Month: December 2022

Lee, Kyeong published the artcileDiscovery of a novel series of benzimidazole derivatives as diacylglycerol acyltransferase inhibitors, SDS of cas: 1798-04-5, the publication is Bioorganic & Medicinal Chemistry Letters (2012), 22(24), 7456-7460, database is CAplus and MEDLINE.

A novel series of benzimidazole derivatives was prepared and evaluated for their diacylglycerol acyltransferase (DGAT) inhibitory activity using microsome from rat liver. Among the newly synthesized compounds, a furfurylamine containing benzimidazole carboxamide showed the most potent DGAT inhibitory effect (IC₅₀= 4.4 ¦ÌM) and inhibited triglyceride formation in HepG2 cells.

Bioorganic & Medicinal Chemistry Letters published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C12H16O3, SDS of cas: 1798-04-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Burleson, Garrett Lee published the artcileForensic analysis of a single particle of partially burnt gunpowder by solid phase micro-extraction-gas chromatography-nitrogen phosphorus detector, SDS of cas: 1821-27-8, the publication is Journal of Chromatography A (2009), 1216(22), 4679-4683, database is CAplus and MEDLINE.

Solid phase micro-extraction (SPME) was adopted to extract organic gun shot residues (OGSRs) from a single particle of partially burnt gunpowder. The partially burnt particle samples were collected from gun shot residue (GSR) deposited near the target areas. OGSRs, such as diphenylamine (DPA), methyl centralite (MC), Et centralite (EC), from only one single particle of partially burnt gunpowder were successfully extracted by SPME and analyzed by a gas chromatog. coupled to a nitrogen phosphorus detector (GC-NPD). The results confirmed that the new extraction procedure is capable of extracting trace amount of MC and EC as signature mols. for the identification of GSR. The method represents a solvent-free extraction as a complementary anal. procedure for the forensic anal. of GSR-related evidences. The new extraction scheme with the capability of analyzing single particle of partially burnt gunpowder can also be applied to the identification of explosive residues, such as in post-blast investigations of improvised explosive devices.

Journal of Chromatography A published new progress about 1821-27-8. 1821-27-8 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Amine,Benzene, name is Bis(4-nitrophenyl)amine, and the molecular formula is C12H9N3O4, SDS of cas: 1821-27-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Huang, Jiarong published the artcileA stretchable elastomer with recyclability and shape memory assisted self-healing capabilities based on dynamic disulfide bonds, Name: 2,2′-Dithiodibenzoic acid, the publication is Polymer (2022), 124569, database is CAplus.

Shape memory assisted self-healing (SMASH) material is a kind of smart materials that can automatically close local microscopic cracks and heal those cracks by bonding the damaged surfaces. Here, the authors designed a SMASH elastomer via introducing polylactide (PLA) and disulfide bonds into the epoxidized natural rubber (ENR). PLA chains were interspersed in ENR network as control switch to fix or release the temporary shape, providing ENR with enhanced mech. strength and shape memory properties. After achieving the phys. contact of crack surfaces by intrinsic shape memory, the exchange reaction of disulfide bonds healed the damaged area at elevated temperature Meanwhile, the dynamic feature of disulfide bonds endowed ENR with recyclability, which could be further promoted by the thermoplasticity of PLA phase. Addnl., the authors also verified the feasibility of this strategy in designing PLA/ENR thermoplastic vulcanizate with SMASH behavior via dynamic vulcanization, expanding the research scope of self-healing elastomers and dynamic vulcanization.

Polymer published new progress about 119-80-2. 119-80-2 belongs to catalysis-chemistry, auxiliary class sulfides,Carboxylic acid,Benzene, name is 2,2′-Dithiodibenzoic acid, and the molecular formula is C14H10O4S2, Name: 2,2′-Dithiodibenzoic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Li, Xiong published the artcileThe influence of isomerism on the self-assembly behavior and complexation property of 1,3-alternate tetraaminopyridyl-thiacalix[4]arene derivatives, Synthetic Route of 1798-04-5, the publication is Tetrahedron (2008), 64(27), 6230-6237, database is CAplus.

A series of 1,3-alternate conformation thiacalix[4]arenes containing different isomeric aminopyridyl pendent arms have been synthesized. It was found that their self-assembly behaviors and complexation properties strongly depended on the structures of aminopyridyl pendent arms. The crystal structures demonstrate that tetra(meta-aminopyridyl)-thiacalix[4]arene motif is capable of forming intramol. hydrogen bondings between the sp² nitrogen donors in the meta position of the aminopyridyl groups and the facing amide N-H of the adjacent aminopyridyl groups, and self-assembles via C-H¡¤¡¤¡¤O weak hydrogen bondings and C-H¡¤¡¤¡¤¦Ð interaction to generate a double stranded rectilineal networks. By contrast, in the case of tetra(para-aminopyridyl)-thiacalix[4]arene, the presence of para-aminopyridyl units enables the formation of N-H¡¤¡¤¡¤N strong hydrogen bondings between the individual mols. leading to the solid-state structure with water-bridged double strands. Their complexation properties had been also studied by measurement of the stability constants for their complexation in a range of metal cations and investigation of their binding models via ¹H NMR titration and ESI-MS experiments It was found that the three ligands exhibited high and selective extractability toward Ag⁺, and their stoichiometry of ligand to Ag⁺ was 1:1, while the meta-aminopyridyl derivative showed the best extraction capacity and possessed the most efficient binding sites.

Tetrahedron published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C12H16O3, Synthetic Route of 1798-04-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wang, Lin published the artcileFormal Total Synthesis of N-Methylmaysenine, SDS of cas: 4141-48-4, the publication is Organic Letters (2009), 11(8), 1809-1812, database is CAplus and MEDLINE.

A novel synthetic approach for the formal total synthesis of N-methylmaysenine has been developed through the asym. synthesis of I. Key steps involve the Ti-mediated vinylogous Mukaiyama aldol reaction of chiral ketene silyl N,O-acetal with ¦Â-dithiane-substituted aldehyde, an aldol condensation, and a ring-closing metathesis reaction.

Organic Letters published new progress about 4141-48-4. 4141-48-4 belongs to catalysis-chemistry, auxiliary class Aryl phosphine ligand,Mono-phosphine Ligands, name is Allyldiphenylphosphine oxide, and the molecular formula is C10H16O2, SDS of cas: 4141-48-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Li, Huaifeng published the artcileDiverse catalytic reactivity of a dearomatized PN³P*-nickel hydride pincer complex towards CO₂ reduction, Synthetic Route of 2909-77-5, the publication is Chemical Communications (Cambridge, United Kingdom) (2018), 54(81), 11395-11398, database is CAplus and MEDLINE.

A dearomatized PN³P*-nickel hydride complex has been prepared using an oxidative addition process. The first nickel-catalyzed hydrosilylation of CO₂ to methanol has been achieved, with unprecedented turnover numbers Selective methylation and formylation of amines with CO₂ were demonstrated by such a PN³P*-nickel hydride complex, highlighting its versatile functions in CO₂ reduction

Chemical Communications (Cambridge, United Kingdom) published new progress about 2909-77-5. 2909-77-5 belongs to catalysis-chemistry, auxiliary class Amine,Benzene, name is 2,6-Diisopropyl-N,N-dimethylaniline, and the molecular formula is C14H23N, Synthetic Route of 2909-77-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Ferreira, Everton Geraldo Capote published the artcileRevealing potential functions of hypothetical proteins induced by genistein in the symbiosis island of Bradyrhizobium japonicum commercial strain SEMIA 5079 (= CPAC 15), HPLC of Formula: 63-68-3, the publication is BMC Microbiology (2022), 22(1), 122, database is CAplus and MEDLINE.

Bradyrhizobium japonicum strain SEMIA 5079 (= CPAC 15) is a nitrogen-fixing symbiont of soybean broadly used in com. inoculants in Brazil. Its genome has about 50% of hypothetical (HP) protein-coding genes, many in the symbiosis island, raising questions about their putative role on the biol. nitrogen fixation (BNF) process. This study aimed to infer functional roles to 15 HP genes localized in the symbiosis island of SEMIA 5079, and to analyze their expression in the presence of a nod-gene inducer. A workflow of bioinformatics tools/databases was established and allowed the functional annotation of the HP genes. Most were enzymes, including transferases in the biosynthetic pathways of cobalamin, amino acids and secondary metabolites that may help in saprophytic ability and stress tolerance, and hydrolases, that may be important for competitiveness, plant infection, and stress tolerance. Putative roles for other enzymes and transporters identified are discussed. Some HP proteins were specific to the genus Bradyrhizobium, others to specific host legumes, and the anal. of orthologues helped to predict roles in BNF. All 15 HP genes were induced by genistein and high induction was confirmed in five of them, suggesting major roles in the BNF process.

BMC Microbiology published new progress about 63-68-3. 63-68-3 belongs to catalysis-chemistry, auxiliary class Natural product, name is (S)-2-Amino-4-(methylthio)butanoic acid, and the molecular formula is C5H11NO2S, HPLC of Formula: 63-68-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Silavwe, Ned D. published the artcileReduction of carbon dioxide and other substrates using photochemical reactions of the decacarbonylditungstate(2-) complex, Safety of Tetrabutylammonium hydrogencarbonate, the publication is Inorganic Chemistry (1989), 28(7), 1231-6, database is CAplus.

The photochem. of W₂(CO)₁₀^2- was studied with the goal of determining if irradiation of this dimer generates a powerful reducing agent, presumably a 19-electron species. In general, the photochem. of W₂(CO)₁₀^2- is comparable to that of other metal-metal-bonded carbony dimers. Irradiation into the low-energy tail of the d¦Ð ¡ú ¦Ò^* electronic transition of W₂(CO)₁₀^2- led to W-W bond homolysis. The resulting 17-electron W(CO)₅^– radicals could be trapped with suitable ligands such as 4-cyanopyridine to give 19-electron adducts [adducts that form when 17-electron radicals react with 2-electron ligands]. Evidence is presented that PPh₃ and PBu₃ also react with photogenerated W(CO)₅^– to form adducts: W(CO)₅^– + PR₃ ¡ú W(CO)₅PR₃^–. These adducts are powerful reducing agents, and they were used to reduce CO₂ to formate and CO. The only organometallic product formed in the reaction was W(CO)₅PPh₃, the oxidized form of the 19-electron complex. In a similar manner, Mn₂(CO)₁₀ was reduced to Mn(CO)₅^–, Cp₂Co⁺ to Cp₂Co, benzophenone to the radical anion, and methylviologen (MV²⁺) to MV⁺. Alternative reduction mechanisms involving the W(CO)₅^– radical, W(CO)₅^2-, or HW₂(CO)₁₀^– as reductants were shown not to be operating. Nineteen-electron complexes generated by irradiation of Cp₂Mo₂(CO)₆ proved incapable of reducing CO₂.

Inorganic Chemistry published new progress about 17351-62-1. 17351-62-1 belongs to catalysis-chemistry, auxiliary class Salt,Amine, name is Tetrabutylammonium hydrogencarbonate, and the molecular formula is C15H12O6, Safety of Tetrabutylammonium hydrogencarbonate.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Vasilopoulos, Aristidis published the artcileCopper-Catalyzed C-H Fluorination/Functionalization Sequence Enabling Benzylic C-H Cross Coupling with Diverse Nucleophiles, Synthetic Route of 457-68-1, the publication is Organic Letters (2020), 22(15), 5753-5757, database is CAplus and MEDLINE.

Alkylbenzenes underwent regioselective fluorination with N-fluorobenzenesulfonimide in the presence of CuOAc and bathophenanthroline mediated by methylboronic acid and lithium carbonate in chlorobenzene to yield secondary and tertiary benzylic fluorides. The benzylic fluorides generated in these reactions were reactive electrophiles in the presence of the hydrogen-bond donor hexafluoroisopropanol or the Lewis acid BF₃¡¤Et₂O, yielding benzylic ethers, alcs., protected amines, and diarylalkanes directly from the alkylarenes.

Organic Letters published new progress about 457-68-1. 457-68-1 belongs to catalysis-chemistry, auxiliary class Fluoride,Benzene, name is Bis(4-fluorophenyl)methane, and the molecular formula is C22H23BO4, Synthetic Route of 457-68-1.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Chen, Si-Jie published the artcileCopper-Catalyzed Cross-Coupling of Benzylic C-H Bonds and Azoles with Controlled N-Site Selectivity, Safety of Bis(4-fluorophenyl)methane, the publication is Journal of the American Chemical Society (2021), 143(36), 14438-14444, database is CAplus and MEDLINE.

A copper-catalyzed method that achieves site-selective cross-coupling of pyrazoles and other N-H heterocycles with substrates bearing (hetero)benzylic C-H bonds was reported. Excellent N-site selectivity was achieved, with preferred site controlled by identity of co-catalytic additives. This cross-coupling strategy featured broad scope for both N-H heterocycle and benzylic C-H coupling partners, enabling application of this method to complex mol. synthesis and medicinal chem.

Journal of the American Chemical Society published new progress about 457-68-1. 457-68-1 belongs to catalysis-chemistry, auxiliary class Fluoride,Benzene, name is Bis(4-fluorophenyl)methane, and the molecular formula is C13H10F2, Safety of Bis(4-fluorophenyl)methane.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia