Tag: M.W=200-250

Gandomkar, Somayyeh published the artcileEnantioselective Oxidative Aerobic Dealkylation of N-Ethyl Benzylisoquinolines by Employing the Berberine Bridge Enzyme, Category: catalysis-chemistry, the publication is Angewandte Chemie, International Edition (2015), 54(50), 15051-15054, database is CAplus and MEDLINE.

N-Dealkylation methods are well described for organic chem. and the reaction is known in nature and drug metabolism; however, to our knowledge, enantioselective N-dealkylation has not been yet reported. In this study, exclusively the (S)-enantiomers of racemic N-Et tertiary amines (1-benzyl-N-ethyl-1,2,3,4-tetrahydroisoquinolines) were dealkylated to give the corresponding secondary (S)-amines in an enantioselective fashion at the expense of mol. oxygen. The reaction is catalyzed by the berberine bridge enzyme, which is known for C-C bond formation. The dealkylation was demonstrated on a 100 mg scale and gave optically pure dealkylated products (ee>99 %).

Angewandte Chemie, International Edition published new progress about 1860-58-8. 1860-58-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(3-(Benzyloxy)phenyl)acetic acid, and the molecular formula is C15H14O3, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Hanumantha Rao, K. published the artcileSolution chemistry of mixed cationic/anionic collectors and flotation separation of feldspar from quartz, Safety of Dodecylamineacetate, the publication is Mines & Carrieres: Les Techniques (1994), 66-71, database is CAplus.

The behavior of cationic and anionic collector mixtures in the feldspar-quartz flotation system has been investigated through conductivity, surface tension, zeta-potential and flotation studies. The results show the formation of mol. complexes between oppositely charged collector ions through charge neutralization. The mol. complexes are found to have a higher surface activity than the individual components. The mole ratio of the mixed composition is found to have a significant effect on flotation. Mole ratio less than unity (anionic/cationic) of collector mixtures increases the flotation recoveries. If the mole fraction of the anionic collector is greater than the mole fraction of cationic collector in a mixed composition, flotation ceases. The flotation selectivity principally depends on the inherent differences in the surface charges of feldspar and quartz at the flotation pH values of ¡Ü2. The zeta-potential and flotation results are discussed in terms of the adsorption behavior of mixed collectors on these minerals.

Mines & Carrieres: Les Techniques published new progress about 2016-56-0. 2016-56-0 belongs to catalysis-chemistry, auxiliary class Active Esterification, name is Dodecylamineacetate, and the molecular formula is C14H31NO2, Safety of Dodecylamineacetate.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Rao, K. Hanumantha published the artcileSolution chemistry of mixed cationic/anionic collectors and flotation separation of feldspar from quartz, HPLC of Formula: 2016-56-0, the publication is Publications of the Australasian Institute of Mining and Metallurgy (1993), 3/93(XVIII International Mineral Processing Congress), 837-44, database is CAplus.

The behavior of cationic and anionic collector mixtures in the feldspar-quartz flotation system was studied through conductivity, surface tension, zeta-potential, and flotation studies. The results show the formation of mol. complexes between oppositely charged collector ions through charge neutralization. The mol. complexes have a higher surface activity than the individual components. The mole ratio of the mixed composition has a significant effect on flotation. Use of collector mixtures with a mole ratio <1 (anionic/cationic) increases the flotation recoveries. If the mole fraction of the anionic collector is greater than the mole fraction of the cationic collector in a mixed composition, flotation ceases. The flotation selectivity principally depends on the inherent differences in the surface charges of feldspar and quartz at flotation pH ¡Ü2. The zeta-potential and flotation results are discussed in terms of the adsorption behavior of mixed collectors on these minerals.

Publications of the Australasian Institute of Mining and Metallurgy published new progress about 2016-56-0. 2016-56-0 belongs to catalysis-chemistry, auxiliary class Active Esterification, name is Dodecylamineacetate, and the molecular formula is C14H31NO2, HPLC of Formula: 2016-56-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Bottino, Francesco published the artcileConvenient synthesis of unsymmetrical aryl sulfides, Quality Control of 77189-99-2, the publication is Journal of Organic Chemistry (1981), 46(13), 2793-5, database is CAplus.

A simple procedure to prepare a variety of largely unknown unsym. substituted di-Ph sulfides in high yield, by coupling equimolar amounts of arenesulfenyl chlorides with appropriate aromatic substrates in EtNO₂, is reported. Furthermore, a suitable synthetic route for introducing under mild conditions the mercaptide group into strongly activated substrates is described. Thiophenols I (R¹ = H, Cl) were prepared in good yields via a 2-step synthesis by Fe-catalyzed sulfuration of benzenes II with S₂Cl₂ in CS₂ to give polysulfides III (R¹ = H, x = 3; R¹ = Cl, x = 2), which were reduced with Zn and HCl in C₆H₆.

Journal of Organic Chemistry published new progress about 77189-99-2. 77189-99-2 belongs to catalysis-chemistry, auxiliary class Thiophenol,Benzene,Ether, name is 2,4,6-Trimethoxybenzenethiol, and the molecular formula is C9H12O3S, Quality Control of 77189-99-2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Bottino, Francesco published the artcileMass spectral behavior of some m-dimethoxybenzene and sym-trimethoxybenzene sulfur derivatives, Quality Control of 77189-99-2, the publication is Organic Mass Spectrometry (1981), 16(7), 289-93, database is CAplus.

Mass spectra were recorded for the title compounds I (R = H, OMe; R¹ = H, Cl), II (n = 1, 2; R = H, OMe; R¹ = H, Cl) and II (n = 3; R = H, R¹ = Cl; R = OMe, R¹ = H, Cl), and the main fragmentation paths elucidated. The primary skeletal rearrangement of the mol. ions occurring in S-bridged compounds is a sensitive diagnostic tool in both structure elucidation and in locating OMe substituents.

Organic Mass Spectrometry published new progress about 77189-99-2. 77189-99-2 belongs to catalysis-chemistry, auxiliary class Thiophenol,Benzene,Ether, name is 2,4,6-Trimethoxybenzenethiol, and the molecular formula is C9H12O3S, Quality Control of 77189-99-2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Frohn, H.-J. published the artcile(Fluoroorgano)fluoroboranes and -fluoroborates. I. Synthesis and spectroscopic characterization of potassium fluoroaryltrifluoroborates and fluoroaryldifluoroboranes, Application In Synthesis of 1206-46-8, the publication is Journal of Organometallic Chemistry (2000), 598(1), 127-135, database is CAplus.

A convenient preparation of K[ArBF₃] (Ar = 2-C₆H₄F, 3-C₆H₄F, 4-C₆H₄F, 2,6-C₆H₃F₂, 3,5-C₆H₃F₂, 2,4,6-C₆H₂F₃, 3,4,5-C₆H₂F₃, 2,3,4,5-C₆HF₄, C₆F₅) is offered and the IR and multinuclear NMR spectra of these salts are reported. Treatment of the trifluoroborate salts with BF₃ in chlorocarbon solvents provides an easy synthetic route to the corresponding aryldifluoroboranes ArBF₂. The multinuclear NMR spectra of ArBF₂ are presented. The electron substituent effect of the [-BF₃]^–-group shows this substituent as one of the strongest ¦Ò-electron donors, while its ¦Ð-electron influence is negligible (¦Ò_I = -0.32, ¦Ò_R = -0.07).

Journal of Organometallic Chemistry published new progress about 1206-46-8. 1206-46-8 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Trimethyl(perfluorophenyl)silane, and the molecular formula is C9H9F5Si, Application In Synthesis of 1206-46-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zhang, Yun published the artcileN-Heterocyclic carbene-palladium(II)-1-methylimidazole complex catalyzed Suzuki-Miyaura coupling of benzylic chlorides with arylboronic acids or potassium phenyltrifluoroborate in neat water, Application of Bis(4-fluorophenyl)methane, the publication is Organic & Biomolecular Chemistry (2013), 11(14), 2266-2272, database is CAplus and MEDLINE.

An easily available N-heterocyclic carbene-palladium(II)-1-methylimidazole complex (I) showed efficient catalytic activity in the Suzuki-Miyaura coupling of benzylic chlorides with arylboronic acids or potassium phenyltrifluoroborate in neat water under mild conditions, providing an alternative method for the synthesis of diarylmethane derivatives, which widely exist in mols. with pharmaceutical activities and are also frequently found as subunits in supramols. Under the optimal conditions, all reactions performed well to give the desired products in moderate to almost quant. yields in an environmentally benign medium within 12 h, extending their applications toward potentially industrial processes.

Organic & Biomolecular Chemistry published new progress about 457-68-1. 457-68-1 belongs to catalysis-chemistry, auxiliary class Fluoride,Benzene, name is Bis(4-fluorophenyl)methane, and the molecular formula is C15H15OP, Application of Bis(4-fluorophenyl)methane.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Manz, Thomas A. published the artcileThe nature of aryloxide and arylsulfide ligand bonding in dimethyltitanium complexes containing cyclopentadienyl ligation, Related Products of catalysis-chemistry, the publication is Dalton Transactions (2005), 668-674, database is CAplus and MEDLINE.

A series of dimethyltitanium compounds [CpTi(EAr)Me₂] (E = O, S) ligated by one ¦Ç⁵-cyclopentadienyl (Cp) and one aryloxide (OAr) or aryl sulfide (SAr) were prepared and structurally characterized. Reaction of [CpTiCl₃] with LiSAr afforded [CpTi(SAr)Cl₂], which was methylated to give [CpTi(SAr)Me₂] (1, 2; Ar = 2,4,6-Me₃C₆H₂, 2,4,6-ⁱPr₃C₆H₂). The same complexes 1 and 2 were formed by protonolysis of CpTiMe₃ by HSAr. Crystal structures of 1 and 2 are reported; the structures are compared with known structures of the aryloxy-complexes. Exptl. structures were compared to those predicted by d. functional theory (DFT). Bonding in the aryl sulfide systems was found to be significantly different from bonding in the aryloxide systems. The aryloxide ligands exhibited wide Ti-O-Ar angles (¡Ý150¡ã) with the Ar group oriented proximal to the Cp group. DFT computations revealed two conformers for the aryl sulfide systems. Aryl sulfides with the Ar group proximal to the Cp group had a predicted Ti-S-Ar angle of ?120¡ã while those with the Ar group distal to the Cp group had a measured and predicted Ti-S-Ar angle of ?100¡ã. Mol. and natural bond orbital (NBO) analyses were employed to explain the nature of ligand bonding in these systems.

Dalton Transactions published new progress about 22693-41-0. 22693-41-0 belongs to catalysis-chemistry, auxiliary class Other Functionalization Reagent, name is 2,4,6-Triisopropylbenzenethiol, and the molecular formula is C15H24S, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Weinert, Charles S. published the artcileSynthesis, structures and reactivity of novel germanium(II) aryloxide and arylsulfide complexes, Quality Control of 22693-41-0, the publication is Dalton Transactions (2003), 532-539, database is CAplus.

The protonolysis reactions between Ge[N(SiMe₃)₂]₂ and substituted phenols give rise to new germanium(II) aryloxide complexes [Ge(OAr)₂]_n (n = 2, ArO = OC₆H₂Me₃-2,4,6 (1) or OC₆H₃ⁱPr₂-2,6 (2); n = 1, ArO = OC₆H₃Ph₂-2,6 (3) or OC₆HPh₄-2,3,5,6 (4)). The solid state structures of 1–3 and 4¡¤3C₆H₆ were determined by x-ray diffraction and compared to their spectroscopic properties. Compounds 1 and 2 contain bridging aryloxide ligands and the environment about the germanium atoms is pyramidal. Compound 1 reacts with benzil to yield a five-coordinate germanium complex [Ge(OC₆H₂Me₃-2,4,6)(O₂C₂Ph₂)(O₂C₂HPh₂)] (5), while compound 4 reacts with the same reagent to give [Ge(OC₆HPh₄-2,3,5,6)₂(O₂C₂Ph₂)] (6). The x-ray crystal structures of 5¡¤C₆H₆ and 6¡¤0.5C₆H₆ also were determined Compound 4 also undergoes an oxidative addition reaction with CH₃I to yield the germane [Ge(OC₆HPh₄-2,3,5,6)₂(Me)(I)] (7). A novel arylsulfidegermane, [HGe(SC₆H₂ⁱPr₃-2,4,6)₃] (8), was isolated in the reaction between Ge[N(SiMe₃)₂]₂ and HSC₆H₂ⁱPr₃-2,4,6 and was characterized by NMR spectroscopy and an x-ray crystal structure.

Dalton Transactions published new progress about 22693-41-0. 22693-41-0 belongs to catalysis-chemistry, auxiliary class Other Functionalization Reagent, name is 2,4,6-Triisopropylbenzenethiol, and the molecular formula is C9H9NO, Quality Control of 22693-41-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Mayr, Toni published the artcileOptimized Trientine-dihydrochloride Therapy in Pediatric Patients With Wilson Disease: Is Weight-based Dosing Justified?, Recommanded Product: N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride, the publication is Journal of Pediatric Gastroenterology and Nutrition (2021), 72(1), 115-122, database is CAplus and MEDLINE.

The aim of the study was to investigate the efficacy and safety of trientine-dihydrochloride (TD) in pediatric patients with Wilson disease (WD) and the effect of different weight-based dosages on their clin. and biochem. outcome. We retrospectively reviewed the clin. data of 31 children with WD receiving TD therapy ages under 18 years at the time of diagnosis. Outcome measures included parameters of copper metabolism and liver function tests. To examine the impact of different weight-based dosages, 2 dosage subgroups were analyzed. Group 1 received less than 20mg/kg TD per day, group 2 more than 20mg¡¤kg^-1¡¤day^-1. Median follow-up was 60 (5-60) months in the total study group. During TD therapy, nonceruloplasmin-bound copper was reduced from mean 1.53 (0.01-6.95) at baseline to 0.62 (0.01-4.57) ¦Ìmol/l. 24h-urinary copper excretion diminished to 1.85 (0.8-9.6) ¦Ìmol/day approximating the therapeutic goal of 1.6¦Ìmol/day. Seven of 31 patients (22.6%) required discontinuation of TD treatment, in 4 cases it was because of adverse events (ulcerative colitis, gingival and breast hypertrophy, hirsutism, elevation of transaminases). Investigations about weight-based dosage showed no significant difference of any laboratory parameter between the 2 cohorts. But in terms of clin. safety, adverse effects because of TD were only found in 6.7% of children in group 1 (<20mg¡¤kg^-1¡¤day^-1, median follow-up 60 [14-60] months), it was 63.6%. TD proves to be an efficacious alternative chelating agent for children with WD. Weight-based dosages above the recommended 20mg¡¤kg^-1¡¤day^-1 may increase the rate of adverse effects in pediatric patients.

Journal of Pediatric Gastroenterology and Nutrition published new progress about 38260-01-4. 38260-01-4 belongs to catalysis-chemistry, auxiliary class Chelating Agents, name is N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride, and the molecular formula is C6H20Cl2N4, Recommanded Product: N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia