Month: December 2022

Liu, Zheng-Tang published the artcileTitanium, aluminum and zinc complexes containing diamine-bis(benzotriazole phenolate) ligands: Synthesis, structural characterization and catalytic studies for ring-opening polymerization of ¦Å-caprolactone, Synthetic Route of 140-28-3, the publication is Journal of Molecular Structure (2017), 395-403, database is CAplus.

Structurally diverse metal complexes bearing diamine-bis(benzotriazole phenolate) (DiBTP) ligands were synthesized and fully characterized by single crystal x-ray crystallog. The reaction of Ti(OⁱPr)₄ with ^C8MEADiBTP-H₂ or ^C8BEADiBTP-H₂ (1.0 mol equivalent) generated the monomeric Ti alkoxy complexes [(^C8MEADiBTP)Ti(OⁱPr)₂] (1) and [(^C8BEADiBTP)Ti(OⁱPr)₂] (2), resp. Also, ^C8BEADiBTP-H₂ reacted with 2.0 molar equivalent of AlMe₃ to give the tetracoordinated di-Al complex [(^C8BEADiBTP)Al₂Me₄] (3). Zn complex [(^C8BEADiBTP)Zn₂Et₂] (4) could be obtained by the alkane elimination of ZnEt₂ (2.0 equiv) with ^C8BEADiBTP-H₂ as the pro-ligand under similar synthetic methods in good yield. Single-crystal x-ray diffraction indicates that 3 is a bimetallic Al di-Me complex with a tetradentate ^C8BEADiBTP moiety chelating two metal atoms, whereas complex 4 displays the dinuclear feature containing both tetra- and pentacoordinated Zn atoms bonded by one ONNON-pentadentate ^C8BEADiBTP ligand. Catalytic studies for ring-opening polymerization of ¦Å-caprolactone of complex 1–4 were systematic explored; the comparative studies of such polymerization are also discussed.

Journal of Molecular Structure published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, Synthetic Route of 140-28-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Feng, Yu-Xi published the artcileImplications of the fate of hydrogen sulfide derived from assimilation of thiocyanate in rice plants, Name: (S)-2-Amino-4-(methylthio)butanoic acid, the publication is Chemosphere (2022), 135500, database is CAplus and MEDLINE.

Thiocyanate (SCN-) is a sulfur-containing pollutant, which is frequently detected in irrigation water and has neg. effects on plant growth and crop yields. Uptake and assimilation of exogenous SCN- in rice plants was evident, in which two metabolic pathways, carbonyl sulfide (COS) and cyanate (CNO), are activated. Hydrogen sulfide (H2S) is an important concomitant derived from detoxification of exogenous SCN- in rice plants, which may cause coupling action on the endogenous source of H2S from sulfur metabolism Since H2S has dual regulatory effects, the fate of H2S derived from assimilation of SCN- in plants is critical for clarifying the inclusiveness of H2S in various physiol. activities. In fact, application of exogenous H2S not only pos. changed the root phenotype traits of SCN–treated seedlings, but also effectively mitigated the toxic effects of SCN- in rice seedlings by stimulating the process of the PSII repair cycle. In this study, it is tempting to analyze and clarify the flux of the concomitant production of H2S from assimilation of exogenous SCN- into the innate pool, which may function in signaling regulation and other physiol. processes in rice plants. This study would update our understanding of the fate of H2S derived from assimilation of SCN- in plants and provide new insights into the affirmative actions of H2S in direct proximity to SCN- exposure.

Chemosphere published new progress about 63-68-3. 63-68-3 belongs to catalysis-chemistry, auxiliary class Natural product, name is (S)-2-Amino-4-(methylthio)butanoic acid, and the molecular formula is C5H11NO2S, Name: (S)-2-Amino-4-(methylthio)butanoic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Yu, Ming-jun published the artcileStructure-activity relationship studies on Pd176252 derivatives leading to discovery of novel GRP receptor antagonist with potent anticancer activity, Recommanded Product: 4-Nitrophenylacetic acid, the publication is Medicinal Chemistry Research (2021), 30(11), 2069-2089, database is CAplus.

Abstract: Gastrin-releasing peptide (GRP)/gastrin-releasing peptide receptor (GRPR) have various physiol. effects, and many studies report that GRPR is a potential anticancer target. Pd176252 is a typical small-mol. GRPR antagonist that exhibits anti-proliferation activity against most cancers. In this study, 31 novel Pd176252 analogs were designed, synthesized, and evaluated for anti-proliferation activity against human prostate cancer (PC3), mouse pancreatic cancer (Pan02), human gastric cancer (HGC-27), and hepatocellular carcinoma (HepG2) cell lines. Of all the compounds evaluated, 5a and 6e showed better anti-proliferation activity compared to Pd176252 against PC3 (half-maximal inhibitory concentration [IC50] = 4.97 and 9.88 ¦ÌM, resp.), Pan02 (IC50 = 4.36 and 2.50 ¦ÌM, resp.), and HGC-27 (IC50 = 4.36 and 2.50 ¦ÌM, resp.), cell lines. Moreover, combining 5a or 6e with a histone deacetylase (HDAC) inhibitor further improved the in vitro anti-proliferation activity. Further research showed that 5a caused HGC-27 cell apoptosis by downregulating Bcl-2 and upregulating Bax. In addition, a mol. docking anal. showed that compounds 5a and 6e could bind to GRPR. In conclusion, compounds 5a and 6e are novel GRPR antagonists with potent anticancer activity. [graphic not available: see fulltext]

Medicinal Chemistry Research published new progress about 104-03-0. 104-03-0 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Carboxylic acid,Benzene, name is 4-Nitrophenylacetic acid, and the molecular formula is C20H28B2O4S2, Recommanded Product: 4-Nitrophenylacetic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zhang, Yanhui published the artcileRegulation of MRI contrast and cellular retention time by cellular interfacial distribution of Gd agents: Implications for stem cell tracking, Recommanded Product: Fmoc-Pro-OH, the publication is Magnetic Resonance Letters (2022), 2(1), 48-55, database is CAplus.

Human mesenchymal stem cells (hMSCs) were labeled with Dotarem or (Gd-DOTA)2- EM7 (EM7Gd2) via electroporation (EP). Cellular transmission electron microscopy (TEM) reveals free distribution of Gd agents and formation of EM7Gd2 clusters in the cytosol. Cellular magnetic resonance imaging (MRI) reveals that the free Gd agents induce MRI signal enhancement effect due to its fast exocytosis and subsequent interaction with intercellular water mols. The EM7Gd2 clusters exhibits a longer intracellular retention time and induce a persistent MRI signal reduction effect. The cellular MRI results are interpreted by taking into account both T1 and T2 relaxation rates and their correlation with cellular binding structures of Dotarem and EM7Gd2.

Magnetic Resonance Letters published new progress about 71989-31-6. 71989-31-6 belongs to catalysis-chemistry, auxiliary class Amino acide derivatives,pyrrolidine, name is Fmoc-Pro-OH, and the molecular formula is C9H9BO2, Recommanded Product: Fmoc-Pro-OH.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Thorburn Burns, D. published the artcileSystematic approach to the identification of water-gel explosives, Recommanded Product: Dodecylamineacetate, the publication is Analytica Chimica Acta (1998), 375(3), 255-260, database is CAplus.

Anal. procedures are described for qual. and quant. characterization of water-gel (slurry) explosives by way of identification of major constituents (i.e., Al, Na⁺, Ca²⁺, NH₄⁺, CH₃NH₃⁺, NO₃^–, laurylamine acetate), using gravimetry (for Al), reversed-phase liquid chromatog. after benzoyl chloride derivatization (for ethylene glycol), ion chromatog. with cation and anion anal. (for inorganic materials), and electrospray mass spectrometry for detection of laurylamine acetate. Three explosive samples of similar composition were discriminated using this systematic approach.

Analytica Chimica Acta published new progress about 2016-56-0. 2016-56-0 belongs to catalysis-chemistry, auxiliary class Active Esterification, name is Dodecylamineacetate, and the molecular formula is C9H7NO2, Recommanded Product: Dodecylamineacetate.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Cupane, A. published the artcileTwo-dimensional electronic spectroscopy signatures of the glass transition, Computed Properties of 10510-54-0, the publication is Spectroscopy (Amsterdam, Netherlands) (2010), 24(3,4), 393-397, database is CAplus.

Two-dimensional electronic spectroscopy is a sensitive probe of solvation dynamics. Using a pump-probe geometry with a pulse shaper [Optics Express 15 (2007), 16681-16689; Optics Express 16 (2008), 17420-17428], we present temperature dependent 2D spectra of laser dyes dissolved in glass-forming solvents. At low waiting times, the system has not yet relaxed, resulting in a spectrum that is elongated along the diagonal. At longer times, the system loses its memory of the initial excitation frequency, and the 2D spectrum rounds out. As the temperature is lowered, the time scale of this relaxation grows, and the elongation persists for longer waiting times. This can be measured in the ratio of the diagonal width to the anti-diagonal width; the behavior of this ratio is representative of the frequency-frequency correlation function [Optics Letters 31 (2006), 3354-3356]. Near the glass transition temperature, the relaxation behavior changes. Understanding this change is important for interpreting temperature-dependent dynamics of biol. systems.

Spectroscopy (Amsterdam, Netherlands) published new progress about 10510-54-0. 10510-54-0 belongs to catalysis-chemistry, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Inhibitor,Inhibitor, name is 5,9-Diaminobenzo[a]phenoxazin-7-ium acetate, and the molecular formula is C18H15N3O3, Computed Properties of 10510-54-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Frohn, H.-J. published the artcileReactions of methyl(pentafluorophenyl)- and methyl(pentafluorophenyl)phenylsilanes with electrophiles. A convenient preparative route to halo(methyl)pentafluorophenylsilanes C₆F₅SiMe₂X and C₆F₅SiMeX₂ (X = F, Cl and Br), Application In Synthesis of 1206-46-8, the publication is Journal of Organometallic Chemistry (1998), 570(2), 255-263, database is CAplus.

Halo(methyl)pentafluorophenylsilanes C₆F₅SiMe_nX_3-n (n = 1, 2) (X = F, Cl, Br) were prepared in good yields from the corresponding phenylsilanes C₆F₅SiMe_nPh_3-n by reactions with the electrophiles anhydrous HF, HCl-AlCl₃, Br₂-AlBr₃ or AlX₃ (X = Cl, Br) in halogenated hydrocarbons. Addnl., reactions of C₆F₅SiMe₃ and (C₆F₅)₂SiMe₂ with selected electrophiles were studied.

Journal of Organometallic Chemistry published new progress about 1206-46-8. 1206-46-8 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Trimethyl(perfluorophenyl)silane, and the molecular formula is C9H9F5Si, Application In Synthesis of 1206-46-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Klug, Stephan published the artcileEffects of valproic acid, some of its metabolites and analogs on prenatal development of rats in vitro and comparison with effects in vivo, COA of Formula: C10H20O2, the publication is Archives of Toxicology (1990), 64(7), 545-53, database is CAplus and MEDLINE.

Using a whole-embryo culture system, valproic acid (VPA) and some of its metabolites and analogs were tested for their teratogenic effects. With regard to embryonic growth, development, and abnormality rate, the tested compounds showed a wide range of teratogenic potency in vitro. Pregnant rats were also treated s.c. on day 10 of gestation with 2 ¡Á 330 mg VPA/kg or 2 ¡Á 400 mg 2-en-VPA/kg. Evaluation of the embryos was performed on day 11.5 of gestation, corresponding to the in vitro experiments VPA showed a high potential to induce abnormal development in vivo as well as in vitro, whereas 2-en-VPA was inactive. The predictive value of an in vitro test system for the detection of embryotoxic effects, such as validation and significance of pharmacokinetic data, are discussed.

Archives of Toxicology published new progress about 3115-28-4. 3115-28-4 belongs to catalysis-chemistry, auxiliary class Aliphatic Chain, name is 2-Butylhexanoic acid, and the molecular formula is C10H20O2, COA of Formula: C10H20O2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Koritzer, Richard T. published the artcileEnhanced fluoride penetration and retention in enamel, Product Details of C12H10F2Si, the publication is Caries Research (1979), 13(5), 259-64, database is CAplus and MEDLINE.

Fluorosilanes enhanced the retention and improved the penetration of fluoride into enamel in vitro. The efficacy of this treatment seemed to lie in its ability to utilize the enamel organic network as a conduit to increase the enamel prism surface area accessible to reaction with fluoride. Thus, silanes may be effective as a vehicle to transport fluoride via the organic network to loci best suited for therapeutic effectiveness.

Caries Research published new progress about 312-40-3. 312-40-3 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Difluorodiphenylsilane, and the molecular formula is C12H10F2Si, Product Details of C12H10F2Si.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Mayrand, Robert R. published the artcileUrea and ethylene glycol-facilitated transport systems in the human red cell membrane. Saturation, competition, and asymmetry, Name: 1,1-Dimethylthiourea, the publication is Journal of General Physiology (1983), 81(2), 221-37, database is CAplus and MEDLINE.

The equilibrium exchange of [¹⁴C]urea and ethylene glycol was measured using a new type of fast flow system. Approx. equal volumes of saline and air were mixed to form a segmented fluid stream into which ¹⁴C-loaded red cells are injected. The stream flows through 3 filter chambers which allow sampling of the ¹⁴C in the extracellular fluid at 3 time points. The chambers are designed so that they do not disrupt the segmented bubble pattern. The alternating air and saline segments prevent laminar dispersion in the flowing stream and ensure good mixing at the injection and sampling sites. The equilibrium exchange of both urea and ethylene glycol showed saturation kinetics. The maximum permeability (P₀) measured in the limit of zero solute concentration is 1.16 ¡Á 10^-3 cm/s for urea and 4.8 ¡Á 10^-4 cm/s for ethylene glycol (23¡ã). The apparent dissociation constant (K_m) was 218 mM for urea and 175 mM for ethylene glycol. The P₀ for thiourea is 2.3 ¡Á 10^-6 cm/s and the K_m is 19 mM. Urea and thiourea inhibit the transport of each other and the inhibition constant (K_i) is approx. equal to the K_m for both compounds Fifty-three other analogs of urea were screened for their inhibition of urea or thiourea transport. Several analogs [e.g., 1-(3,4-dichloro-phenyl)-2-thiorea] had a K_i in the range of 0.03 mM. The affinity of the inhibitor increased as it was made more hydrophobic. The urea analogs did not significantly inhibit the ethylene glycol or osmotic permeability. Glycerol inhibited ethylene glycol permeability with a K_i of 1200 mM.

Journal of General Physiology published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C3H8N2S, Name: 1,1-Dimethylthiourea.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia