Tag: M.W=200-250

Aaberg, Boerje published the artcilePlant growth regulators. XL. Some halogeno- and alkyl-phenoxyacetic and optically active -phenoxypropionic acids, COA of Formula: C12H16O3, the publication is Swedish Journal of Agricultural Research (1980), 10(3), 107-14, database is CAplus.

Optically active 4-fluoro- [405-79-8], 3-tert-butyl- [1878-55-3], and 4-tert-butylphenoxypropionic acid [6941-12-4], 2-bromo-4-chloro- [77228-66-1], 4-bromo-2-chloro- [77228-67-2], and 2,4-diiodophenoxyacetic acid [77228-65-0], 4-chloro-2-methylphenoxythioacetic acid [22716-96-7], 4-methyl-2-tert-butyl- [25141-22-4], 2-methyl-5-isopropyl- [19728-20-2], and 5-methyl-2-isopropylphenoxyacetic acid [5333-40-4] have been studied with respect to their growth effect on oat coleoptile cylinders, wheat and flax roots, and have been compared with related substances. There are increases in auxin activity from the acetic to the D(+)-propionic acids, and the L(-)-propionic acids are antiauxinic. The effects of the disubstituted phenoxyacetic acids are in agreement with those expected from a comparison with the corresponding monosubstituted acids. A change from a carboxyl to a thiocarboxyl group has only slight effect on the growth activity.

Swedish Journal of Agricultural Research published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C12H16O3, COA of Formula: C12H16O3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

?Berg, Boerje published the artcileStudies on Plant Growth Regulators. IX. Para-alkyl-phenoxy-acetic and -propionic Acids, and Some Related Derivatives of Naturally Occurring Phenols, Safety of 2-(4-(tert-Butyl)phenoxy)acetic acid, the publication is Physiologia Plantarum (2006), 7(2), 241-252, database is CAplus.

This article discussed about application of plant growth regulators in flax roots and seedlings as well as effects of para-alkyl phenoxy acetic acids and para-alky-phenoxy propionic acids derived from naturally occurring phenols and some chloro-phenoxy acetic acids. Plant growth regulators including auxins improved roots and seedlings of flax plants whereas plant growth was inhibited by application of 2,4-D.

Physiologia Plantarum published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C12H16O3, Safety of 2-(4-(tert-Butyl)phenoxy)acetic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Aberg, Borje published the artcilePlant-growth regulators. IX. p-Alkylphenoxyacetic and -propionic acids, and some related derivatives of naturally occurring phenols, Recommanded Product: 2-(4-(tert-Butyl)phenoxy)acetic acid, the publication is Physiologia Plantarum (1954), 241-52, database is CAplus.

cf. C.A. 48, 5937a; 49, 10443h. The following compounds were studied to determine their auxin or antiauxin activity in the flax root test: (4-methylphenoxy)acetic acid (I); 2-(4-methylphenoxy)propionic acid (II); (4-ethylphenoxy)acetic acid (III); 2-(4-ethylphenoxy)propionic acid (IV); (4-isopropylphenoxy)acetic acid (V); 2-(4-isopropylphenoxy)propionic acid (VI); (4-tert-butylphenoxy)acetic acid (VII); 2-(4-tert-butylphenoxy)propionic acid (VIII); carvacroxyacetic acid (IX); thymoxyacetic acid (X); (4-chlorothymoxy)acetic acid (XI); eugenoxyacetic acid (XII); and isoeugenoxyacetic acid (XIII). Phenoxyacetic acid is antiauxinic but the introduction of the 4-Me group in I imparts some auxin activity which then diminishes with increasing size of the 4-alkyl substituent in III, V, and VII. A similar effect is observed with the series II, IV, VI, and VIII but these must be resolved into their respective enantiomorphs before a clear analysis is possible. XII and XIII also show conspicuous antiauxin activity, probably due to the bulky 4-alkyl substituents. IX is of intermediate activity, while the isomeric X shows only antiauxin activity which is greatly increased in XI by introduction of the Cl atom in the 4-position. This parallels the similar difference to be found between the 2,6-dichloro- and 2,4,6-trichlorophenoxyacetic acids.

Physiologia Plantarum published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C12H16O3, Recommanded Product: 2-(4-(tert-Butyl)phenoxy)acetic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Aberg, Borje published the artcilePlant growth regulators. XII. Monosubstituted phenoxyacetic acids, COA of Formula: C12H16O3, the publication is Kgl. Lantbruks-H?gskol. Ann. (1957), 375-92, database is CAplus.

cf. C.A. 49, 10443h. Tests of the effect on growth were made on flax seedling roots, wheat seedling roots, and oat coleoptile cylinders as previously described (cf. ?berg, Chemistry and Mode of Action of Plant Growth Substances, London, 1956, pp. 93-116). The results were not consistent in some cases. Initial inhibition that could be relieved by indoleacetic acid (IAA) was shown by 2-substituted phenoxyacetic acids at low concentrations and stimulation of the oat cylinders at high concentrations High IAA-like activity by 2-Me- and 2-iso-Pr-compounds contrasted with low of 2-methoxy and 2-NO₂-compounds Low concentrations of 3-Cl-, 3-Br-, 3-Me-, 3-MeO- and 3-NO₂-compounds stimulated growth of wheat roots. Growth of flax roots was inhibited, which could be relieved by ¦Á-(1-naphthylmethylthio)propionic acid. The IAA-like effect of the 4-substituted compounds grew less with increasing size of the substituent. Auxin effects may be caused at high concentrations by the same substance that causes antiauxin effects at low concentration

Kgl. Lantbruks-H?gskol. Ann. published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C12H16O3, COA of Formula: C12H16O3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Sheng, Xijun published the artcileSynthesis and Biological Activity of 4-[(Substituted Phenoxyacetoxy)methyl]-2,6,7-trioxa-1-phosphabicyclo[2.2.2]octane-1-one, Recommanded Product: 2-(4-(tert-Butyl)phenoxy)acetic acid, the publication is Journal of Heterocyclic Chemistry (2017), 54(1), 165-170, database is CAplus.

A series of novel 4-[(substituted phenoxyacetoxy)methyl]-2,6,7-trioxa-1-phosphabicyclo[2.2.2]octane-1-one were synthesized. Their structures were confirmed by IR, ¹H NMR, mass spectroscopy, and elemental analyses. The results of preliminary bioassays show that some of the title compounds exhibit moderate to good herbicidal and fungicidal activities. For example, some title compounds possess 90-100% inhibition against the growth of roots of both rape and barnyard grass at 10 mg/L. Moreover, some of the title compounds possess 75-89% inhibition against Botrytis cinerea at the concentration of 50 mg/L.

Journal of Heterocyclic Chemistry published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C10H11NO4, Recommanded Product: 2-(4-(tert-Butyl)phenoxy)acetic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Lu, Xiyan published the artcileAllylic carbon-phosphorus bond formation catalyzed by nickel complexes, Computed Properties of 4141-48-4, the publication is Journal of Molecular Catalysis (1987), 41(1-2), 235-43, database is CAplus.

Formation of allylic carbon-phosphorus bonds catalyzed by nickel(0) complexes are described. The method describes the nickel(0)-catalyzed reaction of allylic acetates or carbonates with HP(O)R¹R² (R¹,R² = alkyl, aryl or alkoxy group) in the presence of N,O-bis(trimethylsilyl)acetamide. Phosphinates and phosphine oxides can be synthesized in a similar way. The mechanism of the reaction is briefly discussed.

Journal of Molecular Catalysis published new progress about 4141-48-4. 4141-48-4 belongs to catalysis-chemistry, auxiliary class Aryl phosphine ligand,Mono-phosphine Ligands, name is Allyldiphenylphosphine oxide, and the molecular formula is C15H15OP, Computed Properties of 4141-48-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Sun, Haifeng published the artcileAsymmetric total synthesis and identification of tetrahydroprotoberberine derivatives as new antipsychotic agents possessing a dopamine D₁, D₂ and serotonin 5-HT_1A multi-action profile, Category: catalysis-chemistry, the publication is Bioorganic & Medicinal Chemistry (2013), 21(4), 856-868, database is CAplus and MEDLINE.

An effective and rapid method for the microwave-assisted preparation of the key intermediate for the total synthesis of tetrahydroprotoberberines (THPBs) including l-stepholidine (l-SPD) was developed. Thirty-one THPB derivatives with diverse substituents on A and D ring were synthesized, and their binding affinity to dopamine D₁, D₂ and serotonin 5-HT_1A and 5-HT_2A receptors were determined Compounds (I) and (II) were identified as partial agonists at the D₁ receptor with K_i values of 50 and 6.3 nM, while both compounds act as D₂ receptor antagonists (K_i = 305 and 145 nM, resp.) and 5-HT_1A receptor full agonists (K_i = 149 and 908 nM, resp.). These two THPBs compounds exerted antipsychotic actions in animal models. Further electrophysiol. studies employing single-unit recording in intact animals demonstrated that I-excited dopaminergic (DA) neurons are associated with its 5-HT_1A receptor agonistic activity. These results suggest that these two compounds targeted to multiple neurotransmitter receptors may present novel lead drugs with new pharmacol. profiles for the treatment of schizophrenia.

Bioorganic & Medicinal Chemistry published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C19H21N3O3S, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Nguyen, Suong T. published the artcilePCET-Enabled Olefin Hydroamidation Reactions with N-Alkyl Amides, COA of Formula: C15H24S, the publication is ACS Catalysis (2019), 9(5), 4502-4507, database is CAplus and MEDLINE.

Olefin aminations are important synthetic technologies for the construction of aliphatic C-N bonds. Here we report a catalytic protocol for olefin hydroamidation that proceeds through transient amidyl radical intermediates that are formed via proton-coupled electron transfer (PCET) activation of the strong N-H bonds in N-alkyl amides by an excited-state iridium photocatalyst and a dialkyl phosphate base. This method exhibits a broad substrate scope, high functional group tolerance, and amenability to use in cascade polycyclization reactions. The feasibility of this PCET protocol in enabling the intermol. anti-Markovnikov hydroamidation reactions of unactivated olefins is also demonstrated.

ACS Catalysis published new progress about 22693-41-0. 22693-41-0 belongs to catalysis-chemistry, auxiliary class Other Functionalization Reagent, name is 2,4,6-Triisopropylbenzenethiol, and the molecular formula is C15H24S, COA of Formula: C15H24S.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Qin, Yangzhong published the artcileMechanistic Investigation and Optimization of Photoredox Anti-Markovnikov Hydroamination, Application In Synthesis of 22693-41-0, the publication is Journal of the American Chemical Society (2021), 143(27), 10232-10242, database is CAplus and MEDLINE.

The reaction mechanism and the origin of the selectivity for the photocatalytic intermol. anti-Markovnikov hydroamination of unactivated alkenes with primary amines to furnish secondary amines have been revealed by time-resolved laser kinetics measurements of the key reaction intermediates. We show that back-electron transfer (BET) between the photogenerated aminium radical cation (ARC) and reduced photocatalyst complex (Ir(II)) is nearly absent due to rapid deprotonation of the ARC on the sub-100 ns time scale. The selectivity for primary amine alkylation is derived from the faster addition of the primary ARCs (as compared to secondary ARCs) to alkenes. The turnover of the photocatalyst occurs via the reaction between Ir(II) and a thiyl radical; the in situ formation of an off-cycle disulfide from thiyl radicals suppresses this turnover, diminishing the efficiency of the reaction. With these detailed mechanistic insights, the turnover of the photocatalyst has been optimized, resulting in a >10-fold improvement in the quantum yield. These improvements enabled the development of a scalable flow protocol, demonstrating a potential strategy for practical applications with improved energy efficiency and cost-effectiveness.

Journal of the American Chemical Society published new progress about 22693-41-0. 22693-41-0 belongs to catalysis-chemistry, auxiliary class Other Functionalization Reagent, name is 2,4,6-Triisopropylbenzenethiol, and the molecular formula is C15H24S, Application In Synthesis of 22693-41-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Hu, Cui published the artcileDesign, synthesis and anti-cancer evaluation of novel podophyllotoxin derivatives as potent tubulin-targeting agents, SDS of cas: 1798-04-5, the publication is Medicinal Chemistry Research (2018), 27(2), 351-365, database is CAplus.

A series of podophyllotoxin derivatives (M1-M16) that were selectively acylated by various phenoxy acids at the C-4 position of podophyllotoxin were synthesized, and their biol. activities were also evaluated. Among them, compound M4 showed the most potent anti-cancer activity against HeLa cells with an IC₅₀ value of 1.64 ¡À 0.41 ¦ÌM. Addnl., flow cytometry anal. results indicated that it could cause a remarkable cell cycle arrest at G2/M phase, but the effect on apoptosis inducing was not significant. Moreover, the expression of cell cycle relative protein CDK1 was up regulated while cyclin B1 and Cdc25C, two proteins required for mitotic initiation were down regulated. Furthermore, the confocal assay and extracellular polymerized tubulin expression anal. also demonstrated that M4 was a potent tubulin polymerization inhibitor and the effect was comparable to that of colchicine. Finally, docking simulation results showed that M4 could nicely bind to the colchicine binding site of tubulin which further confirmed the tubulin inhibition activity of M4. Podophyllotoxin-phenoxyacid analogs.

Medicinal Chemistry Research published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C12H16O3, SDS of cas: 1798-04-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia