Tag: M.W=300-350

Chavda, Jaydeepsinh published the artcileBODIPY-peptide conjugate: Synthesis, photo-physical and cell viability studies, Product Details of C20H19NO4, the publication is Journal of Porphyrins and Phthalocyanines (2021), 25(10/12), 1230-1239, database is CAplus.

The synthesis and biol. studies of BODIPY-GPR peptide conjugate (BD-2) are reported. As compared to the parent BODIPY (BD-1), the peptide linked BD-2showed blue shifted absorption and emission with excellent Stokes shift of 201 nm. Mol. docking studies on EGFR protein kinase indicated very efficient binding affinity of BD-2 as compared to the standard drug (Erlotinib). The cell viability experiments of BD-2on normal (HEK293T) and lung cancer (A549) cell lines indicated 85-95% viability. Bioimaging studies showed that, BD-2was able to penetrate the lung cancer cell line.

Journal of Porphyrins and Phthalocyanines published new progress about 71989-31-6. 71989-31-6 belongs to catalysis-chemistry, auxiliary class Amino acide derivatives,pyrrolidine, name is Fmoc-Pro-OH, and the molecular formula is C20H19NO4, Product Details of C20H19NO4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Dvoretsky, Alexander G. published the artcileFatty acids in the circulatory system of an invasive king crab from the Barents Sea, Safety of Docosahexaenoic Acid, the publication is Journal of Food Composition and Analysis (2022), 104528, database is CAplus.

We assayed fatty acids in the cardiac muscle and hemolymph of adult crabs collected in the coastal Barents Sea. Polyunsaturated fatty acids were the major fatty acids (273μg mL^-1 or 42.8% in the hemolymph and 3130μg g^-1 or 59.7% in the cardiac muscle) followed by saturated fatty acids (201μg mL^-1 or 33.9% and 1290μg g^-1 or 24.8%, resp.) and monounsaturated fatty acids (143μg mL^-1 or 23.3% and 815μg g-1 or 15.6%, resp.). The n-3/n-6 ratios in these tissues were 3.4 and 4.3, resp. Fatty acid profiles were similar in females and males, in crabs with different shell conditions and in different-sized crabs. The crabs captured on soft bottoms contained significantly higher concentrations of fatty acids in their hemolymph than the crabs from hard bottoms probably owing to differences in their diets. In general, fatty acid levels in the cardiac muscle were 1.5-3 times higher than in the leg muscle reflecting higher functional load of the heart compared to walking legs. We suggest that both byproducts that now are discarded during red king crab processing could be considered addnl. sources for extracting valuable n-3 fatty acids.

Journal of Food Composition and Analysis published new progress about 6217-54-5. 6217-54-5 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Aliphatic hydrocarbon chain,Metabolic Enzyme,RAR/RXR,Natural product, name is Docosahexaenoic Acid, and the molecular formula is C22H32O2, Safety of Docosahexaenoic Acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Lopez, John published the artcileMissing link: enabling loading of 2-chlorotrityl chloride resin in N-butylpyrrolidinone as a green solvent, Recommanded Product: Fmoc-Pro-OH, the publication is Organic Process Research & Development (2022), 26(5), 1450-1457, database is CAplus.

The 2-chlorotrityl chloride (2-CTC) resin is one of the most frequently used and most versatile resins for the large-scale manufacture of peptides. As a part of our efforts in greening solid-phase peptide synthesis, here, we disclose an efficient procedure for the loading of the first amino acid onto the 2-CTC resin using the green solvent N-butylpyrrolidinone. By applying a design of experiment models, key critical process parameters such as amino acid equivalent and water content were identified. The results obtained suggest that the conditions found can be generalized and applied to any Fmoc-amino acid (Fmoc = 9-fluorenylmethoxycarbonyl). Moreover, they serve as a starting point for the optimization of green resin loading.

Organic Process Research & Development published new progress about 71989-31-6. 71989-31-6 belongs to catalysis-chemistry, auxiliary class Amino acide derivatives,pyrrolidine, name is Fmoc-Pro-OH, and the molecular formula is C20H19NO4, Recommanded Product: Fmoc-Pro-OH.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Fuchte, Hanna E. published the artcileA look down the drain: Identification of dissolved and particle bound organic pollutants in urban runoff waters and sediments, Computed Properties of 191-07-1, the publication is Environmental Pollution (Oxford, United Kingdom) (2022), 119047, database is CAplus and MEDLINE.

Urban runoff contains a range of organic micropollutants which, if not removed during wastewater treatment, pose a risk to aquatic environments. These mixtures are complex and often site-specific. Street drains provide an ideal sampling point given they collect the runoff from local and defined catchments. In this study, runoff was collected and sampled in five street drains located in a medium sized town in Germany. A specially constructed trap was used to collect the particulate and total water fractions of the runoff. In addition, passive samplers were deployed to determine the freely dissolved concentrations of selected compounds in the runoff. In sum, 187 polar organic micropollutants could be quantified using LC-HRMS. Thirty of these could only be detected by the use of passive samplers. Traffic derived pollutants such as corrosion inhibitors, rubber- and plastic additives, but also pollutants of industrial origin were strongly represented with sum median concentrations of 100μg/kg dry weight (DW) in the sediment and 400 ng/L in the water fraction. Several of these substances are of concern due to their environmental persistence and mobility. Perfluorinated compounds and pesticides occurred at lower levels of several μg/kg DW sediment or ng/L water. A number of substances including pharmaceuticals, sweeteners and stimulants indicated domestic wastewater influences. Furthermore, a total of 62 parent and alkylated PAHs were quantified by GC-MS and contributed 30-70% to the sum concentrations of the micropollutants. Non-EPA PAHs dominated the carcinogenic PAH toxicity. The increased PAH alkylation indexes (0.7-0.9) showed these primarily came from combustion sources. The runoff particles were addnl. microscopically characterized, and correlations were found between the rubber particle counts and the PAH alkylation-index as well as the levels of 2-(methylthio)benzothiazole, a marker compound for tire leaching.

Environmental Pollution (Oxford, United Kingdom) published new progress about 191-07-1. 191-07-1 belongs to catalysis-chemistry, auxiliary class Electronic Materials, name is Coronene, and the molecular formula is C24H12, Computed Properties of 191-07-1.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Webster, Ian J. published the artcilePhotochemical Synthesis and Spectroscopy of Covalent PAH Dimers, Name: Coronene, the publication is Journal of Physical Chemistry A (2022), 126(7), 1144-1157, database is CAplus and MEDLINE.

Laser photochem. of pressed-pellet samples of polycyclic aromatic hydrocarbons (PAHs) produces covalently bonded dimers and some higher polymers. This chem. was discovered initially via laser desorption time-of-flight mass spectrometry experiments, which produced masses (m/z) of 2M-2 and 2M-4 (where M is the monomer parent mass). Dimers are believed to be formed from photochem. dehydrogenation and radical polymerization chem. in the desorption plume. Replication of these ablation conditions at higher throughput allowed PAH dimers of pyrene, perylene, and coronene to be produced and collected in milligram quantities. Differential sublimation provided purification of the dimers and elimination of residual monomers. The purified dimers were investigated with UV-visible, IR, and Raman spectroscopy, complemented by computational studies using d. functional theory at the CAM-B3LYP/def2-TZV level. Calculations and predicted spectra were calibrated by comparison with the corresponding monomers and used to determine the lowest energy dimer structures. IR and Raman spectroscopy provided few distinctive signatures, but UV-visible spectra detected new transitions for each dimer. The comparison of simulated and exptl. spectra allows determination of the most prevalent structures for the PAH dimers. The work presented here provides interesting insights into the spectroscopy of extended aromatic systems and a new strategy for the photochem. synthesis of large PAH dimers.

Journal of Physical Chemistry A published new progress about 191-07-1. 191-07-1 belongs to catalysis-chemistry, auxiliary class Electronic Materials, name is Coronene, and the molecular formula is C11H21BF4N2O2, Name: Coronene.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Aboal, M. published the artcilePhotoautotrophs and macroinvertebrate trophic relations in calcareous semiarid streams: The role of Cyanobacteria, Computed Properties of 6217-54-5, the publication is Science of the Total Environment (2022), 838(Part_3), 156206, database is CAplus and MEDLINE.

Photoautotrophs and macroinvertebrate trophic relations in Mediterranean streams, especially from semiarid areas, are still poorly known, as is the role of Cyanobacteria, which is the most frequently dominant photoautotroph. To investigate the role of Cyanobacteria as a food resource in these systems, the fatty acid composition of primary and secondary producers was investigated in two streams on a semiarid climatic gradient between 200 and 500 mm of rainfall in SE Spain. Fatty acid composition of photoautotrophs and macroinvertebrates differed among streams in summer and among seasons in each stream. Fatty acid fingerprints show that macroinvertebrates usually fed on the dominant photoautotroph assemblage and that Cyanobacteria represent the main food for all the feeding groups in the Alharabe stream in winter although filamentous green algae were preferred in summer. Only scrapers consuming Chlorophyta displayed a selective feeding behavior. The results show the importance of cyanobacteria as food for all collected macroinvertebrates in winter in some semiarid streams and confirm that fatty acids can be used as temporal and spatial markers in fluvial systems.

Science of the Total Environment published new progress about 6217-54-5. 6217-54-5 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Aliphatic hydrocarbon chain,Metabolic Enzyme,RAR/RXR,Natural product, name is Docosahexaenoic Acid, and the molecular formula is C22H32O2, Computed Properties of 6217-54-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Beketov, V. I. published the artcileEffect of Temperature on Parameters of Fluorescence Spectra of Solvatochromic Indicator Solutions in Stationary Phases for Gas-Liquid Chromatography, Recommanded Product: Coronene, the publication is Journal of Applied Spectroscopy (2022), 89(3), 433-438, database is CAplus.

Luminescence spectra of several polarity indicators, including Coumarin 153 and coronene that were previously studied at room temperature and Nile Red and Pigment Red 179, were recorded at 20 and 120°C in solutions of liquid stationary phases of various polarities. The effect of temperature on the spectral parameters sensitive to the stationary phase polarity was estimated for these indicators. The prospects for estimating the polarity of stationary liquid phases using luminescent methods at high temperatures was demonstrated.

Journal of Applied Spectroscopy published new progress about 191-07-1. 191-07-1 belongs to catalysis-chemistry, auxiliary class Electronic Materials, name is Coronene, and the molecular formula is C24H12, Recommanded Product: Coronene.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Cunningham, Drew W. published the artcileReversible and Selective CO₂ to HCO₂^– Electrocatalysis near the Thermodynamic Potential, Quality Control of 17351-62-1, the publication is Angewandte Chemie, International Edition (2020), 59(11), 4443-4447, database is CAplus and MEDLINE.

Reversible catalysis is a hallmark of energy-efficient chem. transformations, but can only be achieved if the changes in free energy of intermediate steps are minimized and the catalytic cycle is devoid of high transition-state barriers. Using these criteria, the authors demonstrate reversible CO₂/HCO₂^– conversion catalyzed by [Pt(depe)₂]²⁺ (depe = 1,2-bis(diethylphosphino)ethane). Direct measurement of the free energies associated with each catalytic step correctly predicts a slight bias towards CO₂ reduction The exptl. measured free energy of each step directly contributes to the <50 mV overpotential. Also for CO₂ reduction, H₂ evolution is negligible and the faradaic efficiency for HCO₂^– production is nearly quant. A free-energy anal. reveals H₂ evolution is endergonic, providing a thermodn. basis for highly selective CO₂ reduction

Angewandte Chemie, International Edition published new progress about 17351-62-1. 17351-62-1 belongs to catalysis-chemistry, auxiliary class Salt,Amine, name is Tetrabutylammonium hydrogencarbonate, and the molecular formula is C17H37NO3, Quality Control of 17351-62-1.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Maldonado-Pereira, Lisaura published the artcileEvaluation of the nutritional quality of ultra-processed foods (ready to eat + fast food): Fatty acids, sugar, and sodium, Application of Docosahexaenoic Acid, the publication is Journal of Food Science (2022), 87(8), 3659-3676, database is CAplus and MEDLINE.

The average American consumes more than 50% of their total dietary energy from ultra-processed foods (UPFs). From a nutritional standpoint, as UPFs intake increases, fiber, vitamin, and mineral intake decrease. High consumption of UPFs, mainly from fast foods (FF) and ready-to-eat (RTE) food items, emerges as a critical public health concern linking nutritional quality and food safety. In the present work, a systematic database of the fatty acid composition of the most consumed UPFs in the Midwest is reported. Saturated and monounsaturated fatty acids were predominant in RTE (42.5%) and FF (43.2%), resp. In addition, the fatty acid profile in UPFs is reported according to six food categories: meat and poultry, eggs and derivatives, dairy products, seafood, baby foods, and others. Meat and poultry, and dairy products were the dominant food categories among UPFs. Meanwhile, polyunsaturated fatty acids were abundant in the eggs and seafood groups UPFs (61.8% and 46.4%, resp.) regardless of the food group. Furthermore, no significant differences were found in sugar content in UPFs. Caloric content was pos. correlated with sodium (ρ = 0.748) and price (ρ = 0.534). The significance of this study relies on providing new quant. data on the fat, sodium, and sugar contents of the most consumed UPFs in the Midwestern area of the United States. This information suggests paying more attention to these nutritional attributes, aiming to reduce their incorporation in UPF preparations Addnl., more quant. data are needed regarding other nutritional parameters such as protein and lipid degradation in UPFs.

Journal of Food Science published new progress about 6217-54-5. 6217-54-5 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Aliphatic hydrocarbon chain,Metabolic Enzyme,RAR/RXR,Natural product, name is Docosahexaenoic Acid, and the molecular formula is C22H32O2, Application of Docosahexaenoic Acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Krishnamurti, Vinayak published the artcileAqueous Base Promoted O-Difluoromethylation of Carboxylic Acids with TMSCF₂Br: Bench-Top Access to Difluoromethyl Esters, Quality Control of 119-80-2, the publication is Organic Letters (2019), 21(23), 9377-9380, database is CAplus and MEDLINE.

A method for the O-difluoromethylation of carboxylic acids using com. available TMSCF₂Br is disclosed. The devised bench-top reaction system is air-stable and offers mild reaction conditions while using readily available reagents and solvents. The method is applicable to both aliphatic and aromatic carboxylic acids while demonstrating compatibility with a range of commonly encountered functional groups. The difluoromethyl esters of FDA approved drugs and pharmaceutically relevant mols. are also presented, demonstrating the potential for late-stage functionalization.

Organic Letters published new progress about 119-80-2. 119-80-2 belongs to catalysis-chemistry, auxiliary class sulfides,Carboxylic acid,Benzene, name is 2,2′-Dithiodibenzoic acid, and the molecular formula is C14H10O4S2, Quality Control of 119-80-2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia