Peifer, Christian’s team published research in Journal of Medicinal Chemistry in 52 | CAS: 16909-09-4

Journal of Medicinal Chemistry published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C11H12O4, Synthetic Route of 16909-09-4.

Peifer, Christian published the artcile3,4-Diaryl-isoxazoles and -imidazoles as Potent Dual Inhibitors of p38α Mitogen Activated Protein Kinase and Casein Kinase 1δ, Synthetic Route of 16909-09-4, the publication is Journal of Medicinal Chemistry (2009), 52(23), 7618-7630, database is CAplus and MEDLINE.

In this study, we report on the discovery of isoxazole 1 as a potent dual inhibitor of p38α (IC50 = 0.45 μM) and CK1δ (IC50 = 0.23 μM). Because only a few effective small mol. inhibitors of CK1 have been described so far, we aimed to develop this structural class toward specific agents. Mol. modeling studies comparing p38α/CK1δ suggested an optimization strategy leading to design, synthesis, biol. characterization, and SAR of highly potent compounds including 9 (IC50 p38α = 0.006 μM; IC50 CK1δ = 1.6 μM), 13 (IC50 p38α = 2.52 μM; IC50 CK1δ = 0.033 μM), 17 (IC50 p38α = 0.019 μM; IC50 CK1δ = 0.004 μM; IC50 CK1ε = 0.073 μM), and 18 (CKP138) (IC50 p38α = 0.041 μM; IC50 CK1δ = 0.005 μM; IC50 CK1ε = 0.447 μM) possessing differentiated specificity. Selected compounds were profiled over 76 kinases and evaluation of their cellular efficacy showed 18 (CKP138) to be a highly potent and dual-specific inhibitor of CK1δ and p38α.

Journal of Medicinal Chemistry published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C11H12O4, Synthetic Route of 16909-09-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Amesh, P.’s team published research in Journal of Radioanalytical and Nuclear Chemistry in 331 | CAS: 13822-56-5

Journal of Radioanalytical and Nuclear Chemistry published new progress about 13822-56-5. 13822-56-5 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is 3-(Trimethoxysilyl)propan-1-amine, and the molecular formula is C6H17NO3Si, Quality Control of 13822-56-5.

Amesh, P. published the artcileSuccinic acid functionalized magnetic mesoporous silica for the magnetic assisted separation of uranium from aqueous solution, Quality Control of 13822-56-5, the publication is Journal of Radioanalytical and Nuclear Chemistry (2022), 331(6), 2719-2733, database is CAplus.

The magnetite embedded mesoporous silica was prepared and functionalized with succinic acid, (abbreviated as Fe-MCM-SUC) for targeted adsorption of uranium from aqueous solution The adsorbent Fe-MCM-SUC was characterized with various advanced spectroscopic and anal. techniques and its adsorption performance towards uranium was evaluated under different conditions of aqueous medium. An apparent uranium adsorption capacity of 430 mg·g-1 was observed from pH â‰?6 solution The adsorbed uranium was recovered easily using dilute Na2CO3 solution and the recovered adsorbent was tested for uranium adsorption in multiple cycles for checking the feasibility of regeneration. The results showed that the adsorbent, Fe-MCM-SUC, is a potential candidate for the recovery of uranium from aqueous solution

Journal of Radioanalytical and Nuclear Chemistry published new progress about 13822-56-5. 13822-56-5 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is 3-(Trimethoxysilyl)propan-1-amine, and the molecular formula is C6H17NO3Si, Quality Control of 13822-56-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia