Catalysis-chemistry

Ai, Teng published the artcileN-(1-Benzyl-3,5-dimethyl-1H-pyrazol-4-yl)benzamides: Antiproliferative Activity and Effects on mTORC1 and Autophagy, Formula: C14H12O3, the publication is ACS Medicinal Chemistry Letters (2017), 8(1), 90-95, database is CAplus and MEDLINE.

Guided by antiproliferative activity in MIA PaCa-2 cells, the authors have performed preliminary structure-activity relationship studies on N-(1-benzyl-3,5-dimethyl-1H-pyrazol-4-yl)benzamides. Two selected compounds showed submicromolar antiproliferative activity and good metabolic stability. Both compounds reduced mTORC1 activity and increased autophagy at the basal level. In addition, they disrupted autophagic flux by interfering with mTORC1 reactivation and clearance of LC3-II under starvation/re-feed conditions, as evidenced by accumulation of LC3-II and abnormal LC3 labeled punctae. Therefore, N-(1-benzyl-3,5-dimethyl-1H-pyrazol-4-yl)benzamides may represent a new class of autophagy modulators that possesses potent anticancer activity and potentially a novel mechanism of action.

ACS Medicinal Chemistry Letters published new progress about 31719-76-3. 31719-76-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 4-(Phenoxymethyl)benzoic acid, and the molecular formula is C14H12O3, Formula: C14H12O3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Lim, Booyong S. published the artcileMonodithiolene Molybdenum(V,VI) Complexes: A Structural Analogue of the Oxidized Active Site of the Sulfite Oxidase Enzyme Family, HPLC of Formula: 22693-41-0, the publication is Journal of the American Chemical Society (2001), 123(34), 8343-8349, database is CAplus and MEDLINE.

The active sites of the xanthine oxidase and sulfite oxidase enzyme families contain one pterin-dithiolene cofactor ligand bound to a Mo atom. Consequently, monodithiolene Mo complexes were sought by exploratory synthesis for structural and reactivity studies. Reaction of [MoO(S₂C₂Me₂)₂]^1- or [MoO(bdt)₂]^1- with PhSeCl results in removal of one dithiolate ligand and formation of [MoOCl₂(S₂C₂Me₂)]^1- (1) or [MoOCl₂(bdt)]^1- (2), which undergoes ligand substitution reactions to form other monodithiolene complexes [MoO(2-AdS)₂(S₂C₂Me₂)]^1- (3), [MoO(SR)₂(bdt)]^1- (R = 2-Ad (4), 2,4,6-Prⁱ₃C₆H₂ (5)), and [MoOCl(SC₆H₂-2,4,6-Prⁱ₃)(bdt)]^1- (6) (Ad = 2-adamantyl, bdt = benzene-1,2-dithiolate). These complexes have square pyramidal structures with apical oxo ligands, exhibit rhombic EPR spectra, and 3–5 are electrochem. reducible to Mo^IVO species. Complexes 1–6 constitute the 1st examples of five-coordinate monodithiolene Mo^VO complexes; 6 approaches the proposed structure of the high-pH form of sulfite oxidase. Treatment of [MoO₂(OSiPh₃)₂] with Li₂(bdt) in THF affords [MoO₂(OSiPh₃)(bdt)]^1- (8). Reaction of 8 with 2,4,6-Prⁱ₃C₆H₂SH in MeCN gives [MoO₂(SC₆H₂-2,4,6-Prⁱ₃)(bdt)]^1- (9, 55%). Complexes 8 and 9 are square pyramidal with apical and basal oxo ligands. With one dithiolene and one thiolate ligand of a square pyramidal Mo^VIO₂S₃ coordination unit, 9 closely resembles the oxidized sites in sulfite oxidase and assimilatory nitrate reductase as deduced from crystallog. (sulfite oxidase) and Mo EXAFS. The complex is the 1st structural analog of the active sites in fully oxidized members of the sulfite oxidase family. This work provides a starting point for the development of both structural and reactivity analogs of members of this family.

Journal of the American Chemical Society published new progress about 22693-41-0. 22693-41-0 belongs to catalysis-chemistry, auxiliary class Other Functionalization Reagent, name is 2,4,6-Triisopropylbenzenethiol, and the molecular formula is C15H24S, HPLC of Formula: 22693-41-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Tyrra, Wieland published the artcileA facile preparative route for pentafluorophenylsilver, AgC₆F₅ and its use as an oxidative pentafluorophenyl group transfer reagent in reactions with group 12 to 16 elements – the single crystal structure of AgC₆F₅¡¤EtCN, the first arylsilver derivative crystallizing in infinite chains, Recommanded Product: Trimethyl(perfluorophenyl)silane, the publication is Zeitschrift fuer Anorganische und Allgemeine Chemie (2002), 628(8), 1841-1847, database is CAplus.

AgC₆F₅ is directly and quant. formed from room temperature reactions of AgF and Me₃SiC₆F₅ in N-donor solvents, particularly EtCN. Solutions of AgC₆F₅ prepared by this method exhibit excellent oxidative properties in reactions with a variety of groups 12 to 16 elements giving the corresponding pentafluorophenyl element compounds in moderate to excellent yields. AgC₆F₅-EtCN crystallizes with monoclinic symmetry (C2/c, Z = 8, a = 2301.4(5) pm, b = 1078.8(4) pm, c = 948.0(2) pm, ¦Â = 113.19(1)¡ã) and exhibits chains of silver atoms with bridging C₆F₅ groups.

Zeitschrift fuer Anorganische und Allgemeine Chemie published new progress about 1206-46-8. 1206-46-8 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Trimethyl(perfluorophenyl)silane, and the molecular formula is C37H30ClIrOP2, Recommanded Product: Trimethyl(perfluorophenyl)silane.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Guertin, Donald L. published the artcileInfrared absorption spectra of branched-chain fatty acids, COA of Formula: C10H20O2, the publication is Anal. Chem. (1956), 1194-5, database is CAplus.

Infrared absorption spectra of the branch-chained hexanoic acids showed that the relative intensities of bands at 7.8 and 8.1 ¦Ì could be valuable in the identification of ¦Á-substitution, thus extending the work of Freeman (cf. C.A. 48, 10560e) for long branched-chain fatty acids. Additionally, relative intensities at 6.8 and 7.1 ¦Ì are available for identification of ¦Á-substitution in acids containing less than 14 C atoms.

Anal. Chem. published new progress about 3115-28-4. 3115-28-4 belongs to catalysis-chemistry, auxiliary class Aliphatic Chain, name is 2-Butylhexanoic acid, and the molecular formula is C10H20O2, COA of Formula: C10H20O2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Guertin, Donald L. published the artcileInfrared absorption of branched-chain fatty acids and derivatives in the carbon-hydrogen stretching region, Recommanded Product: 2-Butylhexanoic acid, the publication is Journal of the American Oil Chemists’ Society (1956), 172-4, database is CAplus.

Investigations of the LiF region make it possible to characterize a number of structural isomers of branched-chain fatty acids, such as 2-methyl-, 3-methyl-, and 5-methylhexanoic acids. Similarly, 2-propyl- and 2-isopropylhexanoic acids can be differentiated and 2-butylhexanoic acid can be identified. Absorption bands at 2960 cm.^-1 and 2930 cm. ^-1 were assigned, resp., to asym. Me modes and in-phase vibrations of the methylene group. Absorption at 2870 cm.^-1 is associated with symmetrical stretching modes of the Me group. The absorption at 2860 cm. ^-1 has been assigned to the out-of-phase vibrations of the methylene group. These assignments correspond to those of Fox and Martin (C.A. 34, 4989.6) and Pozefsky and Coggeshall (C.A. 46, 3857f). The absorption bands at 2930 cm. ^-1 and 2860 cm. ^-1 are stronger than those at 2960 cm.^-1 and 2870 cm. ^-1 when the ratio of methylene groups to Me groups equals or exceeds 3 to 1. The one exception to this rule is the case of 2-methylhexanoic acid and the corresponding Ag salt and di-soap. An interaction between the Me group in the 2-position and the acid group has been proposed as an explanation for the case. As the spectra of the fatty acids and their Ag salt and Al di-soap derivatives are identical in the C-H region, it is obvious that other derivatives of these acids can be identified by reference to the spectra reported.

Journal of the American Oil Chemists’ Society published new progress about 3115-28-4. 3115-28-4 belongs to catalysis-chemistry, auxiliary class Aliphatic Chain, name is 2-Butylhexanoic acid, and the molecular formula is C10H20O2, Recommanded Product: 2-Butylhexanoic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Fox, C. P. published the artcileFlame out! End-Triassic mass extinction polycyclic aromatic hydrocarbons reflect more than just fire, Recommanded Product: Coronene, the publication is Earth and Planetary Science Letters (2022), 117418, database is CAplus.

Global warming induced-wildfires of the 21st century reveal the catastrophic effects that widespread biomass burning has on flora and fauna. During mass extinction events, similar wildfire episodes are considered to play an important role in driving perturbations in terrestrial ecosystems. To better evaluate the record of biomass burning and potential carbon cycle feedbacks at the end-Triassic mass extinction (~202 Ma; ETE), we investigated the relative abundances of a range of polycyclic aromatic hydrocarbons (PAHs) and the ¦Ä13C values of regular isoprenoids and n-alkanes at key sections in the SW UK. These data reveal little evidence for intensive wildfire activity during the extinction event, in contrast to what has been reported elsewhere in European, Chinese, and Greenland ETE sections. Herein, PAHs instead reflect greater contributions from an episode of soil erosion that we attribute to Large Igneous Province (LIP)-driven acid rain, and possible distal sources of smoke, suggestive of fire elsewhere in the UK/European basins. This terrestrial ecosystem perturbation is coincident with those in the marine realm, indicating ecosystem perturbations occurred across multiple habitats throughout the latest Rhaetian in the SW UK. Addnl., this geochem. approach reveals that the precursor carbon isotope excursion (CIE) routinely used in chemostratigraphic correlations is unrelated to LIP activity, but instead results from the increased input of terrestrially derived 13C-depleted plant material. Furthermore, we find the initial CIE (commonly used to mark the extinction level, but which is now known to precede the ETE) is also unrelated to biomass burning. Collectively, these data reveal that processes other than combustion of terrestrial material are important for the terrestrial phase of the ETE in the SW UK. Similar investigations are required on other ETE sections, both those in close proximity to the LIP driving the extinction and those further afield, to more clearly determine the neg. effect(s) of LIPs and their geog. extent in the terrestrial realm.

Earth and Planetary Science Letters published new progress about 191-07-1. 191-07-1 belongs to catalysis-chemistry, auxiliary class Electronic Materials, name is Coronene, and the molecular formula is C24H12, Recommanded Product: Coronene.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Liu, Mengjie published the artcileEngineering of a biologically active insulin dimer, Synthetic Route of 71989-31-6, the publication is Journal of Medicinal Chemistry (2021), 64(23), 17448-17454, database is CAplus and MEDLINE.

The growing epidemic of diabetes means that there is a need for therapies that are more efficacious, safe, and convenient. Here, we report the efficient synthesis of a novel disulfide dimer of human insulin tethered at the N-terminus of its B-chain through placement of a cysteine residue. The resulting peptide was shown to bind to both the insulin receptor isoform B and insulin-like growth factor-1 receptor with comparable affinity to native insulin. In in vivo insulin tolerance tests, the dimer was equipotent to Actrapid insulin and possessed a sustained duration of action greater than that of Actrapid and Glargine. While the secondary structure of our dimeric insulin was similar to that of insulin, it was more resistant to proteolysis. More importantly, our analog was produced in quant. yield from a monomeric thiol insulin scaffold. Our results suggest that this dimer has significant potential to address the clin. needs in the treatment of diabetes.

Journal of Medicinal Chemistry published new progress about 71989-31-6. 71989-31-6 belongs to catalysis-chemistry, auxiliary class Amino acide derivatives,pyrrolidine, name is Fmoc-Pro-OH, and the molecular formula is C20H19NO4, Synthetic Route of 71989-31-6.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Liaw, Joshua Y published the artcileLessons to be learned: Using National Immunisation strategies to improve adherence to acute rheumatic fever secondary prophylaxis., Formula: C16H20N2, the publication is Journal of paediatrics and child health (2019), 55(10), 1170-1176, database is MEDLINE.

Rheumatic heart disease, as a result of a single or recurrent episode of acute rheumatic fever (ARF), remains a significant cause of morbidity and mortality in northern and remote Australia; ARF has a peak incidence among 5-14-year-old Aboriginal and Torres Strait Islander children. Long-term regular benzathine penicillin G injections are the only currently successful secondary prevention strategy; however, rates of adherence remain critically low. In contrast, rates of adherence to immunisations on the National Immunisation Program (NIP) Schedule are high, even among this target population. This article compares strategies used to implement and improve ARF secondary prophylaxis with those used in the NIP. Some successful NIP strategies, such as Service Incentive Payment for health providers, home-visiting delivery models and integration into the National Immunisation Register, if applied to ARF secondary prophylaxis have the potential to improve benzathine penicillin G adherence.

Journal of paediatrics and child health published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, Formula: C16H20N2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Crawford, Sarah M. published the artcileProbing the effect of donor-fragment substitution in Mor-DalPhos on palladium-catalyzed C-N and C-C cross-coupling reactivity, Application In Synthesis of 1237588-12-3, the publication is Canadian Journal of Chemistry (2018), 96(6), 578-586, database is CAplus.

The competitive catalytic screening of 18 known and newly prepared Mor-DalPhos ligand variants, 1-R₂N-2-PR¹₂C₆H₄ (R = Me; R₂N = 4-morpholinyl, 1-azetidinyl, 1-pyrrolidinyl, 1-piperidinyl, 2-tetrahydroisoquinolinyl, 1-piperazinyl; R¹ = Ph, 2-MeC₆H₄, Cy, ^tBu, 1-adamantyl, 3,5-dimethyl-1-adamantyl) in the palladium-catalyzed cross-coupling of chlorobenzene with aniline, octylamine, morpholine, indole, ammonia, or acetone is presented, including ligands derived from the new secondary phosphine HP(^Me2Ad)₂ (^Me2Ad = 3,5-dimethyl-1-adamantyl). Although triarylphosphine ancillary ligand variants performed poorly in these test reactions, ligands featuring either PAd₂ or P(^Me2Ad)₂ donors (Ad = 1-adamantyl) gave rise to superior catalytic performance. Multiple Mor-DalPhos variants proved effective in cross-couplings involving aniline, octylamine, or morpholine; conversely, only a smaller subset of ligands proved useful in related cross-couplings of indole, ammonia, or acetone. In the case of the N-arylation of indole, a Mor-DalPhos ligand variant featuring ortho-disposed PAd₂ and dimethylmorpholino donor fragments (L13) proved superior to all other ligands surveyed, including the parent ligand Mor-DalPhos (L5). Conversely, L5 was found to be superior to all other ligands in the palladium-catalyzed monoarylation of ammonia. Ligand L6 (i.e., the P(^Me2Ad)₂ variant of L5) proved superior to all other ligands in the monoarylation of acetone and, with the exception of indole N-arylation, was the most broadly useful of the Mor-DalPhos ligands surveyed herein.

Canadian Journal of Chemistry published new progress about 1237588-12-3. 1237588-12-3 belongs to catalysis-chemistry, auxiliary class Mono-phosphine Ligands, name is 4-(2-(Di(adamantan-1-yl)phosphino)phenyl)morpholine, and the molecular formula is C30H42NOP, Application In Synthesis of 1237588-12-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Helmer, Bradley J. published the artcileSilicon-29 NMR of pentacoordinate silicon derivatives, Product Details of C12H10F2Si, the publication is Journal of Organometallic Chemistry (1983), 251(3), 295-8, database is CAplus.

The temperature dependence of chem. shifts in o-(Me₂NCH₂)C₆H₄SiRR¹R² (I; R, R¹, R² = Me, Ph, 1-C₁₀H₇, H, F, Cl, OMe, OEt) and PhSiRR¹R² indicated the existence of an equilibrium between tetra- and penta-coordinate forms. I (R = 1-C₁₀H₇, R¹ = R² = H) is the 1st Si derivative without halogen or chalcogen to show intramol. pentacoordination. This coordination may account for the reactivity of the Si-H bond in this compound

Journal of Organometallic Chemistry published new progress about 312-40-3. 312-40-3 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Difluorodiphenylsilane, and the molecular formula is C12H10F2Si, Product Details of C12H10F2Si.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia