Tag: M.W=300-350

Mikes, Monica published the artcileTranslating PUFA omega 6:3 ratios from wild to captive hibernators (Urocitellus parryii) enhances sex-dependent mass-gain without increasing physiological stress indicators, Name: Docosahexaenoic Acid, the publication is Journal of Comparative Physiology, B: Biochemical, Systems, and Environmental Physiology (2022), 192(3-4), 529-540, database is CAplus and MEDLINE.

Omega 3 polyunsaturated fatty acids (PUFAs) are well-documented for their influence on health and weight loss. Recent studies indicate omega 3 PUFAs may exert a neg. impact on cellular stress and physiol. in some hibernators. We asked if physiol. stress indicators, lipid peroxidation and mass gain in Arctic Ground Squirrels (AGS) were neg. influenced by naturally occurring dietary omega 3 PUFA levels compared to omega 3 PUFA levels found in common laboratory diets. We found plasma fatty acid profiles of free-ranging AGS to be high in omega 3 PUFAs with balanced omega 6:3 ratios, while standard laboratory diets and plasma of captive AGS are high in omega 6 and low in omega 3 PUFAs with higher omega 6:3 ratios. Subsequently, we designed a diet to mimick free-range AGS omega 6:3 ratios in captive AGS. Groups of wild-caught juvenile AGS were either fed: (1) Mazuri Rodent Chow (Standard Rodent chow, 4.95 omega 6:3 ratio), or (2) balanced omega 6:3 chow (Balanced Diet, 1.38 omega 6:3). AGS fed the Balanced Diet had plasma omega 6:3 ratios that mimicked plasma profiles of wild AGS. Balanced Diet increased female body mass before hibernation, but did not influence levels of cortisol in plasma or levels of the lipid peroxidation product 4-HNE in brown adipose tissue. Overall, as the mass gain is critical during pre-hibernation for obligate hibernators, the results show that mimicking a fatty acid profile of wild AGS facilitates sex-dependent mass accumulation without increasing stress indicators.

Journal of Comparative Physiology, B: Biochemical, Systems, and Environmental Physiology published new progress about 6217-54-5. 6217-54-5 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Aliphatic hydrocarbon chain,Metabolic Enzyme,RAR/RXR,Natural product, name is Docosahexaenoic Acid, and the molecular formula is C22H32O2, Name: Docosahexaenoic Acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Habte-Tsion, H.-Michael published the artcileThe effects of fish meal substitution by clam meal on the growth and health of Florida pompano (Trachinotus carolinus), Recommanded Product: Docosahexaenoic Acid, the publication is Scientific Reports (2022), 12(1), 7696, database is CAplus and MEDLINE.

A 12-wk feeding trial was conducted to evaluate the effects of fish meal (FM) substitution by clam meal (CM, at 10%, 20% and 30% of the diet) on the growth, feed utilization, hepatic antioxidant enzymes, plasma parameters, fatty acid and amino acid composition, and gut microbiome of juvenile Florida pompano, Trachinotus carolinus. The results indicated that: (1) juveniles fed 10% and 20% CM had a significantly higher final weight than the group fed the control (0% CM); and the control group also showed significantly lower weight gain, feed intake, protein retention value, whole-body crude protein and total amino acids composition, but higher hepatosomatic index and whole-body crude fat; (2) hepatic peroxide content and superoxide dismutase activity were not significantly affected by the substitution of CM, but it did affect glutathione peroxidase activity, with higher levels found in fish fed 30% CM compared to 0% and 10% CM; (3) plasma total protein, alk. phosphatase, alanine aminotransferase, and IgM showed no significant differences among the treatments; (4) there were no significant differences among treatments in terms of fatty acids composition and microbial diversity. Overall, this study concluded that CM has comparable benefit in the diet of Florida pompano as FM does.

Scientific Reports published new progress about 6217-54-5. 6217-54-5 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Aliphatic hydrocarbon chain,Metabolic Enzyme,RAR/RXR,Natural product, name is Docosahexaenoic Acid, and the molecular formula is C22H32O2, Recommanded Product: Docosahexaenoic Acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Ghosh, Anindya published the artcileFabrication of a hollow sphere N,S co-doped bifunctional carbon catalyst for sustainable fixation of CO₂ to cyclic carbonates, HPLC of Formula: 191-07-1, the publication is Green Chemistry (2022), 24(4), 1673-1692, database is CAplus.

Execution of compositional doping by more than one element simultaneously inside a carbon matrix is a challenging task for designing advanced carbon-based materials and nanotechnol. Herein, we have integrated a template-free methodol. for the preparation of a hollow sphere N,S co-doped carbon material utilizing melamine and p-toluenesulfonic acid as a nitrogen and sulfur precursor, highlighting a cost-effective, simple, and green process. This N,S dual doped carbon material acted as a promising bifunctional catalyst for sustainable CO₂ fixation to form a cyclic carbonate with an epoxide, and this strategy is appealing for the conversion of CO₂ to chems. The as-synthesized catalyst was comprehensively characterized by FESEM and HRTEM techniques, showing that the formed nanosheets arranged randomly in the shape of a sphere and turned out to be a hollow sphere after carbonization. The XPS anal. revealed that the randomly arranged nanosheets are linked via -C-S-S-C- linkages. The abundance of weakly acidic and basic sites helps to achieve very high activity (GC conversion 95% and selectivity 98%) in a CO₂-epichlorohydrin cycloaddition reaction at 343 K temperature in the presence of a co-catalyst. The exptl. results coupled with the theor. adsorption energy calculation led us to propose that majorly the CO₂ mol. gets adsorbed on the pyridinic N species while epichlorohydrin prefers a terminal -SO₂H acidic site for adsorption. Addnl., the DFT study elucidated the detailed reaction mechanism for the CO₂-epichlorohydrin reaction and identified the attack of CO₂ by the iodoalkoxy anion as the rate-determining step. Beneficially, this study establishes a definitive relationship between CO₂ utilization and an advanced heteroatom doped carbon-based catalyst.

Green Chemistry published new progress about 191-07-1. 191-07-1 belongs to catalysis-chemistry, auxiliary class Electronic Materials, name is Coronene, and the molecular formula is C24H12, HPLC of Formula: 191-07-1.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Petit, Angelique published the artcileNutrient sources differ in the fertilised eggs of two divergent broiler lines selected for meat ultimate pH, SDS of cas: 6217-54-5, the publication is Scientific Reports (2022), 12(1), 5533, database is CAplus and MEDLINE.

The pHu+ and pHu- lines, which were selected based on the ultimate pH (pHu) of the breast muscle, represent a unique model to study the genetic and physiol. controls of muscle energy store in relation with meat quality in chicken. Indeed, pHu+ and pHu- chicks show differences in protein and energy metabolism soon after hatching, associated with a different ability to use energy sources in the muscle. The present study aimed to assess the extent to which the nutritional environment of the embryo might contribute to the metabolic differences observed between the two lines at hatching. Just before incubation (E0), the egg yolk of pHu+ exhibited a higher lipid percentage compared to the pHu- line (32.9% vs. 27.7%). Although 1H-NMR spectroscopy showed clear changes in egg yolk composition between E0 and E10, there was no line effect. In contrast, 1H-NMR anal. performed on amniotic fluid at embryonic day 10 (E10) clearly discriminated the two lines. The amniotic fluid of pHu+ was richer in leucine, isoleucine, 2-oxoisocaproate, citrate and glucose, while choline and inosine were more abundant in the pHu- line. Our results highlight quant. and qual. differences in metabolites and nutrients potentially available to developing embryos, which could contribute to metabolic and developmental differences observed after hatching between the pHu+ and pHu- lines.

Scientific Reports published new progress about 6217-54-5. 6217-54-5 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Aliphatic hydrocarbon chain,Metabolic Enzyme,RAR/RXR,Natural product, name is Docosahexaenoic Acid, and the molecular formula is C22H32O2, SDS of cas: 6217-54-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Rao, N. Venkateswara published the artcileCerimetric estimation of ascorbic acid using different indicators, Quality Control of 10510-54-0, the publication is Indian Journal of Pharmaceutical Sciences (1978), 40(4), 128-9, database is CAplus.

Methods for the cerimetric titration of ascorbic acid [50-81-7] in com. tablets and syrups using 9 azine and oxazine dyes, Lissamine Blue BF [6448-97-1], Brilliant Cresyl Blue [4712-70-3], Capri Blue [1787-57-1], Solochrome Prune AS [6416-51-9], Gallamine Blue [1563-02-6], Celestine Blue [1562-90-9], Meldola’s Blue [7057-57-0], Cresyl Fast Violet Acetate [10510-54-0], Resazurin [550-82-3] as redox indicators were developed.

Indian Journal of Pharmaceutical Sciences published new progress about 10510-54-0. 10510-54-0 belongs to catalysis-chemistry, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Inhibitor,Inhibitor, name is 5,9-Diaminobenzo[a]phenoxazin-7-ium acetate, and the molecular formula is C18H15N3O3, Quality Control of 10510-54-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Sobczak, Szymon published the artcileSqueezing Out the Catalysts: A Sustainable Approach to Disulfide Bond Exchange in Aryl Disulfides, Synthetic Route of 119-80-2, the publication is ACS Sustainable Chemistry & Engineering (2021), 9(20), 7171-7178, database is CAplus.

High-pressure conditions can be considered as an alternative, environmentally responsible way for the equilibrium reactions, such as disulfide exchange. This approach is capable of eliminating the catalysts or stimuli, such as reducing agents, strong bases, UV light, or ultrasound. The exchange of aryl disulfides in the absence of catalysts or other stimuli has been systematically studied. The effects of pressure in the range between 100 and 400 MPa, accessible in large-scale technol. installations, have been tested for promoting exchange reactions between various homodimeric aryl disulfides. For the optimized conditions, 100% yields of the heterodimer in pure single-crystal form were obtained. The reactions were performed in a diamond anvil cell, as well as in a hydraulic piston-and-cylinder press, and the products were characterized by X-ray diffraction, mass spectrometry, and NMR spectroscopy. The prominent role of high-entropy states, not attainable under ambient conditions, as well as the high-entropy nucleation, kinetic crystallization, and other effects associated with the high-pressure environment, has been demonstrated. These entropy-driven reactions represent an efficient, environmentally friendly, one-pot method for obtaining pure crystalline heterodimeric disulfides.

ACS Sustainable Chemistry & Engineering published new progress about 119-80-2. 119-80-2 belongs to catalysis-chemistry, auxiliary class sulfides,Carboxylic acid,Benzene, name is 2,2′-Dithiodibenzoic acid, and the molecular formula is C6H8O6, Synthetic Route of 119-80-2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Li, Yu-Lei published the artcileComparison of different strategies towards the chemical synthesis of long-chain scorpion toxin AaH-II, Recommanded Product: Fmoc-Pro-OH, the publication is Journal of Peptide Science (2022), 28(2), e3365, database is CAplus and MEDLINE.

Long-chain scorpion toxin AaH-II isolated from Androctonus australis Hector can selectively inhibit mammalian voltage-gated sodium ion channel Na_v1.7 responsible for pain sensation. Efficient chem. synthesis of AaH-II and its derivatives is beneficial to the study of the function and mechanism of Na_v1.7 and the development of potential peptide inhibitors. Herein, we compared three different strategies, namely, direct solid-phase peptide synthesis, hydrazide-based two-segment native chem. ligation, and hydrazide-based three-segment native chem. ligation for the synthesis of AaH-II. The hydrazide-based two-segment native chem. ligation affords the target toxin with the optimal efficiency, which provides a practically robust procedure for the preparation of tool mols. derived from AaH-II to study the biol. functions and modulation of Na_v1.7. Our work highlights the importance of selecting suitable segment condensation approach in the chem. synthesis of protein toxins.

Journal of Peptide Science published new progress about 71989-31-6. 71989-31-6 belongs to catalysis-chemistry, auxiliary class Amino acide derivatives,pyrrolidine, name is Fmoc-Pro-OH, and the molecular formula is C20H19NO4, Recommanded Product: Fmoc-Pro-OH.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wang, Limin published the artcileSynthesis, uptake mechanism characterization and biological evaluation of ¹⁸F labeled fluoroalkyl phenylalanine analogs as potential PET imaging agents, Application of Tetrabutylammonium hydrogencarbonate, the publication is Nuclear Medicine and Biology (2011), 38(1), 53-62, database is CAplus and MEDLINE.

Introduction: Amino acids based tracers represent a promising class of tumor metabolic imaging agents with successful clin. applications. Two new phenylalanine derivatives, p-(2-[¹⁸F]fluoroethyl)-L-phenylalanine (FEP, [¹⁸F]2) and p-(3-[¹⁸F]fluoropropyl)-L-phenylalanine (FPP, [¹⁸F]3) were synthesized and evaluated in comparison to clin. utilized O-(2-[¹⁸F]fluoroethyl)-L-tyrosine (FET, [¹⁸F]1). Methods: FEP ([¹⁸F]2) and FPP ([¹⁸F]3) were successfully synthesized by a rapid and efficient two-step nucleophilic fluorination of tosylate precursors and deprotection reaction. In vitro cell uptake studies were carried out in 9L glioma cells. In vivo studies, 9L tumor xenografts were implanted in Fisher 344 rats. Results: FEP ([¹⁸F]2) and FPP ([¹⁸F]3) could be efficiently labeled within 90 min with good enantiomeric purity (>95%), good yield (11-37%) and high specific activity (21-69 GBq/¦Ìmol). Cell uptake studies showed FEP had higher uptake than FPP as well as reference ligand FET ([¹⁸F]1). Uptake mechanism studies suggested that FEP is a selective substrate for system L and prefers its subtype LAT1. In vivo biodistribution studies demonstrated FEP had specific accumulation in tumor cells and tumor to background ratio reached 1.45 at 60 min. Small animal positron emission tomog. (PET) imaging studies showed FEP was comparable to FET for imaging rats bearing 9L tumor model. FEP had high uptake in 9L tumor compared to surrounding tissue and was quickly excreted through urinary tract. Conclusion: Biol. evaluations indicate that FEP ([¹⁸F]2) is a potential useful tracer for tumor imaging with PET.

Nuclear Medicine and Biology published new progress about 17351-62-1. 17351-62-1 belongs to catalysis-chemistry, auxiliary class Salt,Amine, name is Tetrabutylammonium hydrogencarbonate, and the molecular formula is C8H6ClF3, Application of Tetrabutylammonium hydrogencarbonate.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Surya, S. Sarah published the artcileDegree-based molecular descriptors of certain chemical graphs and drugs of COVID 19, Formula: C24H12, the publication is Eurasian Chemical Communications (2022), 4(1), 113-123, database is CAplus.

Spectral Graph Theory is the interface that connects the graphs and the matrixes associated with them. Chem. is the branch of science which has benefitted the most out of this interaction as the information-theoretic matrixes of the mol. graphs offer immensely useful mol. descriptors. Graph energy and topol. indexes are chem.-initiated directions of research in mathematics. In this paper, we compute the characteristic polynomial of Circum-coronene(n) series of benzenoid graphs, 1 ¡Ü n ¡Ü 3 and few degree-based topol. indexes of Circumpolyacenes(m, n), Circum-pyrene(n) and Circum-trizene(n). Also, the graph invariants namely energy, spectral radius, Wiener index, first Zagreb index, modified first Zagreb index, second Zagreb index and modified second Zagreb index have been computed for few proposed drugs against COVID-19, their extensions and coronoid networks. We have also verified our results using MATLAB programs.

Eurasian Chemical Communications published new progress about 191-07-1. 191-07-1 belongs to catalysis-chemistry, auxiliary class Electronic Materials, name is Coronene, and the molecular formula is C12H20O6, Formula: C24H12.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wangler, Bjorn published the artcileKit-Like ¹⁸F-Labeling of Proteins: Synthesis of 4-(Di-tert-butyl[¹⁸F]fluorosilyl)benzenethiol (Si[¹⁸F]FA-SH) Labeled Rat Serum Albumin for Blood Pool Imaging with PET, Category: catalysis-chemistry, the publication is Bioconjugate Chemistry (2009), 20(2), 317-321, database is CAplus and MEDLINE.

Radiosyntheses of ¹⁸F-radiopharmaceuticals for positron emission tomog. (PET) normally require an extraordinarily high effort of tech. equipment and specially trained personnel. We recently reported a novel method for the introduction of fluorine-18 into peptides for PET-imaging based on silicon-¹⁸F-chem. (SiFA technique). We herewith introduce the first SiFA-based Kit-like radio-fluorination of a protein (rat serum albumin, RSA) and demonstrate its usefulness for in vivo imaging with ¦ÌPET in normal rats as well as in a rat heterotropic transplanted heart model. As a labeling agent, we prepared 4-(di-tert-butyl[¹⁸F]fluorosilyl)benzenethiol (Si[¹⁸F]FA-SH) by simple isotopic exchange in 40-60% radiochem. yield (RCY) and coupled it directly to a Sulfo-SMCC derivatized RSA in an overall RCY of 12% within 20-30 min. The tech. simple labeling procedure does not require any elaborated purification procedures and is a straightforward example of a successful application of Si-¹⁸F chem. for in vivo imaging with PET.

Bioconjugate Chemistry published new progress about 17351-62-1. 17351-62-1 belongs to catalysis-chemistry, auxiliary class Salt,Amine, name is Tetrabutylammonium hydrogencarbonate, and the molecular formula is C18H28N2O7, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia