Month: December 2022

Manna, Utsab published the artcileDual Guest [(Chloride)₃-DMSO] Encapsulated Cation-Sealed Neutral Trimeric Capsular Assembly: Meta-Substituent Directed Halide and Oxyanion Binding Discrepancy of Isomeric Neutral Disubstituted Bis-Urea Receptors, Synthetic Route of 17351-61-0, the publication is Crystal Growth & Design (2016), 16(12), 7163-7174, database is CAplus.

A logically synthesized ortho-phenylenediamine based chloro-Me disubstituted neutral organic bis-urea receptor L₁ with the aid of three symmetry-independent units encapsulates an unusual triangular [(chloride)₃-DMSO] guest assembly (complex 1a) via formation of DMSO + host + salt cocrystals within its trimeric paddle-wheel shaped cavity sealed by three n-TBA cations and exhibits diverse anion binding properties with oxyanions along with the chloride complex of its isomeric bromo-Me disubstituted bis-urea receptor L₂. Receptor L₂ and L₁ both form a similar kind of noncapsular 2:2 host-guest assembly in the presence of excess chloride (complex 2a) and acetate (complex 1b) resp. by noncooperative H-bonding interactions of urea groups which are attributed to the effect of meta-functionalization with respect to the adjacent N-H part of the urea moiety, whereas another planar oxyanion carbonate is doubly encapsulated within the tetrameric capsular cavity of L₁ in the solid state (complex 1c). Moreover, receptor L₂ conforms to a similar kind of cation sealed 2:1 host-guest pseudocapsular complex in the presence of larger coordinating anions such as tetrahedral sulfate (complex 2b) and octahedral hexafluorosilicate (complex 2c). ¹H NMR titration experiments are also performed using n-TBA/TEA salts of anions to investigate the solution state anion binding behavior of isomeric L₁ and L₂ and corroborate the results obtained in the solid-state studies.

Crystal Growth & Design published new progress about 17351-61-0. 17351-61-0 belongs to catalysis-chemistry, auxiliary class Phase Transfer Catalyst, name is Tetraethylammonium hydrogencarbonate, and the molecular formula is C9H21NO3, Synthetic Route of 17351-61-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Naganaboina, Ram Tilak published the artcileTrifluoroacetic acid-promoted Michael addition-cyclization reactions of vinylogous carbamates, Formula: C10H11NO4, the publication is Organic & Biomolecular Chemistry (2014), 12(21), 3366-3370, database is CAplus and MEDLINE.

A simple and efficient methodol. was developed for the synthesis of pyrrolobenzoxazine and 3-arylamino coumarin derivatives promoted by trifluoroacetic acid. The initial step in the current protocol involves a Michael addition of the 1,4-benzoxazinone derivatives, a novel class of vinylogous carbamates to the Michael acceptors and subsequent cyclization.

Organic & Biomolecular Chemistry published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, Formula: C10H11NO4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Notake, Takashi published the artcileSolution growth of high-quality organic N-benzyl-2-methyl-4-nitroaniline crystal for ultra-wideband tunable DFG-THz source, Safety of N-Benzyl-2-methyl-4-nitroaniline, the publication is Optical Materials Express (2012), 2(2), 119-125, database is CAplus.

We firstly obtained organic N-benzyl-2-methyl-4-nitroaniline (BNA) single crystals using solution growth method. The crystal quality obtained by solution growth method was much better than that of crystals grown by the Bridgman method. Furthermore, using difference frequency generation (DFG) in solution-grown BNA, we generated ultra-wideband tunable THz radiation.

Optical Materials Express published new progress about 201157-13-3. 201157-13-3 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Amine,Benzene, name is N-Benzyl-2-methyl-4-nitroaniline, and the molecular formula is C14H14N2O2, Safety of N-Benzyl-2-methyl-4-nitroaniline.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Tyrra, Wieland published the artcileOn the attempted synthesis of salts with the trimethyl[bis(pentafluorophenyl)]silicate ion, [Me₃Si(C₆F₅)₂]^–-A polyphenyl problem, Application of Trimethyl(perfluorophenyl)silane, the publication is Journal of Fluorine Chemistry (2005), 126(9-10), 1303-1306, database is CAplus.

Reactions of Me₃SiC₆F₅ and MF (M = Cs, [NMe₄]) in molar ratios varying from 1:1 to 2:1 in a temperature range between -70 ¡ãC and ambient proceed more or less selectively to form 1-H-perfluoro-4,4′-polyphenyls, 1-H(C₆F₄)_nF, independent of the solvent used (DME, THF). The silicates expected, M[Me₃Si(C₆F₅)F] and M[Me₃Si(C₆F₅)₂], were not detected even in low temperature NMR experiments The polymeric material formed was identified after aqueous working up as a mixture of 1-H(C₆F₄)_nF (n = 4-13) by elemental analyses and EI mass spectrometric studies.

Journal of Fluorine Chemistry published new progress about 1206-46-8. 1206-46-8 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Trimethyl(perfluorophenyl)silane, and the molecular formula is C15H14O3, Application of Trimethyl(perfluorophenyl)silane.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Panne, Patricia published the artcileCyanide initiated perfluoroorganylations with perfluoroorgano silicon compounds, Name: Trimethyl(perfluorophenyl)silane, the publication is Journal of Fluorine Chemistry (2001), 112(2), 283-286, database is CAplus.

Cyanophenylphosphines, Ph₂PCN or PhP(CN)₂, do not react with Me₃SiCF₃ or Me₃SiC₆F₅ in the absence of cyanide ions. Catalytic amounts of ionic cyanides such as [NEt₄]CN, [18-crown-6-K]CN or NaCN initiate perfluoroorganylation reactions. The trifluoromethylphosphines, Ph₂PCF₃ and PhP(CF₃)₂, as well as the pentafluorophenylphosphines, Ph₂PC₆F₅ and PhP(C₆F₅)₂, are isolated in 60-75% yield. In DMF or acetone solutions, side reactions are observed while reactions in CH₂Cl₂ and MeCN proceed selectively. Me₃SiCF₃ addition to the carbonyl groups of DMF and acetone occurs on treatment of Me₃SiCF₃ solutions of these solvents with catalytic amounts of cyanide, cyanate or thiocyanate salts even at low temperature The formation of the reactive silicate [Me₃Si(CN)CF₃]^– in reactions with an excess of [18-crown-6-K]CN is proved by low temperature NMR studies.

Journal of Fluorine Chemistry published new progress about 1206-46-8. 1206-46-8 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Trimethyl(perfluorophenyl)silane, and the molecular formula is C9H9F5Si, Name: Trimethyl(perfluorophenyl)silane.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Maggiarosa, Nicola published the artcileBis(pentafluorophenyl)xenon, Xe(C₆F₅)₂: a homoleptic diorganoxenon derivative, Name: Trimethyl(perfluorophenyl)silane, the publication is Angewandte Chemie, International Edition (2000), 39(24), 4588-4591, database is CAplus and MEDLINE.

Reaction of Me₃SiC₆F₅/[Me₄N]F with XeF₂ in propionitrile, propionitrile/acetonitrile, acetonitrile, or CH₂Cl₂ gave Xe(C₆F₅)₂, the first [10-Xe-2] with two xenon-carbon bond. When the same reaction was carried in 1:1 stoichiometry, C₆F₅XeF was formed predominantly. Reaction of C₆F₅XeF with Me₃SiOSO₂CF₃ gave [C₆F₅Xe]⁺OSO₂CF₃.

Angewandte Chemie, International Edition published new progress about 1206-46-8. 1206-46-8 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Trimethyl(perfluorophenyl)silane, and the molecular formula is C9H9F5Si, Name: Trimethyl(perfluorophenyl)silane.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Loescher, W. published the artcilePharmacological evaluation of various metabolites and analogs of valproic acid. Anticonvulsant and toxic potencies in mice, SDS of cas: 3115-28-4, the publication is Neuropharmacology (1985), 24(5), 427-35, database is CAplus and MEDLINE.

Thirty-two metabolites and analogs of the antiepileptic drug valproic acid (2-propylpentanoic acid) (VPA) were tested for anticonvulsant and toxic effects in mice, in an attempt to find out if any of these compounds were more potent than valproic acid. Valproic acid and ethosuximide, another clin. established antiepileptic drug, were included in these studies for comparison. After i.p. administration, the anticonvulsant potency of the various drugs was determined in 3 seizure tests: the threshold for maximal electroconvulsants, the maximal electroshock seizure test and seizures induced by s.c. injection of pentylenetetrazole. For the most potent compounds median minimal neurotoxic doses (TD₅₀s) and LD₅₀s (after i.p. and i.v. injection) were determined Valpramide??[2430-27-5], the primary amide of valproic acid, proved to be the most potent compound in the 3 seizure tests, used, being 2-5 times as potent as valproic acid, but valpramide was also considerably more sedative and toxic than valproic acid or ethosuximide. Of the metabolites of valproic acid tested, the unsaturated compounds 4-en-valproic?acid (4-en-VPA) [1575-72-0] and the trans-isomer of 2-en-valproic acid (2-en-VPA) [33786-47-9] were the most potent and, depending on the seizure test used, reached 60-100% of the efficacy of the parent drug. Both metabolites had LD₅₀ values which were similar or greater than those of valproic acid but they were more sedative than the parent compound Analogs of valproic acid with shorter side-chain lengths were only weakly active as anticonvulsants, whereas elongation of the side-chains led to increases in anticonvulsant cyclic compounds in which the side-chains have been closed to a ring were inactive or only weakly active. However, addition of a Me group in position 1 at the ring of cyclohexanoic acid markedly increased the anticonvulsant potency without altering LD₅₀ values. Similarly, introduction of an addnl. branching with a Me group at C2 of analogs of valproic acid led to considerable enhancement of anticonvulsant effectiveness. Although these methyl substituted compounds were more sedative than valproic acid, they seem to be interesting tools with regard to the structural prerequisites of anticonvulsant, toxic and teratogenic effects of branched fatty acids.

Neuropharmacology published new progress about 3115-28-4. 3115-28-4 belongs to catalysis-chemistry, auxiliary class Aliphatic Chain, name is 2-Butylhexanoic acid, and the molecular formula is C10H20O2, SDS of cas: 3115-28-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Meegan, Mary J. published the artcilePiperlongumine (piplartine) and analogues: Antiproliferative microtubule-destabilising agents, Safety of (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, the publication is European Journal of Medicinal Chemistry (2017), 453-463, database is CAplus and MEDLINE.

Piperlongumine (piplartine, 1) is a small mol. alkaloid that is receiving intense interest due to its antiproliferative and anticancer activities. We investigated the effects of 1 on tubulin and microtubules. Using both an isolated tubulin assay, and a combination of sedimentation and western blotting, we demonstrated that 1 is a tubulin-destabilizing agent. This result was confirmed by immunofluorescence and confocal microscopy, which showed that microtubules in MCF-7 breast cancer cells were depolymerized when treated with 1. We synthesized a number of analogs of 1 to explore structure-activity relationships. Compound 13 had the best cytotoxic profile of this series, showing potent effects in human breast carcinoma MCF-7 cells while being relatively non-toxic to non-tumorigenic MCF-10a cells. These compounds will be further developed as potential clin. candidates for the treatment of breast cancer.

European Journal of Medicinal Chemistry published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C11H12O4, Safety of (E)-3-(2,4-Dimethoxyphenyl)acrylic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Deo, Namita published the artcileBiodegradation of some organic flotation reagents by Bacillus polymyxa, Formula: C14H31NO2, the publication is Bioremediation Journal (1998), 2(3-4), 205-214, database is CAplus.

The soil bacterium, Bacillus polymyxa, is shown to effectively remove organic flotation collectors such as dodecyl amine, diamine, sodium iso-Pr xanthate, and sodium oleate from alk. solutions Adsorption and bacterial growth studies indicated enhanced surface affinity of the amine collectors toward the bacterial cells. All the organic reagents were efficiently removed from alk. solutions through bacterial interaction. UV-visible and Fourier transform IR spectra during biodegradation of these reagents revealed the stages in biodegradation Possible mechanisms are outlined.

Bioremediation Journal published new progress about 2016-56-0. 2016-56-0 belongs to catalysis-chemistry, auxiliary class Active Esterification, name is Dodecylamineacetate, and the molecular formula is C14H31NO2, Formula: C14H31NO2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Deo, Namita published the artcileBiodegradation of some organic reagents from mineral process effluents, HPLC of Formula: 2016-56-0, the publication is Process Metallurgy (1999), 687-696, database is CAplus.

Bacillus polymyxa were studied for the removal of organics such as dodecylamine, ether diamine, iso-Pr xanthate and Na oleate from wastewater. Time-bound removal of these organics from an alk. solution was studied under different exptl. conditions during bacterial growth and in the presence of metabolites by frequent monitoring of residual concentrations as a function of time, reagent concentration and cell d. The stages and mechanisms in the biodegradation process were monitored through UV-visible and FTIR spectroscopy. Surface chem. of the bacterial cells as well as the biosorption tendency for various organics were established through electrokinetic and adsorption d. measurements. Cationic amines were biosorbed followed by their degradation through bacterial metabolism The presence of the organics promoted bacterial growth through effective bacterial utilization of N and C from the organics Under optimal conditions, complete degradation and bioremoval of all the organics could be achieved.

Process Metallurgy published new progress about 2016-56-0. 2016-56-0 belongs to catalysis-chemistry, auxiliary class Active Esterification, name is Dodecylamineacetate, and the molecular formula is C14H31NO2, HPLC of Formula: 2016-56-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia