Catalysis-chemistry

Hu, Binjing published the artcileRhenium-Catalyzed Arylation-Acyl Cyclization between Enol Lactones and Organomagnesium Halides: Facile Synthesis of Indenones, SDS of cas: 613-33-2, the publication is Angewandte Chemie, International Edition (2021), 60(28), 15497-15502, database is CAplus and MEDLINE.

A set of rhenium-catalyzed arylation-acyl cyclizations between (hetero)arylmagnesium halides and enol lactones through a cascade C(sp²)-C(sp²)/C(sp²)-C(sp²) bond formation under mild reaction conditions was developed. Indeed, a wide range of functional groups on both organomagnesium halides and enol lactones was well tolerated by the simple rhenium catalysis, thus furnishing polyfunctionalized indenones in one-pot fashion and with complete control of the regioselectivity. Moreover, this approach also provided a straightforward synthetic route to neolignan and (iso)pauciflorol F. Mechanistic studies demonstrated that the reaction involved a sequence of syn-carborhenation and intramol. nucleophilic addition

Angewandte Chemie, International Edition published new progress about 613-33-2. 613-33-2 belongs to catalysis-chemistry, auxiliary class Benzene, name is 4,4′-Dimethyldiphenyl, and the molecular formula is C14H14, SDS of cas: 613-33-2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Jibril, Liban published the artcilePolymer-Mediated Particle Coarsening within Hollow Silica Shell Nanoreactors, Synthetic Route of 13822-56-5, the publication is Chemistry of Materials (2022), 34(11), 5094-5102, database is CAplus.

Inspired by the scanning probe block copolymer lithog. process, hollow silica shells were loaded with polymer-metal ink mixtures and investigated as solution-based nanoreactors for the synthesis of gold nanoparticles. The incorporation of poly(ethylene oxide) (PEO) into these hollow silica nanoreactors (approx. 40 nm in size) and the use of a two-step reductive annealing process (first at 200¡ãC and then at 600¡ãC) results in a high yield (76%) of larger (?6 nm) single nanoparticles; when the polymer is not used, smaller (?3 nm) particles dominate, and the yield of single particles is only 6%. It was determined that particle coarsening mostly occurs in the temperature range where the polymer is present and not degraded (i.e., <400¡ãC for PEO), as indicted by correlative in situ scanning/transmission electron microscopy in a reductive gas-phase environment. Thus, polymer incorporation in this nanoreactor system, which is amenable to scale up, drives the complete conversion of nanoreactor contents without excessive metal loss, highlighting the impact of nanoreactor composition and structural design on particle synthesis.

Chemistry of Materials published new progress about 13822-56-5. 13822-56-5 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is 3-(Trimethoxysilyl)propan-1-amine, and the molecular formula is C6H17NO3Si, Synthetic Route of 13822-56-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Jiang, Chengjun published the artcileSynergistic Effect of Pd/C and Novozyme 435 on the Dynamic Kinetic Resolution of 1,1,1-trifluoroisopropylamine, Category: catalysis-chemistry, the publication is Chemical Engineering Communications (2016), 203(9), 1222-1226, database is CAplus.

Response surface methodol. (RSM) was successfully applied to study the synergistic effect of Pd/C and Novozyme 435 on the dynamic kinetic resolution of 1,1,1-trifluoroisopropylamine (TFPA). The variables taken into consideration were reaction temperature, substrate concentration, the Pd/C amount, and the Novozyme 435 amount A statistical model was used to evaluate the influence of the variables on the conversion and enantiomeric excess (ee). It was found that the interaction between the Novozyme 435 and Pd/C was a significant parameter that affected TFPA conversion. The optimum conditions for RSM were: reaction temperature of 35¡ãC, substrate (¡À) – 1 concentration of 0.4 mol/L, 60 g/L of Novozyme 435, and 42.4 g/L of Pd/C (3 wt% of Pd on active carbon). The actual exptl. conversion was 95.6% under optimum conditions, which was comparable to the maximum predicted value of 95.7%.

Chemical Engineering Communications published new progress about 421-49-8. 421-49-8 belongs to catalysis-chemistry, auxiliary class Trifluoromethyl,Fluoride,Amine,Aliphatic hydrocarbon chain, name is 1,1,1-Trifluoropropan-2-amine, and the molecular formula is C3H6F3N, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Jiang, C. J. published the artcileEconomical and practical strategies for synthesis of ¦Á-trifluoromethylated amines, Synthetic Route of 421-49-8, the publication is Asian Journal of Chemistry (2015), 27(7), 2406-2408, database is CAplus.

A powerful approach to synthesize ¦Á-trifluoromethylated amines RCH(CF₃)NH₂ (R = CH₃, CH₃CH₂, C₆H₅, etc.) has been developed. The method is operationally simple, broad in substrate scope and amenable to scale-up using trifluoroacetic anhydride. Meanwhile, the strategy not only provided a versatile approach to synthesize ¦Á-trifluoromethylated amines but also provides a new method for exploring the new reactivity of trifluoroacetic anhydride.

Asian Journal of Chemistry published new progress about 421-49-8. 421-49-8 belongs to catalysis-chemistry, auxiliary class Trifluoromethyl,Fluoride,Amine,Aliphatic hydrocarbon chain, name is 1,1,1-Trifluoropropan-2-amine, and the molecular formula is C3H6F3N, Synthetic Route of 421-49-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Fan, Jinda published the artcileMultifunctional Thio-Stabilized Gold Nanoparticles for Near-Infrared Fluorescence Detection and Imaging of Activated Caspase-3, Recommanded Product: Fmoc-Pro-OH, the publication is Current Analytical Chemistry (2021), 17(8), 1182-1193, database is CAplus and MEDLINE.

Gold nanoparticles (AuNPs) are commonly used in nanomedicine because of their unique spectral properties, chem. and biol. stability, and ability to quench the fluorescence of organic dyes attached to their surfaces. However, the utility of spherical AuNPs for activatable fluorescence sensing of mol. processes have been confined to resonance-matched fluorophores in the 500 nm to 600 nm spectral range to maximize dye fluorescence quenching efficiency. Expanding the repertoire of fluorophore systems into the NIR fluorescence regimen with emission >800 nm will facilitate the anal. of multiple biol. events with high detection sensitivity. The primary goal of this study is to determine if spherical AuNP-induced radiative rate suppression of non-resonant near-IR (NIR) fluorescent probes can serve as a versatile nanoconstruct for highly sensitive detection and imaging of activated caspase-3 in aqueous media and cancer cells. This required the development of activatable NIR fluorescence sensors of caspase-3 designed to overcome the nonspecific degradation and release of the surface coatings in aqueous media. We harnessed the fluorescence-quenching properties and multivalency of spherical AuNPs to develop AuNP-templated activatable NIR fluorescent probes to detect activated caspase-3, an intracellular reporter of early cell death. Freshly AuNPs were coated with a multifunctional NIR fluorescent dye-labeled peptide (LS422) consisting of an RGD peptide sequence that targets ¦Áv¦Â3 -integrin protein (¦Áv¦Â3)on the surface of cancer cells to mediate the uptake and internalization of the sensors in tumor cells; a DEVD peptide sequence for reporting the induction of cell death through caspase-3 mediated NIR fluorescence enhancement; and a multidentate hexacysteine sequence for enhancing self-assembly and stabilizing the multifunctional construct on AuNPs. The integrin-binding affinity of LS422 and caspase-3 kinetics were determined by competitive radioligand binding and fluorogenic peptide assays, resp. Detection of intracellular caspase-3, cell viability, and the internalization of LS422 in cancer cells was determined by confocal NIR fluorescence spectroscopy and microscopy. Narrow size AuNPs (13 nm) were prepared and characterized by transmission electron microscopy and dynamic light scattering. When assembled on the AuNPs, the binding constant of LS422 for¦Áv¦Â3 improved 11- fold from 13.2 nM to 1.2 nM. Whereas the catalytic turnover of caspase-3 by LS422-AuNPs was similar to the reference fluorogenic peptide, the binding affinity for the enzyme increased by a factor of 2. Unlike the ¦Áv¦Â3 pos., but caspase-3 neg. breast cancer MCF-7 cells, treatment of the ¦Áv¦Â3 and caspase-3 pos. lung cancer A549 cells with Paclitaxel showed significant fluorescence enhancement within 30 min, which correlated with caspase-3 specific activation of LS422-AuNPs fluorescence. The incorporation of a 3.5 mW NIR laser source into our spectrofluorometer increased the detection sensitivity by an order of magnitude (limit of detection ?0.1 nM of cypate) and significantly decreased the signal noise relative to a xenon lamp. This gain in sensitivity enabled the detection of substrate hydrolysis at a broad range of inhibitor concentrations without photobleaching the cypate dye. The multifunctional AuNPs demonstrate the use of a non-resonant quenching strategy to design activatable NIR fluorescence mol. probes. The nanoconstruct offers a selective reporting method for detecting activated caspase-3, imaging of cell viability, identifying dying cells, and visualizing the functional status of intracellular enzymes. Performing these tasks with NIR fluorescent probes creates an opportunity to translate the in vitro and cellular anal. of enzymes into in vivo interrogation of their functional status using deep tissue penetrating NIR fluorescence anal. methods.

Current Analytical Chemistry published new progress about 71989-31-6. 71989-31-6 belongs to catalysis-chemistry, auxiliary class Amino acide derivatives,pyrrolidine, name is Fmoc-Pro-OH, and the molecular formula is C20H19NO4, Recommanded Product: Fmoc-Pro-OH.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Ng, Shan Shan published the artcilePalladium-Catalyzed Chemoselective Borylation of (Poly)halogenated Aryl Triflates and Their Application in Consecutive Reactions, Safety of 4-(2-(Di(adamantan-1-yl)phosphino)phenyl)morpholine, the publication is Advanced Synthesis & Catalysis (2022), 364(9), 1596-1601, database is CAplus.

Chemoselective palladium-phosphine-catalyzed borylation of halogenated aryl triflates TfOC₆H_nY_4-nX (X = Cl, Br; Y = H, OMe, F, Me, PhCH₂, aryl, CN) gave boryl triflates TfOC₆H_nY_4-nBpin, which can be applied for Suzuki coupling with aryl chlorides in one-pot two-step procedure, giving functionalized biaryls. This study reports the palladium-catalyzed chemoselective borylation of (poly)halogenated aryl triflates with a reactivity order of C-Cl>C-OTf. A catalyst system comprising Pd(OAc)₂ and SelectPhos (L1) enables a reaction with high reactivity and chemoselectivity. The consecutively chemoselective borylation reaction followed by the chemoselective intermol. Suzuki-Miyaura reaction can be performed using a one-pot two-step approach to synthesize unsym. biaryl compounds containing the triflate moiety. The reaction can be scaled up to the gram scale without diminishing the yield and chemoselectivity.

Advanced Synthesis & Catalysis published new progress about 1237588-12-3. 1237588-12-3 belongs to catalysis-chemistry, auxiliary class Mono-phosphine Ligands, name is 4-(2-(Di(adamantan-1-yl)phosphino)phenyl)morpholine, and the molecular formula is C30H42NOP, Safety of 4-(2-(Di(adamantan-1-yl)phosphino)phenyl)morpholine.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Chen, Xiangmeng published the artcileExploration of Aryl Phosphates in Palladium-Catalyzed Mono-¦Á-arylation of Aryl and Heteroaryl Ketones, Application of 4-(2-(Di(adamantan-1-yl)phosphino)phenyl)morpholine, the publication is Journal of Organic Chemistry (2019), 84(10), 6337-6346, database is CAplus and MEDLINE.

This paper presents the first general examples of selective palladium-catalyzed mono-¦Á-arylation of aryl and heteroaryl ketones with aryl phosphates. The catalyst system, consisting of [Pd(2-butenyl)Cl]₂ and MorDalPhos, exhibited high catalytic reactivity toward this reaction. A wide range of aryl phosphates were efficiently coupled with aryl and heteroaryl ketones with good selectivity. Excellent-to-good product yields were afforded. The gram-scale reaction was conducted smoothly. Reductive elimination or transmetalation might be a rate-determining step in this reaction.

Journal of Organic Chemistry published new progress about 1237588-12-3. 1237588-12-3 belongs to catalysis-chemistry, auxiliary class Mono-phosphine Ligands, name is 4-(2-(Di(adamantan-1-yl)phosphino)phenyl)morpholine, and the molecular formula is C30H42NOP, Application of 4-(2-(Di(adamantan-1-yl)phosphino)phenyl)morpholine.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Huang, Hongfeng published the artcileSubstrate Modification for High-Performance Thermoelectric Materials and Generators Based on Polymer and Carbon Nanotube Composite, Application In Synthesis of 13822-56-5, the publication is Advanced Materials Interfaces (2022), 9(23), 2201193, database is CAplus.

Polymer and carbon nanotube composites have aroused extensive attention for thermoelec. materials owing to the combination of low thermal conductivity of polymer and high elec. conductivity of carbon nanotubes. Surface properties of the substrate are of great importance for the charge transport behaviors of semiconducting thin films, which are less explored in thermoelec. applications. Herein, self-assembled monolayers (SAMs) are used to modify the substrate for thermoelec. polymer composites. The trifluoromethyl (CF₃)-terminated SAM is beneficial for an improved elec. conductivity; while the SAM with amino group is found to improve their Seebeck coefficient and decrease the elec. conductivity,. As a result, polymer composites on CF₃-SAM-modified substrate show a high room-temperature power factor of 285¦ÌW m^-1 K^-2 and a large output power of 2.36¦ÌW for thermoelec. generator at a temperature gradient of 50 K. This work demonstrates that surface modification by SAMs is a promising strategy for improving performance of thermoelec. materials and devices.

Advanced Materials Interfaces published new progress about 13822-56-5. 13822-56-5 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is 3-(Trimethoxysilyl)propan-1-amine, and the molecular formula is C6H17NO3Si, Application In Synthesis of 13822-56-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Fang, Hongbin published the artcileSynthesis and biological activity of amide derivatives derived from natural product Waltherione F, Related Products of catalysis-chemistry, the publication is Medicinal Chemistry Research (2022), 31(3), 485-496, database is CAplus.

Structural optimization based on natural products has become an effective way to develop new fungicides, which provides important guiding significance for practicing the new development concept and promoting the green development of pesticides. In this project, the target compounds containing 4-quinolone and piperazine substructures based on waltherione F were synthesized through the combination of the fungicidal amide lead compound X-I-4 discovered in our previous work and various of fungicidal piperazine derivatives Screening of their biol. activities suggested that products I-3, I-5, II-3, II-7, II-10, II-11 and II-13 displayed higher inhibition rates against Rhizoctonia solani than other tested compounds The in vitro cellular cytotoxicity assay revealed that compounds II-6 and II-11 exhibited higher cytotoxicity against HepG2 than other tested compounds The fluorescence characteristics investigation showed that the absolute fluorescence QY value of the methanol solution of the compound I-6 was higher than those of I-2, I-3, I-7 and I-8, which was further elucidated by TD-DFT.

Medicinal Chemistry Research published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C8H8O2, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Chen, Wei published the artcileDHA alleviates diet-induced skeletal muscle fiber remodeling via FTO/m6A/DDIT4/PGC1alpha signaling, Related Products of catalysis-chemistry, the publication is BMC Biology (2022), 20(1), 39, database is CAplus and MEDLINE.

Obesity leads to a decline in the exercise capacity of skeletal muscle, thereby reducing mobility and promoting obesity-associated health risks. Dietary intervention has been shown to be an important measure to regulate skeletal muscle function, and previous studies have demonstrated the beneficial effects of docosahexaenoic acid (DHA; 22:6 ¦Ø-3) on skeletal muscle function. At the mol. level, DHA and its metabolites were shown to be extensively involved in regulating epigenetic modifications, including DNA methylation, histone modifications, and small non-coding microRNAs. However, whether and how epigenetic modification of mRNA such as N6-methyladenosine (m6A) mediates DHA regulation of skeletal muscle function remains unknown. Here, we analyze the regulatory effect of DHA on skeletal muscle function and explore the involvement of m6A mRNA modifications in mediating such regulation. DHA supplement prevented HFD-induced decline in exercise capacity and conversion of muscle fiber types from slow to fast in mice. DHA-treated myoblasts display increased mitochondrial biogenesis, while slow muscle fiber formation was promoted through DHA-induced expression of PGC1¦Á. Further anal. of the associated mol. mechanism revealed that DHA enhanced expression of the fat mass and obesity-associated gene (FTO), leading to reduced m6A levels of DNA damage-induced transcript 4 (Ddit4). Ddit4 mRNA with lower m6A marks could not be recognized and bound by the cytoplasmic m6A reader YTH domain family 2 (YTHDF2), thereby blocking the decay of Ddit4 mRNA. Accumulated Ddit4 mRNA levels accelerated its protein translation, and the consequential increased DDIT4 protein abundance promoted the expression of PGC1¦Á, which finally elevated mitochondria biogenesis and slow muscle fiber formation. DHA promotes mitochondrial biogenesis and skeletal muscle fiber remodeling via FTO/m6A/DDIT4/PGC1¦Á signaling, protecting against obesity-induced decline in skeletal muscle function.

BMC Biology published new progress about 6217-54-5. 6217-54-5 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Aliphatic hydrocarbon chain,Metabolic Enzyme,RAR/RXR,Natural product, name is Docosahexaenoic Acid, and the molecular formula is C22H32O2, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia