Tag: M.W=450-500

Wang, Youliang published the artcileIntramolecular Insertions into Unactivated C(sp³)-H Bonds by Oxidatively Generated ¦Â-Diketone-¦Á-Gold Carbenes: Synthesis of Cyclopentanones, HPLC of Formula: 1237588-12-3, the publication is Journal of the American Chemical Society (2015), 137(16), 5316-5319, database is CAplus and MEDLINE.

Generation of reactive ¦Á-oxo gold carbene intermediates via gold-catalyzed oxidation of alkynes has become an increasing versatile strategy of replacing hazardous diazo carbonyl compounds with benign and readily available alkynes in the development of efficient synthetic methods. However, one of the hallmarks of metal carbene/carbenoid chem., i.e., insertion into an unactivated C(sp³)-H bond, has not be realized. This study reveals for the first time that this highly valuable transformation can be readily realized intramolecularly by oxidatively generated ¦Â-diketone-¦Á-gold carbenes using ynones as substrates. Substrate conformation control via the Thorpe-Ingold effect is the key design feature that enables generally good to excellent efficiencies, and synthetically versatile cyclopentanones including spiro-, bridged, and fused bicyclic ones can be readily accessed.

Journal of the American Chemical Society published new progress about 1237588-12-3. 1237588-12-3 belongs to catalysis-chemistry, auxiliary class Mono-phosphine Ligands, name is 4-(2-(Di(adamantan-1-yl)phosphino)phenyl)morpholine, and the molecular formula is C10H12O5, HPLC of Formula: 1237588-12-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wu, Gongde published the artcileOne-step synthesis of methanesulfonyloxymethyl ketones via gold-catalyzed oxidation of terminal alkynes: A combination of ligand and counter anion enables high efficiency and a one-pot synthesis of 2,4-disubstituted thiazoles, Related Products of catalysis-chemistry, the publication is Advanced Synthesis & Catalysis (2014), 356(6), 1229-1234, database is CAplus.

The Au(I) complex of (2-morpholinophenyl)diadamantanylphosphine (Mor-DalPhos) as P,N-bidentate ligand and mesylate as counter ion catalyzed efficient oxidative transformations of various terminal alkynes into synthetically versatile [(methanesulfonyl)oxy]methyl ketones. The mild reaction conditions and high efficiency permit the one-pot synthesis of a range of valuable 2,4-disubstituted thiazoles by subjecting the resulting reaction mixture to a further condensation with thioamides under mild conditions.

Advanced Synthesis & Catalysis published new progress about 1237588-12-3. 1237588-12-3 belongs to catalysis-chemistry, auxiliary class Mono-phosphine Ligands, name is 4-(2-(Di(adamantan-1-yl)phosphino)phenyl)morpholine, and the molecular formula is C8H10O2, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Yi, Xin published the artcileLigands binding and molecular simulation: the potential investigation of a biosensor based on an insect odorant binding protein, Application In Synthesis of 30670-30-5, the publication is International Journal of Biological Sciences (2015), 11(1), 75-87, 13 pp., database is CAplus and MEDLINE.

Based on mimicking biol. olfaction, biosensors have been applied for the detection of various ligands in complex environment, which could represent one of the most promising research fields. In this study, the basic characters of one insect odorant binding protein (OBP) as a biosensor were explored. To explore the mol. recognition process, the tertiary structure of the protein was modeled and the protein-ligand interactions with 1,536,550 chems. were investigated by the mol. docking. The availability of large amount of recombinant SlitOBP1 overcame the difficulty to obtain biol. sensing material. After obtained the purified recombinant protein, the result of fluorescence binding assays proved the candidate protein has good affinities with the majority of the tested chems. With the aid of simulation docking, the key conserved amino acids within the binding site were identified and then mutated to alanine. After mutation, the protein-ligand binding characteristics were recorded, and the competitive binding assays were carried out to provide exptl. verification. The detailed information on its structure and affinities investigated in this study could allow the design of specific mutants with desired characteristics, which provides a solid base for tailoring OBP for biosensor and provides a role model for screening the other elements in olfactory system for different applications.

International Journal of Biological Sciences published new progress about 30670-30-5. 30670-30-5 belongs to catalysis-chemistry, auxiliary class Polyfluoroalkanes, name is 3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-Heptadecafluorodecan-1-amine, and the molecular formula is C15H10O2, Application In Synthesis of 30670-30-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Crawford, Sarah M. published the artcileProbing the effect of donor-fragment substitution in Mor-DalPhos on palladium-catalyzed C-N and C-C cross-coupling reactivity, Application In Synthesis of 1237588-12-3, the publication is Canadian Journal of Chemistry (2018), 96(6), 578-586, database is CAplus.

The competitive catalytic screening of 18 known and newly prepared Mor-DalPhos ligand variants, 1-R₂N-2-PR¹₂C₆H₄ (R = Me; R₂N = 4-morpholinyl, 1-azetidinyl, 1-pyrrolidinyl, 1-piperidinyl, 2-tetrahydroisoquinolinyl, 1-piperazinyl; R¹ = Ph, 2-MeC₆H₄, Cy, ^tBu, 1-adamantyl, 3,5-dimethyl-1-adamantyl) in the palladium-catalyzed cross-coupling of chlorobenzene with aniline, octylamine, morpholine, indole, ammonia, or acetone is presented, including ligands derived from the new secondary phosphine HP(^Me2Ad)₂ (^Me2Ad = 3,5-dimethyl-1-adamantyl). Although triarylphosphine ancillary ligand variants performed poorly in these test reactions, ligands featuring either PAd₂ or P(^Me2Ad)₂ donors (Ad = 1-adamantyl) gave rise to superior catalytic performance. Multiple Mor-DalPhos variants proved effective in cross-couplings involving aniline, octylamine, or morpholine; conversely, only a smaller subset of ligands proved useful in related cross-couplings of indole, ammonia, or acetone. In the case of the N-arylation of indole, a Mor-DalPhos ligand variant featuring ortho-disposed PAd₂ and dimethylmorpholino donor fragments (L13) proved superior to all other ligands surveyed, including the parent ligand Mor-DalPhos (L5). Conversely, L5 was found to be superior to all other ligands in the palladium-catalyzed monoarylation of ammonia. Ligand L6 (i.e., the P(^Me2Ad)₂ variant of L5) proved superior to all other ligands in the monoarylation of acetone and, with the exception of indole N-arylation, was the most broadly useful of the Mor-DalPhos ligands surveyed herein.

Canadian Journal of Chemistry published new progress about 1237588-12-3. 1237588-12-3 belongs to catalysis-chemistry, auxiliary class Mono-phosphine Ligands, name is 4-(2-(Di(adamantan-1-yl)phosphino)phenyl)morpholine, and the molecular formula is C30H42NOP, Application In Synthesis of 1237588-12-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Fu, Zheng-Jun published the artcileDual-layer membrane with hierarchical hydrophobicity and transport channels for nonpolar organic solvent nanofiltration, Product Details of C10H6F17N, the publication is AIChE Journal (2021), 67(4), e17138, database is CAplus.

Nonpolar solvent separation is widely used in petroleum, chem., food industries, but traditional separation methods consume intensive energy. State-of-art organic solvent nanofiltration membranes require complex modifications for nonpolar solvent transport. For the first time, we propose the concurrent modification of the surface, interface and support layer of dual-layer membranes with three additives (perfluorodecylamine, fluoro substituted aromatic amine, silica nanoparticles) in a one-step cocasting process. A delamination-free dual-layer membrane was obtained with a hierarchical hydrophobicity and transport channels. The novel designed structure elevated the pure n-hexane permeance (28.75 L m^-2 hr^-1 bar^-1) by 3 orders of magnitude with a high lecithin rejection (98.7%). This method of synergistically controlling the hierarchical structures and properties of dual-layer membranes can significantly shorten the preparation process of high-performance nonpolar solvent nanofiltration membranes.

AIChE Journal published new progress about 30670-30-5. 30670-30-5 belongs to catalysis-chemistry, auxiliary class Polyfluoroalkanes, name is 3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-Heptadecafluorodecan-1-amine, and the molecular formula is C10H6F17N, Product Details of C10H6F17N.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wu, Gongde published the artcileOne-step synthesis of 2,4-disubstituted thiazoles in Au(I) complex/zinc salt catalytic system, HPLC of Formula: 1237588-12-3, the publication is Youji Huaxue (2015), 35(12), 2537-2544, database is CAplus.

Ten typical P,N-bidentate ligands were selected to synthesize the corresponding Au(I) complexes. The catalytic system of Au(I) complex/metal salt was employed in the catalytic oxidation of terminal alkynes with the oxidant of 8-methylquinoline N-oxide. And then 2,4-disubstituted thiazoles were synthesized from the oxidized alkynes and thioamides. It was found that the catalytic system of 5 mol% Mor-DalPhosAuCl/10 mol% Zn(NTf₂)₂ showed the optimum catalytic performance in this reaction via adjusting reaction parameters. Furthermore, ten kinds of 2,4-disubstituted thiazoles were effectively synthesized in one-step. So a simple and direct synthetic route was explored for the preparation of thiazoles and their derivatives

Youji Huaxue published new progress about 1237588-12-3. 1237588-12-3 belongs to catalysis-chemistry, auxiliary class Mono-phosphine Ligands, name is 4-(2-(Di(adamantan-1-yl)phosphino)phenyl)morpholine, and the molecular formula is C8H10O2, HPLC of Formula: 1237588-12-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wu, Gongde published the artcileHighly efficient one-pot synthesis of 2,4-disubstituted thiazoles using Au(I) catalyzed oxidation system at room temperature, Formula: C30H42NOP, the publication is Catalysts (2016), 6(8), 126/1-126/9, database is CAplus.

A gold complex catalysts with Mor-DalPhos ligands were successfully prepared using mesylates as counter ions. Seven ammonium sulfonates were synthesized to promote the production of intermediate sulfonyloxymethyl ketone. It was found that low-acidity N,N-dimethylbenzenaminium methanesulfonate showed excellent activity in the reaction. Furthermore, the catalysts effectively avoided the loss of activity due to the low acidity. Various thioamides were directly added to the resulting reaction mixture without the separation of intermediate product. Then, twenty kinds of 2,4-disubstituted thiazoles were efficiently synthesized at room temperature with the highest yield of 91%. An efficiency and mild gold-catalyzed oxidation system for the one-pot synthesis of thiazole and its derivatives was provided.

Catalysts published new progress about 1237588-12-3. 1237588-12-3 belongs to catalysis-chemistry, auxiliary class Mono-phosphine Ligands, name is 4-(2-(Di(adamantan-1-yl)phosphino)phenyl)morpholine, and the molecular formula is C10H18O, Formula: C30H42NOP.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Jouani, Mohamed Azzedine published the artcileSynthesis of F-alkylated 5,6-dihydro-2-uracils, SDS of cas: 30670-30-5, the publication is Bulletin de la Societe Chimique de France (1996), 133(9), 839-842, database is CAplus.

A two-step synthesis of 3-fluoroalkylated dihydrouracils consists of reacting a 3-aminopropanoic acid derivative with 2-(fluoroalkyl)ethyl isocyanates and treating the resulting product with catalytic amounts of hydrochloric acid. The treatment of 3-[2-(fluoroalkyl)ethylamino]propanoic acid derivatives with benzoyl isocyanate followed by acid-catalyzed cyclization gives 1-fluoroalkylated dihydrouracils.

Bulletin de la Societe Chimique de France published new progress about 30670-30-5. 30670-30-5 belongs to catalysis-chemistry, auxiliary class Polyfluoroalkanes, name is 3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-Heptadecafluorodecan-1-amine, and the molecular formula is C10H6F17N, SDS of cas: 30670-30-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Borjian, Sogol published the artcilePd(¦Ç³-1-PhC₃H₄)(¦Ç⁵-C₅H₅) as a Catalyst Precursor for Buchwald-Hartwig Amination Reactions, COA of Formula: C30H42NOP, the publication is Organometallics (2014), 33(15), 3928-3935, database is CAplus.

The compound Pd(¦Ç³-1-Ph-C₃H₄)(¦Ç⁵-C₅H₅) (I) reacts cleanly with many tertiary phosphines L to undergo reductive elimination of PhC₃H₄-C₅H₅ and form palladium(0) species of the types PdL_n (n = 2, 3), long believed to be exemplary catalysts for Suzuki-Miyaura, Heck-Mizoroki, and Sonogashira cross-coupling reactions. I has accordingly been generally much more effective for these catalytic processes than are conventional catalyst precursors such as Pd(PPh₃)₄, Pd₂(dba)₃, PdCl₂, and Pd(OAc)₂, in large part because I stands alone in this series for its ability to generate specifically and efficiently the desired species PdL₂ in many cases. Authors have now investigated I as a precursor for prototypical Buchwald-Hartwig amination reactions of 4-bromo- and 4-chloroanisole with morpholine, making comparisons with Pd₂(dba)₃, Pd(OAc)₂, and [Pd(¦Ç³-1-Ph-C₃H₄)Cl]₂ (IV). In this work authors have utilized PBu^t₃ because of its general effectiveness, and have also assessed XPhos and Mor-Dalphos, representatives of important classes of phosphines utilized elsewhere for amination reactions.

Organometallics published new progress about 1237588-12-3. 1237588-12-3 belongs to catalysis-chemistry, auxiliary class Mono-phosphine Ligands, name is 4-(2-(Di(adamantan-1-yl)phosphino)phenyl)morpholine, and the molecular formula is C30H42NOP, COA of Formula: C30H42NOP.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Nasreddine, M. published the artcileNew and effective route to N-(2-F-alkyl ethyl) ¦Á-amino acids, Application of 3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-Heptadecafluorodecan-1-amine, the publication is Synthetic Communications (1992), 22(11), 1547-54, database is CAplus.

A new and effective procedure is described for the synthesis of the title ¦Á-amino acids F₃C(CF₂)_nCH₂CH₂NHCHRCO₂H (I; n = 5, 7, R = H, Me, Et, Pr, Bu) which involves a solid-liquid phase transfer catalysis method. Thus, substitution of bromoalkanoates BrCHRCO₂Et with amines F₃C(CF₂)_nCH₂CH₂NH₂ in MeCN in the presence of K₂CO₃ and PhCH₂N⁺Et₃ Cl^– gave 76-96% of the corresponding amino esters, which were saponified to give 71-97% I.

Synthetic Communications published new progress about 30670-30-5. 30670-30-5 belongs to catalysis-chemistry, auxiliary class Polyfluoroalkanes, name is 3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-Heptadecafluorodecan-1-amine, and the molecular formula is C10H6F17N, Application of 3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-Heptadecafluorodecan-1-amine.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia