Catalysis-chemistry

Talavera, Maria published the artcileC-H and C-F Bond Activation Reactions of Fluorinated Propenes at Rhodium: Distinctive Reactivity of the Refrigerant HFO-1234yf, Recommanded Product: Difluorodiphenylsilane, the publication is Angewandte Chemie, International Edition (2019), 58(31), 10688-10692, database is CAplus and MEDLINE.

The reaction of [Rh(H)(PEt₃)₃] (1) with the refrigerant HFO-1234yf (2,3,3,3-tetrafluoropropene) affords an efficient route to obtain [Rh(F)(PEt₃)₃] (3) by C-F bond activation. Catalytic hydrodefluorinations were achieved in the presence of the silane HSiPh₃. In the presence of a fluorosilane, 3 provides a C-H bond activation followed by a 1,2-fluorine shift to produce [Rh{(E)-C(CF₃):CHF}(PEt₃)₃] (4). Similar rearrangements of HFO-1234yf were observed at [Rh(E)(PEt₃)₃] [E = Bpin (6), C₇D₇ (8), Me (9)]. The ability to favor C-H bond activation using 3 and fluorosilane is also demonstrated with 3,3,3-trifluoropropene. Studies are supported by DFT calculations

Angewandte Chemie, International Edition published new progress about 312-40-3. 312-40-3 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Difluorodiphenylsilane, and the molecular formula is C4H8Cl2S2, Recommanded Product: Difluorodiphenylsilane.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Liu, Yaxu published the artcileVersatile and Highly Efficient trans-[Pd(NHC)Cl₂(DMS/THT)] Precatalysts for C-N and C-C Coupling Reactions in Green Solvents, Synthetic Route of 613-33-2, the publication is European Journal of Organic Chemistry (2022), 2022(14), e202200309, database is CAplus.

A straightforward synthetic procedure to well-defined, air- and moisture- stable trans-[Pd(NHC)Cl₂(DMS/THT)] (NHC=IPr, SIPr, IMes, IPrCl, IPr*, IPr#) pre-catalysts was reported. These complexes were obtained by reacting NHC.HCl imidazolium salts with trans-[PdCl₂(DMS/THT)2] precursors with the assistance of the weak base K₂CO₃ in green acetone at40¡ãC. The scalability of this protocol was demonstrated. The catalytic activity of the synthesized complexes was studied in the Buchwald-Hartwig and Suzuki-Miyaura reactions. Remarkably, most of the synthesized complexes exhibited higher catalytic activity with respect to their PEPPSI congeners in the Buchwald-Hartwig amination in 2-MeTHF. In particular, complex trans-[Pd(IPr#)Cl₂(DMS)] enabled the coupling of various (hetero)aryl chlorides and primary/secondary amines with a 0.2 mol% catalyst loading. In addition, trans-[Pd(IPr)Cl₂(DMS)] showed excellent performance in the room-temperature Suzuki-Miyaura reaction involving various (hetero)aryl chlorides and aryl boronic acids. In summary, the synthesized complexes, especially trans-[Pd(NHC)Cl₂(DMS)], was considered as greener alternatives to classical PEPPSI type catalysts based on the lower toxicity of the throw-away DMS ligand compared to 3-chloropyridine.

European Journal of Organic Chemistry published new progress about 613-33-2. 613-33-2 belongs to catalysis-chemistry, auxiliary class Benzene, name is 4,4′-Dimethyldiphenyl, and the molecular formula is C14H14, Synthetic Route of 613-33-2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Mermer, Arif published the artcileBenzotriazole-oxadiazole hybrid Compounds: Synthesis, anticancer Activity, molecular docking and ADME profiling studies, Recommanded Product: 2-Methylbenzoic acid, the publication is Journal of Molecular Liquids (2022), 119264, database is CAplus.

Herein the designed novel benzotriazole-oxadiazole hybrid compounds were synthesized using both conventional method and ultrasound sonication (US) as an environmentally friendly method. It was observed that the US method provided an increase in reaction yields by reducing the reaction time approx. 3-fold. The synthesized compounds were investigated against PANC-1 cell line. All obtained compounds were characterized by FT-IR, ¹H NMR, ¹³C NMR and MS spectroscopic techniques. The compounds 1-{[5-(3,4-dimethoxyphenyl)-1,3,4-oxadiazol-2-yl]methyl}-1H1,2,3-benzotriazole and 1-{[5-(3,4-dietoksiphenyl)-1,3,4-oxadiazol-2-yl]methyl}-1H1,2,3-benzotriazole exhibited very promising anticancer activity results with IC₅₀ values of 117.5 ¡À 0.084 ¦ÌM and 87.82 ¡À 4.319 ¦ÌM, resp. Further, mol. docking studies to suggest how the synthesized compounds interact with the kinase domain of human DDR1 in complex of pancreatic Cancer proteins (PDB ID: 6HP9), and the crystal structure of PDEd of pancreatic Cancer proteins (PDB ID: 5E80). It was concluded from the docking studies that the compound 1-{[5-(3,4-dietoksiphenyl)-1,3,4-oxadiazol-2-yl]methyl}-1H1,2,3-benzotriazole demonstrated the highest binding score values for active site of both proteins. Afterwards, ADME calculations were performed to examine the drug properties of benzotriazole-oxadiazole hybrid compounds

Journal of Molecular Liquids published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C8H8O2, Recommanded Product: 2-Methylbenzoic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Popielarz, Roman published the artcileEffect of coinitiator type on initiation efficiency of two-component photoinitiator systems based on eosin, COA of Formula: C14H23N, the publication is Journal of Polymer Science, Part A: Polymer Chemistry (2008), 46(11), 3519-3532, database is CAplus.

The effect of coinitiator structure on the relative initiation efficiency of two-component eosin/coinitiator systems was evaluated quant. in the polymerization of polyethylene glycol diacrylate as an example monomer. The initiation efficiency was measured by the fluorescence probe technique (FPT), using eosin both as a photoinitiator component and as a fluorescent probe. A LED/fiber optic-based measurement system was developed and used in this study. From among 17 compounds tested, the following coinitiators form most efficient photoinitiating systems in combination with eosin, when exposed to visible light: coinitiator, relative efficiency = triethanolamine, 1.0; 2,6-diisopropyl-N,N-dimethylaniline, 0.70; 2-benzyl-2-(dimethylamino)-4′-morpholinobutyrophenone (Irgacure 369), 0.91; carbon tetrabromide, 2.1; [4-[(2-hydroxytetradecyl)oxy]phenyl]phenyliodonium hexafluoroantimonate (SarCat 1012), 28. These relative efficiencies refer to the following component concentrations: [eosin] = 8.6 ¡Á 10^-4 M, (0.05% by weight); [coinitiator] = 4.3 ¡Á 10^-2 M. The factors affecting the initiation efficiency of the systems studied are discussed.

Journal of Polymer Science, Part A: Polymer Chemistry published new progress about 2909-77-5. 2909-77-5 belongs to catalysis-chemistry, auxiliary class Amine,Benzene, name is 2,6-Diisopropyl-N,N-dimethylaniline, and the molecular formula is C14H23N, COA of Formula: C14H23N.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Drozdov, V. A. published the artcileInteraction of alkyl(aryl)chloro- and fluorosilanes with acetonitrile, Synthetic Route of 312-40-3, the publication is Zhurnal Obshchei Khimii (1972), 42(6), 1356-8, database is CAplus.

The nD and deviations of calculated nD as a function of concentration in MeCN were observed for R3SiX (where X = F or Cl and R = Me, Et, Ph, p-MeC6H4 or p-ClC6H4). Ir spectra of such systems were described and evidence of acid-base interaction was found for the fluoro- and chlorosilanes in which Si atoms are sp3d2-hybridized. Solid adducts Ph3SiF.2MeCN and Ph2SiF2.4MeCN were isolated.

Zhurnal Obshchei Khimii published new progress about 312-40-3. 312-40-3 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Difluorodiphenylsilane, and the molecular formula is C12H10F2Si, Synthetic Route of 312-40-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Os’kina, I. A. published the artcileReaction of polyfluoroarylamine N-anions with polyfluoro- and nitrohaloaromatic compounds, Application In Synthesis of 1821-27-8, the publication is Izvestiya Sibirskogo Otdeleniya Akademii Nauk SSSR, Seriya Khimicheskikh Nauk (1984), 102-13, database is CAplus.

The reactions of 4-RC₆F₄NH^– Na⁺ (R = F, MeCO, Me, H, CF₃, NC) and the Na salts of 2,3,5,6-tetrafluoro-4-pyridinamine, 4-O₂NC₆H₄NH₂, and 4-nitro-1-naphthylamine with polyfluoro- and nitrohaloarom. compounds were studied in DMF and Me₂SO. The relative rate constants (k) were correlated with the pK values of the corresponding arylamines by log k = 0.74 pK – 14.01. A F atom ortho to the amino group had little effect on the nucleophilic reactivity of the N-anions.

Izvestiya Sibirskogo Otdeleniya Akademii Nauk SSSR, Seriya Khimicheskikh Nauk published new progress about 1821-27-8. 1821-27-8 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Amine,Benzene, name is Bis(4-nitrophenyl)amine, and the molecular formula is C12H9N3O4, Application In Synthesis of 1821-27-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Mirabile, Salvatore published the artcileEvaluation of 4-(4-Fluorobenzyl)piperazin-1-yl]-Based Compounds as Competitive Tyrosinase Inhibitors Endowed with Antimelanogenic Effects, Related Products of catalysis-chemistry, the publication is ChemMedChem (2021), 16(19), 3083-3093, database is CAplus and MEDLINE.

There is a considerable attention for the development of inhibitors of tyrosinase (TYR) as therapeutic strategy for the treatment of hyperpigmentation disorders in humans. Continuing in our efforts to identify TYR inhibitors, we describe the design, synthesis and pharmacophore exploration of new small mols. structurally characterized by the presence of the 4-fluorobenzylpiperazine moiety as key pharmacophoric feature for the inhibition of TYR from Agaricus bisporus (AbTYR). Our investigations resulted in the discovery of the competitive inhibitor [4-(4-fluorobenzyl)piperazin-1-yl]-(3-chloro-2-nitro-phenyl)methanone 26 (I, IC₅₀=0.18¦ÌM) that proved to be ?100-fold more active than reference compound kojic acid (IC₅₀=17.76¦ÌM). Notably, compound 26 exerted antimelanogenic effect on B16F10 cells in absence of cytotoxicity. Docking anal. suggested its binding mode into AbTYR and into modelled human TYR.

ChemMedChem published new progress about 104-03-0. 104-03-0 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Carboxylic acid,Benzene, name is 4-Nitrophenylacetic acid, and the molecular formula is C8H7NO4, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Pfennig, Victoria S. published the artcileMechanochemical Grignard Reactions with Gaseous CO₂ and Sodium Methyl Carbonate, Formula: C8H8O2, the publication is Angewandte Chemie, International Edition (2022), 61(9), e202116514, database is CAplus and MEDLINE.

A one-pot, three-step protocol for the preparation of Grignard reagents from organobromides RBr [R = 2-naphthyl, 2-thienyl, 1-adamantyl, etc.] in a ball mill and their subsequent reactions with gaseous carbon dioxide (CO₂) or sodium Me carbonate providing aryl and alkyl carboxylic acids RC(O)OH in up to 82% yield are reported. The preparation has the short reaction times and the significantly reduced solvent amounts [2.0 equivalent for liquid assisted grinding (LAG) conditions]. Unexpectedly, aryl bromides with methoxy substituents lead to sym. ketones such as 2,2′-dimethoxybenzophenone and 2,2′,5,5′-tetramethoxybenzophenone as major products.

Angewandte Chemie, International Edition published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C8H8O2, Formula: C8H8O2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Matos, Maria Joao published the artcileStructure-Based Optimization of Coumarin hA₃ Adenosine Receptor Antagonists, Product Details of C8H7NO4, the publication is Journal of Medicinal Chemistry (2020), 63(5), 2577-2587, database is CAplus and MEDLINE.

Adenosine receptors are involved in several physiol. processes. Mols. able to selectively modulate one of these receptors represent promising multifunctional agents to treat or slow down the progression of different diseases. 3-Arylcoumarins have already been studied as neuroprotective agents by the group. Here, differently 8-substituted 3-arylcoumarins are complementarily studied as ligands of adenosine receptors, performing radioligand binding assays. Among the synthesized compounds, selective A3 receptor antagonists have been identified. 3-(4-Bromophenyl)-8-hydroxycoumarin (I) proved to be the most potent and selective A3 receptor antagonist (Ki = 258 nM). An anal. of its x-ray diffraction provided detailed information on its structure. Further evaluation of a selected series of compounds indicated that it is the nature and position of the substituents that determine their activity and selectivity. Theor. modeling calculations corroborate and explain the exptl. data, suggesting this novel scaffold has desirable properties for the development of potential multitarget drug candidates.

Journal of Medicinal Chemistry published new progress about 104-03-0. 104-03-0 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Carboxylic acid,Benzene, name is 4-Nitrophenylacetic acid, and the molecular formula is C8H7NO4, Product Details of C8H7NO4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Li, Zhen published the artcile5-(Diarylimino)- and 5-(sulfoximido)dibenzothiophenium triflates: syntheses and applications as electrophilic aminating reagents, Safety of Bis(4-fluorophenyl)methane, the publication is Organic & Biomolecular Chemistry (2021), 19(13), 2941-2948, database is CAplus and MEDLINE.

The one-pot synthesis of well-defined 5-(diarylimino) and 5-(sulfoximido)dibenzothiophenium triflates, resp. from diarylimines or sulfoximines, was reported and the structures of a series of these compounds were elucidated by X-ray crystallog. In analogy to their hypervalent I(III) analogs, the iminoyl and sulfoximidoyl groups of these compounds can be selectively transferred to organic substrates. Specifically, the uncatalyzed imination of thiols or sulfinates proceeds with good yields, while under the mild reaction conditions offered by visible light photoredox catalysis, the radical amination of hydrazones or the sulfoximidation of benzylic, allylic and propargylic C-H bonds takes place satisfactorily.

Organic & Biomolecular Chemistry published new progress about 457-68-1. 457-68-1 belongs to catalysis-chemistry, auxiliary class Fluoride,Benzene, name is Bis(4-fluorophenyl)methane, and the molecular formula is C13H10F2, Safety of Bis(4-fluorophenyl)methane.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia