Tag: M.W=300-350

Dewangan, Rikeshwer Prasad published the artcileSpermine-conjugated short proline-rich lipopeptides as broad-spectrum intracellular targeting antibacterial agents, Synthetic Route of 71989-31-6, the publication is Journal of Medicinal Chemistry (2022), 65(7), 5433-5448, database is CAplus and MEDLINE.

Toward the design of new proline-rich peptidomimetics, a short peptide segment, present in several proline-rich antimicrobial peptides (AMPs), was selected. Fatty acids of varying lengths and spermine were conjugated at the N- and C-terminals of the peptide, resp. Spermine-conjugated lipopeptides, C₁₀-PR-Spn and C₁₂-PR-Spn, exhibited min. inhibitory concentrations within 1.5-6.2¦ÌM against the tested pathogens including resistant bacteria and insignificant hemolytic activity against human red blood cells up to 100¦ÌM concentrations and demonstrated resistance against trypsin digestion. C₁₀-PR-Spn and C₁₂-PR-Spn showed synergistic antimicrobial activity against multidrug-resistant methicillin-resistant Staphylococcus aureus with several tested antibiotics. These lipopeptides did not permeabilize bacterial membrane-mimetic lipid vesicles or damage the Escherichia coli membrane like the nonmembrane-lytic AMP, buforin-II. The results suggested that C₁₀-PR-Spn and C₁₂-PR-Spn could interact with the 70S ribosome of E. coli and inhibit its protein synthesis. C₁₀-PR-Spn and C₁₂-PR-Spn demonstrated superior clearance of bacteria from the spleen, liver, and kidneys of mice, infected with S. aureus ATCC 25923 compared to levofloxacin.

Journal of Medicinal Chemistry published new progress about 71989-31-6. 71989-31-6 belongs to catalysis-chemistry, auxiliary class Amino acide derivatives,pyrrolidine, name is Fmoc-Pro-OH, and the molecular formula is C20H19NO4, Synthetic Route of 71989-31-6.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Park, Kwang-Won published the artcileLarge-Area Heteroepitaxial Nanostructuring of Molecular Semiconductor Films for Enhanced Optoelectronic Response in Flexible Electronics, Recommanded Product: Coronene, the publication is Advanced Functional Materials (2022), 32(22), 2113085, database is CAplus.

Organized nano- and microstructures of mol. semiconductors display interesting optical and photonic properties, and enhanced charge carrier mobilities, as compared to disordered thin films. However, known directed-growth and self-organization strategies cannot create structured mol. heterojunctions and cannot be practically incorporated into existing device fabrication routines to create large-area optoelectronic devices. Here, an ultrathin (<2 nm) seed layer of the compound coronene creates 1D nanostructures of an electron-transporting mol. (IFD) is shown, which possesses an intrinsic proclivity to form disordered thin films in the absence of the seed layer. It is revealed that nanostructured IFD films exhibit enhanced light absorption and emission, and greater electron mobilities, as compared to amorphous counterparts. This seed layer strategy creates uniform IFD nanowires over large areas of up to 18 mm² at low processing temperatures Notably, the coronene seed layer creates IFD nanowires when applied over either oxide surfaces or predeposited organic layers, meaning that this structuring approach can be integrated into diode manufacturing routines to realize large-area flexible optoelectronic devices. Flexible organic light-emitting diodes and fullerene-free organic solar cells containing IFD nanowires in the photoactive layer to demonstrate that mol. nanostructures can lead to robust, large-area device arrays on flexible substrates being fabricated.

Advanced Functional Materials published new progress about 191-07-1. 191-07-1 belongs to catalysis-chemistry, auxiliary class Electronic Materials, name is Coronene, and the molecular formula is C24H12, Recommanded Product: Coronene.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Teeter, T. E. published the artcileReduction of carbon dioxide on mercury cathodes, Synthetic Route of 17351-62-1, the publication is Proc. 6th Meeting Intern. Comm. Electrochem. Thermodynam. and Kinet. (1955), 538-42, database is CAplus.

cf. C.A. 48, 10451g. A summary of polarographic work on solutions of CO₂ in quaternary ammonium salts, of cathodic polarization experiments with solutions of KCl, NH₄Cl, NaHCO₃, N(CH₃)₄Br, etc., through which CO₂ was continuously bubbled, and of electrolysis experiments showing that HCOOH was the chief product of CO₂ reduction on Hg cathodes. Current efficiencies of HCOOH production were as follows (all solutions 0.1M): KCl 99.8; KBr 99.9; KI 99.2; NaHCO₃ 99; N(CH₃)₄HCO₃ 100; N(C₂H₅)₄HCO₃ 97; N(C₃H₇)₄HCO₃ 85; N(C₄H₈)₄HCO₃ 78%. The HCO_3- was found to be unreducible, while CO₂ was either directly reduced or reduced by amalgams or H formed in primary cathodic processes.

Proc. 6th Meeting Intern. Comm. Electrochem. Thermodynam. and Kinet. published new progress about 17351-62-1. 17351-62-1 belongs to catalysis-chemistry, auxiliary class Salt,Amine, name is Tetrabutylammonium hydrogencarbonate, and the molecular formula is C11H8F2, Synthetic Route of 17351-62-1.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Yakati, Venu published the artcileEnhancing the anticancer effect of paclitaxel by using polymeric nanoparticles decorated with colorectal cancer targeting CPKSNNGVC-peptide, Safety of Fmoc-Pro-OH, the publication is Journal of Drug Delivery Science and Technology (2022), 103125, database is CAplus.

The major disadvantage of cancer chemotherapy is its lack of specificity. In recent years, selective delivery of chemotherapeutic agents to tumor sites has evolved rapidly in the form of both diagnostic and therapeutic tools in combating cancer. Herein, we develop a new polymeric nanoparticle delivery system that targets both monocarboxylate transporter 1 (MCT1) receptor-pos. cancer cells and angiogenic endothelial cells using a tumor homing peptide (CPKSNNGVC, CPK in short) as a nanoparticle surface-bound targeting ligand. By using an emulsion-solvent evaporation method, multipotent drug paclitaxel (PTX)-encapsulated poly (DL-lactide-co-glycolide) (PLGA) nanoparticles (diameter of 215 ¡À 4 nm; zeta potential of -12 ¡À 3 mV; 16-17.5% weight/weight PTX) were synthesized. CPK peptide was thereafter conjugated to the surface of nanoparticles via maleimide-thiol chem. (CPK-PTX-NPs). Importantly, the highly stable CPK-PTX-NPs exhibited MCT1 receptor-mediated cellular uptake and apoptosis-mediated cell death in MCT1 receptor-overexpressing colorectal cancer (CRC) cells, while the other nontargeting nanoparticles failed to show MCT1 receptor-mediated cellular uptake. Remarkably, the targeted CPK-PTX-NPs selectively inhibited the formation of new blood vessels from pre-existing blood vessels (angiogenesis) in a chick embryo angiogenesis assay. In conclusion, our findings show that MCT1 receptor-selective, PTX-encapsulated and CPK peptide-decorated polymeric nanoparticles act as effective carriers for CRC-specific delivery of antineoplastic drugs to ensure significantly enhanced therapeutic efficacy.

Journal of Drug Delivery Science and Technology published new progress about 71989-31-6. 71989-31-6 belongs to catalysis-chemistry, auxiliary class Amino acide derivatives,pyrrolidine, name is Fmoc-Pro-OH, and the molecular formula is C3H12Cl2N2, Safety of Fmoc-Pro-OH.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Mateus-Fontecha, Lady published the artcileUnderstanding aerosol composition in a tropical inter-Andean valley impacted by agro-industrial and urban emissions, Safety of Coronene, the publication is Atmospheric Chemistry and Physics (2022), 22(13), 8473-8495, database is CAplus.

Agro-industrial areas are frequently affected by various sources of atm. pollutants that have a neg. impact on public health and ecosystems. However, air quality in these areas is infrequently monitored because of their smaller population compared to large cities, especially in developing countries. The Cauca River valley (CRV) is an agro-industrial region in southwestern Colombia, where a large fraction of the area is devoted to sugarcane and livestock production The CRV is also affected by road traffic and industrial emissions. This study aims to elucidate the chem. composition of particulate matter fine mode (PM_2.5) and to identify the main pollutant sources before source attribution. A sampling campaign was carried out at a representative site in the CRV region, where daily averaged mass concentrations of PM_2.5 and the concentrations of water-soluble ions, trace metals, organic and elemental carbon, and various fractions of organic compounds (carbohydrates, n alkanes, and polycyclic aromatic hydrocarbons – PAHs) were measured. The mean PM_2.5 was 14.4 ¡À 4.4¦Ìg m^-3, and the most abundant constituent was organic material (52.7% ¡À 18.4%), followed by sulfate (12.7% ¡À 2.8%), and elemental carbon (7.1% ¡À 2.5%), which indicates the presence of secondary aerosol formation and incomplete combustion. Levoglucosan was present in all samples, with a mean concentration of (113.8 ¡À 147.2 ng m^-3), revealing biomass burning as a persistent source. Mass closure using the elemental carbon (EC) tracer method explained 88.4% on PM_2.5, whereas the organic tracer method explained 70.9% of PM_2.5. We attribute this difference to the lack of information of specific organic tracers for some sources, both primary and secondary. Organic material and inorganic ions were the dominant groups of species (79% of PM_2.5). OMprim and OMsec contribute 24.2% and 28.5% to PM_2.5. Inorganic ions as sulfate, nitrate, and ammonia constitute 19.0%, EC 7.1%, dust 3.5%, particle-bounded water (PBW) 5.3%, and trace element oxides (TEOs), 0.9% of PM_2.5. The aerosol was acidic, with a pH of 2.5 ¡À 0.4, mainly because of the abundance of organic and sulfur compounds Diagnostic ratios and tracer concentrations indicate that most PM_2.5 was emitted locally and had contributions of both pyrogenic and petrogenic sources, that biomass burning was ubiquitous during the sampling period and was the main source of PAHs, and that the relatively low PM_2.5 concentrations and mutagenic potentials are consistent with low-intensity, year-long biomass burning (BB) and sugarcane pre-harvest burning in the CRV.

Atmospheric Chemistry and Physics published new progress about 191-07-1. 191-07-1 belongs to catalysis-chemistry, auxiliary class Electronic Materials, name is Coronene, and the molecular formula is C24H12, Safety of Coronene.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Hira, Kenichiro published the artcileAssociation of blood eicosapentaenoic acid levels with intracerebral hemorrhage during the COVID-19 pandemic: preliminary experience from a single-center in Japan, HPLC of Formula: 6217-54-5, the publication is BMC Neurology (2022), 22(1), 128, database is CAplus and MEDLINE.

The COVID-19 pandemic has forced lockdowns and declarations of states of emergency, resulting in marked changes to daily life such as dietary habits in many countries. Though serum omega-3 polyunsaturated fatty acids levels have been shown to be useful markers for recurrent vascular events or worse prognosis in cardiovascular diseases and ischemic stroke, the relationship between serum omega-3 PUFA levels and the occurrence of intracerebral hemorrhage has essentially been unknown. We explored the association of serum omega-3 polyunsaturated fatty acids with intracerebral hemorrhage during the COVID-19 pandemic. Participants comprised patients admitted to Juntendo University Hospital (Tokyo, Japan) with intracerebral hemorrhage between Jan. 1, 2016 and Apr. 30, 2020. Clin. characteristics including serum omega-3 polyunsaturated fatty acid levels were compared between patients developing intracerebral hemorrhage during the period from Jan. 1, 2016 to Feb. 29, 2020, and the subsequent COVID-19 pandemic period (March 1 to Apr. 30, 2020). Clin. characteristics independently related to intracerebral hemorrhage during the COVID-19 pandemic were analyzed by comparing these two cohorts of intracerebral hemorrhage patients in different periods. A total of 103 patients (age, 67.0 ¡À 13.9 years; 67 males) with intracerebral hemorrhage were enrolled. Intracerebral hemorrhage developed in 91 patients before and 12 patients during the COVID-19 pandemic. Monthly averages of intracerebral hemorrhage patients admitted to our hospital during and before the COVID-19 pandemic were 6 and 1.82, resp. Serum eicosapentaenoic acid levels were significantly lower in intracerebral hemorrhage patients during the COVID-19 pandemic than before (31.87 ¡À 12.93¦Ìg/mL vs. 63.74 ¡À 43.29¦Ìg/mL, p = 0.007). Multiple logistic regression anal. showed that, compared to before the COVID-19 pandemic, dyslipidemia (odds ratio 0.163, 95% confidence interval 0.031-0.852; p = 0.032) and eicosapentaenoic acid levels (odds ratio 0.947, 95% confidence interval 0.901-0.994; p = 0.029) were associated with intracerebral hemorrhage during the COVID-19 pandemic. From our preliminary results, low eicosapentaenoic acid levels were linked with intracerebral hemorrhage during the COVID-19 pandemic. Low levels of eicosapentaenoic acid might be an endogenous surrogate marker for intracerebral hemorrhage during the COVID-19 pandemic.

BMC Neurology published new progress about 6217-54-5. 6217-54-5 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Aliphatic hydrocarbon chain,Metabolic Enzyme,RAR/RXR,Natural product, name is Docosahexaenoic Acid, and the molecular formula is C22H32O2, HPLC of Formula: 6217-54-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Acar, Tayfun published the artcileAngiotensin(1-7)-stearic acid conjugate: synthesis and characterization, Name: Fmoc-Pro-OH, the publication is Journal of the Turkish Chemical Society, Section A: Chemistry (2022), 9(2), 331-338, database is CAplus.

The novel coronavirus, SARS-CoV-2, broken out as the COVID-19 epidemic, is transported into the cytoplasm by angiotensin-converting enzyme-2 (ACE2), a key protein of the renin-angiotensin-system (RAS). ACE2 is a protective protein that reduces angiotensin (Ang) II, the bioactive component of RAS, by converting it to its potent antagonist, Ang-(1-7) peptide, in order to provide a pathophysiol. response to stimuli. Although ACE-2 is upregulated especially in pulmonary endothelial cells and alveolar epithelial cells, downregulation of ACE-2 in the lung owing to loss of key regulatory factors explains the enzyme-dependent lethality of SARS-CoV-2. The N-terminal domain (NTD) of S1, one of the protein subunits of coronaviruses, is known to recognize acetylated sialic acids on glycosylated cell surface receptors. In this study, the stearic acid-peptide conjugate mimicking the sialic acid structure was synthesized, which will be able to balance uncontrolled inflammatory response and excessive cytokine production, and depending on these to suppress pneumonia and acute respiratory distress syndrome (ARDS), against SARS-CoV-2. It was expected that fatty acid acylation would greatly enhance cellular internalization and cytosolic distribution of the peptide through the cell membrane. Thus, we synthesized fatty acyl derivative of the N-Ac-Gly4-Ang (1-7) peptide. The peptide was synthesized using Fmoc/tBu solid-phase peptide chem. and characterized by FT-IR, Zetasizer, and LC-ESI-MS. This study provided more detailed insights into understanding and meeting the basic structural requirements for optimal cellular delivery and formulation of the stearyl Ang (1-7)-peptide conjugate.

Journal of the Turkish Chemical Society, Section A: Chemistry published new progress about 71989-31-6. 71989-31-6 belongs to catalysis-chemistry, auxiliary class Amino acide derivatives,pyrrolidine, name is Fmoc-Pro-OH, and the molecular formula is C20H19NO4, Name: Fmoc-Pro-OH.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Du, Yuan-Hang published the artcileDevelopment of a kinetics-integrated CFD model for the industrial scale-up of DHA fermentation using Schizochytrium sp., Formula: C22H32O2, the publication is AIChE Journal (2022), 68(9), e17750, database is CAplus.

In this work, a kinetics-integrated CFD model based on coupling computational fluid dynamics (CFD) and biokinetic was developed to guide the industrial scale-up for fermentation of docosahexaenoic acid (DHA). Two-substrate biokinetic equations for a 5 L bioreactor with oxygen and nitrogen source as limiting substrates were established, which were further coupled with CFD to simulate the biomass growth and lipid accumulation as well as flow field environment in the fermentation process. The coupled CFD-biokinetic model can accurately reflect the changes of each relevant variable in the 50 L bioreactor under different operating conditions. The optimal working conditions of a 35 m³ bioreactor were predicted by this model and have secured the one-step scale-up of DHA fermentation, resulting in a biomass, lipid concentration, and DHA content in lipids of 99.2 g/L, 55.7 g/L, and 52.5%, resp. This study thus provides an effective strategy for rapid industrial scale-up of DHA production

AIChE Journal published new progress about 6217-54-5. 6217-54-5 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Aliphatic hydrocarbon chain,Metabolic Enzyme,RAR/RXR,Natural product, name is Docosahexaenoic Acid, and the molecular formula is C22H32O2, Formula: C22H32O2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Jiang, Senhao published the artcileComparison of biochemical composition of commercial sea cucumbers, Apostichopus japonicus and Parastichopus californicus, under the same culture conditions, Safety of Docosahexaenoic Acid, the publication is Journal of the Science of Food and Agriculture (2022), 102(12), 5452-5459, database is CAplus and MEDLINE.

Apostichopus japonicus and Parastichopus californicus are two of the most important and profitable com. sea cucumbers along the North Pacific coast. This study compared the body wall production rate (BWPR), proximate composition, amino acid, fatty acid, trace element and vitamin composition, and nonspecific immune enzyme activities of A. japonicus and P. californicus cultured in an artificial pond. The BWPR, crude fat and ash content in the body walls of A. japonicus and P. californicus showed remarkable differences (P < 0.05). For the 18 amino acids tested, differences in the contents of 15 were significant (P < 0.05) between the two species, except for threonine, methionine and histidine, and their first limiting amino acids were both methionine+cysteine. There were seven saturated and ten unsaturated fatty acids in their body walls, and except for 18:1 and 20:1, the content differences of the other 15 fatty acids were all significant (P < 0.05). Furthermore, between the two sea cucumbers, differences in the content of seven trace elements (Cu, Fe, Mn, Zn, Cr, Ni, Se) and six vitamins (B1, B3, B5, B9, C, E) were significant (P < 0.05). The activities of superoxide dismutase (SOD), catalase (CAT), acid phosphatase (ACP) and alk. phosphatase (AKP) also showed distinct differences (P < 0.05). There are greater differences in the biochem. compositions and contents between A. japonicus and P. californicus, each with its own unique quality advantages. A. japonicus and P. californicus have high nutritional value, which are both the superior sea cucumbers. 2022 Society of Chem. Industry.

Journal of the Science of Food and Agriculture published new progress about 6217-54-5. 6217-54-5 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Aliphatic hydrocarbon chain,Metabolic Enzyme,RAR/RXR,Natural product, name is Docosahexaenoic Acid, and the molecular formula is C22H32O2, Safety of Docosahexaenoic Acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

di Mauro, Chiara published the artcileEnhancing the Recyclability of a Vegetable Oil-Based Epoxy Thermoset through Initiator Influence, SDS of cas: 119-80-2, the publication is ACS Sustainable Chemistry & Engineering (2020), 8(20), 7690-7700, database is CAplus.

Bisphenol A based epoxy thermosets involve both environmental and health risks. By reacting a vegetal oil-based epoxide with an aromatic diacid containing S-S bonds a thermoset is produced. Herein, reprocessable thermosets were synthesized, the recyclability being designed through a dual mechanism: that of disulfide metathesis and of transesterifications. To assess the feasibility of the reprocessing, a series of ten initiators were tested to probe their effect not only on the crosslinking reaction but also on the recyclability. This study introduces for the first time the key role of the initiator on the material performances and on their reprocessing. A very good reprocessability was obtained for thermosets prepared using as initiator the imidazole. Moreover, the thermosets exhibit complete chem. recyclability in 1N NaOH at 80¡ãC, after 3 days, without needing addnl. chems. The reprocessed materials have similar performances with the virgin ones, even after 10 cycles of reprocessing.

ACS Sustainable Chemistry & Engineering published new progress about 119-80-2. 119-80-2 belongs to catalysis-chemistry, auxiliary class sulfides,Carboxylic acid,Benzene, name is 2,2′-Dithiodibenzoic acid, and the molecular formula is C14H10O4S2, SDS of cas: 119-80-2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia