chemistry, auxiliary class Salt,sulfides,Amine,Aliphatic hydrocarbon chain, name is 2-(Methylthio)ethanamine hydrochloride, and the molecular formula is C3H10ClNS, Quality Control of 6950-53-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zhang, Long published the artcileDiscovery of a potent dual EGFR/HER-2 inhibitor L-2 (selatinib) for the treatment of cancer, Computed Properties of 6950-53-4, the publication is European Journal of Medicinal Chemistry (2013), 833-841, database is CAplus and MEDLINE.

To develop potent dual EGFR/HER-2 inhibitors with improved druggability, a series of new lapatinib analogs were designed and synthesized. Compared with lapatinib, L-2, 6-(5-((2-(Sulfamoyl)ethylamino)methyl)furan-2-yl)-N-(4-(3-fluorobenzyloxy)-3-chlorophenyl) quinazolin-4-amine (L-4) and 1-(4-((5-(4-(3-Chloro-4-(3-fluorobenzyloxy)phenylamino) quinazolin-6-yl)furan-2-yl)methyl)piperazin-1-yl)ethanone (M-6) were more active against BT-474 or NCI-N87 cells. In vivo efficacy studies indicated that L-2 significantly suppressed tumor growth in NCI-N87 (94.8% inhibition) or SK-OV-3 xenograft (85.7% inhibition) without causing significant loss of body weight And the inhibition rates of lapatinib in the two xenograft models were 89.7% and 78.8%, resp. Moreover, further studies revealed that the potent in vivo activities of L-2 may be mainly attributed to its superior aqueous solubility and oral bioavailability. In addition, a high-yielding one-pot procedure was developed for the synthesis of lapatinib and its analogs.

European Journal of Medicinal Chemistry published new progress about 6950-53-4. 6950-53-4 belongs to catalysis-chemistry, auxiliary class Salt,sulfides,Amine,Aliphatic hydrocarbon chain, name is 2-(Methylthio)ethanamine hydrochloride, and the molecular formula is C13H19Br2ClN2O, Computed Properties of 6950-53-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Huang, Tzu-Lun published the artcileCalcium complexes containing oxalamidinate ligands as catalysts for ¦Å-caprolactone polymerization, Recommanded Product: 2-(Methylthio)ethanamine hydrochloride, the publication is Dalton Transactions (2013), 42(25), 9255-9262, database is CAplus and MEDLINE.

A series of calcium complexes containing oxalamidinate ligands is described. Reactions of oxalamidinate ligand precursors, [PhN:C{NH(CH₂)₂OMe}-C{NH(CH₂)₂OMe}:NPh] (1), [PhN:C{NH(CH₂)₂NMe₂}-C{NH(CH₂)₂NMe₂}:NPh] (2), [Ph^TriMeN:C{NH(CH₂)₂OMe}-C{NH(CH₂)₂OMe}:NPh^TriMe] (3), [Ph^TriMeN:C{NH(CH₂)₂SMe}-C{NH(CH₂)₂SMe}:NPh^TriMe] (4), [Ph^TriMeN:C{NHCH₂Py}-C{NHCH₂Py}:NPh^TriMe] (5), with two molar equivalents of Ca[N(SiMe₃)₂]₂(THF)₂ gave calcium oxalamidinate complexes, [Ca{N(SiMe₃)₂}(THF)(PhN)C{N(CH₂)₂OMe}-]₂ (6), [Ca{N(SiMe₃)₂}(THF)(PhN)C{N(CH₂)₂NMe₂}-]₂ (7), [Ca{N(SiMe₃)₂}(THF)(Ph^TriMeN)C{N(CH₂)₂OMe}-]₂ (8), [Ca{N(SiMe₃)₂}(THF)(Ph^TriMeN)C{N(CH₂)₂SMe}-]₂ (9), [Ca{N(SiMe₃)₂}(THF)(Ph^TriMeN)C{NCH₂Py}-]₂ (10), resp. The mol. structure of complex 7 was further characterized by the single crystal x-ray diffraction technique. The catalytic activities of complexes 6-10 toward the ring opening polymerization of ¦Å-caprolactone were studied. Complex 8 exhibited excellent activity for the polymerization of ¦Å-caprolactone with controlled mol. weights and polydispersities.

Dalton Transactions published new progress about 6950-53-4. 6950-53-4 belongs to catalysis-chemistry, auxiliary class Salt,sulfides,Amine,Aliphatic hydrocarbon chain, name is 2-(Methylthio)ethanamine hydrochloride, and the molecular formula is C3H10ClNS, Recommanded Product: 2-(Methylthio)ethanamine hydrochloride.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wang, Su-Sun published the artcileKinetic studies at high pH of the trypsin-catalyzed hydrolysis of N(super spa)-benzoyl derivatives of L-arginamide, L-lysinamide, and S-2-aminoethyl-L-cysteinamide and related compounds, Recommanded Product: 2-(Methylthio)ethanamine hydrochloride, the publication is Journal of Biological Chemistry (1968), 243(13), 3702-10, database is CAplus and MEDLINE.

A steady state kinetic anal. made of the trypsin-catalyzed hydrolysis of N¦Á-benzoyl-L-arginamide, N¦Á-benzoyl-L-lysinamide, and N¦Á-benzoyl-S-2-aminoethyl-L-cysteinamide at pH 8-10.7 at 30¡ã. The apparent Michaelis constant, Km (app), of the arginine derivative changes from 2.5 to 4.5 ¡Á 10-3M while that of the lysine derivative increases from 4.6 to 17.2 ¡Á 10-3M in going from pH 8 to 10.7. Over the same range the kcat (kcat = Vmax./enzyme concentration at 0 time) for the arginine derivative decreases from 2.8 to 1.5 sec.-1 while the value for the lysine derivative decreases from 1.9 to 1.3 sec.-1 At pH 8.0, the Km (app) for the aminoethylcysteine derivative (4.3 ¡Á 10-3M) was about the same as that for lysine derivative whereas the value of kcat of 0.33 sec.-1 was considerably lower. At pH 9, ¡Ü30¡ã, the conditions in which the reaction was first order with respect to substrate concentration, the relative rate of cleavage of the arginyl, lysyl, and aminoethylcysteinyl bonds was 100:40:7. From the effect of pH on Km (app) and kcat of the arginine derivative, it was deduced that the enzyme possessed an ionizable group with a pKa of 10.4 which must be protonated in order to have a fully active enzyme. After correcting for the ionization of the enzyme, the effect of pH on the kinetic parameters of lysine and aminoethylcysteine derivatives could be correlated with the dissociation of their distal amino groups. The ionization constants of these groups as determined by the kinetic method agreed within 0.3 pH unit of their values as determined by titration in distilled water. More importantly, it was found by titration that the pKa of the ¦Á-amino group of the aminoethylcysteine derivative was 9.4 while the pKa for the ¦Å-amino group of the lysine derivative was 10.3. The same difference in the ionization constant was determined by the kinetic method. As a result of the difference in pK values between the basic groups of arginyl, lysyl, and aminoethylcysteinyl residues, it should be possible at high pH (10.7) to catalyze the hydrolysis of arginyl bonds in an aminoethylated protein with no cleavage of aminoethylcysteinyl bonds and with only slight cleavage of lysyl bonds. At pH 7.9, there was no indication of substrate activation by the above mentioned amides or by N¦Á-tosyl-L-arginamide or N¦Á-tosyl-L-lysinamide over the substrate range of 5 ¡Á 10-5 to 5 ¡Á 10-2M. Under the same conditions the phenomenon attributed to substrate activation was observed for N¦Á-tosyl-L-arginine Me ester and N¦Á-tosyl-L-lysine Me ester. These studies were performed with trypsin that had been treated with the chymotrypsin inhibitor, L-(1-tosylamido-2-phenyl)ethyl ketone, and subjected to chromatog. on CM-cellulose. The chromatog. revealed 2 active components which were apparently interconvertible on rechromatog.

Journal of Biological Chemistry published new progress about 6950-53-4. 6950-53-4 belongs to catalysis-chemistry, auxiliary class Salt,sulfides,Amine,Aliphatic hydrocarbon chain, name is 2-(Methylthio)ethanamine hydrochloride, and the molecular formula is C6H4ClNO2, Recommanded Product: 2-(Methylthio)ethanamine hydrochloride.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Cater, Henry L. published the artcileUser Guide to Ring-Opening Metathesis Polymerization of endo-Norbornene Monomers with Chelated Initiators, Computed Properties of 6950-53-4, the publication is Macromolecules (Washington, DC, United States) (2022), 55(15), 6671-6679, database is CAplus.

The development of facile synthetic strategies to access well-defined polymers promises to provide advanced soft materials with functionality that rivals that observed from nature. To this end, ring-opening metathesis polymerization (ROMP) presents a compositionally simple and rapid strategy for controlled polymerization, yet it has received far less attention relative to radical counterparts. This limited attention arises in part from scattered reports on optimization strategies and a narrow monomer scope. Contemporary ROMP methods favor the use of exo-norbornene derivatives and highly reactive nonchelated Ru-alkylidenes, such as Grubbs Catalysts. In contrast, endo-norbornene derivatives, from which analogous exo-forms are often generated, present a more accessible alternative, yet examples of their utility in ROMP remain scarce. Herein, a systematic examination of ROMP with endo-norbornene monomers using stable chelated Ru-alkylidene initiators is presented. Through initiator screening and polymerization optimization, the ROMP process is shown to be versatile and robust, providing rapid access to polymers with excellent mol. weight control, low dispersities (D < 1.1), good functional group tolerance, and high chain-end fidelity that enabled the preparation of block copolymers via sequential monomer addition Furthermore, the process is oxygen-tolerant, allowing for ROMP to be performed under ambient conditions on the bench, which was showcased in synthesizing mech. robust endo-norbornene imide thermoplastics with high glass transition and decomposition temperatures This report provides a comprehensive overview of the scope and limitations of endo-norbornene ROMP with chelated initiators, serving as a user guide for the polymer chem. community to develop well-defined next-generation functional plastics.

Macromolecules (Washington, DC, United States) published new progress about 6950-53-4. 6950-53-4 belongs to catalysis-chemistry, auxiliary class Salt,sulfides,Amine,Aliphatic hydrocarbon chain, name is 2-(Methylthio)ethanamine hydrochloride, and the molecular formula is C3H10ClNS, Computed Properties of 6950-53-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia