Month: November 2022

Kurfurst, Antonin published the artcile4-(5-Phenyl-1,3,4-oxadiazol-2-yl)biphenyl-4′-carboxylic acid: its functional derivatives and their heterocyclization into 1,3-thiazine-6-thiones, Safety of 1,1-Dimethylthiourea, the publication is Collection of Czechoslovak Chemical Communications (1990), 55(11), 2722-30, database is CAplus.

The title acid (I; R = CO₂H) was prepared by hypobromite oxidation of acetyl derivative (I; R = COMe). The C-acylation of Cl₂C:CH₂ with acyl chloride (I; R = COCl) gave dichloroethenyl ketone (I; R = COCH:CCl₂), which on cyclocondensation with appropriate thioamides gave thiazinethiones (II; R¹ = Me, Ph, SMe, NH₂, NMe₂; X = O, S) and (III).

Collection of Czechoslovak Chemical Communications published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C3H8N2S, Safety of 1,1-Dimethylthiourea.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Sakaguchi, Tomoya published the artcileSimple Modifications for the Facile Preparation of 1,1,2,3,4,4-Hexaaryl-1,3-butadienes, Computed Properties of 613-33-2, the publication is Helvetica Chimica Acta (2022), 105(2), e202100232, database is CAplus.

In this reaction system, the insertion of alkynes into the palladium-carbon bond was accelerated by changing the palladium intermediate to the cationic one. When silver nitrate was used, the reaction of diarylalkynes with arylboronic acids took place smoothly under mild reaction conditions without any ligand to give the coupling diene products in excellent yields. On the contrary, the reaction hardly proceeded with silver oxide and silver carbonate. Poly(hexaphenyl-1,3-butadiene) (PHB) with a similar mol. weight to the previously prepared one was also synthesized from the reaction of diphenylacetylene with phenyldiboronic acid under mild reaction conditions.

Helvetica Chimica Acta published new progress about 613-33-2. 613-33-2 belongs to catalysis-chemistry, auxiliary class Benzene, name is 4,4′-Dimethyldiphenyl, and the molecular formula is C14H14, Computed Properties of 613-33-2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Sheiman, B. M. published the artcileSynthesis of alkylphenols from borates by the Friedel-Crafts reaction, Related Products of catalysis-chemistry, the publication is Izvestiya Vysshikh Uchebnykh Zavedenii, Khimiya i Khimicheskaya Tekhnologiya (1960), 876-80, database is CAplus.

Two preparations of alkylphenols from sym. boric esters [trialkyl borates and triphenyl borate(I)] in the presence of AlCl₃, and through a preliminary preparation of mixed boric esters were given. The yields reached 70-98% and the alkylphenols obtained did not contain nonphenolic compounds A mixture of 23 g. tributyl borate, 18.8 g. PhOH, and 0.2 g. PhONa was heated to 200-30¡ã (maintaining the temperature of BuOH below 120-30¡ã) to yield 14.8 g. BuOH [i.e., the theoretical amount, assuming the formation of (PhO)₂BOBu (II)], n²⁰_D 1.4000. To a mixture of 1 g. II in 200 ml. pyridine was added, portionwise, with cooling, 52 g. freshly sublimed AlCl₃. The mixture heated 15-20 min. to 80¡ã and 15 min. at 80-5¡ã, poured into a mixture of ice and HCl, and extracted with Et₂O, and the phenols extracted with 10% NaOH and treated as usual gave 80% mixture of o- and p-butylphenol, b_5.5 92-106¡ã, further fractionated to yield 11.6% o-sec-butylphenol, b_6.5 92.5¡ã, n²⁰_D 1.5228, d₂₀ 0.9876, MR_D 46.42 (o-sec-butylphenoxyacetic acid m. 109.5-110¡ã; the toluide m. 69.5-70.5¡ã) and 81.2% p-sec-butylphenol, b_6.5 105.5¡ã, m. 57-7.5¡ã (petr. ether), n²⁰_D 1.5200, d₂₀ 0.9787, MR_D 46.59 (the toluidide of p-sec-butylphenoxyacetic acid m. 90-1¡ã). In an analogous manner, 58 g. I and 18.8 g. triisopropyl borate dissolved in 150 ml. ligroine and 52 g. AlCl₃ yielded a fraction b₁₀ 99-120¡ã, further fractionated to yield o-isopropylphenol, b_2.5 67-7.5¡ã, n²⁰_D 1.5282, d₂₀ 1.0127, MR_D 41.43. Propyl diphenyl borate was obtained by the simultaneous esterification of 18 g. PrOH and 56.4 g. phenol with 18.6 g. boric acid in 80 ml. toluene in a Dean-Stark apparatus; after distillation of PhCH₃ and the unreacted phenol in vacuo (water-jet pump), 150 ml. ligroine and 52 g. AlCl₃ were added, and the mixture treated as above to yield 73% propylphenol isomers, b₁₀ 103-4¡ã, n²⁰_D 1.5253, d₂₀ 0.9972, MR_D 41.88; the phenoxyacetic acid m. 63-5¡ã; phenylurethan m. 77-85¡ã. A mixture of 76.7 g. triisobutyl borate, 193.4 g. I dissolved in 450 ml. ligroine, and 133.5 g. AlCl₃ was heated 2 hrs. at 35-60¡ã and about 1 hr. at 85-90¡ã, and treated as usual to yield 70% p-tert-butylpbenol, b₅ 99-9.5¡ã, m. 98.5-99¡ã (petr. ether); (the phenoxyacetic acid m. 85.5-86¡ã) and 2 high-boiling fractions of polyalkyl phenols b₅ 120-30¡ã (10.3 g.), and b₅ 150-65¡ã (4 g.). I (58 g.) and 30.8 g. tricyclohexyl borate 100 ml. ligroine heated 30 min. at 90¡ã with 40 g. AlCl₃ yielded 42.2% p-cyclohexylphenol b₁₁ 1.50-3¡ã, m. 127.5-8¡ã (benzene); benzoate derivative m. 114-14.5¡ã (alc.). The nonphenolic part yielded 10.8 g. of a fraction, b₆ 101-3¡ã, n²⁰_D 1.5283, d₂₀ 0.9586, and 6.2 g. of a fraction b₆ 178-80¡ã, n²⁰_D 1.5432. 27 references.

Izvestiya Vysshikh Uchebnykh Zavedenii, Khimiya i Khimicheskaya Tekhnologiya published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C8H5F3O3, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Diaz, Celine published the artcileDetermining novel functions of Arabidopsis 14-3-3 proteins in central metabolic processes, COA of Formula: C3H12Cl2N2, the publication is BMC Systems Biology (2011), 192, database is CAplus and MEDLINE.

Background: 14-3-3 proteins are considered master regulators of many signal transduction cascades in eukaryotes. In plants, 14-3-3 proteins have major roles as regulators of nitrogen and carbon metabolism, conclusions based on the studies of a few specific 14-3-3 targets. Results: In this study, extensive novel roles of 14-3-3 proteins in plant metabolism were determined through combining the parallel analyses of metabolites and enzyme activities in 14-3-3 overexpression and knockout plants with studies of protein-protein interactions. Decreases in the levels of sugars and nitrogen-containing-compounds and in the activities of known 14-3-3-interacting-enzymes were observed in 14-3-3 overexpression plants. Plants overexpressing 14-3-3 proteins also contained decreased levels of malate and citrate, which are intermediate compounds of the tricarboxylic acid (TCA) cycle. These modifications were related to the reduced activities of isocitrate dehydrogenase and malate dehydrogenase, which are key enzymes of TCA cycle. In addition, we demonstrated that 14-3-3 proteins interacted with one isocitrate dehydrogenase and two malate dehydrogenases. There were also changes in the levels of aromatic compounds and the activities of shikimate dehydrogenase, which participates in the biosynthesis of aromatic compounds Conclusion: Taken together, our findings indicate that 14-3-3 proteins play roles as crucial tuners of multiple primary metabolic processes including TCA cycle and the shikimate pathway.

BMC Systems Biology published new progress about 10517-44-9. 10517-44-9 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is Propane-1,3-diamine dihydrochloride, and the molecular formula is C3H12Cl2N2, COA of Formula: C3H12Cl2N2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Nakamura, Shuichi published the artcile1,4-Asymmetric reduction of ¦Ã-keto sulfoxides bearing the 2,4,6-triisopropylphenyl group, Category: catalysis-chemistry, the publication is Perkin 1 (2000), 3143-3148, database is CAplus.

Reduction of ¦Ã-keto sulfoxides bearing the 2,4,6-triisopropylphenyl group with DIBAL gives ¦Ã-hydroxy sulfoxides with high stereoselectivity in the ratio 95:5. In comparison with the lower stereoselectivities obtained in the reaction of ¦Ã-keto sulfoxides bearing p-tolyl or 2,4,6-trimethylphenyl groups, the sterically bulky (2,4,6-triisopropylphenyl)sulfinyl group is extremely efficient in effecting high 1,4-remote asym. induction.

Perkin 1 published new progress about 22693-41-0. 22693-41-0 belongs to catalysis-chemistry, auxiliary class Other Functionalization Reagent, name is 2,4,6-Triisopropylbenzenethiol, and the molecular formula is C15H24S, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Ishikawa, Nobuo published the artcilePreparation and properties of alkali metal dialkyl(or -aryl)tetrafluorosilicates, Recommanded Product: Difluorodiphenylsilane, the publication is Nippon Kagaku Zasshi (1968), 89(7), 699-702, database is CAplus.

PhSiCl2(C6H4-Me-p), b6 152-4¡ã, was prepared from p-MeC6H4MgBr and PhSiCl3 in 60% yield. RR’SiCl2 was converted to RR’SiF2 (I) by heating with Na2SiF6. Thus, PhSiF2(C6H4Me-p), b11 130.5-1.5¡ã, was prepared in 70% yield. I and MF (where M is an alkali metal) in tetrahydrofuran, Me2CO, or MeCN stirred for 20 hrs. at room temperature gave alkali dialkyltetrafluorosilicate. Thus, K2[Ph2SiF4], Na2[Ph2SiF4], Cs2[Ph2SiF4], K2[MePhSiF4], Na2-[MePhSiF4], Cs2[MePhSiF4] and Cs2[Me2SiF4] were prepared These compounds are all hygroscopic substances, possess ir absorptions at approx. 1530 and approx. 1260 cm.-1 and decompose to R2SiF2 and MF on standing in the air. Thus, these complexes cannot be prepared in aqueous solution The rate of formation of C6H6 from Ph2SiF2 and PrNH3F or PhNH3F was measured and found to be faster with PrNH3F. The results are interpreted by assuming that complex formation is the rate-determining step and is dependent on the concentration of F-.

Nippon Kagaku Zasshi published new progress about 312-40-3. 312-40-3 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Difluorodiphenylsilane, and the molecular formula is C12H10F2Si, Recommanded Product: Difluorodiphenylsilane.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Ishikawa, Nobuo published the artcileOrganic fluorine silicon compounds. VI. Preparation and reactions of functional diorganofluorosilanes, HPLC of Formula: 312-40-3, the publication is Kogyo Kagaku Zasshi (1969), 72(12), 2602-5, database is CAplus.

Ph2SiF2 (I) (0.1 mole) and 0.1 mole Ph2SiCl2 or (EtO)2SiPh2 was heated at 180-90¡ã C in the presence of 0.002 mole AlCl3 to give Ph2SiClF (II) and EtOSiFPh2 (III): for II, ¦¤G-(460¡ãK) = -0.26 kcal/mole K(460¡ãK) = 1.33; for III, the values were -2.65, 18.1. II was also formed (30%) by partial chlorination of I with AlCl3 in ether. Diorganochlorofluoro-silanes reacted with alkylamines, alcs. (phenol), and water to give diorganoalkylaminofluorosilanes, diorganoalkoxyfluoro-silanes, and 1,1,3,3-tetraorgano-1,3-difluorosiloxanes, resp. in 70-95% yields. The following RR1SiXF were prepared (R, R1, X, and b.p./mm given): Ph, Ph, NHPr, 130-5¡ã/3; Ph, Ph, morpholino(Z), 142-6¡ã/3; Ph, Me, NHPr, 63-6¡ã/3; Ph, Me, Z, 95-100¡ã/5; Ph, Ph, OEt, 110-13¡ã/3; Ph, Ph, OPr, 101-3¡ã/3; Ph, Ph, OBu, 109-13¡ã/2; Ph, Ph, OPh, 133-7¡ã/2; Ph, Me, OEt, 75-7¡ã/14; Ph, Me, OPr, 55-6¡ã/3; Ph, Me, OBu, 66-7¡ã/3; and Ph, Me, OPh, 98-100¡ã/3; The following RR1SiFOSiFRR1 were also prepared (R, R1, and b.p./mm given): Ph, Ph, 194-6¡ã/-3; and Ph, Me, 95-100¡ã/2. II and III were hydrolyzed to octaorganocyclotetrasiloxanes in the presence of alkylamines. NMR and ir spectral data were given.

Kogyo Kagaku Zasshi published new progress about 312-40-3. 312-40-3 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Difluorodiphenylsilane, and the molecular formula is C12H10F2Si, HPLC of Formula: 312-40-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Ono, K. published the artcileUpgrading of MgO in dolomite ore by froth flotation, Computed Properties of 2016-56-0, the publication is Publications of the Australasian Institute of Mining and Metallurgy (2010), 2215-2223, database is CAplus.

The dolomite deposit coexists with limestone (nearly 100% calcite) deposits in many cases in Japan. The mixing of limestone ore is inevitable in quarrying operation of dolomite ore and it is one reason to degrade the MgO grade of dolomite ore. Removing limestone from dolomite ore is, therefore, effective for upgrading the MgO content of products. However, as the mineralogical structure and phys. characteristics of dolomite mineral are similar to those of calcite, a fine grade separation of the both mineral particles is generally presumed to be difficult and practicable method for the beneficiation of dolomite has not been reported. A method for beneficiation of low grade dolomite ore is, herein, investigated for effective utilization of dolomitic resources in Japan. In order to meet the requirements from industries, the grade of MgO component of processed dolomite is targeted to be 19.0% or more in this research. The targeted grade for beneficiation was achieved by froth flotation with a cationic collector, i.e. Dodecylamine Acetate (DAA). Results of the flotation and the effects of other parameters influencing effectiveness of floatation and phenomenon observed in the floatation experiments of dolomite ore are herein reported.

Publications of the Australasian Institute of Mining and Metallurgy published new progress about 2016-56-0. 2016-56-0 belongs to catalysis-chemistry, auxiliary class Active Esterification, name is Dodecylamineacetate, and the molecular formula is C14H31NO2, Computed Properties of 2016-56-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Pottie, Eline published the artcileSynthesis and Functional Characterization of 2-(2,5-Dimethoxyphenyl)-N-(2-fluorobenzyl)ethanamine (25H-NBF) Positional Isomers, Quality Control of 4230-93-7, the publication is ACS Chemical Neuroscience (2021), 12(9), 1667-1673, database is CAplus and MEDLINE.

Synthes of positional isomers of 25H-NBF, with two methoxy groups placed on different positions of the Ph group of the phenethylamine moiety. These isomers were then functionally characterized in an in vitro bioassay monitoring the recruitment of ¦Â-arrestin 2 to the 5-HT2AR through luminescent readout via the NanoBiT technol. The obtained results provide insight into the optimal substitution pattern of the Ph group of the phenethylamine moiety of N-benzyl derived substances, a feature so far mostly explored in the phenethylamines underived at the N-position. In the employed bioassay, the most potent substances were 24H-NBF (EC₅₀ value of 158 nM), 26H-NBF (397 nM), and 25H-NBF (448 nM), with 23H-NBF, 35H-NBF, and 34H-NBF yielding ¦ÌM EC50 values. A similar ranking was obtained for the compounds’ efficacy: taking as a reference LSD (lysergic acid diethylamide), 24H-, 26H-, and 25H-NBF had an efficacy of 106-107%, followed by 23H-NBF (96.1%), 34H-NBF (75.2%), and 35H-NBF (58.9%). The stronger activity of 24H-, 25H-, and 26H-NBF emphasizes the important role of the methoxy group at position 2 of the phenethylamine moiety for the in vitro functionality of NBF substances.

ACS Chemical Neuroscience published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, Quality Control of 4230-93-7.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Luo, Yuqing published the artcileComparison of 4,4′-Dimethylbiphenyl from Biomass-Derived Furfural and Oil-Based Resource: Technoeconomic Analysis and Life-Cycle Assessment, Related Products of catalysis-chemistry, the publication is Industrial & Engineering Chemistry Research (2022), 61(25), 8963-8972, database is CAplus.

Replacing oil-based toluene with biomass-derived furfural for 4,4′-dimethylbiphenyl (DMBP) production can pave the way for sustainable polyester manufacture This work compared the economic and environmental performances of two conceptual designs of 4,4′-DMBP production The first toluene-based route consists of toluene alkylation to (methylcyclohexyl)toluene (MCHT), MCHT dehydrogenation to DMBP, and isomerization of lower-valued 3,3′-DMBP. The renewable furfural-based route includes hydrogenation of furfural to 2-methylfuran (MF), oxidative coupling of MF to 5,5′-dimethylfuran (DMBF), and tandem Diels-Alder dehydration of 5,5′-DMBF to 4,4′-DMBP. The reaction conditions are optimized to achieve a more economically feasible process using furfural feedstock. At a scale of 83 kmol/h feedstock, the 4,4′-DMBP min. selling price of the furfural-based route is $3044/t, while that of the toluene-based route is $2488/t. The feedstock and 3,4′-DMBP isomer prices are identified as critical parameters for the economic evaluation by sensitivity anal. A “cradle-to-gate” life-cycle assessment confirms that furfural-based DMBP production emits significantly fewer greenhouse gas (5.00 kg CO₂ equiv/kg DMBP) as compared to the toluene-based counterpart (8.28 kg CO₂ equiv/kg DMBP).

Industrial & Engineering Chemistry Research published new progress about 613-33-2. 613-33-2 belongs to catalysis-chemistry, auxiliary class Benzene, name is 4,4′-Dimethyldiphenyl, and the molecular formula is C14H14, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia