Tag: M.W=300-350

Medvedev, Alexander published the artcileComprehensive assessment of NR ligand polypharmacology by a multiplex reporter NR assay, Computed Properties of 6217-54-5, the publication is Scientific Reports (2022), 12(1), 3115, database is CAplus and MEDLINE.

Nuclear receptors (NR) are ligand-modulated transcription factors that regulate multiple cell functions and thus represent excellent drug targets. However, due to a considerable NR structural homol., NR ligands often interact with multiple receptors. Here, we describe a multiplex reporter assay (the FACTORIAL NR) that enables parallel assessment of NR ligand activity across all 48 human NRs. The assay comprises one-hybrid GAL4-NR reporter modules transiently transfected into test cells. To evaluate the reporter activity, we assessed their RNA transcripts. We used a homogeneous RNA detection approach that afforded equal detection efficacy and permitted the multiplex detection in a single-well format. For validation, we examined a panel of selective NR ligands and polypharmacol. agonists and antagonists of the progestin, estrogen, PPAR, ERR, and ROR receptors. The assay produced highly reproducible NR activity profiles (r > 0.96) permitting quant. assessment of individual NR responses. The inferred EC50 values agreed with the published data. The assay showed excellent quality (<Z> = 0.73) and low variability (<CV> = 7.2%). Furthermore, the assay permitted distinguishing direct and non-direct NR responses to ligands. Therefore, the FACTORIAL NR enables comprehensive evaluation of NR ligand polypharmacol.

Scientific Reports published new progress about 6217-54-5. 6217-54-5 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Aliphatic hydrocarbon chain,Metabolic Enzyme,RAR/RXR,Natural product, name is Docosahexaenoic Acid, and the molecular formula is C22H32O2, Computed Properties of 6217-54-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Lv, Qian published the artcileTotal Aqueous Synthesis of Au@Cu_2-xS Core-Shell Nanoparticles for In Vitro and In Vivo SERS/PA Imaging-Guided Photothermal Cancer Therapy, Name: 5,9-Diaminobenzo[a]phenoxazin-7-ium acetate, the publication is Advanced Healthcare Materials (2019), 8(2), n/a, database is CAplus and MEDLINE.

Both accurate tumor navigation and nanostructures with high photothermal (PT) conversion efficiency are important but remain challenging to achieve in current biomedical applications. This study reports an anion exchange-based facile and green approach for synthesizing Au@Cu_2-xS core-shell nanoparticles (NPs) in an aqueous system. In addition to the PT effect of the suggested NPs, the surface-enhanced Raman scattering (SERS) is also significantly improved due to the tailored localized surface plasmon resonance coupling between the Au metal core and the Cu_2-xS semiconductor shell. Using an epitaxial strategy, Au@Cu₂O NPs are first obtained by the in situ reduction of cupric hydroxide on a cresyl violet acetate-coated Au core; then, Au@Cu_2-xS NPs are obtained via anion exchange between the S^2- and Cu₂O shell. Both the Cu/S at. ratio and the Cu_2-xS shell thickness can be adjusted conveniently. Hence, the ideal integration of the plasmonic Au core and Cu_2-xS shell into a single unit is conducive not only to highly efficient PT conversion but also to the construction of a SERS-based navigator. This new type of SERS-guided NP, with enhanced photoacoustic signals, is an important candidate for both accurate tumor navigation and nondestructive PT treatment guided in vivo by two modes of optical imaging.

Advanced Healthcare Materials published new progress about 10510-54-0. 10510-54-0 belongs to catalysis-chemistry, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Inhibitor,Inhibitor, name is 5,9-Diaminobenzo[a]phenoxazin-7-ium acetate, and the molecular formula is C18H15N3O3, Name: 5,9-Diaminobenzo[a]phenoxazin-7-ium acetate.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Jiang, Xiaolin published the artcilePreparation and molecular dynamics study of polyurethane damping elastomer containing dynamic disulfide bond and multiple hydrogen bond, SDS of cas: 119-80-2, the publication is European Polymer Journal (2022), 110893, database is CAplus.

Using damping materials is an effective measure to control vibration and noise, which is widely used. However, it is relatively difficult for polymer damping materials to find a balance between damping and mech. properties. Herein, a polyurethane is designed containing dynamic disulfide bonds and hydrogen bonds of different strength to address the dilemma. The polyurethane is endowed with good damping and mech. properties (effective damping temperature range of 117¡ãC and a tensile strength of 14.98 ¡À 0.50 MPa). The mol. dynamics were studied by combining dynamic mech. anal. (DMA) and broadband dielec. relaxation spectroscopy (BDRS). The microphase separation morphol. and degrees of separation were used to help explain mol. dynamics. The segmental motion of soft phase becomes difficult in the glass-transition temperature (T_g) and faster in a high temperature with increasing 2,2′-dithiodibenzoic acid (DTSA) contents. These results explain the mechanism improving damping performance and provide some references for designing damping materials in the future.

European Polymer Journal published new progress about 119-80-2. 119-80-2 belongs to catalysis-chemistry, auxiliary class sulfides,Carboxylic acid,Benzene, name is 2,2′-Dithiodibenzoic acid, and the molecular formula is C14H10O4S2, SDS of cas: 119-80-2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Steeno, Roelof published the artcileHost-guest chemistry under confinement: peeking at early self-assembly events, SDS of cas: 191-07-1, the publication is Chemical Communications (Cambridge, United Kingdom) (2022), 58(19), 3138-3141, database is CAplus and MEDLINE.

Nanoscopic lateral confinement created on a graphite surface enabled the study of embryonic stages of mol. self-assembly on solid surfaces using scanning tunneling microscopy performed at the solution/solid interface.

Chemical Communications (Cambridge, United Kingdom) published new progress about 191-07-1. 191-07-1 belongs to catalysis-chemistry, auxiliary class Electronic Materials, name is Coronene, and the molecular formula is C19H18O2, SDS of cas: 191-07-1.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Hartman, Christian K. published the artcileMapping the Intricate Reactivity of Nanojars toward Molecules of Varying Acidity and Their Conjugate Bases Leading To Exchange of Pyrazolate Ligands, Product Details of C17H37NO3, the publication is Inorganic Chemistry (2017), 56(17), 10609-10624, database is CAplus and MEDLINE.

A comprehensive reactivity study of nanojars toward 18 different acidic compounds with varying pK_a, including 12 different carboxylic acids (both aliphatic and aromatic mono- and dicarboxylic acids), p-toluenesulfonic acid, hydrogen sulfate, hydrogen carbonate, carbonic acid, 1-decanethiol, and methanol, as well as four different conjugate bases (formate, acetate, benzoate, 2-bromoethanesulfonate) was carried out with the aid of electrospray-ionization mass spectrometry. Thus, the effect on nanojar substitution and breakdown pattern of a number of variables, such as concentration of reagent (acid or conjugate base), acidity of reagent (pK_a), effect of acid vs. conjugate base, steric effects, aromaticity, incarcerated anion and size of the nanojar, is evaluated. Of the substitution and breakdown products identified by mass spectrometry, acetate-substituted nanojars (Bu₄N)₂[CO₃?{Cu₂₇(¦Ì-OH)₂₇(¦Ì-pz)_27-x(¦Ì-CH₃COO)_x}] (x = 1 and 2), as well as dimeric complexes (Bu₄N)₂[Cu₂(¦Ì-pz)₂A₂] (A = CO₃^2- and SO₄^2-) were isolated and characterized by single-crystal x-ray diffraction. The prepared complexes are (Bu₄N)₂[CO₃?{Cu_27-x(¦Ì-pz)_27-x(¦Ì-CH₃COO)_x}](C₆H₅CH₃)₆ (x = 1 and 2) (1), (Bu₄N)₂[Cu₂(¦Ì-pz)₂(SO₄)₂] (2), (Bu₄N)₂[Cu₂(¦Ì-pz)₂(CO₃)₂] (3) and (Bu₄N)₂[Cu₂(¦Ì-pz)₂(CO₃)(SO₄)]¡¤CH₃OH (4). This study offers a detailed understanding of the behavior of nanojars of various sizes and with different incarcerated anions in the presence of the above-mentioned compounds at varying concentrations and tests the limits of the pyrazolate/carboxylate structural analogy in multinuclear metal complexes. The results point to the possibility of obtaining functionalized nanojars via pyrazolate/carboxylate ligand exchange, an aid in the design of anion extraction processes using nanojars or similar complexes as extracting agents.

Inorganic Chemistry published new progress about 17351-62-1. 17351-62-1 belongs to catalysis-chemistry, auxiliary class Salt,Amine, name is Tetrabutylammonium hydrogencarbonate, and the molecular formula is C17H37NO3, Product Details of C17H37NO3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wang, Yi published the artcileCoronene and Phthalocyanine Trapping Efficiency of a Two-Dimensional Kagome Host-Nanoarchitecture, Safety of Coronene, the publication is Nanomaterials (2022), 12(5), 775, database is CAplus and MEDLINE.

The trapping of coronene and zinc phthalocyanine (ZnPc) mols. at low concentration by a two-dimensional self-assembled nanoarchitecture of a push-pull dye is investigated using scanning tunneling microscopy (STM) at the liquid-solid interface. The push-pull mols. adopt an L-shaped conformation and self-assemble on a graphite surface into a hydrogen-bonded Kagome’ network with porous hexagonal cavities. This porous host-structure is used to trap coronene and ZnPc guest mols. STM images reveal that only 11% of the Kagome network cavities are filled with coronene mols. In addition, these guest mols. are not locked in the host-network and are desorbing from the surface. In contrast, STM results reveal that the occupancy of the Kagome’; cavities by ZnPc evolves linearly with time until 95% are occupied and that the host structure cavities are all occupied after few hours.

Nanomaterials published new progress about 191-07-1. 191-07-1 belongs to catalysis-chemistry, auxiliary class Electronic Materials, name is Coronene, and the molecular formula is C12H14O2, Safety of Coronene.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Biju, Vasudevanpillai published the artcileIntermittent Single-Molecule Interfacial Electron Transfer Dynamics, Synthetic Route of 10510-54-0, the publication is Journal of the American Chemical Society (2004), 126(30), 9374-9381, database is CAplus and MEDLINE.

The authors report on single-mol. studies of photosensitized interfacial electron transfer (ET) processes in Coumarin 343 (C343)-TiO₂ nanoparticles (NP) and Cresyl Violet (CV⁺)-TiO₂ NP systems, using time-correlated single-photon counting coupled with scanning confocal fluorescence microscopy. Fluorescence intensity trajectories of individual dye mols. adsorbed on a semiconductor NP surface showed fluorescence fluctuations and blinking, with time constants distributed from milliseconds to seconds. The fluorescence fluctuation dynamics were found to be inhomogeneous from mol. to mol. and from time to time, showing significant static and dynamic disorders in the interfacial ET reaction dynamics. The authors attribute fluorescence fluctuations to the interfacial ET reaction rate fluctuations, associating redox reactivity intermittency with the fluctuations of mol.-TiO₂ electronic and Franck-Condon coupling. Intermittent interfacial ET dynamics of individual mols. could be characteristic of a surface chem. reaction strongly involved with and regulated by mol.-surface interactions. The intermittent interfacial reaction dynamics that likely occur among single mols. in other interfacial and surface chem. processes can typically be observed by single-mol. studies but not by conventional ensemble-averaged experiments

Journal of the American Chemical Society published new progress about 10510-54-0. 10510-54-0 belongs to catalysis-chemistry, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Inhibitor,Inhibitor, name is 5,9-Diaminobenzo[a]phenoxazin-7-ium acetate, and the molecular formula is C18H15N3O3, Synthetic Route of 10510-54-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Ferreira Azevedo, L. published the artcileThe alternative analog plasticizer BPS displays similar phenotypic and metabolomic responses to BPA in HepG2 and INS-1E cells, Computed Properties of 6217-54-5, the publication is Food and Chemical Toxicology (2022), 167(Suppl._1), 113266, database is CAplus and MEDLINE.

Bisphenols A (BPA) and S (BPS) are endocrine-disrupting chems. that affect energy metabolism, leading to impairment of glucose and lipid homeostasis. We aimed at identifying metabolic pathways regulated by both compounds in human liver cells and rat pancreatic ¦Â-cells that could impair energy homeostasis regulation. We assessed the effects on growth, proliferation, and viability of hepatocarcinoma (HepG2) and insulinoma (INS-1E) cells exposed to either BPA or BPS in a full range concentration between 0.001 and 100¦ÌM. Both the dose and duration of exposure caused a differential response on growth and viability of both cells. Effects were more pronounced on HepG2, as these cells exhibited non-linear dose-responses following exposure to xenobiotics. For INS-1E, effect was observed only at the highest concentration In addition, we profiled their intracellular state by untargeted metabolomics at 24, 48, and 72 h of exposure. This anal. revealed time- and dose-dependently mol. changes for HepG2 and INS-1E that were similar between BPA and BPS. Both increased levels of inflammatory mediators, such as metabolites pertaining to linolenic and linoleic acid metabolic pathway. In summary, this study shows that BPS also disrupts mol. functions in cells that regulate energy homeostasis, displaying similar but less pronounced responses than BPA.

Food and Chemical Toxicology published new progress about 6217-54-5. 6217-54-5 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Aliphatic hydrocarbon chain,Metabolic Enzyme,RAR/RXR,Natural product, name is Docosahexaenoic Acid, and the molecular formula is C22H32O2, Computed Properties of 6217-54-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Fujiwara, Daisuke published the artcileChemical Modification of Phage-Displayed Helix-Loop-Helix Peptides to Construct Kinase-Focused Libraries, COA of Formula: C20H19NO4, the publication is ChemBioChem (2021), 22(24), 3406-3409, database is CAplus and MEDLINE.

Conformationally constrained peptides hold promise as mol. tools in chem. biol. and as a new modality in drug discovery. The construction and screening of a target-focused library could be a promising approach for the generation of de novo ligands or inhibitors against target proteins. Here, we have prepared a protein kinase-focused library by chem. modifying helix-loop-helix (HLH) peptides displayed on phage and subsequently tethered to adenosine. The library was screened against aurora kinase A (AurA). The selected HLH peptide Bip-3 retained the ¦Á-helical structure and bound to AurA with a K_D value of 13.7 ¦ÌM. Bip-3 and the adenosine-tethered peptide Bip-3-Adc provided IC₅₀ values of 103 ¦ÌM and 7.7 ¦ÌM, resp., suggesting that Bip-3-Adc bivalently inhibited AurA. In addition, the selectivity of Bip-3-Adc to several protein kinases was tested, and was highest against AurA. These results demonstrate that chem. modification can enable the construction of a kinase-focused library of phage-displayed HLH peptides.

ChemBioChem published new progress about 71989-31-6. 71989-31-6 belongs to catalysis-chemistry, auxiliary class Amino acide derivatives,pyrrolidine, name is Fmoc-Pro-OH, and the molecular formula is C20H19NO4, COA of Formula: C20H19NO4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Mauro, Chiara Di published the artcileInfluence of the presence of disulphide bonds in aromatic or aliphatic dicarboxylic acid hardeners used to produce reprocessable epoxidized thermosets, Related Products of catalysis-chemistry, the publication is Polymers (Basel, Switzerland) (2021), 13(4), 534, database is CAplus and MEDLINE.

The design of polymers from renewable resources with recycling potential comes from economic and environmental problems. This work focused on the impact of disulfide bonds in the dicarboxylic acids reactions with three epoxidized vegetable oils (EVOs). For the first time, the comparison between aromatic vs. aliphatic dicarboxylic acids, containing or not S-S bonds with EVOs was discussed and evaluated by dynamic scanning calorimetry. The obtained thermosets showed reprocessability, by the dual dynamic exchange mechanism. The virgin and reprocessed materials were characterized and the thermomech. properties were compared. The thermosets derived from EVOs with high epoxy content combined with aromatic diacids containing disulfide bridges showed high glass transition values (~111¡ãC), high crosslink densities and good solvent stability.

Polymers (Basel, Switzerland) published new progress about 119-80-2. 119-80-2 belongs to catalysis-chemistry, auxiliary class sulfides,Carboxylic acid,Benzene, name is 2,2′-Dithiodibenzoic acid, and the molecular formula is C14H10O4S2, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia