Tag: M.W=300-350

Ma, Lin published the artcileRegulation of the Assembled Structure of a Flexible Porphyrin Derivative Containing Tetra Isophthalic Acids by Coronene or Different Pyridines, Recommanded Product: Coronene, the publication is Langmuir (2022), 38(14), 4434-4441, database is CAplus and MEDLINE.

Based on previous research, a new coassembly formed by a porphyrin derivative (IPETPP), which contains a flexible substituent of m-phthalic acid, is observed with coronene (COR) mols. at a higher concentration Besides, a fresh IPETPP self-assembly formed at a lower concentration and another new coassembly with COR mols. are obtained. Moreover, the addition of a series of bipyridines alters the diamond arrangement of IPETPP, which enhances the stability of the two-component structures. It is unprecedented that bipyridine derivatives break intermol. hydrogen bonds containing m-phthalic acid substituents. All the coassemblies are investigated by scanning tunneling microscopy on a highly oriented pyrolytic graphite. Combined with d. functional theory, the formation mechanism of the assembled structures is revealed. These results would contribute to understanding the interfacial crystal behaviors and probably provide an efficient pathway to regulate the binary structures.

Langmuir published new progress about 191-07-1. 191-07-1 belongs to catalysis-chemistry, auxiliary class Electronic Materials, name is Coronene, and the molecular formula is C24H12, Recommanded Product: Coronene.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Xie, Yihui published the artcileDevelopment of Fmoc-protected bis-amino acids toward automated synthesis of highly functionalized spiroligomers, Safety of Fmoc-Pro-OH, the publication is Organic Letters (2022), 24(18), 3421-3425, database is CAplus and MEDLINE.

We report the fluorenylmethoxycarbonyl (Fmoc) protection of functionalized bis-amino acid building blocks using a temporary Cu²⁺ complexation strategy, together with an efficient multikilogram-scale synthesis of bis-amino acid precursors. This allows the synthesis of stereochem. and functionally diverse spiroligomers utilizing solid-phase Fmoc/tBu (Fmoc = 9-fluorenylmethoxycarbonyl) chem. to facilitate the development of applications. Four tetramers were assembled on a semiautomated microwave peptide synthesizer. We determined their secondary structures with two-dimensional NMR spectroscopy.

Organic Letters published new progress about 71989-31-6. 71989-31-6 belongs to catalysis-chemistry, auxiliary class Amino acide derivatives,pyrrolidine, name is Fmoc-Pro-OH, and the molecular formula is C6H8N2, Safety of Fmoc-Pro-OH.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wang, Shihui published the artcileComparison of edible yield and quality of female Chinese mitten crab between two-year-old and three-year-old, Related Products of catalysis-chemistry, the publication is Journal of Food Composition and Analysis (2022), 104687, database is CAplus.

To expand the new germplasm of Chinese mitten crab (Eriocheir sinensis) and explain its quality characteristics, this study used two-year-old mature female E. sinensis (TWC) as the control to explore the differences in edible yield, color, proximate composition, fatty acids, free amino acids and mineral elements of three-year-old mature female E. sinensis (THC). TWC had a significantly higher hepatosomatic index (HSI) but a lower gonadosomatic index (GSI) than THC (P < 0.05). The eicosapentaenoic acid (EPA) content in the hepatopancreas, ovary and muscle tissues of TWC were higher than those of THC. However, the content of docosahexaenoic acid (DHA), arachidonic acid (ARA), polyunsaturated fatty acids (PUFA), total essential fatty acids (¦²EFA), total highly unsaturated fatty acids (¦²HUFA), ¦²n-6 PUFA and DHA/EPA were lower than those of THC. Total essential free amino acids (¦²EFAA), total free amino acids (¦²FAA) and percentage of ¡ÆEFAA to ¡ÆFAA (PETFAA) in the hepatopancreas, ¦²EFAA and PETFAA in the ovary and ¦²FAA in the muscle of TWC were higher than those of THC (P > 0.05). The values of total umami values (¦²TUV) and total sweetness values (¦²TSV) in the hepatopancreas, ovary and muscle tissue and total bitterness values (¦²TBV) in the hepatopancreas and muscle of TWC were higher than those of THC. Except for the higher Zn in TWC, the contents of the other elements measured were lower than those in THC. Overall, the edible yield and quality of THC was greater than that of the TWC, and THC was a new high-quality germplasm of E. sinensis.

Journal of Food Composition and Analysis published new progress about 6217-54-5. 6217-54-5 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Aliphatic hydrocarbon chain,Metabolic Enzyme,RAR/RXR,Natural product, name is Docosahexaenoic Acid, and the molecular formula is C6H6N2O, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Li, Jianqiao published the artcileThe effect of multiple pairs of meta-dicarboxyl groups on molecular self-assembly and the selective adsorption of coronene by hydrogen bonding and van der Waals forces, Related Products of catalysis-chemistry, the publication is Nano Research (2022), 15(2), 1691-1697, database is CAplus.

The prediction of two-dimensional mol. self-assembly structures has always been a problem to be solved. The mols. with meta-dicarboxyl groups can self-assemble into a specific hexagonal cavity, which has an important influence on the prediction of mol. self-assembly structures and the application of functional mols. with meta-dicarboxyl groups. Two kinds of mols. with four pairs of meta-dicarboxyl groups, 1,3,6,8-tetrakis(3,5-isophthalic acid)pyrene (H8TIAPy) and 4¡ä,4¡ä¡ä¡ä,4¡ä¡ä¡ä¡ä¡ä,4¡ä¡ä¡ä¡ä¡ä¡ä¡ä-(ethene-1,1,2,2-tetrayl)tetrakis(([1,1¡ä-biphenyl]-3,5-dicarboxylic acid)) (H8ETTB) mols. were chosen to observe the self-assembly behavior at the heptanoic acid/highly oriented pyrolytic graphite (HA/HOPG) interface. H8TIAPy mols. self-assembled into well-ordered quadrilateral structures and could be regulated into kagome networks with hexagonal pores by coronene (COR) mols. H8ETTB mols. self-assembled into lamellar structures and transformed into acid-COR-acid-COR co-assembled structures at low concentration of COR solution and acid-COR dimer-acid-COR dimer co-assembled structures at high concentration of COR solution The reason that H8ETTB mols. could not be regulated into hexagonal porous architecture was attributed to the steric hindrance by the similar length and width of H8ETTB mols. The H8ETTB templates had stronger adsorption for COR than that of hexaphenylbenzene (HPB), regardless of the order of mol. introduction.

Nano Research published new progress about 191-07-1. 191-07-1 belongs to catalysis-chemistry, auxiliary class Electronic Materials, name is Coronene, and the molecular formula is C24H12, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Benediktsdottir, Andrea published the artcileAntibacterial sulfonimidamide-based oligopeptides as type I signal peptidase inhibitors: Synthesis and biological evaluation, Quality Control of 71989-31-6, the publication is European Journal of Medicinal Chemistry (2021), 113699, database is CAplus and MEDLINE.

Oligopeptide boronates with a lipophilic tail are known to inhibit the type I signal peptidase in E. coli, which is a promising drug target for developing novel antibiotics. Antibacterial activity depends on these oligopeptides having a cationic modification to increase their permeation. Unfortunately, this modification is associated with cytotoxicity, motivating the need for novel approaches. The sulfonimidamide functionality has recently gained much interest in drug design and discovery, as a means of introducing chirality and an imine-handle, thus allowing for the incorporation of addnl. substituents. This in turn can tune the chem. and biol. properties, which are here explored. We show that introducing the sulfonimidamide between the lipophilic tail and the peptide in a series of signal peptidase inhibitors resulted in antibacterial activity, while the sulfonamide isostere and previously known non-cationic analogs were inactive. Addnl., we show that replacing the sulfonamide with a sulfonimidamide resulted in decreased cytotoxicity, and similar results were seen by adding a cationic sidechain to the sulfonimidamide motif. This is the first report of incorporation of the sulfonimidamide functional group into bioactive peptides, more specifically into antibacterial oligopeptides, and evaluation of its biol. effects.

European Journal of Medicinal Chemistry published new progress about 71989-31-6. 71989-31-6 belongs to catalysis-chemistry, auxiliary class Amino acide derivatives,pyrrolidine, name is Fmoc-Pro-OH, and the molecular formula is C20H19NO4, Quality Control of 71989-31-6.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Meng, Ting published the artcileSelf-Assembly of Triphenylamine Macrocycles and Co-assembly with Guest Molecules at the Liquid-Solid Interface Studied by STM: Influence of Different Side Chains on Host-Guest Interaction, Safety of Coronene, the publication is Langmuir (2022), 38(11), 3568-3574, database is CAplus and MEDLINE.

The side chains of macrocyclic mols. have a non-negligible effect on the two-dimensional (2D) supramol. networks at the liquid/solid interface. In this study, we investigated the self-assembly behaviors of two conjugated triphenylamine (TPA) macrocycles modified with different alkyl chains, and constructed the host-guest supramol. nanopatterns on the highly oriented pyrolytic graphite (HOPG) by scanning tunneling microscope (STM). Combined with d. functional theory (DFT) calculations, how different side chains affected the host-guest interaction were discussed. This work will provide insights into constructing 2D host-guest dynamic coassembly on the surface.

Langmuir published new progress about 191-07-1. 191-07-1 belongs to catalysis-chemistry, auxiliary class Electronic Materials, name is Coronene, and the molecular formula is C24H12, Safety of Coronene.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Tachikawa, Hiroto published the artcileStructures and electronic states of trimer radical cations of coronene: DFT-ESR simulation study, Related Products of catalysis-chemistry, the publication is Physical Chemistry Chemical Physics (2022), 24(17), 10318-10324, database is CAplus and MEDLINE.

Coronene (C₂₄H₁₂), a charge transfer complex with low-cost and high-performance energy storage, has recently attracted attention as a model mol. of graphene nano-flakes (GNFs). The stacking structures of the trimer radical cation correlate strongly with the conduction states of the GNFs. In the present paper, the structures and electronic states of the monomer, dimer and trimer radical cations of coronene were investigated by means of d. functional theory calculations In particular, the proton hyperfine coupling constants of these species were determined The radical cation of coronene+ (monomer) showed two structures corresponding to the ²A_u and ²B_3u states due to the Jahn-Teller effect. The 2Au state was more stable than the ²B_3u state, although the energy difference between the two states was only 0.03 kcal mol^-1. The dimer and trimer radical cations took stacking structures distorted from a full overlap structure. The intermol. distances of the mol. planes were 3.602 ? (dimer) and 3.564 and 3.600 ? (trimer). The binding energies of the dimer and trimer were calculated to be 8.7 and 13.3 kcal mol^-1, resp. The spin d. was equivalently distributed on both coronene planes in the dimer cation. In contrast, the central plane in the trimer cation had a larger spin d., ¦Ñ = 0.72, than the upper and lower planes, both with ¦Ñ = 0.14. The proton hyperfine coupling constants calculated from these structures and the electronic states of the monomer, dimer, and trimer radical cations of coronene were in excellent agreement with previous ESR spectra of coronene radical cations. The structures and electronic states of (coronene)_n⁺ (n = 1-3) were discussed on the basis of the theor. results.

Physical Chemistry Chemical Physics published new progress about 191-07-1. 191-07-1 belongs to catalysis-chemistry, auxiliary class Electronic Materials, name is Coronene, and the molecular formula is C26H41N5O7S, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zhu, Lin published the artcileAn improved radiosynthesis of [¹⁸F]AV-133: a PET imaging agent for vesicular monoamine transporter 2, SDS of cas: 17351-62-1, the publication is Nuclear Medicine and Biology (2010), 37(2), 133-141, database is CAplus and MEDLINE.

Recently, a PET tracer, 9-[¹⁸F]fluoropropyl-(+)-dihydrotetrabenazine ([¹⁸F]AV-133), targeting vesicular monoamine transporter 2 (VMAT2) in the central nervous system was reported. It is currently under Phase II clin. trials to establish its usefulness in the diagnosis of neurodegenerative diseases including dementia with Lewy bodies and Parkinson’s disease. The radiolabeling of [¹⁸F]AV-133, nucleophilic fluorination reaction and potential effects of pseudo-carrier were evaluated by in vivo biodistribution. The preparation of [¹⁸F]AV-133 was evaluated under different conditions, specifically by employing different precursors (-OTs or -Br as the leaving group at the 9-propoxy position), reagents (K222/K₂CO₃ vs. tributylammonium bicarbonate) and solvents (acetonitrile vs. DMSO), reaction temperature and reaction time. With optimized conditions from these experiments, radiosynthesis and purification with solid-phase extraction (SPE) of [¹⁸F]AV-133 were performed by an automated nucleophilic [¹⁸F]fluorination module. In vivo biodistribution in mice on [¹⁸F]AV-133 purified by either HPLC (no-carrier-added) or the SPE method (containing a pseudo-carrier) was performed and the results compared. Under a mild fluorination condition (heating at 115¡ãC for 5 min in DMSO), [¹⁸F]AV-133 was obtained in a high yield using either -OTs or -Br as the leaving group. However, the -OTs precursor gave better radiochem. yields (>70%, thin layer chromatog. anal.) compared to those of the -Br precursor. The optimized reaction conditions were successfully implemented to an automated nucleophilic fluorination module. Labeling and purification of [¹⁸F]AV133 were readily achieved via this automatic module in good radiochem. yield of 21-41% (n=10) in 40 min. The radiochem. purity was larger than 95%. Biodistribution of SPE-purified product (containing a pseudo-carrier) in mice showed a high striatum/cerebellum ratio (4.18¡À0.51), which was comparable to that of HPLC-purified [¹⁸F]AV-133 (4.51¡À0.10). The formation of [¹⁸F]AV-133 was evaluated under different labeling conditions. These improved labeling conditions and SPE purification were successfully implemented into an automated synthesis module. This offers a short preparation time (about 40 min), simplicity in operation and ready applicability for routine clin. operation.

Nuclear Medicine and Biology published new progress about 17351-62-1. 17351-62-1 belongs to catalysis-chemistry, auxiliary class Salt,Amine, name is Tetrabutylammonium hydrogencarbonate, and the molecular formula is C12H9N3O4, SDS of cas: 17351-62-1.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Yang, Haiyao published the artcileHydrophobic carbon dots with blue dispersed emission and red aggregation-induced emission, Application In Synthesis of 119-80-2, the publication is Nature Communications (2019), 10(1), 1-11, database is CAplus and MEDLINE.

Carbon dots (CDs) have been studied for years as one of the most promising fluorescent nanomaterials. However, CDs with red or solid-state fluorescence are rarely reported. Herein, through a one-pot solvothermal treatment, hydrophobic CDs (H-CDs) with blue dispersed emission and red aggregation-induced emission are obtained. When water is introduced, the hydrophobic interaction leads to aggregation of the H-CDs. The formation of H-CD clusters induces the turning off of the blue emission, as the carbonized cores suffer from ¦Ð-¦Ð stacking interactions, and the turning on of the red fluorescence, due to restriction of the surfaces’ intramol. rotation around disulfide bonds, which conforms to the aggregation-induced-emission phenomenon. This on-off fluorescence of the H-CDs is reversible when the H-CD powder is completely dissolved. Moreover, the H-CD solution dispersed in filter paper is nearly colorless. Finally, we develop a reversible two switch-mode luminescence ink for advanced anti-counterfeiting and dual-encryption.

Nature Communications published new progress about 119-80-2. 119-80-2 belongs to catalysis-chemistry, auxiliary class sulfides,Carboxylic acid,Benzene, name is 2,2′-Dithiodibenzoic acid, and the molecular formula is C14H24N2O2, Application In Synthesis of 119-80-2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Pei, Jingyan published the artcileTransport, Stability, and In Vivo Hypoglycemic Effect of a Broccoli-Derived DPP-IV Inhibitory Peptide VPLVM, Quality Control of 71989-31-6, the publication is Journal of Agricultural and Food Chemistry (2022), 70(16), 4934-4941, database is CAplus and MEDLINE.

Diabetes is a major metabolic disease that requires long-term pharmacotherapy. Bioactive peptides have unique advantages such as higher potency, selectivity, and safety over small mols. and have achieved great success in the treatment of diabetes. We previously isolated a dipeptidyl peptidase-IV (DPP-IV) inhibitory peptide VPLVM with IC₅₀ = 99.68¦ÌM from the protein hydrolyzates of broccoli stems and leaves. Here, we evaluated the interaction with DPP-IV, transport, stability, and in vivo hypoglycemic effects of VPLVM. VPLVM interacted closely and steadily with DPP-IV at S1 and S2 pockets. VPLVM had a good gastrointestinal enzyme resistance and was transported through the Caco-2 cell monolayer via paracellular diffusion and by the PepT1 with a P_app of 6.96 x 10^-7 cm/s. VPLVM has a t_1/2 of 12.56 ¡À 0.41 min in vitro plasma stability. In the oral glucose tolerance test, VPLVM showed an excellent hypoglycemic effect at 30 min after administration. VPLVM has potential as a candidate for the treatment of hyperglycemia.

Journal of Agricultural and Food Chemistry published new progress about 71989-31-6. 71989-31-6 belongs to catalysis-chemistry, auxiliary class Amino acide derivatives,pyrrolidine, name is Fmoc-Pro-OH, and the molecular formula is C20H19NO4, Quality Control of 71989-31-6.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia